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Segment, Geographic and Other Revenue Information (Tables)
9 Months Ended
Oct. 02, 2016
Segment Reporting [Abstract]  
Reconciliation of Revenue from Segments to Consolidated
The following table provides selected income statement information by reportable segment:
 
 
Three Months Ended
 
 
Revenues
 
Earnings(a)
(MILLIONS OF DOLLARS)
 
October 2,
2016

 
September 27,
2015

 
October 2,
2016

 
September 27,
2015

Reportable Segments:
 
 
 
 
 
 
 
 
IH(b)
 
$
7,332

 
$
6,752

 
$
4,187

 
$
4,018

EH(c)
 
5,712

 
5,335

 
3,128

 
3,181

Total reportable segments
 
13,045

 
12,087

 
7,315

 
7,199

Other business activities(d)
 

 

 
(786
)
 
(715
)
Reconciling Items:
 
 
 
 
 
 

 
 

Corporate(e)
 

 

 
(1,504
)
 
(1,376
)
Purchase accounting adjustments(e)
 

 

 
(966
)
 
(960
)
Acquisition-related costs(e)
 

 

 
(280
)
 
(541
)
Certain significant items(f)
 

 

 
(1,969
)
 
(837
)
Other unallocated
 

 

 
(206
)
 
(73
)
 
 
$
13,045

 
$
12,087


$
1,604

 
$
2,697

 
 
 
 
 
 
 
 
 
 
 
Nine Months Ended
 
 
Revenues
 
Earnings(a)
(MILLIONS OF DOLLARS)
 
October 2,
2016

 
September 27,
2015

 
October 2,
2016

 
September 27,
2015

Reportable Segments:
 
 
 
 
 
 
 
 
IH(b)
 
$
21,471

 
$
19,120

 
$
12,470

 
$
10,831

EH(c)
 
17,725

 
15,683

 
9,985

 
9,540

Total reportable segments
 
39,196

 
34,804

 
22,454

 
20,371

Other business activities(d)
 

 

 
(2,190
)
 
(2,127
)
Reconciling Items:
 
 
 
 
 
 
 
 
Corporate(e)
 

 

 
(4,123
)
 
(3,949
)
Purchase accounting adjustments(e)
 

 

 
(3,103
)
 
(2,698
)
Acquisition-related costs(e)
 

 

 
(598
)
 
(631
)
Certain significant items(f)
 

 

 
(4,112
)
 
(1,369
)
Other unallocated
 

 

 
(753
)
 
(278
)
 
