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      <regCity>Boston</regCity>
      <regStateConditional regCountry="US" regState="US-MA"/>
      <regZipOrPostalCode>02110</regZipOrPostalCode>
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      <repPdEnd>2022-03-31</repPdEnd>
      <repPdDate>2021-09-30</repPdDate>
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      <totLiabs>769403.140000000000</totLiabs>
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        <title>Facebook Inc</title>
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        <isRestrictedSec>N</isRestrictedSec>

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        <name>IDEXX LABS INC.</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ILLUMINA INC</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>Illumina Inc</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
          <ticker value="ILMN"/>
          <other otherDesc="Internal Id" value="452327109"/>
        </identifiers>
        <balance>136709.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>55450537.490000000000</valUSD>
        <pctVal>2.6175900869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>INTUIT INC.</name>
        <lei>VI90HBPH7XSFMB9E4M29</lei>
        <title>Intuit Inc</title>
        <cusip>461202103</cusip>
        <identifiers>
          <isin value="US4612021034"/>
          <ticker value="INTU"/>
          <other otherDesc="Internal Id" value="461202103"/>
        </identifiers>
        <balance>181391.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>97862258.410000000000</valUSD>
        <pctVal>4.6196716766</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ESTEE LAUDER COMPANIES INC. (THE)</name>
        <lei>549300VFZ8XJ9NUPU221</lei>
        <title>Estee Lauder Cos Inc/The</title>
        <cusip>518439104</cusip>
        <identifiers>
          <isin value="US5184391044"/>
          <ticker value="EL"/>
          <other otherDesc="Internal Id" value="518439104"/>
        </identifiers>
        <balance>148417.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44514710.810000000000</valUSD>
        <pctVal>2.1013550276</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ELI LILLY AND COMPANY</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>Eli Lilly &amp; Co</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY"/>
          <other otherDesc="Internal Id" value="532457108"/>
        </identifiers>
        <balance>138894.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32091458.700000000000</valUSD>
        <pctVal>1.5149047777</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MSCI INC</name>
        <lei>549300HTIN2PD78UB763</lei>
        <title>MSCI Inc</title>
        <cusip>55354G100</cusip>
        <identifiers>
          <isin value="US55354G1004"/>
          <ticker value="MSCI"/>
          <other otherDesc="Internal Id" value="55354G100"/>
        </identifiers>
        <balance>113819.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>69240650.460000000000</valUSD>
        <pctVal>3.2685641738</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MATCH GROUP INC</name>
        <lei>15OMOPB0A8K0EFUVD031</lei>
        <title>Match Group Inc</title>
        <cusip>57667L107</cusip>
        <identifiers>
          <isin value="US57667L1070"/>
          <ticker value="MTCH"/>
          <other otherDesc="Internal Id" value="57667L107"/>
        </identifiers>
        <balance>478476.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>75115947.240000000000</valUSD>
        <pctVal>3.5459125874</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NIKE INC</name>
        <lei>787RXPR0UX0O0XUXPZ81</lei>
        <title>NIKE Inc</title>
        <cusip>654106103</cusip>
        <identifiers>
          <isin value="US6541061031"/>
          <ticker value="NKE"/>
          <other otherDesc="Internal Id" value="654106103"/>
        </identifiers>
        <balance>588282.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>85436194.860000000000</valUSD>
        <pctVal>4.0330887103</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NVIDIA CORP</name>
        <lei>549300S4KLFTLO7GSQ80</lei>
        <title>NVIDIA Corp</title>
        <cusip>67066G104</cusip>
        <identifiers>
          <isin value="US67066G1040"/>
          <ticker value="NVDA"/>
          <other otherDesc="Internal Id" value="67066G104"/>
        </identifiers>
        <balance>418212.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>86636797.920000000000</valUSD>
        <pctVal>4.0897642054</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PayPal Holdings Inc</name>
        <lei>5493005X2GO78EFZ3E94</lei>
        <title>PayPal Holdings Inc</title>
        <cusip>70450Y103</cusip>
        <identifiers>
          <isin value="US70450Y1038"/>
          <ticker value="PYPL"/>
          <other otherDesc="Internal Id" value="70450Y103"/>
        </identifiers>
