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        <balance>4502</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1215.54</valUSD>
        <pctVal>0.0005715439</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rhythm Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>RHYTHM PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
          <ticker value="RYTM US"/>
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        <balance>7936</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>501475.84</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apogee Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
          <ticker value="APGE US"/>
        </identifiers>
        <balance>13302</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>577705.86</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc.</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
          <ticker value="RCKT US"/>
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        <balance>23535</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>57660.75</valUSD>
        <pctVal>0.0271119404</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>State Street Bank and Trust Company</name>
        <lei>571474TGEMMWANRLN572</lei>
        <title>SCC GOVERMENT MM GVXX 20301231 00001.0000000000</title>
        <cusip>7839989D1</cusip>
        <identifiers>
          <ticker value="7839989D1010"/>
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        <balance>499999.8</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>499999.8</valUSD>
        <pctVal>0.2350986548</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Arcellx Inc.</name>
        <lei>N/A</lei>
        <title>ARCELLX INC COMMON STOCK USD.001</title>
        <cusip>03940C100</cusip>
        <identifiers>
          <isin value="US03940C1009"/>
          <ticker value="ACLX US"/>
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        <balance>9687</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>637888.95</valUSD>
        <pctVal>0.2999337881</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>argenx SE</name>
        <lei>N/A</lei>
        <title>ARGENX SE ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
          <ticker value="ARGX US"/>
        </identifiers>
        <balance>13002</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7166962.44</valUSD>
        <pctVal>3.3698878051</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sana Biotechnology Inc.</name>
        <lei>N/A</lei>
        <title>SANA BIOTECHNOLOGY INC COMMON STOCK USD.0001</title>
        <cusip>799566104</cusip>
        <identifiers>
          <isin value="US7995661045"/>
          <ticker value="SANA US"/>
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        <balance>54773</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>149530.29</valUSD>
        <pctVal>0.0703087682</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sanofi</name>
        <lei>549300E9PC51EN656011</lei>
        <title>SANOFI SA ADR</title>
        <cusip>80105N105</cusip>
        <identifiers>
          <isin value="US80105N1054"/>
          <ticker value="SNY US"/>
        </identifiers>
        <balance>26965</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1302679.15</valUSD>
        <pctVal>0.6125164766</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arvinas Inc.</name>
        <lei>N/A</lei>
        <title>ARVINAS INC COMMON STOCK USD.001</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
          <ticker value="ARVN US"/>
        </identifiers>
        <balance>4849</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35688.64</valUSD>
        <pctVal>0.0167807092</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Celldex Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CELLDEX THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
          <ticker value="CLDX US"/>
        </identifiers>
        <balance>17861</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>363471.35</valUSD>
        <pctVal>0.1709033192</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corporation</name>
        <lei>N/A</lei>
        <title>SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK US"/>
        </identifiers>
        <balance>39504</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1399231.68</valUSD>
        <pctVal>0.6579152346</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GeneDx Holdings Corp.</name>
        <lei>N/A</lei>
        <title>GENEDX HOLDINGS CORP GENEDX HOLDINGS CORP</title>
        <cusip>81663L119</cusip>
        <identifiers>
          <isin value="US81663L1199"/>
          <ticker value="WGSWW"/>
        </identifiers>
        <balance>4862</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>320.89</valUSD>
        <pctVal>0.0001508817</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Centessa Pharmaceuticals plc</name>
        <lei>N/A</lei>
        <title>CENTESSA PHARMACEUTICALS PLC ADR USD.0001</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
          <ticker value="CNTA US"/>
        </identifiers>
        <balance>69050</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>907317</valUSD>
        <pctVal>0.4266181830</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CG Oncology Inc.</name>
        <lei>N/A</lei>
        <title>CG ONCOLOGY INC COMMON STOCK</title>
        <cusip>156944100</cusip>
        <identifiers>
          <isin value="US1569441009"/>
          <ticker value="CGON US"/>
        </identifiers>
        <balance>26067</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>677742</valUSD>
        <pctVal>0.3186725925</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sionna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SIONNA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>829401108</cusip>
        <identifiers>
          <isin value="US8294011080"/>
          <ticker value="SION US"/>
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        <balance>7726</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>134046.1</valUSD>
        <pctVal>0.0630281408</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Soleno Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SOLENO THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>834203309</cusip>
        <identifiers>