 
$
39,196

 
$
34,804

 
$
7,575

 
$
9,319

(a) 
Income from continuing operations before provision for taxes on income.
(b) 
Effective as of the beginning of the second quarter of 2016, in connection with the formation of the GPD organization, certain development-related functions transferred from IH to GPD. We have reclassified approximately $76 million of costs in the first quarter of 2016, approximately $77 million of costs in the third quarter of 2015 and approximately $223 million of costs in the first nine months of 2015 from IH to GPD to conform to the current period presentation as part of GPD. Additionally, Anacor's and Medivations’s commercial operations are included in IH's operating results in our condensed consolidated statements of income. As a result, commencing from the acquisition date of June 24, 2016, IH's operating results for the third quarter and first nine months of 2016 include approximately three months of legacy Anacor operations, which were immaterial, and commencing from the acquisition date of September, 28, 2016, IH's operating results for the third quarter and first nine months of 2016 reflect three business days of legacy Medivation operations, which were immaterial.
(c) 
On September 3, 2015, we acquired Hospira. Commencing from the acquisition date, our condensed consolidated statement of income includes the operating results of Hospira. As a result, legacy Hospira commercial operations, including the legacy Hospira One-2-One contract manufacturing business, are included in EH’s operating results in our condensed consolidated statements of income for the third quarter and first nine months of 2016. In accordance with our domestic and international reporting periods, our results of operations and EH's operating results for the third quarter and first nine months of 2015 reflect only one month of legacy Hospira U.S. operations but no financial results from legacy Hospira international operations. See Note 2A for additional information. Effective as of the beginning of 2016, our entire contract manufacturing business, Pfizer CentreOne (previously known as Pfizer CentreSource or PCS), is part of EH. Pfizer CentreOne consists of (i) the revenues and expenses of legacy Pfizer's contract manufacturing and active pharmaceutical ingredient sales operation, including the revenues and expenses related to our manufacturing and supply agreements with Zoetis; and (ii) the revenues and expenses of legacy Hospira's One-2-One sterile injectables contract manufacturing operation, which has been included in EH since we acquired Hospira on September 3, 2015. Prior to 2016, PCS was managed outside our operating segments as part of PGS and reported as "Other Business Activities". We have reclassified prior period PCS operating results ($116 million of PCS revenues and $15 million of PCS earnings in the third quarter of 2015, and $360 million of PCS revenues and $66 million of PCS earnings in the first nine months of 2015) to conform to the current period presentation as part of EH. As noted above, also effective as of the beginning of 2016, in connection with the formation of a new EH R&D organization, certain functions transferred from Pfizer’s WRD organization to the new EH R&D organization. We have reclassified approximately $68 million of costs in the third quarter of 2015 and $202 million of costs in the first nine months of 2015 from WRD to EH to conform to the current period presentation as part of EH.
(d) 
Other business activities includes the costs managed by our WRD, GPD and Pfizer Medical organizations.
(e) 
For a description, see the “Other Costs and Business Activities” section above.
(f) 
Certain significant items are substantive and in some cases recurring (such as restructuring or legal charges), or unusual items that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis.
For Earnings in the third quarter of 2016, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $375 million, (ii) income for certain legal matters of $40 million, (iii) an impairment charge related to the write-down of the HIS net assets to fair value less estimated costs to sell of $1.4 billion, (iv) certain asset impairment charges of $126 million, (v) charges for business and legal entity alignment of $69 million and (vi) other charges of $17 million. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the third quarter of 2015, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $107 million, (ii) certain asset impairment charges of $633 million, (iii) charges for business and legal entity alignment of $60 million and (iv) other charges of $36 million. For additional information, see Note 3 and Note 4.
For Earnings in the first nine months of 2016, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $743 million, (ii) charges for certain legal matters of $506 million, (iii) an impairment charge related to the write-down of the HIS net assets to fair value less estimated costs to sell of $1.4 billion, (iv) certain asset impairment charges of $1.1 billion, (v) charges for business and legal entity alignment of $180 million and (vi) other charges of $189 million. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the first nine months of 2015, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $302 million, (ii) certain asset impairment charges of $633 million, (iii) charges for business and legal entity alignment of $224 million, (iv) charges for certain legal matters of $92 million, and (v) other charges of $117 million. For additional information, see Note 3 and Note 4.
Reconciliation of Operating Profit (Loss) from Segments to Consolidated
The following table provides selected income statement information by reportable segment:
 
 
Three Months Ended
 
 
Revenues
 
Earnings(a)
(MILLIONS OF DOLLARS)
 
October 2,
2016

 
September 27,
2015

 
October 2,
2016

 
September 27,
2015

Reportable Segments:
 
 
 
 
 
 
 
 
IH(b)
 
$
7,332

 
$
6,752

 
$
4,187

 
$
4,018

EH(c)
 
5,712

 
5,335

 
3,128

 
3,181

Total reportable segments
 
13,045

 
12,087

 
7,315

 
7,199

Other business activities(d)
 

 

 
(786
)
 
(715
)
Reconciling Items:
 
 
 
 
 
 

 
 

Corporate(e)
 

 

 
(1,504
)
 
(1,376
)
Purchase accounting adjustments(e)
 

 

 
(966
)
 
(960
)
Acquisition-related costs(e)
 

 

 
(280
)
 
(541
)
Certain significant items(f)
 

 

 
(1,969
)
 
(837
)
Other unallocated
 

 

 
(206
)
 
(73
)
 
 
$
13,045

 
$
12,087


$
1,604

 
$
2,697

 
 
 
 
 
 
 
 
 
 
 
Nine Months Ended
 
 
Revenues
 
Earnings(a)
(MILLIONS OF DOLLARS)
 
October 2,
2016

 
September 27,
2015

 
October 2,
2016

 
September 27,
2015

Reportable Segments:
 
 
 
 
 
 
 
 
IH(b)
 
$
21,471

 
$
19,120

 
$
12,470

 
$
10,831

EH(c)
 
17,725

 
15,683

 
9,985

 
9,540

Total reportable segments
 
39,196

 
34,804

 
22,454

 
20,371

Other business activities(d)
 

 

 
(2,190
)
 
