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Segment, Geographic and Other Revenue Information (Tables)
9 Months Ended
Sep. 30, 2018
Segment Reporting [Abstract]  
Reconciliation of Revenue from Segments to Consolidated
The following table provides selected income statement information by reportable segment:
 
 
Three Months Ended
 
 
Revenues
 
Earnings(a)
(MILLIONS OF DOLLARS)
 
September 30,
2018

 
October 1,
2017

 
September 30,
2018

 
October 1,
2017

Reportable Segments:
 
 
 
 
 
 
 
 
IH(b)
 
$
8,471

 
$
8,118

 
$
5,388

 
$
5,000

EH(b)
 
4,826

 
5,050

 
2,527

 
2,801

Total reportable segments
 
13,298

 
13,168

 
7,915

 
7,801

Other business activities(c), (d)
 

 

 
(736
)
 
(759
)
Reconciling Items:
 
 
 
 
 
 

 
 

Corporate(b), (d)
 

 

 
(1,337
)
 
(1,363
)
Purchase accounting adjustments(d)
 

 

 
(1,309
)
 
(1,154
)
Acquisition-related costs(d)
 

 

 
(112
)
 
(155
)
Certain significant items(e)
 

 

 
213

 
(449
)
Other unallocated(b), (d)
 

 

 
(457
)
 
(335
)
 
 
$
13,298

 
$
13,168


$
4,177

 
$
3,585

 
 
 
Nine Months Ended
 
 
Revenues
 
Earnings(a)
(MILLIONS OF DOLLARS)
 
September 30,
2018

 
October 1,
2017

 
September 30,
2018

 
October 1,
2017

Reportable Segments:
 
 
 
 
 
 
 
 
IH(b)
 
$
24,573

 
$
23,204

 
$
15,419

 
$
14,534

EH(b)
 
15,097

 
15,639

 
8,133

 
8,672

Total reportable segments
 
39,670

 
38,843

 
23,552

 
23,206

Other business activities(c), (d)
 

 

 
(2,130
)
 
(2,205
)
Reconciling Items:
 
 
 
 
 
 
 
 
Corporate(b), (d)
 

 

 
(3,633
)
 
(3,908
)
Purchase accounting adjustments(d)
 

 

 
(3,665
)
 
(3,527
)
Acquisition-related costs(d)
 

 

 
(221
)
 
(347
)
Certain significant items(e)
 

 

 
(8
)
 
(797
)
Other unallocated(b), (d)
 

 

 
(1,064
)
 
(1,070
)
 
