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Acquisitions, Divestitures, Assets and Liabilities Held for Sale, Licensing Arrangements, Research and Development and Collaborative Arrangements, Equity-Method Investments and Privately Held Investment - Privately Held Investment (Details) - AM Pharma BV [Member] - USD ($)
$ in Millions
1 Months Ended
Apr. 30, 2015
Dec. 31, 2017
Schedule of Equity Method Investments [Line Items]    
Impairment of investment   $ 43.0
Long-term Investments [Member]    
Schedule of Equity Method Investments [Line Items]    
Cost method investment, upfront and milestone payments $ 87.5