<?xml version="1.0" encoding="UTF-8"?><informationTable xmlns="http://www.sec.gov/edgar/document/thirteenf/informationtable" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><infoTable><nameOfIssuer>ALLOGENE THERAPEUTICS INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>019770106</cusip><value>32166778</value><shrsOrPrnAmt><sshPrnamt>22032040</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>22032040</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>AN2 THERAPEUTICS INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>037326105</cusip><value>972801</value><shrsOrPrnAmt><sshPrnamt>715295</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>DFND</investmentDiscretion><votingAuthority><Sole>0</Sole><Shared>715295</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>ARVINAS INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>04335A105</cusip><value>24273861</value><shrsOrPrnAmt><sshPrnamt>3457815</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>3457815</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>BIOHAVEN LTD</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>G1110E107</cusip><value>12155706</value><shrsOrPrnAmt><sshPrnamt>505645</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>505645</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>BIONTECH SE</nameOfIssuer><titleOfClass>SPONSORED ADS</titleOfClass><cusip>09075V102</cusip><value>333130353</value><shrsOrPrnAmt><sshPrnamt>3658361</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>3658361</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>BOLT BIOTHERAPEUTICS INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>097702104</cusip><value>250444</value><shrsOrPrnAmt><sshPrnamt>626109</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>DFND</investmentDiscretion><votingAuthority><Sole>0</Sole><Shared>626109</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>CARDIFF ONCOLOGY INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>14147L108</cusip><value>7572346</value><shrsOrPrnAmt><sshPrnamt>2411575</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>2411575</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>CARIBOU BIOSCIENCES INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>142038108</cusip><value>4282833</value><shrsOrPrnAmt><sshPrnamt>4690431</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>4690431</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>CELCUITY INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>15102K100</cusip><value>3532495</value><shrsOrPrnAmt><sshPrnamt>349406</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>349406</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>ESSA PHARMA INC</nameOfIssuer><titleOfClass>COM NEW</titleOfClass><cusip>29668H708</cusip><value>2646500</value><shrsOrPrnAmt><sshPrnamt>1675000</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>1675000</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>GINKGO BIOWORKS HOLDINGS INC</nameOfIssuer><titleOfClass>CL A NEW</titleOfClass><cusip>37611X209</cusip><value>1408</value><shrsOrPrnAmt><sshPrnamt>247</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>247</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>GINKGO BIOWORKS HOLDINGS INC</nameOfIssuer><titleOfClass>CL A NEW</titleOfClass><cusip>37611X209</cusip><value>15282</value><shrsOrPrnAmt><sshPrnamt>2681</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>DFND</investmentDiscretion><votingAuthority><Sole>0</Sole><Shared>2681</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>NEXTCURE INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>65343E108</cusip><value>152952</value><shrsOrPrnAmt><sshPrnamt>318451</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>318451</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>NEXTCURE INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>65343E108</cusip><value>755662</value><shrsOrPrnAmt><sshPrnamt>1573312</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>DFND</investmentDiscretion><votingAuthority><Sole>0</Sole><Shared>1573312</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>ORIC PHARMACEUTICALS INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>68622P109</cusip><value>30000000</value><shrsOrPrnAmt><sshPrnamt>5376344</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>5376344</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>PYXIS ONCOLOGY INC</nameOfIssuer><titleOfClass>COMMON STOCK</titleOfClass><cusip>747324101</cusip><value>5832623</value><shrsOrPrnAmt><sshPrnamt>5952263</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>5952263</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>PYXIS ONCOLOGY INC</nameOfIssuer><titleOfClass>COMMON STOCK</titleOfClass><cusip>747324101</cusip><value>1058789</value><shrsOrPrnAmt><sshPrnamt>1080507</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>DFND</investmentDiscretion><votingAuthority><Sole>0</Sole><Shared>1080507</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>Q32 BIO INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>746964105</cusip><value>458332</value><shrsOrPrnAmt><sshPrnamt>277777</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>277777</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>SENSEONICS HLDGS INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>81727U105</cusip><value>28492</value><shrsOrPrnAmt><sshPrnamt>43426</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>DFND</investmentDiscretion><votingAuthority><Sole>0</Sole><Shared>43426</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>SPERO THERAPEUTICS INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>84833T103</cusip><value>1700891</value><shrsOrPrnAmt><sshPrnamt>2362348</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>2362348</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>TOURMALINE BIO INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>89157D105</cusip><value>19350375</value><shrsOrPrnAmt><sshPrnamt>1272214</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>1272214</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>WAVE LIFE SCIENCES LTD</nameOfIssuer><titleOfClass>SHS</titleOfClass><cusip>Y95308105</cusip><value>15150000</value><shrsOrPrnAmt><sshPrnamt>1875000</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>DFND</investmentDiscretion><votingAuthority><Sole>0</Sole><Shared>1875000</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>ZENTALIS PHARMACEUTICALS INC</nameOfIssuer><titleOfClass>COM</titleOfClass><cusip>98943L107</cusip><value>1516596</value><shrsOrPrnAmt><sshPrnamt>953834</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>953834</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable><infoTable><nameOfIssuer>ZURA BIO LTD</nameOfIssuer><titleOfClass>CLASS A ORD SHS</titleOfClass><cusip>G9TY5A101</cusip><value>3831328</value><shrsOrPrnAmt><sshPrnamt>2970022</sshPrnamt><sshPrnamtType>SH</sshPrnamtType></shrsOrPrnAmt><investmentDiscretion>SOLE</investmentDiscretion><votingAuthority><Sole>2970022</Sole><Shared>0</Shared><None>0</None></votingAuthority></infoTable></informationTable><!-- tableEntryCount=24 tableValueTotal=500836847 -->