          <isin value="US8342033094"/>
          <ticker value="SLNO US"/>
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        <balance>12538</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1050433.64</valUSD>
        <pctVal>0.4939112690</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>The Cooper Companies Inc.</name>
        <lei>QJKMVPIGLH7530PCUE20</lei>
        <title>COOPER COS INC/THE COMMON STOCK USD.1</title>
        <cusip>216648501</cusip>
        <identifiers>
          <isin value="US2166485019"/>
          <ticker value="COO US"/>
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        <balance>21033</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1496708.28</valUSD>
        <pctVal>0.7037484880</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Immunome Inc.</name>
        <lei>N/A</lei>
        <title>IMMUNOME INC COMMON STOCK USD.0001</title>
        <cusip>45257U108</cusip>
        <identifiers>
          <isin value="US45257U1088"/>
          <ticker value="IMNM US"/>
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        <balance>56594</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>526324.2</valUSD>
        <pctVal>0.2474763218</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Tarsus Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>TARSUS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>87650L103</cusip>
        <identifiers>
          <isin value="US87650L1035"/>
          <ticker value="TARS US"/>
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        <balance>7654</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>310063.54</valUSD>
        <pctVal>0.1457911006</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Thermo Fisher Scientific Inc.</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO US"/>
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        <balance>16290</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6604943.4</valUSD>
        <pctVal>3.1056278588</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Immunocore Holdings plc</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC ADR GBP.0001</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
          <ticker value="IMCR US"/>
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        <balance>18135</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>569076.3</valUSD>
        <pctVal>0.2675782522</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Insmed Incorporated</name>
        <lei>N/A</lei>
        <title>INSMED INC COMMON STOCK USD.01</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <ticker value="INSM US"/>
        </identifiers>
        <balance>46148</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4644334.72</valUSD>
        <pctVal>2.1837545636</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc.</name>
        <lei>N/A</lei>
        <title>ULTRAGENYX PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
          <ticker value="RARE US"/>
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        <balance>16546</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>601612.56</valUSD>
        <pctVal>0.2828767203</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>United Therapeutics Corporation</name>
        <lei>N/A</lei>
        <title>UNITED THERAPEUTICS CORP COMMON STOCK USD.01</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
          <ticker value="UTHR US"/>
        </identifiers>
        <balance>1551</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>445679.85</valUSD>
        <pctVal>0.2095575502</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intuitive Surgical Inc.</name>
        <lei>54930052SRG011710797</lei>
        <title>INTUITIVE SURGICAL INC COMMON STOCK USD.001</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
          <ticker value="ISRG US"/>
        </identifiers>
        <balance>22909</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12448979.69</valUSD>
        <pctVal>5.8534790986</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mettler-Toledo International Inc.</name>
        <lei>5493000BD5GJNUDIUG10</lei>
        <title>METTLER-TOLEDO INTERNATIONAL I COMMON STOCK USD.01</title>
        <cusip>592688105</cusip>
        <identifiers>
          <isin value="US5926881054"/>
          <ticker value="MTD US"/>
        </identifiers>
        <balance>692</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>812906.24</valUSD>
        <pctVal>0.3822264799</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UnitedHealth Group Incorporated</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC COMMON STOCK USD.01</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNH US"/>
        </identifiers>
        <balance>34934</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10898359.98</valUSD>
        <pctVal>5.1243815911</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Universal Health Services Inc.</name>
        <lei>549300YGMGQDO0NMJD09</lei>
        <title>UNIVERSAL HEALTH SERVICES INC COMMON STOCK USD.01</title>
        <cusip>913903100</cusip>
        <identifiers>
          <isin value="US9139031002"/>
          <ticker value="UHS US"/>
        </identifiers>
        <balance>1300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>235495</valUSD>
        <pctVal>0.1107291597</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molina Healthcare Inc.</name>
        <lei>549300NQQCEQ46YHZ591</lei>
        <title>MOLINA HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>60855R100</cusip>
        <identifiers>
          <isin value="US60855R1005"/>
          <ticker value="MOH US"/>
        </identifiers>
        <balance>4954</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1475796.6</valUSD>
        <pctVal>0.6939158684</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roivant Sciences Ltd.</name>
        <lei>N/A</lei>
        <title>ROIVANT SCIENCES LTD COMMON STOCK USD.0000001</title>
        <cusip>G76279101</cusip>
        <identifiers>
          <isin value="BMG762791017"/>
          <ticker value="ROIV US"/>
        </identifiers>
        <balance>18400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>207368</valUSD>
        <pctVal>0.0975039147</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vaxcyte Inc.</name>
