The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AKERO THERAPEUTICS INC COM 00973Y108   15,652,255 562,626 SH   SOLE   562,626 0 0
ALLOGENE THERAPEUTICS INC COM 019770106   46,928,245 22,032,040 SH   SOLE   22,032,040 0 0
AN2 THERAPEUTICS INC COM 037326105   987,107 715,295 SH   DFND   0 715,295 0
ARVINAS INC COM 04335A105   66,286,314 3,457,815 SH   SOLE   3,457,815 0 0
BIOHAVEN LTD COM G1110E107   18,885,841 505,645 SH   SOLE   505,645 0 0
BIONTECH SE SPONSORED ADS 09075V102   416,870,236 3,658,361 SH   SOLE   3,658,361 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104   335,031 626,109 SH   DFND   0 626,109 0
CARDIFF ONCOLOGY INC COM 14147L108   10,466,236 2,411,575 SH   SOLE   2,411,575 0 0
CARIBOU BIOSCIENCES INC COM 142038108   7,457,785 4,690,431 SH   SOLE   4,690,431 0 0
CELCUITY INC COM 15102K100   4,573,725 349,406 SH   SOLE   349,406 0 0
ESSA PHARMA INC COM NEW 29668H708   2,998,250 1,675,000 SH   SOLE   1,675,000 0 0
GINKGO BIOWORKS HOLDINGS INC CL A NEW 37611X209   2,426 247 SH   SOLE   247 0 0
GINKGO BIOWORKS HOLDINGS INC CL A NEW 37611X209   26,328 2,681 SH   DFND   0 2,681 0
HALEON PLC SPON ADS 405552100   1,881,564,202 197,228,952 SH   SOLE   197,228,952 0 0
NEXTCURE INC COM 65343E108   318,451 245,526 SH   SOLE   245,526 0 0
NEXTCURE INC COM 65343E108   1,573,312 1,213,024 SH   DFND   0 1,213,024 0
ORIC PHARMACEUTICALS INC COM 68622P109   43,387,096 5,376,344 SH   SOLE   5,376,344 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101   9,285,530 5,952,263 SH   SOLE   9,285,530 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101   1,685,591 1,080,507 SH   DFND   0 1,080,507 0
Q32 BIO INC COM 746964105   955,553 277,777 SH   SOLE   277,777 0 0
SENSEONICS HLDGS INC COM 81727U105   22,729 43,426 SH   DFND   0 43,426 0
SPERO THERAPEUTICS INC COM 84833T103   2,433,218 2,362,348 SH   SOLE   2,362,348 0 0
TOURMALINE BIO INC COM 89157D105   25,800,500 1,272,214 SH   SOLE   1,272,214 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   23,193,750 1,875,000 SH   DFND   0 1,875,000 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107   2,890,117 953,834 SH   SOLE   953,834 0 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101   7,425,055 2,970,022 SH   SOLE   2,970,022 0 0