<?xml version="1.0" encoding="UTF-8"?>
<edgarSubmission xsi:schemaLocation="http://www.sec.gov/edgar/thirteenffiler eis_13F_Filer.xsd" xmlns:ns1="http://www.sec.gov/edgar/common" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://www.sec.gov/edgar/thirteenffiler">
  <headerData>
    <submissionType>13F-NT</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags/>
      <filer>
        <credentials>
          <cik>0000763848</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>12-31-2021</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>12-31-2021</reportCalendarOrQuarter>
      <isAmendment>false</isAmendment>
      <filingManager>
        <name>NWQ Investment Management Company, LLC</name>
        <address>
          <ns1:street1>2029 Century Park East</ns1:street1>
          <ns1:street2>16th Floor</ns1:street2>
          <ns1:city>Los Angeles</ns1:city>
          <ns1:stateOrCountry>CA</ns1:stateOrCountry>
          <ns1:zipCode>90067</ns1:zipCode>
        </address>
      </filingManager>
      <reportType>13F NOTICE</reportType>
      <form13FFileNumber>028-01474</form13FFileNumber>
      <otherManagersInfo>
        <otherManager>
          <form13FFileNumber>028-14498</form13FFileNumber>
          <name>Nuveen Asset Management, LLC</name>
        </otherManager>
      </otherManagersInfo>
      <provideInfoForInstruction5>N</provideInfoForInstruction5>
    </coverPage>
    <signatureBlock>
      <name>Jon D. Bosse</name>
      <title>Chief Investment Officer</title>
      <phone>(310)-552-5114</phone>
      <signature>/s/ Jon D. Bosse</signature>
      <city>Los Angeles</city>
      <stateOrCountry>CA</stateOrCountry>
      <signatureDate>02-11-2022</signatureDate>
    </signatureBlock>
    <summaryPage>
      <otherIncludedManagersCount>2</otherIncludedManagersCount>
      <tableEntryTotal>0</tableEntryTotal>
      <tableValueTotal>0</tableValueTotal>
      <isConfidentialOmitted>false</isConfidentialOmitted>
      <otherManagers2Info>
        <otherManager2>
          <sequenceNumber>1</sequenceNumber>
          <otherManager>
            <form13FFileNumber>028-11405</form13FFileNumber>
            <name>Nuveen Investments, Inc.</name>
          </otherManager>
        </otherManager2>
        <otherManager2>
          <sequenceNumber>8</sequenceNumber>
          <otherManager>
            <form13FFileNumber>028-16475</form13FFileNumber>
            <name>SEI Investments Management Corporation</name>
          </otherManager>
        </otherManager2>
      </otherManagers2Info>
    </summaryPage>
  </formData>
</edgarSubmission>