(2,127
)
Reconciling Items:
 
 
 
 
 
 
 
 
Corporate(e)
 

 

 
(4,123
)
 
(3,949
)
Purchase accounting adjustments(e)
 

 

 
(3,103
)
 
(2,698
)
Acquisition-related costs(e)
 

 

 
(598
)
 
(631
)
Certain significant items(f)
 

 

 
(4,112
)
 
(1,369
)
Other unallocated
 

 

 
(753
)
 
(278
)
 
 
$
39,196

 
$
34,804

 
$
7,575

 
$
9,319

(a) 
Income from continuing operations before provision for taxes on income.
(b) 
Effective as of the beginning of the second quarter of 2016, in connection with the formation of the GPD organization, certain development-related functions transferred from IH to GPD. We have reclassified approximately $76 million of costs in the first quarter of 2016, approximately $77 million of costs in the third quarter of 2015 and approximately $223 million of costs in the first nine months of 2015 from IH to GPD to conform to the current period presentation as part of GPD. Additionally, Anacor's and Medivations’s commercial operations are included in IH's operating results in our condensed consolidated statements of income. As a result, commencing from the acquisition date of June 24, 2016, IH's operating results for the third quarter and first nine months of 2016 include approximately three months of legacy Anacor operations, which were immaterial, and commencing from the acquisition date of September, 28, 2016, IH's operating results for the third quarter and first nine months of 2016 reflect three business days of legacy Medivation operations, which were immaterial.
(c) 
On September 3, 2015, we acquired Hospira. Commencing from the acquisition date, our condensed consolidated statement of income includes the operating results of Hospira. As a result, legacy Hospira commercial operations, including the legacy Hospira One-2-One contract manufacturing business, are included in EH’s operating results in our condensed consolidated statements of income for the third quarter and first nine months of 2016. In accordance with our domestic and international reporting periods, our results of operations and EH's operating results for the third quarter and first nine months of 2015 reflect only one month of legacy Hospira U.S. operations but no financial results from legacy Hospira international operations. See Note 2A for additional information. Effective as of the beginning of 2016, our entire contract manufacturing business, Pfizer CentreOne (previously known as Pfizer CentreSource or PCS), is part of EH. Pfizer CentreOne consists of (i) the revenues and expenses of legacy Pfizer's contract manufacturing and active pharmaceutical ingredient sales operation, including the revenues and expenses related to our manufacturing and supply agreements with Zoetis; and (ii) the revenues and expenses of legacy Hospira's One-2-One sterile injectables contract manufacturing operation, which has been included in EH since we acquired Hospira on September 3, 2015. Prior to 2016, PCS was managed outside our operating segments as part of PGS and reported as "Other Business Activities". We have reclassified prior period PCS operating results ($116 million of PCS revenues and $15 million of PCS earnings in the third quarter of 2015, and $360 million of PCS revenues and $66 million of PCS earnings in the first nine months of 2015) to conform to the current period presentation as part of EH. As noted above, also effective as of the beginning of 2016, in connection with the formation of a new EH R&D organization, certain functions transferred from Pfizer’s WRD organization to the new EH R&D organization. We have reclassified approximately $68 million of costs in the third quarter of 2015 and $202 million of costs in the first nine months of 2015 from WRD to EH to conform to the current period presentation as part of EH.
(d) 
Other business activities includes the costs managed by our WRD, GPD and Pfizer Medical organizations.
(e) 
For a description, see the “Other Costs and Business Activities” section above.
(f) 
Certain significant items are substantive and in some cases recurring (such as restructuring or legal charges), or unusual items that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis.
For Earnings in the third quarter of 2016, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $375 million, (ii) income for certain legal matters of $40 million, (iii) an impairment charge related to the write-down of the HIS net assets to fair value less estimated costs to sell of $1.4 billion, (iv) certain asset impairment charges of $126 million, (v) charges for business and legal entity alignment of $69 million and (vi) other charges of $17 million. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the third quarter of 2015, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $107 million, (ii) certain asset impairment charges of $633 million, (iii) charges for business and legal entity alignment of $60 million and (iv) other charges of $36 million. For additional information, see Note 3 and Note 4.
For Earnings in the first nine months of 2016, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $743 million, (ii) charges for certain legal matters of $506 million, (iii) an impairment charge related to the write-down of the HIS net assets to fair value less estimated costs to sell of $1.4 billion, (iv) certain asset impairment charges of $1.1 billion, (v) charges for business and legal entity alignment of $180 million and (vi) other charges of $189 million. For additional information, see Note 2B, Note 3 and Note 4.
For Earnings in the first nine months of 2015, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $302 million, (ii) certain asset impairment charges of $633 million, (iii) charges for business and legal entity alignment of $224 million, (iv) charges for certain legal matters of $92 million, and (v) other charges of $117 million. For additional information, see Note 3 and Note 4.
Schedule of Revenues by Geographic Region
The following table provides revenues by geographic area(a):
 