 
$
39,670

 
$
38,843

 
$
12,831

 
$
11,351

(a) 
Income from continuing operations before provision for taxes on income. IH’s earnings include dividend income of $91 million and $54 million in the third quarter of 2018 and 2017, respectively, and $226 million and $211 million in the first nine months of 2018 and 2017, respectively, from our investment in ViiV. For additional information, see Note 4.
(b) 
In connection with the StratCO reporting change, in the third quarter of 2017, we reclassified approximately $125 million of costs from IH, approximately $36 million of costs from EH and approximately $19 million of costs from Corporate to Other unallocated costs to conform to the current period presentation. In the first nine months of 2017, we reclassified approximately $344 million of costs from IH, approximately $114 million of costs from EH and approximately $40 million of costs from Corporate to Other unallocated costs to conform to the current period presentation.
(c) 
Other business activities includes the costs managed by our WRD and GPD organizations.
(d) 
For a description, see the “Other Costs and Business Activities” section above.
(e) 
Certain significant items are substantive and/or unusual, and in some cases recurring, items (such as restructuring or legal charges) that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis.
For Earnings in the third quarter of 2018, certain significant items includes: (i) restructuring credits and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $35 million, (ii) net charges for certain legal matters of $37 million, (iii) income of $2 million, representing an adjustment to amounts previously recorded to write down the HIS net assets to fair value less costs to sell and (iv) other income of $282 million, which includes, among other things, a non-cash $343 million pre-tax gain in Other (income)/deductions––net associated with our transaction with Bain Capital to create a new biopharmaceutical company, Cerevel, to continue development of a portfolio of clinical and preclinical stage neuroscience assets primarily targeting disorders of the central nervous system. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the third quarter of 2017, certain significant items includes: (i) restructuring credits and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $55 million, (ii) charges for certain legal matters of $183 million, (iii) income of $12 million, representing an adjustment to amounts previously recorded to write down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $127 million, (v) charges for business and legal entity alignment of $16 million and (vi) other charges of $81 million, which includes, among other things, $55 million in inventory losses, overhead costs related to the period in which our Puerto Rico plants were not operational, and incremental costs, all of which resulted from hurricanes in Puerto Rico and are included in Cost of sales. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the first nine months of 2018, certain significant items includes: (i) restructuring credits and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $127 million, (ii) net credits for certain legal matters of $70 million, (iii) income of $1 million, representing an adjustment to amounts previously recorded to write down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $31 million, (v) charges for business and legal entity alignment of $4 million and (vi) other income of $84 million, which includes, among other things, a non-cash $343 million pre-tax gain in Other (income)/deductions––net associated with our transaction with Bain Capital to create a new biopharmaceutical company, Cerevel, to continue development of a portfolio of clinical and preclinical stage neuroscience assets primarily targeting disorders of the central nervous system, a $119 million charge, in the aggregate, in Selling, information and administrative expenses, for a special one-time bonus paid to virtually all Pfizer colleagues, excluding executives, which was one of several actions taken by us after evaluating the expected positive net impact of the December 2017 enactment of the TCJA on us, and a $50 million pre-tax gain in Other (income)/deductions––net as a result of the contribution of our allogeneic chimeric antigen receptor T cell therapy development program assets in connection with our contribution agreement entered into with Allogene. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the first nine months of 2017, certain significant items includes: (i) restructuring credits and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $133 million, (ii) charges for certain legal matters of $191 million, (iii) charges of $52 million, representing adjustments to amounts previously recorded to write-down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $127 million, (v) charges for business and legal entity alignment of $54 million and (v) other charges of $239 million, which include, among other things, $55 million in inventory losses, overhead costs related to the period in which our Puerto Rico plants were not operational, and incremental costs, all of which resulted from hurricanes in Puerto Rico and are included in Cost of sales, and a net loss of $30 million related to the sale of our 40% ownership investment in Teuto, including the extinguishment of a put option for the then remaining 60% ownership interest, which is included in Other (income)/deductions––net. For additional information, see Note 2B, Note 3 and Note 4.
Reconciliation of Operating Profit (Loss) from Segments to Consolidated
The following table provides selected income statement information by reportable segment:
 
 
Three Months Ended
 
 
Revenues
 
Earnings(a)
(MILLIONS OF DOLLARS)
 
September 30,
2018

 
October 1,
2017

 
September 30,
2018

 
October 1,
2017

Reportable Segments:
 
 
 
 
 
 
 
 
IH(b)
 
$
8,471

 
$
8,118

 
$
5,388

 
$
5,000

EH(b)
 
4,826

 
5,050

 
2,527

 
2,801

Total reportable segments
 
13,298

 
13,168

 
7,915

 
7,801

Other business activities(c), (d)
 

 

 
(736
)
 
(759
)
Reconciling Items:
 
 
 
 
 
 

 
 

Corporate(b), (d)
 

 

 
(1,337
)
 
(1,363
)
Purchase accounting adjustments(d)
 

 

 
(1,309
)
 
(1,154
)
Acquisition-related costs(d)
 

 

 
(112
)
 
(155
)
Certain significant items(e)
 

 

 
213

 
(449
)
Other unallocated(b), (d)
 

 

 
(457
)
 
(335
)
 
 
$
13,298

 
$
13,168


$
4,177

 
$
3,585

 
 
 
Nine Months Ended
 
 
Revenues
 
Earnings(a)
(MILLIONS OF DOLLARS)
 
September 30,
2018

 
October 1,
2017

 
September 30,
2018

 
October 1,
2017

Reportable Segments:
 
 
 
 
 
 
 
 
IH(b)
 
$
24,573

 
$
23,204

 
$
15,419

 
$
14,534

EH(b)
 
15,097

 
15,639

 
8,133

 
8,672

Total reportable segments
 
39,670

 
38,843

 
23,552

 
23,206

Other business activities(c), (d)
 

 

 
(2,130
)
 
(2,205
)
Reconciling Items:
 
 
 
 
 
 
 
 
Corporate(b), (d)
 

 

 
(3,633
)
 
(3,908
)
Purchase accounting adjustments(d)
 

 

 
(3,665
)
 
(3,527
)
Acquisition-related costs(d)
 

 

 
(221
)
 
(347
)
Certain significant items(e)
 