        <lei>N/A</lei>
        <title>VAXCYTE INC COMMON STOCK USD.001</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
          <ticker value="PCVX US"/>
        </identifiers>
        <balance>32110</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1043896.1</valUSD>
        <pctVal>0.4908373340</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Veeva Systems Inc.</name>
        <lei>549300YZEXPDB92M2F02</lei>
        <title>VEEVA SYSTEMS INC COMMON STOCK USD.00001</title>
        <cusip>922475108</cusip>
        <identifiers>
          <isin value="US9224751084"/>
          <ticker value="VEEV US"/>
        </identifiers>
        <balance>3109</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>895329.82</valUSD>
        <pctVal>0.4209818409</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MediWound Ltd</name>
        <lei>N/A</lei>
        <title>MEDIWOUND LTD COMMON STOCK ILS.01</title>
        <cusip>M68830112</cusip>
        <identifiers>
          <isin value="IL0011316309"/>
          <ticker value="MDWD US"/>
        </identifiers>
        <balance>5415</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>104888.55</valUSD>
        <pctVal>0.0493183337</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
          <ticker value="VERA US"/>
        </identifiers>
        <balance>27014</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>636449.84</valUSD>
        <pctVal>0.2992571222</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Verona Pharma PLC</name>
        <lei>N/A</lei>
        <title>VERONA PHARMA PLC ADR</title>
        <cusip>925050106</cusip>
        <identifiers>
          <isin value="US9250501064"/>
          <ticker value="VRNA US"/>
        </identifiers>
        <balance>26979</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2551673.82</valUSD>
        <pctVal>1.1997906450</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX US"/>
        </identifiers>
        <balance>18510</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8240652</valUSD>
        <pctVal>3.8747339494</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Viridian Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>VIRIDIAN THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>92790C104</cusip>
        <identifiers>
          <isin value="US92790C1045"/>
          <ticker value="VRDN US"/>
        </identifiers>
        <balance>10200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>142596</valUSD>
        <pctVal>0.0670482824</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Voyager Therapeutics Inc.</name>
        <lei>54930082S4XVR0ZWCC74</lei>
        <title>VOYAGER THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>92915B106</cusip>
        <identifiers>
          <isin value="US92915B1061"/>
          <ticker value="VYGR US"/>
        </identifiers>
        <balance>15964</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49648.04</valUSD>
        <pctVal>0.0233443842</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC COMMON STOCK USD.01</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <ticker value="XNCR US"/>
        </identifiers>
        <balance>13179</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>103586.94</valUSD>
        <pctVal>0.0487063200</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zai Lab Limited</name>
        <lei>N/A</lei>
        <title>ZAI LAB LTD ADR USD.00006</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
          <ticker value="ZLAB US"/>
        </identifiers>
        <balance>4866</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>170164.02</valUSD>
        <pctVal>0.0800106964</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BeOne Medicines Ltd</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEONE MEDICINES LTD COMMON STOCK USD.0001</title>
        <cusip>BVDKGC900</cusip>
        <identifiers>
          <isin value="CH1391448177"/>
          <ticker value="6160 HK"/>
        </identifiers>
        <balance>157998</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.84995"/>
        <valUSD>2988853.38</valUSD>
        <pctVal>1.4053513801</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sensorion</name>
        <lei>N/A</lei>
        <title>SENSORION SA COMMON STOCK EUR.1</title>
        <cusip>BWSW4N905</cusip>
        <identifiers>
          <isin value="FR0012596468"/>
          <ticker value="ALSEN FP"/>
        </identifiers>
        <balance>182870</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.848932"/>
        <valUSD>67343.99</valUSD>
        <pctVal>0.0316649756</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes Public Limited Company</name>
        <lei>549300YHRMYLL071E243</lei>
        <title>ALKERMES PLC COMMON STOCK USD.01</title>
        <cusip>G01767105</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
          <ticker value="ALKS US"/>
        </identifiers>
        <balance>28133</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>804885.13</valUSD>
        <pctVal>0.3784549740</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Ltd.</name>
        <lei>N/A</lei>
        <title>BIOHAVEN LTD COMMON STOCK</title>
        <cusip>G1110E107</cusip>
        <identifiers>
          <isin value="VGG1110E1079"/>
          <ticker value="BHVN US"/>
        </identifiers>
        <balance>39446</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>556583.06</valUSD>
        <pctVal>0.2617039620</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merus N.V.</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>MERUS NV COMMON STOCK EUR.05</title>
        <cusip>N5749R100</cusip>
        <identifiers>
          <isin value="NL0011606264"/>
          <ticker value="MRUS US"/>
        </identifiers>
        <balance>10580</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>556508</valUSD>
        <pctVal>0.2616686690</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pharvaris N.V.</name>
        <lei>N/A</lei>
        <title>PHARVARIS NV COMMON STOCK EUR.12</title>
        <cusip>N69605108</cusip>
        <identifiers>
          <isin value="NL00150005Y4"/>
          <ticker value="PHVS US"/>
        </identifiers>
        <balance>11645</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>204952</valUSD>
