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        <balance>29009</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Alto Neuroscience Inc.</name>
        <lei>N/A</lei>
        <title>ALTO NEUROSCIENCE INC COMMON STOCK USD.0001</title>
        <cusip>02157Q109</cusip>
        <identifiers>
          <isin value="US02157Q1094"/>
          <ticker value="ANRO US"/>
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        <balance>11405</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>48243.15</valUSD>
        <pctVal>0.0204580574</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Bicycle Therapeutics plc</name>
        <lei>N/A</lei>
        <title>BICYCLE THERAPEUTICS PLC ADR USD.01</title>
        <cusip>088786108</cusip>
        <identifiers>
          <isin value="US0887861088"/>
          <ticker value="BCYC US"/>
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        <balance>25602</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>358428</valUSD>
        <pctVal>0.1519954772</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc.</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BIOMARIN PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
          <ticker value="BMRN US"/>
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        <balance>7769</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>510656.37</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Oscar Health Inc.</name>
        <lei>N/A</lei>
        <title>OSCAR HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>687793109</cusip>
        <identifiers>
          <isin value="US6877931096"/>
          <ticker value="OSCR US"/>
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        <balance>58445</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>785500.8</valUSD>
        <pctVal>0.3331005640</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Pacific Biosciences of California Inc.</name>
        <lei>N/A</lei>
        <title>PACIFIC BIOSCI OF CALIFORNIA COMMON STOCK USD.0001</title>
        <cusip>69404D108</cusip>
        <identifiers>
          <isin value="US69404D1081"/>
          <ticker value="PACB US"/>
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        <balance>36531</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>66851.73</valUSD>
        <pctVal>0.0283492378</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Penumbra Inc.</name>
        <lei>549300RGE06P3ECANU72</lei>
        <title>PENUMBRA INC COMMON STOCK USD.001</title>
        <cusip>70975L107</cusip>
        <identifiers>
          <isin value="US70975L1070"/>
          <ticker value="PEN US"/>
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        <balance>11039</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2621541.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Revvity Inc.</name>
        <lei>549300IKL1SDPFI7N655</lei>
        <title>REVVITY INC COMMON STOCK USD1.0</title>
        <cusip>714046109</cusip>
        <identifiers>
          <isin value="US7140461093"/>
          <ticker value="RVTY US"/>
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        <balance>7889</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>880491.29</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sonova Holding AG</name>
        <lei>N/A</lei>
        <title>SONOVA HOLDING AG COMMON STOCK CHF.05</title>
        <cusip>715603908</cusip>
        <identifiers>
          <isin value="CH0012549785"/>
          <ticker value="SOON SW"/>
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        <balance>4515</balance>
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        <currencyConditional curCd="CHF" exchangeRt="0.90755"/>
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        <pctVal>0.6261048934</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Pliant Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PLIANT THERAPEUTICS INC COMMON STOCK</title>
        <cusip>729139105</cusip>
        <identifiers>
          <isin value="US7291391057"/>
          <ticker value="PLRX US"/>
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        <balance>13685</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>180231.45</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Praxis Precision Medicines Inc.</name>
        <lei>N/A</lei>
        <title>PRAXIS PRECISION MEDICINES INC COMMON STOCK USD.0001</title>
        <cusip>74006W207</cusip>
        <identifiers>
          <isin value="US74006W2070"/>
          <ticker value="PRAX US"/>
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        <balance>6932</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>533486.72</valUSD>
        <pctVal>0.2262311220</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Prelude Therapeutics Incorporated</name>
        <lei>N/A</lei>
        <title>PRELUDE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>74065P101</cusip>
        <identifiers>
          <isin value="US74065P1012"/>
          <ticker value="PRLD US"/>
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        <balance>17428</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22220.7</valUSD>
        <pctVal>0.0094229410</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Procept Biorobotics Corporation</name>
        <lei>N/A</lei>
        <title>PROCEPT BIOROBOTICS CORP COMMON STOCK USD.00001</title>
        <cusip>74276L105</cusip>
        <identifiers>
          <isin value="US74276L1052"/>
          <ticker value="PRCT US"/>