 

 
(8
)
 
(797
)
Other unallocated(b), (d)
 

 

 
(1,064
)
 
(1,070
)
 
 
$
39,670

 
$
38,843

 
$
12,831

 
$
11,351

(a) 
Income from continuing operations before provision for taxes on income. IH’s earnings include dividend income of $91 million and $54 million in the third quarter of 2018 and 2017, respectively, and $226 million and $211 million in the first nine months of 2018 and 2017, respectively, from our investment in ViiV. For additional information, see Note 4.
(b) 
In connection with the StratCO reporting change, in the third quarter of 2017, we reclassified approximately $125 million of costs from IH, approximately $36 million of costs from EH and approximately $19 million of costs from Corporate to Other unallocated costs to conform to the current period presentation. In the first nine months of 2017, we reclassified approximately $344 million of costs from IH, approximately $114 million of costs from EH and approximately $40 million of costs from Corporate to Other unallocated costs to conform to the current period presentation.
(c) 
Other business activities includes the costs managed by our WRD and GPD organizations.
(d) 
For a description, see the “Other Costs and Business Activities” section above.
(e) 
Certain significant items are substantive and/or unusual, and in some cases recurring, items (such as restructuring or legal charges) that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis.
For Earnings in the third quarter of 2018, certain significant items includes: (i) restructuring credits and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $35 million, (ii) net charges for certain legal matters of $37 million, (iii) income of $2 million, representing an adjustment to amounts previously recorded to write down the HIS net assets to fair value less costs to sell and (iv) other income of $282 million, which includes, among other things, a non-cash $343 million pre-tax gain in Other (income)/deductions––net associated with our transaction with Bain Capital to create a new biopharmaceutical company, Cerevel, to continue development of a portfolio of clinical and preclinical stage neuroscience assets primarily targeting disorders of the central nervous system. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the third quarter of 2017, certain significant items includes: (i) restructuring credits and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $55 million, (ii) charges for certain legal matters of $183 million, (iii) income of $12 million, representing an adjustment to amounts previously recorded to write down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $127 million, (v) charges for business and legal entity alignment of $16 million and (vi) other charges of $81 million, which includes, among other things, $55 million in inventory losses, overhead costs related to the period in which our Puerto Rico plants were not operational, and incremental costs, all of which resulted from hurricanes in Puerto Rico and are included in Cost of sales. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the first nine months of 2018, certain significant items includes: (i) restructuring credits and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $127 million, (ii) net credits for certain legal matters of $70 million, (iii) income of $1 million, representing an adjustment to amounts previously recorded to write down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $31 million, (v) charges for business and legal entity alignment of $4 million and (vi) other income of $84 million, which includes, among other things, a non-cash $343 million pre-tax gain in Other (income)/deductions––net associated with our transaction with Bain Capital to create a new biopharmaceutical company, Cerevel, to continue development of a portfolio of clinical and preclinical stage neuroscience assets primarily targeting disorders of the central nervous system, a $119 million charge, in the aggregate, in Selling, information and administrative expenses, for a special one-time bonus paid to virtually all Pfizer colleagues, excluding executives, which was one of several actions taken by us after evaluating the expected positive net impact of the December 2017 enactment of the TCJA on us, and a $50 million pre-tax gain in Other (income)/deductions––net as a result of the contribution of our allogeneic chimeric antigen receptor T cell therapy development program assets in connection with our contribution agreement entered into with Allogene. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the first nine months of 2017, certain significant items includes: (i) restructuring credits and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $133 million, (ii) charges for certain legal matters of $191 million, (iii) charges of $52 million, representing adjustments to amounts previously recorded to write-down the HIS net assets to fair value less costs to sell, (iv) certain asset impairment charges of $127 million, (v) charges for business and legal entity alignment of $54 million and (v) other charges of $239 million, which include, among other things, $55 million in inventory losses, overhead costs related to the period in which our Puerto Rico plants were not operational, and incremental costs, all of which resulted from hurricanes in Puerto Rico and are included in Cost of sales, and a net loss of $30 million related to the sale of our 40% ownership investment in Teuto, including the extinguishment of a put option for the then remaining 60% ownership interest, which is included in Other (income)/deductions––net. For additional information, see Note 2B, Note 3 and Note 4.
Schedule of Revenues by Geographic Region
The following table provides revenues by geographic area:
 

Three Months Ended

Nine Months Ended
(MILLIONS OF DOLLARS)

September 30,
2018


October 1,
2017


%
Change


September 30,
2018


October 1,
2017


%
Change

U.S.