        <pctVal>0.0963679175</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Wave Life Sciences Ltd.</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD COMMON STOCK</title>
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      <invstOrSec>
        <name>Sonova Holding AG</name>
        <lei>N/A</lei>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>Praxis Precision Medicines Inc.</name>
        <lei>N/A</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Prelude Therapeutics Incorporated</name>
        <lei>N/A</lei>
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      <invstOrSec>
        <name>Procept Biorobotics Corporation</name>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SomaLogic Inc.</name>
        <lei>N/A</lei>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <fairValLevel>2</fairValLevel>
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      <invstOrSec>
        <name>Stryker Corporation</name>
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        <assetCat>EC</assetCat>
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      <invstOrSec>
        <name>Structure Therapeutics Inc.</name>
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          <isin value="US86366E1064"/>
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        <assetCat>EC</assetCat>
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      <invstOrSec>
        <name>Summit Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SUMMIT THERAPEUTICS INC COMMON STOCK USD.01</title>
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          <isin value="US86627T1088"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AbbVie Inc.</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC COMMON STOCK USD.01</title>
        <cusip>00287Y109</cusip>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Acadia Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ACADIA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>004225108</cusip>
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          <isin value="US0042251084"/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Spyre Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SPYRE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>00773J202</cusip>
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          <isin value="US00773J2024"/>
          <ticker value="SYRE US"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Agios Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>AGIOS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>00847X104</cusip>
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        <assetCat>EC</assetCat>
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        <name>Akero Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>AKERO THERAPEUTICS INC COMMON STOCK USD.0001</title>
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        <assetCat>EC</assetCat>
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        <name>Alector Inc.</name>
        <lei>N/A</lei>
        <title>ALECTOR INC COMMON STOCK USD.0001</title>
        <cusip>014442107</cusip>
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        <assetCat>EC</assetCat>
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        <name>Alignment Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>ALIGNMENT HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>01625V104</cusip>
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        <assetCat>EC</assetCat>
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        <name>Allogene Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC COMMON STOCK USD.001</title>
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        <name>Alnylam Pharmaceuticals Inc.</name>
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        <name>Cencora Inc.</name>
        <lei>AI8GXW8LG5WK7E9UD086</lei>
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        <cusip>03073E105</cusip>
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        <name>Amgen Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
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        <cusip>031162100</cusip>
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        <assetCat>EC</assetCat>
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        <name>Annexon Inc.</name>
        <lei>N/A</lei>
        <title>ANNEXON INC COMMON STOCK</title>
        <cusip>03589W102</cusip>
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        <assetCat>EC</assetCat>
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        <name>Elevance Health Inc.</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>ELEVANCE HEALTH INC COMMON STOCK USD.01</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>Ascendis Pharma A/S</name>
        <lei>N/A</lei>
        <title>ASCENDIS PHARMA A/S ADR DKK1.0</title>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC ADR</title>
        <cusip>046353108</cusip>
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          <ticker value="AZN US"/>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aura Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AURA BIOSCIENCES INC COMMON STOCK USD.00001</title>
        <cusip>05153U107</cusip>
        <identifiers>
          <isin value="US05153U1079"/>
          <ticker value="AURA US"/>
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        <balance>10426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>65266.76</valUSD>
        <pctVal>0.0306882672</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avidity Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AVIDITY BIOSCIENCES INC COMMON STOCK</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
          <ticker value="RNA US"/>
        </identifiers>
        <balance>47552</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1350476.8</valUSD>
        <pctVal>0.6349908120</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Axsome Therapeutics Inc.</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
          <ticker value="AXSM US"/>
        </identifiers>
        <balance>1500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>156585</valUSD>
        <pctVal>0.0736258752</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Bicara Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BICARA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>055477103</cusip>
