X0508 4 2026-02-25 0000078003 PFIZER INC PFE 0001817124 SAHNI PAYAL 66 HUDSON BOULEVARD EAST ATTN: CORPORATE SECRETARY NEW YORK NY 10001-2192 1 Executive Vice President 0 Common Stock 2026-02-25 4 M 0 56888.0000 33.8200 A 82816.0000 D Common Stock 2026-02-25 4 F 0 1083.0000 27.0900 D 81733.0000 D Common Stock 2026-02-25 4 F 0 54066.0000 26.9200 D 27667.0000 D Common Stock 14630.0000 I By Rule 16b-3 Plan Stock Appreciation Rights 33.8200 2026-02-25 4 M 0 56888.0000 0.0000 D 2026-02-25 2026-02-25 Common Stock 56888.0000 0.0000 D The reported transaction constitutes the earn-out of stock appreciation rights (including dividend equivalents thereon). The reported transaction constitutes the withholding of shares to satisfy tax obligations in connection with earn-out of stock appreciation rights. The reported transaction constitutes the withholding of shares to cover payment of exercise price in connection with earn-out of stock appreciation rights (including dividend equivalents thereon). Under the terms of the settlement of the stock appreciation rights the 20-day average of the closing prices of Pfizer common stock ending on the settlement date is used. /s/ Shanice A. Reid, by power of atty, for Payal Sahni 2026-02-27