$
6,361


$
6,534


(3
)

$
18,861


$
19,516


(3
)
Developed Europe(a)

2,231


2,163


3


6,657


6,309


6

Developed Rest of World(b)

1,640


1,632


1


4,795


4,797



Emerging Markets(c)

3,066


2,839


8


9,358


8,222


14

Revenues

$
13,298


$
13,168


1


$
39,670


$
38,843


2

(a) 
Developed Europe region includes the following markets: Western Europe, Scandinavian countries and Finland. Revenues denominated in euros were $1.8 billion and $1.7 billion in the third quarter of 2018 and 2017, respectively, and $5.3 billion and $5.0 billion in the first nine months of 2018 and 2017, respectively.
(b) 
Developed Rest of World region includes the following markets: Japan, Canada, Australia, South Korea and New Zealand.
(c) 
Emerging Markets region includes, but is not limited to, the following markets: Asia (excluding Japan and South Korea), Latin America, Eastern Europe, Africa, the Middle East, Central Europe and Turkey.
Schedule of Significant Product Revenues
The following table provides detailed revenue information:
(MILLIONS OF DOLLARS)
 
 
 
Three Months Ended
 
Nine Months Ended
 
PRODUCT
 
PRIMARY INDICATIONS OR CLASS
 
September 30,
2018

 
October 1,
2017

 
September 30,
2018

 
October 1,
2017

TOTAL REVENUES
 
 
 
$
13,298

 
$
13,168

 
$
39,670

 
$
38,843

PFIZER INNOVATIVE HEALTH (IH)(a)
 
$
8,471

 
$
8,118

 
$
24,573

 
$
23,204

Internal Medicine
 
 
 
$
2,463

 
$
2,455

 
$
7,339

 
$
7,245

Lyrica IH(b)
 
Epilepsy, post-herpetic neuralgia and diabetic peripheral neuropathy, fibromyalgia, neuropathic pain due to spinal cord injury
 
1,132

 
1,150

 
3,398

 
3,382

Eliquis alliance revenues and direct sales
 
Atrial fibrillation, deep vein thrombosis, pulmonary embolism
 
870

 
644

 
2,524

 
1,813

Chantix/Champix
 
An aid to smoking cessation treatment in adults 18 years of age or older
 
261

 
240

 
789

 
727

BMP2
 
Development of bone and cartilage
 
54

 
79

 
206

 
198

Toviaz
 
Overactive bladder
 
67

 
62

 
197

 
187

Viagra IH(c)
 
Erectile dysfunction
 

 
206

 

 
711

All other Internal Medicine
 
Various
 
79

 
75

 
224

 
228

Vaccines
 
 
 
$
1,845

 
$
1,649

 
$
4,708

 
$
4,385

Prevnar 13/Prevenar 13
 
Vaccines for prevention of pneumococcal disease
 
1,660

 
1,522

 
4,290

 
4,069

FSME/IMMUN-TicoVac
 
Tick-borne encephalitis vaccine
 
57

 
43

 
162

 
119

Trumenba
 
Meningococcal Group B vaccine
 
61

 
42

 
95

 
79

All other Vaccines
 
Various
 
67

 
43

 
160

 
117

Oncology
 
 
 
$
1,775

 
$
1,616

 
$
5,294

 
$
4,551

Ibrance
 
Advanced breast cancer
 
1,025

 
878

 
2,985

 
2,410

Sutent
 
Advanced and/or metastatic RCC, adjuvant RCC, refractory GIST (after disease progression on, or intolerance to, imatinib mesylate) and advanced pancreatic neuroendocrine tumor
 
248

 
276

 
785

 
805

Xtandi alliance revenues
 
Castration-resistant prostate cancer
 
180

 
150

 
510

 
422

Xalkori
 
ALK-positive and ROS1-positive advanced NSCLC
 
127

 
146

 
417

 
442

Inlyta
 
Advanced RCC
 
71

 
84

 
226

 
256

Bosulif
 
Philadelphia chromosome–positive chronic myelogenous leukemia
 
69

 
57

 
206

 
163

All other Oncology
 
Various
 
55

 
26

 
164

 
54

Inflammation & Immunology (I&I)
 
 
 