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        <balance>9391</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>756163.32</valUSD>
        <pctVal>0.3206596713</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Protagonist Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
          <ticker value="PTGX US"/>
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        <balance>20348</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>785432.8</valUSD>
        <pctVal>0.3330717278</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Quest Diagnostics Incorporated</name>
        <lei>8MCWUBXQ0WE04KMXBX50</lei>
        <title>QUEST DIAGNOSTICS INC COMMON STOCK USD.01</title>
        <cusip>74834L100</cusip>
        <identifiers>
          <isin value="US74834L1008"/>
          <ticker value="DGX US"/>
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        <balance>6132</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>925073.52</valUSD>
        <pctVal>0.3922879661</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Rapport Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RAPPORT THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>75383L102</cusip>
        <identifiers>
          <isin value="US75383L1026"/>
          <ticker value="RAPP US"/>
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        <balance>19872</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>352529.28</valUSD>
        <pctVal>0.1494940578</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc.</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
          <ticker value="REGN US"/>
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        <balance>6109</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4351623.97</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Relay Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RELAY THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>75943R102</cusip>
        <identifiers>
          <isin value="US75943R1023"/>
          <ticker value="RLAY US"/>
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        <balance>40081</balance>
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        <curCd>USD</curCd>
        <valUSD>165133.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Repligen Corporation</name>
        <lei>54930006QJ0T5AUO1E71</lei>
        <title>REPLIGEN CORP COMMON STOCK USD.01</title>
        <cusip>759916109</cusip>
        <identifiers>
          <isin value="US7599161095"/>
          <ticker value="RGEN US"/>
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        <balance>4558</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>656078.52</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Replimune Group Inc.</name>
        <lei>N/A</lei>
        <title>REPLIMUNE GROUP INC COMMON STOCK USD.001</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
          <ticker value="REPL US"/>
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        <balance>37029</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>448421.19</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</name>
        <lei>N/A</lei>
        <title>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</title>
        <cusip>76105Y109</cusip>
        <identifiers>
          <isin value="US76105Y1091"/>
          <ticker value="76105Y109010"/>
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        <balance>67322.74</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>67322.74</valUSD>
        <pctVal>0.0285489749</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Revolution Medicines Inc.</name>
        <lei>N/A</lei>
        <title>REVOLUTION MEDICINES INC COMMON STOCK</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
          <ticker value="RVMD US"/>
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        <balance>31937</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1396924.38</valUSD>
        <pctVal>0.5923816994</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Revolution Medicines Inc.</name>
        <lei>N/A</lei>
        <title>REVOLUTION MEDICINES INC WARRANTS CALL EXP 17DEC26</title>
        <cusip>76155X118</cusip>
        <identifiers>
          <isin value="US76155X1182"/>
          <ticker value="RVMDW"/>
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        <balance>4502</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>727.52</valUSD>
        <pctVal>0.0003085131</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly and Company</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO COMMON STOCK</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY US"/>
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        <balance>31277</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24145844</valUSD>
        <pctVal>10.2393202574</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lyell Immunopharma Inc.</name>
        <lei>N/A</lei>
        <title>LYELL IMMUNOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>55083R104</cusip>
        <identifiers>
          <isin value="US55083R1041"/>
          <ticker value="LYEL US"/>
        </identifiers>
        <balance>123925</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>79312</valUSD>
        <pctVal>0.0336331573</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MBX Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>MBX BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>55287L101</cusip>
        <identifiers>
          <isin value="US55287L1017"/>
          <ticker value="MBX US"/>
