<?xml version="1.0" encoding="UTF-8"?><sch:edgarSubmission xmlns:sch="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <sch:schemaVersion>X0202</sch:schemaVersion>
<sch:headerData>
    <sch:submissionType>SCHEDULE 13G/A</sch:submissionType>
    <sch:previousAccessionNumber>0001738048-26-000026</sch:previousAccessionNumber>
    <sch:filerInfo>
      <sch:filer>
        <sch:filerCredentials>
          <sch:cik>0000078003</sch:cik>
          <sch:ccc>XXXXXXXX</sch:ccc>
        </sch:filerCredentials>
      </sch:filer>
      <sch:liveTestFlag>LIVE</sch:liveTestFlag>



    </sch:filerInfo>
  </sch:headerData>
  <sch:formData>
    <sch:coverPageHeader>
      <sch:amendmentNo>1</sch:amendmentNo>
      <sch:securitiesClassTitle>Common Stock par value  $0.0001 per share</sch:securitiesClassTitle>
      <sch:eventDateRequiresFilingThisStatement>03/31/2026</sch:eventDateRequiresFilingThisStatement>
      <sch:issuerInfo>
        <sch:issuerCik>0001796280</sch:issuerCik>
        <sch:issuerName>ORIC Pharmaceuticals, Inc.</sch:issuerName>
        <sch:issuerCusips>
          <sch:issuerCusipNumber>68622P109</sch:issuerCusipNumber>
        </sch:issuerCusips>
        <sch:issuerPrincipalExecutiveOfficeAddress>
          <com:street1>240 E. Grand Ave., 2nd Floor</com:street1>
          <com:city>South San Francisco</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94080</com:zipCode>
        </sch:issuerPrincipalExecutiveOfficeAddress>
      </sch:issuerInfo>
      <sch:designateRulesPursuantThisScheduleFiled>
        <sch:designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</sch:designateRulePursuantThisScheduleFiled>
      </sch:designateRulesPursuantThisScheduleFiled>
    </sch:coverPageHeader>
    <sch:coverPageHeaderReportingPersonDetails>


      <sch:reportingPersonName>Pfizer Inc. (IRS Identification No.: 13-5315170)</sch:reportingPersonName>
      <sch:citizenshipOrOrganization>DE</sch:citizenshipOrOrganization>
      <sch:reportingPersonBeneficiallyOwnedNumberOfShares>
        <sch:soleVotingPower>3442940.00</sch:soleVotingPower>
        <sch:sharedVotingPower>0.00</sch:sharedVotingPower>
        <sch:soleDispositivePower>3442940.00</sch:soleDispositivePower>
        <sch:sharedDispositivePower>0.00</sch:sharedDispositivePower>
      </sch:reportingPersonBeneficiallyOwnedNumberOfShares>
      <sch:reportingPersonBeneficiallyOwnedAggregateNumberOfShares>3442940.00</sch:reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <sch:aggregateAmountExcludesCertainSharesFlag>N</sch:aggregateAmountExcludesCertainSharesFlag>
      <sch:classPercent>3.3</sch:classPercent>
      <sch:typeOfReportingPerson>CO</sch:typeOfReportingPerson>
      <sch:comments>Percent of class outstanding represented by the amount in row (11) is based on a total of 103,517,562 shares of common stock outstanding as of April 27, 2026, as reported on the cover of the Issuer's quarterly report on Form 10-Q for the quarterly period ended March 31, 2026 filed by the Issuer with the U.S. Securities and Exchange Commission on May 4, 2026.</sch:comments>
    </sch:coverPageHeaderReportingPersonDetails>
    <sch:items>
      <sch:item1>
        <sch:issuerName>ORIC Pharmaceuticals, Inc.</sch:issuerName>
        <sch:issuerPrincipalExecutiveOfficeAddress>240 E. Grand Ave., 2nd Floor, South San Francisco, California, 94080</sch:issuerPrincipalExecutiveOfficeAddress>
      </sch:item1>
      <sch:item2>
        <sch:filingPersonName>Pfizer Inc.</sch:filingPersonName>
        <sch:principalBusinessOfficeOrResidenceAddress>66 Hudson Boulevard East, New York, NY10001-2192</sch:principalBusinessOfficeOrResidenceAddress>
        <sch:citizenship>Delaware</sch:citizenship>
      </sch:item2>
      <sch:item3>
        <sch:notApplicableFlag>Y</sch:notApplicableFlag>
      </sch:item3>
      <sch:item4>
        <sch:amountBeneficiallyOwned>See the respective responses of the Reporting Persons to Item 9 on the attached cover pages.</sch:amountBeneficiallyOwned>
        <sch:classPercent>See the respective responses of the Reporting Persons to Item 11 on the attached cover pages.</sch:classPercent>
        <sch:numberOfSharesPersonHas>
          <sch:solePowerOrDirectToVote>See the respective responses of the Reporting Persons to Item 5 on the attached cover pages.</sch:solePowerOrDirectToVote>
          <sch:sharedPowerOrDirectToVote>See the respective responses of the Reporting Persons to Item 6 on the attached cover pages.</sch:sharedPowerOrDirectToVote>
          <sch:solePowerOrDirectToDispose>See the respective responses of the Reporting Persons to Item 7 on the attached cover pages.</sch:solePowerOrDirectToDispose>
          <sch:sharedPowerOrDirectToDispose>See the respective responses of the Reporting Persons to Item 8 on the attached cover pages.</sch:sharedPowerOrDirectToDispose>
        </sch:numberOfSharesPersonHas>
      </sch:item4>
      <sch:item5>
        <sch:notApplicableFlag>N</sch:notApplicableFlag>
        <sch:classOwnership5PercentOrLess>Y</sch:classOwnership5PercentOrLess>
      </sch:item5>
      <sch:item6>
        <sch:notApplicableFlag>N</sch:notApplicableFlag>
        <sch:ownershipMoreThan5PercentOnBehalfOfAnotherPerson>Not applicable</sch:ownershipMoreThan5PercentOnBehalfOfAnotherPerson>
      </sch:item6>
      <sch:item7>
        <sch:notApplicableFlag>N</sch:notApplicableFlag>
        <sch:subsidiaryIdentificationAndClassification>Not applicable</sch:subsidiaryIdentificationAndClassification>
      </sch:item7>
      <sch:item8>
        <sch:notApplicableFlag>N</sch:notApplicableFlag>
        <sch:identificationAndClassificationOfGroupMembers>Not applicable</sch:identificationAndClassificationOfGroupMembers>
      </sch:item8>
      <sch:item9>
        <sch:notApplicableFlag>N</sch:notApplicableFlag>
        <sch:groupDissolutionNotice>Not applicable</sch:groupDissolutionNotice>
      </sch:item9>
      <sch:item10>
        <sch:notApplicableFlag>N</sch:notApplicableFlag>
        <sch:certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</sch:certifications>
      </sch:item10>
    </sch:items>
    <sch:signatureInformation>
      <sch:reportingPersonName>Pfizer Inc. (IRS Identification No.: 13-5315170)</sch:reportingPersonName>
      <sch:signatureDetails>
        <sch:signature>/s/ Madelyn D. Purcell</sch:signature>
        <sch:title>Madelyn D. Purcell/Assistant Secretary</sch:title>
        <sch:date>05/12/2026</sch:date>
      </sch:signatureDetails>
    </sch:signatureInformation>
  </sch:formData>
</sch:edgarSubmission>
