Financial Instruments - Investments - Short-term, Long-term and Equity Method Investments (Details) - USD ($) $ in Millions		Dec. 31, 2021	Dec. 31, 2020
Short-term investments
Equity securities with readily determinable fair values	[1]	$ 5,365	$ 567
Available-for-sale debt securities		22,014	9,709
Held-to-maturity debt securities		1,746	161
Total Short-term investments		29,125	10,437
Long-term investments
Equity securities with readily determinable fair values		3,876	2,809
Available-for-sale debt securities		521	128
Held-to-maturity debt securities		34	37
Private equity securities at cost	[2]	623	432
Long-term investments		5,054	3,406
Equity-method investments		16,472	16,856
Total long-term investments and equity-method investments		21,526	20,262
Held-to-maturity cash equivalents		$ 268	$ 89

[1] As of December 31, 2021 and 2020, includes money market funds primarily invested in U.S. Treasury and government debt.

[2] Represent investments in the life sciences sector.