        </identifiers>
        <balance>10682</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>196869.26</valUSD>
        <pctVal>0.0834846528</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MacroGenics Inc.</name>
        <lei>5493001KJQUA83L8MH79</lei>
        <title>MACROGENICS INC COMMON STOCK USD.01</title>
        <cusip>556099109</cusip>
        <identifiers>
          <isin value="US5560991094"/>
          <ticker value="MGNX US"/>
        </identifiers>
        <balance>24089</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>78289.25</valUSD>
        <pctVal>0.0331994485</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MADRIGAL PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
          <ticker value="MDGL US"/>
        </identifiers>
        <balance>3043</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>938978.51</valUSD>
        <pctVal>0.3981845356</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UCB SA</name>
        <lei>N/A</lei>
        <title>UCB SA COMMON STOCK</title>
        <cusip>559699905</cusip>
        <identifiers>
          <isin value="BE0003739530"/>
          <ticker value="UCB BB"/>
        </identifiers>
        <balance>2302</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.965391"/>
        <valUSD>458244.49</valUSD>
        <pctVal>0.1943237971</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Masimo Corporation</name>
        <lei>549300Q4A8JK0PIYCU29</lei>
        <title>MASIMO CORP COMMON STOCK USD.001</title>
        <cusip>574795100</cusip>
        <identifiers>
          <isin value="US5747951003"/>
          <ticker value="MASI US"/>
        </identifiers>
        <balance>3609</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>596567.7</valUSD>
        <pctVal>0.2529813303</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>McKesson Corporation</name>
        <lei>549300WZWOM80UCFSF54</lei>
        <title>MCKESSON CORP COMMON STOCK USD.01</title>
        <cusip>58155Q103</cusip>
        <identifiers>
          <isin value="US58155Q1031"/>
          <ticker value="MCK US"/>
        </identifiers>
        <balance>1335</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>760829.85</valUSD>
        <pctVal>0.3226385665</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sartorius Aktiengesellschaft</name>
        <lei>N/A</lei>
        <title>SARTORIUS AG PREFERENCE</title>
        <cusip>584332902</cusip>
        <identifiers>
          <isin value="DE0007165631"/>
          <ticker value="SRT3 GR"/>
        </identifiers>
        <balance>3334</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.965391"/>
        <valUSD>740926.93</valUSD>
        <pctVal>0.3141985065</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merck and Co. Inc.</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK and CO INC COMMON STOCK USD.5</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
          <ticker value="MRK US"/>
        </identifiers>
        <balance>60933</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6061614.84</valUSD>
        <pctVal>2.5704968368</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molina Healthcare Inc.</name>
        <lei>549300NQQCEQ46YHZ591</lei>
        <title>MOLINA HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>60855R100</cusip>
        <identifiers>
          <isin value="US60855R1005"/>
          <ticker value="MOH US"/>
        </identifiers>
        <balance>5419</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1577199.95</valUSD>
        <pctVal>0.6688296089</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Monte Rosa Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
          <ticker value="GLUE US"/>
        </identifiers>
        <balance>29932</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>207728.08</valUSD>
        <pctVal>0.0880894591</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MoonLake Immunotherapeutics</name>
        <lei>N/A</lei>
        <title>MOONLAKE IMMUNOTHERAPEUTICS COMMON STOCK USD.0001</title>
        <cusip>61559X104</cusip>
        <identifiers>
          <isin value="KY61559X1045"/>
          <ticker value="MLTX US"/>
        </identifiers>
        <balance>29546</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1599915.9</valUSD>
        <pctVal>0.6784625663</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Chugai Pharmaceutical Co. Ltd.</name>
        <lei>N/A</lei>
        <title>CHUGAI PHARMACEUTICAL CO LTD COMMON STOCK</title>
        <cusip>619640006</cusip>
        <identifiers>
          <isin value="JP3519400000"/>
          <ticker value="4519 JP"/>
        </identifiers>
        <balance>29600</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="157.345"/>
        <valUSD>1304801.56</valUSD>
        <pctVal>0.5533159680</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Natera Inc.</name>
        <lei>N/A</lei>
        <title>NATERA INC COMMON STOCK</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
          <ticker value="NTRA US"/>
        </identifiers>
        <balance>9944</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1574135.2</valUSD>
        <pctVal>0.6675299667</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurocrine Biosciences Inc.</name>
        <lei>549300FECER0XBN49756</lei>
        <title>NEUROCRINE BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
          <ticker value="NBIX US"/>
        </identifiers>
        <balance>10324</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1409226</valUSD>