$
1,018

 
$
1,000

 
$
2,951

 
$
2,863

Enbrel (Outside the U.S. and Canada)
 
Rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, plaque psoriasis, pediatric plaque psoriasis, ankylosing spondylitis and nonradiographic axial spondyloarthritis
 
531

 
613

 
1,589

 
1,818

Xeljanz
 
Rheumatoid arthritis, psoriatic arthritis, ulcerative colitis
 
432

 
348

 
1,221

 
935

Eucrisa

Mild-to-moderate atopic dermatitis (eczema)
 
40

 
15

 
104

 
33

All other I&I
 
Various
 
15

 
23

 
37

 
78

Rare Disease
 
 
 
$
531

 
$
569

 
$
1,651

 
$
1,637

BeneFIX
 
Hemophilia
 
132

 
151

 
420

 
453

Genotropin
 
Replacement of human growth hormone
 
143

 
136

 
416

 
375

Refacto AF/Xyntha
 
Hemophilia
 
117

 
140

 
388

 
409

Somavert
 
Acromegaly
 
64

 
65

 
195

 
182

All other Rare Disease
 
Various
 
74

 
77

 
232

 
218

Consumer Healthcare
 
 
 
$
839

 
$
829

 
$
2,631

 
$
2,522

PFIZER ESSENTIAL HEALTH (EH)(d)
 
 
 
$
4,826

 
$
5,050

 
$
15,097

 
$
15,639

Legacy Established Products (LEP)(e)
 
 
 
$
2,533

 
$
2,681

 
$
7,865

 
$
7,995

Lipitor
 
Reduction of LDL cholesterol
 
507

 
491

 
1,539

 
1,341

Norvasc
 
Hypertension
 
247

 
226

 
773

 
684

Premarin family
 
Symptoms of menopause
 
204

 
238

 
605

 
711

Xalatan/Xalacom
 
Glaucoma and ocular hypertension
 
76

 
83

 
233

 
241

Effexor
 
Depression and certain anxiety disorders
 
78

 
76

 
228

 
215

Zoloft
 
Depression and certain anxiety disorders
 
72

 
78

 
223

 
215

Zithromax
 
Bacterial infections
 
54

 
61

 
216

 
202

EpiPen
 
Epinephrine injection used in treatment of life-threatening allergic reactions
 
68

 
82

 
215

 
253

Xanax
 
Anxiety disorders
 
52

 
58

 
163

 
164

Sildenafil Citrate
 
Erectile dysfunction
 
1

 

 
72

 

All other LEP
 
Various
 
1,176

 
1,288

 
3,599

 
3,969

(MILLIONS OF DOLLARS)
 
 
 
Three Months Ended
 
Nine Months Ended
 
PRODUCT
 
PRIMARY INDICATIONS OR CLASS
 
September 30,
2018

 
October 1,
2017

 
September 30,
2018

 
October 1,
2017

Sterile Injectable Pharmaceuticals (SIP)(f)
 
$
1,239

 
$
1,273

 
$
3,928

 
$
4,270

Sulperazon
 
Treatment of infections
 
145

 
114

 
464

 
345

Medrol
 
Steroid anti-inflammatory
 
95

 
109

 
318

 
352

Fragmin
 
Slows blood clotting
 
76

 
79

 
221

 
221

Tygacil
 
Tetracycline class antibiotic
 
60

 
60

 
186

 
192

Zosyn/Tazocin
 
Antibiotic
 
55

 
47

 
175

 
124

Precedex
 
Sedation agent in surgery or intensive care
 
47

 
51

 
166

 
182

All other SIP
 
Various
 
761

 
814

 
2,399

 
2,852

Peri-LOE Products(g)
 
 
 
$
698

 
$
794

 
$
2,208

 
$
2,398

Viagra EH(c)
 
Erectile dysfunction
 
137

 
102

 
509

 
285

Celebrex
 
Arthritis pain and inflammation, acute pain
 
188

 
212

 
494

 
564

Vfend
 
Fungal infections
 
87

 
97

 
294

 
305

Lyrica EH(b)
 
Epilepsy, neuropathic pain and generalized anxiety disorder
 
81

 
134

 
251

 
428

Zyvox
 
Bacterial infections
 
50

 
68

 
184

 
220

Revatio
 
Pulmonary arterial hypertension
 
53

 
58

 
163

 
189

Pristiq
 
Depression
 
52

 
69

 
156

 
230

All other Peri-LOE Products
 
Various
 
49

 
55

 
157

 
176

Biosimilars(h)
 