        <identifiers>
          <isin value="US0554771032"/>
          <ticker value="BCAX US"/>
        </identifiers>
        <balance>31071</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>288649.59</valUSD>
        <pctVal>0.1357223149</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Beam Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
          <ticker value="BEAM US"/>
        </identifiers>
        <balance>24279</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>412985.79</valUSD>
        <pctVal>0.1941848850</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BeOne Medicines Ltd.</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEONE MEDICINES LTD ADR USD.0001</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
          <ticker value="ONC US"/>
        </identifiers>
        <balance>360</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87145.2</valUSD>
        <pctVal>0.0409754550</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Beta Bionics Inc.</name>
        <lei>N/A</lei>
        <title>BETA BIONICS INC COMMON STOCK USD.0001</title>
        <cusip>08659B102</cusip>
        <identifiers>
          <isin value="US08659B1026"/>
          <ticker value="BBNX US"/>
        </identifiers>
        <balance>4325</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>62972</valUSD>
        <pctVal>0.0296092768</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bicycle Therapeutics plc</name>
        <lei>N/A</lei>
        <title>BICYCLE THERAPEUTICS PLC ADR USD.01</title>
        <cusip>088786108</cusip>
        <identifiers>
          <isin value="US0887861088"/>
          <ticker value="BCYC US"/>
        </identifiers>
        <balance>25602</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>177933.9</valUSD>
        <pctVal>0.0836640745</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Blueprint Medicines Corporation</name>
        <lei>N/A</lei>
        <title>BLUEPRINT MEDICINES CORP COMMON STOCK USD.001</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
          <ticker value="BPMC US"/>
        </identifiers>
        <balance>9602</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1230784.36</valUSD>
        <pctVal>0.5787117262</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Boston Scientific Corporation</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>BOSTON SCIENTIFIC CORP COMMON STOCK USD.01</title>
        <cusip>101137107</cusip>
        <identifiers>
          <isin value="US1011371077"/>
          <ticker value="BSX US"/>
        </identifiers>
        <balance>73791</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7925891.31</valUSD>
        <pctVal>3.7267342607</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BrightSpring Health Services Inc.</name>
        <lei>N/A</lei>
        <title>BRIGHTSPRING HEALTH SERVICES I COMMON STOCK USD100.0</title>
        <cusip>10950A106</cusip>
        <identifiers>
          <isin value="US10950A1060"/>
          <ticker value="BTSG US"/>
        </identifiers>
        <balance>39334</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>927889.06</valUSD>
        <pctVal>0.4362911141</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>The Cigna Group</name>
        <lei>N/A</lei>
        <title>CIGNA GROUP/THE COMMON STOCK USD.01</title>
        <cusip>125523100</cusip>
        <identifiers>
          <isin value="US1255231003"/>
          <ticker value="CI US"/>
        </identifiers>
        <balance>13901</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4595392.58</valUSD>
        <pctVal>2.1607420919</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CVS Health Corporation</name>
        <lei>549300EJG376EN5NQE29</lei>
        <title>CVS HEALTH CORP COMMON STOCK USD.01</title>
        <cusip>126650100</cusip>
        <identifiers>
          <isin value="US1266501006"/>
          <ticker value="CVS US"/>
        </identifiers>
        <balance>19771</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1363803.58</valUSD>
        <pctVal>0.6412570306</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cabaletta Bio Inc.</name>
        <lei>N/A</lei>
        <title>CABALETTA BIO INC COMMON STOCK USD.00001</title>
        <cusip>12674W109</cusip>
        <identifiers>
          <isin value="US12674W1099"/>
          <ticker value="CABA US"/>
        </identifiers>
        <balance>9787</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14876.24</valUSD>
        <pctVal>0.0069947708</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Cardinal Health Inc.</name>
        <lei>CCU46N3GJMF4OK4N7U60</lei>
        <title>CARDINAL HEALTH INC COMMON STOCK</title>
        <cusip>14149Y108</cusip>
        <identifiers>
          <isin value="US14149Y1082"/>
          <ticker value="CAH US"/>
        </identifiers>
        <balance>6020</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1011360</valUSD>
        <pctVal>0.4755389412</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CARGO Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CARGO THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>14179K101</cusip>
        <identifiers>
          <isin value="US14179K1016"/>
          <ticker value="CRGX US"/>
        </identifiers>
        <balance>6153</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25350.36</valUSD>
        <pctVal>0.0119196758</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Caris Life Sciences Inc.</name>
        <lei>N/A</lei>
        <title>CARIS LIFE SCIENCES INC COMMON STOCK USD.001</title>
        <cusip>142152107</cusip>
        <identifiers>
          <isin value="US1421521071"/>
          <ticker value="CAI US"/>
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        <balance>5439</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>145330.08</valUSD>
        <pctVal>0.0683338400</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Crinetics Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>CRINETICS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
          <ticker value="CRNX US"/>
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        <balance>22567</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>649026.92</valUSD>