        <pctVal>0.5975983415</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurogene Inc.</name>
        <lei>N/A</lei>
        <title>NEUROGENE INC COMMON STOCK USD.000001</title>
        <cusip>64135M105</cusip>
        <identifiers>
          <isin value="US64135M1053"/>
          <ticker value="NGNE US"/>
        </identifiers>
        <balance>2300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52578</valUSD>
        <pctVal>0.0222963000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novo Nordisk A/S</name>
        <lei>549300DAQ1CVT6CXN342</lei>
        <title>NOVO NORDISK A/S ADR</title>
        <cusip>670100205</cusip>
        <identifiers>
          <isin value="US6701002056"/>
          <ticker value="NVO US"/>
        </identifiers>
        <balance>8608</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>740460.16</valUSD>
        <pctVal>0.3140005674</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nuvalent Inc.</name>
        <lei>N/A</lei>
        <title>NUVALENT INC COMMON STOCK USD.0001</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
          <ticker value="NUVL US"/>
        </identifiers>
        <balance>6015</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>470854.2</valUSD>
        <pctVal>0.1996710883</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Spyre Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SPYRE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>00773J202</cusip>
        <identifiers>
          <isin value="US00773J2024"/>
          <ticker value="SYRE US"/>
        </identifiers>
        <balance>9720</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>226281.6</valUSD>
        <pctVal>0.0959572907</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agilent Technologies Inc.</name>
        <lei>QUIX8Y7A2WP0XRMW7G29</lei>
        <title>AGILENT TECHNOLOGIES INC COMMON STOCK USD.01</title>
        <cusip>00846U101</cusip>
        <identifiers>
          <isin value="US00846U1016"/>
          <ticker value="A US"/>
        </identifiers>
        <balance>8499</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1141755.66</valUSD>
        <pctVal>0.4841744964</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>AGIOS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
          <ticker value="AGIO US"/>
        </identifiers>
        <balance>20838</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>684736.68</valUSD>
        <pctVal>0.2903703908</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akero Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>AKERO THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>00973Y108</cusip>
        <identifiers>
          <isin value="US00973Y1082"/>
          <ticker value="AKRO US"/>
        </identifiers>
        <balance>19059</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>530221.38</valUSD>
        <pctVal>0.2248464173</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alector Inc.</name>
        <lei>N/A</lei>
        <title>ALECTOR INC COMMON STOCK USD.0001</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
          <ticker value="ALEC US"/>
        </identifiers>
        <balance>12104</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22876.56</valUSD>
        <pctVal>0.0097010659</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alignment Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>ALIGNMENT HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>01625V104</cusip>
        <identifiers>
          <isin value="US01625V1044"/>
          <ticker value="ALHC US"/>
        </identifiers>
        <balance>32276</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>363105</valUSD>
        <pctVal>0.1539788123</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
          <ticker value="ALLO US"/>
        </identifiers>
        <balance>100198</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>213421.74</valUSD>
        <pctVal>0.0905039205</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ALNYLAM PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <ticker value="ALNY US"/>
        </identifiers>
        <balance>23413</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5509313.03</valUSD>
        <pctVal>2.3362869615</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Elevance Health Inc.</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>ELEVANCE HEALTH INC COMMON STOCK USD.01</title>
        <cusip>036752103</cusip>
        <identifiers>
          <isin value="US0367521038"/>
          <ticker value="ELV US"/>
        </identifiers>
        <balance>12048</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4444507.2</valUSD>
        <pctVal>1.8847439173</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>APELLIS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
          <ticker value="APLS US"/>
        </identifiers>
        <balance>8077</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>257737.07</valUSD>
        <pctVal>0.1092963411</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apogee Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
          <ticker value="APGE US"/>
        </identifiers>
        <balance>15898</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>720179.4</valUSD>
        <pctVal>0.3054002800</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcellx Inc.</name>
        <lei>N/A</lei>
        <title>ARCELLX INC COMMON STOCK USD.001</title>
        <cusip>03940C100</cusip>
        <identifiers>
          <isin value="US03940C1009"/>