Various
 
$
197

 
$
141

 
$
558

 
$
367

Inflectra/Remsima
 
Inflammatory diseases
 
166

 
112

 
469

 
284

All other Biosimilars
 
Various
 
31

 
28

 
89

 
82

Pfizer CentreOne(i)
 
 
 
$
159

 
$
161

 
$
539

 
$
514

Hospira Infusion Systems (HIS)(j)
 
Various
 
$

 
$

 
$

 
$
97

Total Lyrica(b)
 
Epilepsy, post-herpetic neuralgia and diabetic peripheral neuropathy, fibromyalgia, neuropathic pain due to spinal cord injury
 
$
1,213

 
$
1,285

 
$
3,649

 
$
3,810

Total Viagra(c)
 
Erectile dysfunction
 
$
137

 
$
308

 
$
509

 
$
996

Total Alliance revenues
 
Various
 
$
977

 
$
741

 
$
2,820

 
$
2,112


(a) 
The IH business encompasses Internal Medicine, Vaccines, Oncology, Inflammation & Immunology, Rare Disease and Consumer Healthcare.
(b) 
Lyrica revenues from all of Europe, Russia, Turkey, Israel and Central Asia countries are included in Lyrica EH. All other Lyrica revenues are included in Lyrica IH. Total Lyrica revenues represent the aggregate of worldwide revenues from Lyrica IH and Lyrica EH.
(c) 
Viagra lost exclusivity in the U.S. in December 2017. Beginning in 2018, revenues for Viagra in the U.S. and Canada, which were reported in IH through 2017, are reported in EH (which reported all other Viagra revenues excluding the U.S. and Canada through 2017). Therefore, beginning in 2018, total Viagra revenues are reported in EH. Total Viagra revenues in 2017 represent the aggregate of worldwide revenues from Viagra IH and Viagra EH.
(d) 
The EH business encompasses Legacy Established Products, Sterile Injectable Pharmaceuticals, Peri-LOE Products, Biosimilars, Pfizer CentreOne and HIS (through February 2, 2017).
(e) 
Legacy Established Products primarily include products that have lost patent protection (excluding Sterile Injectable Pharmaceuticals and Peri-LOE Products). In the fourth quarter of 2017, we sold our equity share in Hisun Pfizer. As a result, effective in the first quarter of 2018, Hisun Pfizer-related revenues, previously reported in emerging markets within All Other LEP and All Other SIP, are reported in emerging markets within Pfizer CentreOne.
(f) 
Sterile Injectable Pharmaceuticals includes branded and generic injectables (excluding Peri-LOE Products). In the fourth quarter of 2017, we sold our equity share in Hisun Pfizer. As a result, effective in the first quarter of 2018, Hisun Pfizer-related revenues, previously reported in emerging markets within All Other LEP and All Other SIP, are reported in emerging markets within Pfizer CentreOne.
(g) 
Peri-LOE Products includes products that have recently lost or are anticipated to soon lose patent protection. These products primarily include: Lyrica in Europe, Russia, Turkey, Israel and Central Asia; worldwide revenues for Celebrex, Pristiq, Zyvox, Vfend, Revatio and Inspra; and beginning in 2018, Viagra revenues for all countries (and Viagra revenues for all countries other than the U.S. and Canada in 2017, see note (c) above).
(h) 
Biosimilars includes Inflectra/Remsima (biosimilar infliximab) in the U.S. and certain international markets, Nivestim (biosimilar filgrastim) in certain European, Asian and Africa/Middle Eastern markets and in the U.S. and Retacrit (biosimilar epoetin zeta) in certain European and Africa/Middle Eastern markets.
(i) 
Pfizer CentreOne includes revenues from our contract manufacturing and active pharmaceutical ingredient sales operation, including sterile injectables contract manufacturing, and revenues related to our manufacturing and supply agreements, including with Zoetis Inc. In the fourth quarter of 2017, we sold our equity share in Hisun Pfizer. As a result, effective in the first quarter of 2018, Hisun Pfizer-related revenues, previously reported in emerging markets within All Other LEP and All Other SIP, are reported in emerging markets within Pfizer CentreOne.
(j) 
HIS (through February 2, 2017) includes Medication Management Systems products composed of infusion pumps and related software and services, as well as IV Infusion Products, including large volume IV solutions and their associated administration sets.