 
Three Months Ended
 
Nine Months Ended
(MILLIONS OF DOLLARS)
 
October 2,
2016

 
September 27,
2015

 
%
Change

 
October 2,
2016

 
September 27,
2015

 
%
Change

U.S.
 
$
6,530

 
$
5,565

 
17

 
$
19,561

 
$
14,993

 
30

Developed Europe(b)
 
2,218

 
2,315

 
(4
)
 
6,982

 
7,006

 

Developed Rest of World(c)
 
1,711

 
1,513

 
13

 
4,940

 
4,562

 
8

Emerging Markets(d)
 
2,586

 
2,694

 
(4
)
 
7,714

 
8,243

 
(6
)
Revenues
 
$
13,045

 
$
12,087

 
8

 
$
39,196

 
$
34,804

 
13

(a) 
On September 3, 2015, we acquired Hospira. Commencing from the acquisition date, our condensed consolidated statement of income includes the operating results of Hospira. As a result, legacy Hospira operations are included in our condensed consolidated statements of income for the third quarter and first nine months of 2016. In accordance with our domestic and international reporting periods, our results of operations and EH's operating results for the third quarter and first nine months of 2015 reflect only one month of legacy Hospira U.S. operations but no financial results from legacy Hospira international operations. On June 24, 2016, we acquired Anacor. Commencing from the acquisition date, our condensed consolidated statement of income includes the operating results of Anacor. As a result, legacy Anacor operations are included in our condensed consolidated statements of income for the third quarter and first nine months of 2016. In accordance with our domestic reporting period, our results of operations and IH's operating results for the third quarter and first nine months of 2016 include approximately three months of legacy Anacor operations. Additionally, on September 28, 2016, we acquired Medivation. Commencing from the acquisition date, our condensed consolidated statement of income includes the operating results of Medivation. As a result, legacy Medivation operations are included in our condensed consolidated statements of income for the third quarter and first nine months of 2016. In accordance with our domestic and international reporting periods, our results of operations and IH's operating results for the third quarter and first nine months of 2016 reflect three business days of legacy Medivation operations, which were immaterial. See Note 2A for additional information.
(b) 
Developed Europe region includes the following markets: Western Europe, Finland and the Scandinavian countries. Revenues denominated in euros were $1.7 billion and $1.8 billion in the third quarter of 2016 and 2015, respectively, and $5.3 billion and $5.4 billion in the first nine months of 2016 and 2015, respectively.
(c) 
Developed Rest of World region includes the following markets: Australia, Canada, Japan, New Zealand and South Korea.
(d) 
Emerging Markets region includes, but is not limited to, the following markets: Asia (excluding Japan and South Korea), Latin America, Africa, Eastern Europe, Central Europe, the Middle East and Turkey.
Schedule of Significant Product Revenues
The following table provides detailed revenue information:
 
 
Three Months Ended
 
Nine Months Ended
(MILLIONS OF DOLLARS)
 
October 2,
2016

 
September 27,
2015

 
October 2,
2016

 
September 27,
2015

PFIZER INNOVATIVE HEALTH (IH)(a)
 
$
7,332

 
$
6,752

 
$
21,471

 
$
19,120

Internal Medicine
 
$
2,243

 
$
1,954

 
$
6,557

 
$
5,500

Lyrica IH(b)
 
1,049

 
947

 
3,107

 
2,701

Viagra IH(c)
 
297

 
333

 
897

 
955

Chantix/Champix
 
198

 
159

 
631

 
491

Toviaz
 
60

 
59

 
191

 
193

BMP2
 
63

 
57

 
175

 
169

Alliance revenues(d)
 
417

 
343

 
1,139

 
841

All other Internal Medicine(m)
 