          <ticker value="ACLX US"/>
        </identifiers>
        <balance>16787</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1287395.03</valUSD>
        <pctVal>0.5459345306</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>argenx SE</name>
        <lei>N/A</lei>
        <title>ARGENX SE ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
          <ticker value="ARGX US"/>
        </identifiers>
        <balance>14192</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8728080</valUSD>
        <pctVal>3.7012417686</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arvinas Inc.</name>
        <lei>N/A</lei>
        <title>ARVINAS INC COMMON STOCK USD.001</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
          <ticker value="ARVN US"/>
        </identifiers>
        <balance>12282</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>235445.94</valUSD>
        <pctVal>0.0998435334</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>N/A</lei>
        <title>ASCENDIS PHARMA A/S ADR DKK1.0</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
          <ticker value="ASND US"/>
        </identifiers>
        <balance>18749</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2581174.83</valUSD>
        <pctVal>1.0945765956</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC ADR</title>
        <cusip>046353108</cusip>
        <identifiers>
          <isin value="US0463531089"/>
          <ticker value="AZN US"/>
        </identifiers>
        <balance>76018</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4980699.36</valUSD>
        <pctVal>2.1121223119</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aura Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AURA BIOSCIENCES INC COMMON STOCK USD.00001</title>
        <cusip>05153U107</cusip>
        <identifiers>
          <isin value="US05153U1079"/>
          <ticker value="AURA US"/>
        </identifiers>
        <balance>10426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>85701.72</valUSD>
        <pctVal>0.0363427908</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avidity Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AVIDITY BIOSCIENCES INC COMMON STOCK</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
          <ticker value="RNA US"/>
        </identifiers>
        <balance>45919</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1335324.52</valUSD>
        <pctVal>0.5662595769</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bicara Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BICARA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>055477103</cusip>
        <identifiers>
          <isin value="US0554771032"/>
          <ticker value="BCAX US"/>
        </identifiers>
        <balance>14939</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>260237.38</valUSD>
        <pctVal>0.1103566260</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Beam Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
          <ticker value="BEAM US"/>
        </identifiers>
        <balance>23142</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>573921.6</valUSD>
        <pctVal>0.2433779935</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Becton Dickinson and Company</name>
        <lei>ICE2EP6D98PQUILVRZ91</lei>
        <title>BECTON DICKINSON and CO COMMON STOCK USD1.0</title>
        <cusip>075887109</cusip>
        <identifiers>
          <isin value="US0758871091"/>
          <ticker value="BDX US"/>
        </identifiers>
        <balance>13164</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2986516.68</valUSD>
        <pctVal>1.2664664255</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BeiGene Ltd.</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEIGENE LTD ADR USD.0001</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
          <ticker value="ONC US"/>
        </identifiers>
        <balance>13457</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2485642.47</valUSD>
        <pctVal>1.0540650099</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LENZ Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>LENZ THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>52635N103</cusip>
        <identifiers>
          <isin value="US52635N1037"/>
          <ticker value="LENZ US"/>
        </identifiers>
        <balance>13765</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>397395.55</valUSD>
        <pctVal>0.1685201108</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ocular Therapeutix Inc.</name>
        <lei>N/A</lei>
        <title>OCULAR THERAPEUTIX INC COMMON STOCK USD.0001</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
          <ticker value="OCUL US"/>
        </identifiers>
        <balance>14200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>121268</valUSD>
        <pctVal>0.0514250771</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Orchestra Biomed Holdings Inc.</name>
        <lei>N/A</lei>
        <title>ORCHESTRA BIOMED HOLDINGS INC COMMON STOCK USD.0001</title>
        <cusip>68572M106</cusip>
        <identifiers>
          <isin value="US68572M1062"/>
          <ticker value="OBIO US"/>
        </identifiers>
        <balance>13354</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53416</valUSD>
        <pctVal>0.0226516634</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORIC Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ORIC PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>68622P109</cusip>
        <identifiers>