        <pctVal>0.3051708337</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cytokinetics Incorporated</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC COMMON STOCK USD.001</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
          <ticker value="CYTK US"/>
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        <balance>9735</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>321644.4</valUSD>
        <pctVal>0.1512363920</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Danaher Corporation</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>DANAHER CORP COMMON STOCK USD.01</title>
        <cusip>235851102</cusip>
        <identifiers>
          <isin value="US2358511028"/>
          <ticker value="DHR US"/>
        </identifiers>
        <balance>33834</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6683568.36</valUSD>
        <pctVal>3.1425971183</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Denali Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DENALI THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
          <ticker value="DNLI US"/>
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        <balance>53705</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>751332.95</valUSD>
        <pctVal>0.3532748730</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>DexCom Inc.</name>
        <lei>N/A</lei>
        <title>DEXCOM INC COMMON STOCK USD.001</title>
        <cusip>252131107</cusip>
        <identifiers>
          <isin value="US2521311074"/>
          <ticker value="DXCM US"/>
        </identifiers>
        <balance>7020</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>612775.8</valUSD>
        <pctVal>0.2881256478</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Disc Medicine Inc.</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC COMMON STOCK USD.0001</title>
        <cusip>254604101</cusip>
        <identifiers>
          <isin value="US2546041011"/>
          <ticker value="IRON US"/>
        </identifiers>
        <balance>7393</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>391533.28</valUSD>
        <pctVal>0.1840979685</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Climb Bio Inc.</name>
        <lei>N/A</lei>
        <title>CLIMB BIO INC COMMON STOCK USD.0001</title>
        <cusip>28658R106</cusip>
        <identifiers>
          <isin value="US28658R1068"/>
          <ticker value="CLYM US"/>
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        <balance>9200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11408</valUSD>
        <pctVal>0.0053640131</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Encompass Health Corporation</name>
        <lei>549300FVRPM9DRQZRG64</lei>
        <title>ENCOMPASS HEALTH CORP COMMON STOCK USD.01</title>
        <cusip>29261A100</cusip>
        <identifiers>
          <isin value="US29261A1007"/>
          <ticker value="EHC US"/>
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        <balance>4586</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>562381.18</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Enliven Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>29337E102</cusip>
        <identifiers>
          <isin value="US29337E1029"/>
          <ticker value="ELVN US"/>
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        <balance>7709</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>154642.54</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Entrada Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>ENTRADA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>29384C108</cusip>
        <identifiers>
          <isin value="US29384C1080"/>
          <ticker value="TRDA US"/>
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        <balance>11625</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Exact Sciences Corporation</name>
        <lei>N/A</lei>
        <title>EXACT SCIENCES CORP COMMON STOCK USD.01</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
          <ticker value="EXAS US"/>
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        <balance>20421</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1085171.94</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Generation Bio Co.</name>
        <lei>N/A</lei>
        <title>GENERATION BIO CO COMMON STOCK USD.0001</title>
        <cusip>37148K100</cusip>
        <identifiers>
          <isin value="US37148K1007"/>
          <ticker value="GBIO US"/>
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        <balance>37692</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12065.21</valUSD>
        <pctVal>0.0056730316</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Gilead Sciences Inc.</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC COMMON STOCK USD.001</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
          <ticker value="GILD US"/>
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        <balance>46984</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5209116.08</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Ginkgo Bioworks Holdings Inc.</name>
        <lei>N/A</lei>
        <title>GINKGO BIOWORKS HOLDINGS INC COMMON STOCK USD.0001</title>
        <cusip>37611X209</cusip>
        <identifiers>
          <isin value="US37611X2099"/>
          <ticker value="DNA US"/>
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        <balance>1971</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22173.75</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Guardant Health Inc.</name>
        <lei>N/A</lei>
        <title>GUARDANT HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
          <ticker value="GH US"/>
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        <balance>20059</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1043870.36</valUSD>
        <pctVal>0.4908252311</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>HCA Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>HCA HEALTHCARE INC COMMON STOCK USD.01</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
          <ticker value="HCA US"/>
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        <balance>4490</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1720119</valUSD>