159

 
56

 
416

 
149

Vaccines
 
$
1,641

 
$
1,629

 
$
4,576

 
$
4,536

Prevnar/Prevenar 13
 
1,536

 
1,576

 
4,302

 
4,384

FSME/IMMUN-TicoVac
 
33

 
28

 
102

 
93

All other Vaccines
 
72

 
26

 
172

 
60

Oncology
 
$
1,104

 
$
786

 
$
3,206

 
$
2,026

Ibrance
 
550

 
230

 
1,492

 
408

Sutent
 
260

 
279

 
823

 
815

Xalkori
 
140

 
122

 
415

 
353

Inlyta
 
95

 
105

 
304

 
311

All other Oncology
 
60

 
50

 
172

 
139

Inflammation & Immunology (I&I)
 
$
960

 
$
987

 
$
2,907

 
$
2,816

Enbrel (Outside the U.S. and Canada)
 
701

 
844

 
2,201

 
2,426

Xeljanz
 
235

 
127

 
649

 
351

All other I&I
 
24

 
16

 
57

 
40

Rare Disease
 
$
585

 
$
579

 
$
1,768

 
$
1,776

BeneFIX
 
176

 
194

 
543

 
561

Genotropin
 
147

 
142

 
425

 
447

Refacto AF/Xyntha
 
140

 
130

 
408

 
392

Somavert
 
59

 
54

 
173

 
158

Rapamune
 
38

 
32

 
131

 
138

All other Rare Disease
 
25

 
27

 
88

 
80

Consumer Healthcare
 
$
798

 
$
817

 
$
2,457

 
$
2,465

PFIZER ESSENTIAL HEALTH (EH)(e)
 
$
5,712

 
$
5,335

 
$
17,725

 
$
15,683

Legacy Established Products (LEP)(f)
 
$
2,708

 
$
2,919

 
$
8,373

 
$
8,701

Lipitor
 
422

 
454

 
1,294

 
1,404

Premarin family
 
244

 
263

 
751

 
753

Norvasc
 
238

 
241

 
714

 
744

EpiPen
 
110

 
107

 
300

 
268

Xalatan/Xalacom
 
91

 
98

 
273

 
299

Relpax
 
83

 
91

 
248

 
254

Zoloft
 
72

 
95

 
228

 
274

Effexor
 
70

 
66

 
207

 
213

Zithromax/Zmax(g)
 
56

 
63

 
203

 
203

Xanax/Xanax XR
 
55

 
55

 
163

 
164

Cardura
 
49

 
52

 
143

 
158

Neurontin
 
45

 
45

 
136

 
148

Tikosyn
 
20

 
44

 
136

 
123

Depo-Provera
 
36

 
45

 
103

 
133

All other LEP
 
1,119

 
1,199

 
3,473

 
3,563

Sterile Injectable Pharmaceuticals (SIP)(h)
 
$
1,461

 
$
957

 
$
4,481

 
$
2,436

Medrol(g)
 
102

 
98

 
330

 
284

Sulperazon
 
102

 
72

 
304

 
251

Fragmin
 
80

 
84

 
240

 
246

Tygacil
 
69

 
81

 
203

 
231

All other SIP
 
1,108

 
621

 
3,405

 
1,424

Peri-LOE Products(i)
 
$
1,023

 
$
1,229

 
$
3,224

 
$
4,073

Lyrica EH(b)
 
191

 
273

 
623

 
925

Celebrex
 
194

 
212

 
550

 
640

Pristiq
 
174

 
185

 
546

 
523

Vfend
 
140

 
165

 
459

 
510

Zyvox
 
94

 
165

 
334

 
696

Viagra EH(c)
 
89

 
97

 
286

 
318

Revatio
 
73

 
53

 
213

 
181

All Other Peri-LOE Products
 
68

 
79

 
214

 
280

Infusion Systems(j)
 
$
281

 
$
94

 
$
879

 
$
94

Biosimilars(k)
 
$
83

 
$

 
$
228

 
$

Pfizer CentreOne(l)
 
$
156

 
$
136

 
$
540

 
$
380

Revenues
 
$
13,045

 
$
12,087

 
$
39,196

 
$
34,804

 
 
 
 
 
 
 
 
 
Total Lyrica(b)
 
$
1,240

 
$
1,220

 
$
3,730

 
$
3,626

Total Viagra(c)
 