        <balance>270467.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70378218.070000000000</valUSD>
        <pctVal>3.3222640265</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RingCentral Inc</name>
        <lei>549300C8EH0H1614VE84</lei>
        <title>RingCentral Inc</title>
        <cusip>76680R206</cusip>
        <identifiers>
          <isin value="US76680R2067"/>
          <ticker value="RNG"/>
          <other otherDesc="Internal Id" value="76680R206"/>
        </identifiers>
        <balance>307049.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>66783157.500000000000</valUSD>
        <pctVal>3.1525561150</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SALESFORCE COM</name>
        <lei>RCGZFPDMRW58VJ54VR07</lei>
        <title>salesforce.com Inc</title>
        <cusip>79466L302</cusip>
        <identifiers>
          <isin value="US79466L3024"/>
          <ticker value="CRM"/>
          <other otherDesc="Internal Id" value="79466L302"/>
        </identifiers>
        <balance>273714.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>74236711.080000000000</valUSD>
        <pctVal>3.5044074919</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics Inc</name>
        <lei>549300IKDPIED8J8IG21</lei>
        <title>Sarepta Therapeutics Inc</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
          <ticker value="SRPT"/>
          <other otherDesc="Internal Id" value="803607100"/>
        </identifiers>
        <balance>283750.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26241200.000000000000</valUSD>
        <pctVal>1.2387383080</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SERVICENOW INC</name>
        <lei>549300HJTQM36M0E1G39</lei>
        <title>ServiceNow Inc</title>
        <cusip>81762P102</cusip>
        <identifiers>
          <isin value="US81762P1021"/>
          <ticker value="NOW"/>
          <other otherDesc="Internal Id" value="81762P102"/>
        </identifiers>
        <balance>164150.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>102145620.500000000000</valUSD>
        <pctVal>4.8218714506</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Splunk Inc</name>
        <lei>549300XGDSGBP6UEI867</lei>
        <title>Splunk Inc</title>
        <cusip>848637104</cusip>
        <identifiers>
          <isin value="US8486371045"/>
          <ticker value="SPLK"/>
          <other otherDesc="Internal Id" value="848637104"/>
        </identifiers>
        <balance>314298.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45482063.580000000000</valUSD>
        <pctVal>2.1470197432</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Square Inc</name>
        <lei>549300OHIIUWSTIZME52</lei>
        <title>Square Inc</title>
        <cusip>852234103</cusip>
        <identifiers>
          <isin value="US8522341036"/>
          <ticker value="SQ"/>
          <other otherDesc="Internal Id" value="852234103"/>
        </identifiers>
        <balance>230446.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>55270168.640000000000</valUSD>
        <pctVal>2.6090756210</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Uber Technologies Inc</name>
        <lei>549300B2FTG34FILDR98</lei>
        <title>Uber Technologies Inc</title>
        <cusip>90353T100</cusip>
        <identifiers>
          <isin value="US90353T1007"/>
          <ticker value="UBER"/>
          <other otherDesc="Internal Id" value="90353T100"/>
        </identifiers>
        <balance>1175516.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52663116.800000000000</valUSD>
        <pctVal>2.4860075073</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Visa Inc</name>
        <lei>549300JZ4OKEHW3DPJ59</lei>
        <title>Visa Inc</title>
        <cusip>92826C839</cusip>
        <identifiers>
          <isin value="US92826C8394"/>
          <ticker value="V"/>
          <other otherDesc="Internal Id" value="92826C839"/>
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        <balance>340213.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>75782445.750000000000</valUSD>
        <pctVal>3.5773752201</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>TRANE TECHNOLOGIES PLC</name>
        <lei>549300BURLR9SLYY2705</lei>
        <title>Trane Technologies PLC</title>
        <cusip>G8994E103</cusip>
        <identifiers>
          <isin value="IE00BK9ZQ967"/>
          <ticker value="TT"/>
          <other otherDesc="Internal Id" value="G8994E103"/>
        </identifiers>
        <balance>203025.000000000000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35052266.250000000000</valUSD>
        <pctVal>1.6546722325</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <signature>
      <ncom:dateSigned>2021-10-26</ncom:dateSigned>
      <ncom:nameOfApplicant>Columbia Funds Series Trust I</ncom:nameOfApplicant>
      <ncom:signature>Martha Skinner</ncom:signature>
      <ncom:signerName>Martha Skinner</ncom:signerName>
      <ncom:title>Assistant Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