        <pctVal>0.8087956495</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Heron Therapeutics Inc.</name>
        <lei>549300DR2I1DOPD2IX53</lei>
        <title>HERON THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>427746102</cusip>
        <identifiers>
          <isin value="US4277461020"/>
          <ticker value="HRTX US"/>
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        <balance>43200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>89424</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IDEAYA Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IDEAYA BIOSCIENCES INC COMMON STOCK</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
          <ticker value="IDYA US"/>
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        <balance>8737</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>183651.74</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IDEXX Laboratories Inc.</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX LABORATORIES INC COMMON STOCK USD.1</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
          <ticker value="IDXX US"/>
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        <balance>1698</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>910705.32</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Immunocore Holdings plc</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC SR UNSECURED 02/30 2.5</title>
        <cusip>45258DAB1</cusip>
        <identifiers>
          <isin value="US45258DAB10"/>
          <ticker value="IMCR"/>
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        <balance>277000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>238864.86</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <debtSec>
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          <couponKind>Fixed</couponKind>
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          <isContngtConvrtbl>N</isContngtConvrtbl>
          <dbtSecRefInstruments>
            <dbtSecRefInstrument>
              <name>Immunocore Holdings PLC</name>
              <title>Immunocore Holdings PLC</title>
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                <ticker value="IMCR"/>
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      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc.</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
          <ticker value="IONS US"/>
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        <units>NS</units>
        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Iovance Biotherapeutics Inc.</name>
        <lei>N/A</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC COMMON STOCK USD.000041666</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
          <ticker value="IOVA US"/>
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        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54501.64</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Janux Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>JANUX THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>47103J105</cusip>
        <identifiers>
          <isin value="US47103J1051"/>
          <ticker value="JANX US"/>
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        <balance>10117</balance>
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        <curCd>USD</curCd>
        <valUSD>233702.7</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Krystal Biotech Inc.</name>
        <lei>N/A</lei>
        <title>KRYSTAL BIOTECH INC COMMON STOCK USD.00001</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
          <ticker value="KRYS US"/>
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        <curCd>USD</curCd>
        <valUSD>435473.28</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Kymera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
          <ticker value="KYMR US"/>
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        <balance>28002</balance>
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        <curCd>USD</curCd>
        <valUSD>1222007.28</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Kyverna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYVERNA THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>501976104</cusip>
        <identifiers>
          <isin value="US5019761049"/>
          <ticker value="KYTX US"/>
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        <balance>27613</balance>
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        <curCd>USD</curCd>
        <valUSD>84771.91</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>Lantheus Holdings Inc.</name>
        <lei>N/A</lei>
        <title>LANTHEUS HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
          <ticker value="LNTH US"/>
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        <balance>3453</balance>
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        <curCd>USD</curCd>
        <valUSD>282662.58</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Legend Biotech Corporation</name>
        <lei>N/A</lei>
        <title>LEGEND BIOTECH CORP ADR USD.0001</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
          <ticker value="LEGN US"/>
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        <balance>13773</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>488803.77</valUSD>
        <pctVal>0.2298343095</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly and Company</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO COMMON STOCK</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY US"/>
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        <balance>32643</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25446197.79</valUSD>
        <pctVal>11.9647385257</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lyell Immunopharma Inc.</name>
        <lei>N/A</lei>
        <title>LYELL IMMUNOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>55083R203</cusip>
        <identifiers>
          <isin value="US55083R2031"/>
          <ticker value="LYEL US"/>
        </identifiers>
        <balance>6196</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54772.64</valUSD>
        <pctVal>0.0257539583</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MBX Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>MBX BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>55287L101</cusip>