$
387

 
$
430

 
$
1,183

 
$
1,274

Total Alliance revenues
 
$
419

 
$
349

 
$
1,155

 
$
881


(a) 
The IH business, previously known as the Innovative Products business, encompasses Internal Medicine, Vaccines, Oncology, Inflammation & Immunology, Rare Disease and Consumer Healthcare and includes all legacy Medivation and Anacor commercial operations. Medivation’s and Anacor’s commercial operations are included in IH’s operating results in our condensed consolidated statements of income, commencing from the acquisition date of September 28, 2016 for Medivation and from the acquisition date of June 24, 2016 for Anacor. As a result, IH’s revenues for the third quarter and first nine months of 2016 include three business days of legacy Medivation operations and approximately three months of legacy Anacor operations, which were immaterial.
(b) 
Lyrica revenues from all of Europe, Russia, Turkey, Israel and Central Asia countries are included in Lyrica EH. All other Lyrica revenues are included in Lyrica IH. Total Lyrica revenues represent the aggregate of worldwide revenues from Lyrica IH and Lyrica EH.
(c) 
Viagra revenues from the U.S. and Canada are included in Viagra IH. All other Viagra revenues are included in Viagra EH. Total Viagra revenues represent the aggregate of worldwide revenues from Viagra IH and Viagra EH.
(d) 
Includes Eliquis (2016 and 2015) and Rebif (2015 only).
(e) 
The EH business, previously known as the Established Products business, encompasses Legacy Established Products, Sterile Injectable Pharmaceuticals, Peri-LOE Products, Infusion Systems, Biosimilars and Pfizer CentreOne and includes all legacy Hospira commercial operations. Hospira's commercial operations, including the legacy Hospira One-2-One sterile injectables contract manufacturing business, are included in EH’s operating results in our condensed consolidated statements of income, commencing from the acquisition date of September 3, 2015. Therefore, in accordance with our domestic and international reporting periods, our results of operations and EH's operating results for the third quarter and first nine months of 2015 reflect only one month of legacy Hospira U.S. operations but no financial results from legacy Hospira international operations. Also, effective as of the beginning of 2016, our entire contract manufacturing business, Pfizer CentreOne (previously known as Pfizer CentreSource or PCS), is part of EH. Pfizer CentreOne consists of (i) legacy Pfizer's contract manufacturing and active pharmaceutical ingredient sales operation, including our manufacturing and supply agreements with Zoetis; and (ii) legacy Hospira's One-2-One sterile injectables contract manufacturing operation. Prior to 2016, PCS was managed outside our operating segments and its revenues were reported as other business activities. We have reclassified prior period PCS revenues ($116 million in the third quarter of 2015 and $360 million in the first nine months of 2015) to conform to the current period presentation as part of EH.
(f) 
Legacy Established Products include products that have lost patent protection (excluding Sterile Injectable Pharmaceuticals and Peri-LOE Products).
(g) 
Prior period revenues for Medrol and Zithromax/Zmax may not agree to previously-disclosed revenues because revenues for those products are now split between the Legacy Established Products and the Sterile Injectable Pharmaceuticals categories.
(h) 
Sterile Injectable Pharmaceuticals include generic injectables and proprietary specialty injectables (excluding Peri-LOE Products).
(i)
Peri-LOE Products include products that have recently lost or are anticipated to soon lose patent protection. These products primarily include Lyrica in certain developed Europe markets, Pristiq globally, Celebrex, Zyvox and Revatio in most developed markets, Vfend and Viagra in certain developed Europe markets and Japan, and Inspra in the EU.
(j) 
Infusion Systems include Medication Management Systems products composed of infusion pumps and related software and services, as well as IV Infusion Products, including large volume IV solutions and their associated administration sets.
(k) 
Biosimilars include Inflectra (biosimilar infliximab) in certain European markets, Nivestim (biosimilar filgrastim) in certain Asian markets and Retacrit (biosimilar epoetin zeta) in certain international markets.
(l) 
Pfizer CentreOne (previously known as Pfizer CentreSource or PCS) includes (i) revenues from legacy Pfizer's contract manufacturing and active pharmaceutical ingredient sales operation, including revenues related to our manufacturing and supply agreements with Zoetis; and (ii) revenues from legacy Hospira’s One-2-One sterile injectables contract manufacturing operation.
(m) 
Includes Eliquis direct sales markets.