X0306 4 2019-05-13 0 0001662774 Cortexyme, Inc. CRTX 0000078003 PFIZER INC 235 E 42ND ST NEW YORK NY 10017 0 0 1 0 0001776087 Pfizer Ventures (US) LLC 235 EAST 42ND STREET NEW YORK NY 10017 0 0 1 0 0001776115 Pfizer Strategic Investment Holdings LLC 235 EAST 42ND STREET NEW YORK NY 10017 0 0 1 0 Common Stock 2019-05-13 4 C 0 2360071 0 A 2360071 D Common Stock 2019-05-13 4 C 0 215697 0 A 2575768 D Common Stock 2019-05-13 4 C 0 624205 0 A 3199973 D Common Stock 2019-05-13 4 P 0 50000 17 A 3249973 D Series A Redeemable Convertible Preferred Stock 2019-05-13 4 C 0 2360071 0 D Common Stock 2360071 0 D Series B Redeemable Convertible Preferred Stock 2019-05-13 4 C 0 215697 0 D Common Stock 215697 0 D Series B Redeemable Convertible Preferred Stock 2019-05-13 4 C 0 624205 0 D Common Stock 624205 0 D Each share of the Series A Redeemable Convertible Preferred Common Stock ("Series A Preferred Stock"), which consists of 2,360,071 shares of Series A Preferred Stock held of record by Pfizer Ventures (US) LLC ("PVUS"), a controlled affiliate of Pfizer Inc. ("Pfizer"), and each share of the Series B Redeemable Convertible Preferred Stock ("Series B Preferred Stock" and together with the Series A Preferred Stock, the "Preferred Stock"), which consists of (a) 215,697 shares of Series B Preferred Stock held of record by Pfizer Strategic Investment Holdings LLC, a controlled affiliate of Pfizer, and (b) 624,205 shares of Series B Preferred Stock held of record by Pfizer, converted into common stock of Cortexyme, Inc. (the "Issuer") on a one-for-one basis upon the closing of the Issuer's initial public offering for no additional consideration. The Preferred Stock had no expiration date. Each Reporting Person disclaims beneficial ownership of securities reported on this Form 4, except to the extent of its respective pecuniary interest therein. PVUS purchased 50,000 additional shares of common stock in the Issuer's initial public offering for consideration of $17.00 per share. Pfizer Inc., By /s/ Susan Grant, Assistant Secretary 2019-05-14 Pfizer Ventures (US) LLC, By /s/ Susan Grant, Secretary 2019-05-14 Pfizer Strategic Investment Holdings LLC, By /s/ Susan Grant, Assistant Secretary 2019-05-14