        <identifiers>
          <isin value="US55287L1017"/>
          <ticker value="MBX US"/>
        </identifiers>
        <balance>26494</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>302296.54</valUSD>
        <pctVal>0.1421390767</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MADRIGAL PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
          <ticker value="MDGL US"/>
        </identifiers>
        <balance>3063</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>926986.32</valUSD>
        <pctVal>0.4358666480</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>U C B SA</name>
        <lei>N/A</lei>
        <title>UCB SA COMMON STOCK</title>
        <cusip>559699905</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
          <ticker value="UCB BB"/>
        </identifiers>
        <balance>1373</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.848932"/>
        <valUSD>270148.43</valUSD>
        <pctVal>0.1270231158</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Masimo Corporation</name>
        <lei>549300Q4A8JK0PIYCU29</lei>
        <title>MASIMO CORP COMMON STOCK USD.001</title>
        <cusip>574795100</cusip>
        <identifiers>
          <isin value="US5747951003"/>
          <ticker value="MASI US"/>
        </identifiers>
        <balance>5512</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>927228.64</valUSD>
        <pctVal>0.4359805863</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>McKesson Corporation</name>
        <lei>549300WZWOM80UCFSF54</lei>
        <title>MCKESSON CORP COMMON STOCK USD.01</title>
        <cusip>58155Q103</cusip>
        <identifiers>
          <isin value="US58155Q1031"/>
          <ticker value="MCK US"/>
        </identifiers>
        <balance>433</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>317293.74</valUSD>
        <pctVal>0.1491907226</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sartorius Aktiengesellschaft</name>
        <lei>N/A</lei>
        <title>SARTORIUS AG PREFERENCE</title>
        <cusip>584332902</cusip>
        <identifiers>
          <isin value="DE0007165631"/>
          <ticker value="SRT3 GR"/>
        </identifiers>
        <balance>2158</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.848932"/>
        <valUSD>549638.04</valUSD>
        <pctVal>0.2584384310</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Metsera Inc.</name>
        <lei>N/A</lei>
        <title>METSERA INC COMMON STOCK USD.00001</title>
        <cusip>59267L107</cusip>
        <identifiers>
          <isin value="US59267L1070"/>
          <ticker value="MTSR US"/>
        </identifiers>
        <balance>10966</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>311982.7</valUSD>
        <pctVal>0.1466934849</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Monte Rosa Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
          <ticker value="GLUE US"/>
        </identifiers>
        <balance>29932</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>134993.32</valUSD>
        <pctVal>0.0634735213</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MoonLake Immunotherapeutics</name>
        <lei>N/A</lei>
        <title>MOONLAKE IMMUNOTHERAPEUTICS COMMON STOCK USD.0001</title>
        <cusip>61559X104</cusip>
        <identifiers>
          <isin value="KY61559X1045"/>
          <ticker value="MLTX US"/>
        </identifiers>
        <balance>22471</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1060631.2</valUSD>
        <pctVal>0.4987061362</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tenet Healthcare Corporation</name>
        <lei>0W9AIBT6U6ADJ2I8HK17</lei>
        <title>TENET HEALTHCARE CORP COMMON STOCK USD.05</title>
        <cusip>88033G407</cusip>
        <identifiers>
          <isin value="US88033G4073"/>
          <ticker value="THC US"/>
        </identifiers>
        <balance>12160</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2140160</valUSD>
        <pctVal>1.0062978766</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Helix Acquisition Corp. II</name>
        <lei>N/A</lei>
        <title>HELIX ACQUISITION CORP II COMMON STOCK USD.0001</title>
        <cusip>G4444H101</cusip>
        <identifiers>
          <isin value="KYG4444H1011"/>
          <ticker value="HLXB US"/>
        </identifiers>
        <balance>16298</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>173573.7</valUSD>
        <pctVal>0.0816139194</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Icon Public Limited Company</name>
        <lei>N/A</lei>
        <title>ICON PLC COMMON STOCK EUR.06</title>
        <cusip>G4705A100</cusip>
        <identifiers>
          <isin value="IE0005711209"/>
          <ticker value="ICLR US"/>
        </identifiers>
        <balance>1899</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>276209.55</valUSD>
        <pctVal>0.1298730392</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kestra Medical Technologies Ltd</name>
        <lei>N/A</lei>
        <title>KESTRA MEDICAL TECHNOLOGIES LT COMMON STOCK USD100.0</title>
        <cusip>G52441105</cusip>
        <identifiers>
          <isin value="BMG524411052"/>
          <ticker value="KMTS US"/>
        </identifiers>
        <balance>9069</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>150364.02</valUSD>
        <pctVal>0.0707007859</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UroGen Pharma Ltd.</name>
        <lei>N/A</lei>
        <title>UROGEN PHARMA LTD COMMON STOCK USD.01</title>
        <cusip>M96088105</cusip>
        <identifiers>
          <isin value="IL0011407140"/>
          <ticker value="URGN US"/>
        </identifiers>
        <balance>5500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>75350</valUSD>
        <pctVal>0.0354293814</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Returns are reported without deduction of sales loads and redemption fees, if applicable." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-07-30</ncom:dateSigned>
      <ncom:nameOfApplicant>John Hancock Variable Insurance Trust</ncom:nameOfApplicant>
      <ncom:signature>/s/Salvatore Schiavone</ncom:signature>
      <ncom:signerName>Salvatore Schiavone</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