          <isin value="US68622P1093"/>
          <ticker value="ORIC US"/>
        </identifiers>
        <balance>25630</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>206834.1</valUSD>
        <pctVal>0.0877103567</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Oruka Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ORUKA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>687604108</cusip>
        <identifiers>
          <isin value="US6876041087"/>
          <ticker value="ORKA US"/>
        </identifiers>
        <balance>24101</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>467318.39</valUSD>
        <pctVal>0.1981716877</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rhythm Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>RHYTHM PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
          <ticker value="RYTM US"/>
        </identifiers>
        <balance>6625</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>370867.5</valUSD>
        <pctVal>0.1572705889</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc.</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
          <ticker value="RCKT US"/>
        </identifiers>
        <balance>23535</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>295834.95</valUSD>
        <pctVal>0.1254521812</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>State Street Bank and Trust Company</name>
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        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Sage Therapeutics Inc.</name>
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      <invstOrSec>
        <name>Danaher Corporation</name>
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        <assetCat>EC</assetCat>
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      <invstOrSec>
        <name>Day One Biopharmaceuticals Inc.</name>
        <lei>N/A</lei>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Denali Therapeutics Inc.</name>
        <lei>N/A</lei>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <name>DexCom Inc.</name>
        <lei>N/A</lei>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Disc Medicine Inc.</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC COMMON STOCK USD.0001</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Dyne Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DYNE THERAPEUTICS INC COMMON STOCK USD.0001</title>
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          <isin value="US26818M1080"/>
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        <curCd>USD</curCd>
        <valUSD>269078.76</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Edwards Lifesciences Corporation</name>
        <lei>YA13X31F3V31L8TMPR58</lei>
        <title>EDWARDS LIFESCIENCES CORP COMMON STOCK USD1.0</title>
        <cusip>28176E108</cusip>
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          <isin value="US28176E1082"/>
          <ticker value="EW US"/>
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        <balance>17985</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1331429.55</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Climb Bio Inc.</name>
        <lei>N/A</lei>
        <title>CLIMB BIO INC COMMON STOCK USD.0001</title>
        <cusip>28658R106</cusip>
        <identifiers>
          <isin value="US28658R1068"/>
          <ticker value="CLYM US"/>
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        <balance>9200</balance>
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        <curCd>USD</curCd>
        <valUSD>16560</valUSD>
        <pctVal>0.0070224567</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Encompass Health Corporation</name>
        <lei>549300FVRPM9DRQZRG64</lei>
        <title>ENCOMPASS HEALTH CORP COMMON STOCK USD.01</title>
        <cusip>29261A100</cusip>
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          <isin value="US29261A1007"/>
          <ticker value="EHC US"/>
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        <balance>1300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>120055</valUSD>
        <pctVal>0.0509106906</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Entrada Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>ENTRADA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>29384C108</cusip>
        <identifiers>
          <isin value="US29384C1080"/>
          <ticker value="TRDA US"/>
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        <balance>11625</balance>
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        <curCd>USD</curCd>
        <valUSD>200996.25</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>Exact Sciences Corporation</name>
        <lei>N/A</lei>
        <title>EXACT SCIENCES CORP COMMON STOCK USD.01</title>
        <cusip>30063P105</cusip>
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          <ticker value="EXAS US"/>
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        <curCd>USD</curCd>
        <valUSD>1260959.79</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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      <invstOrSec>
        <name>EyePoint Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>EYEPOINT PHARMACEUTICALS INC COMMON STOCK USD.01</title>
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          <ticker value="EYPT US"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Generation Bio Co.</name>
        <lei>N/A</lei>
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        <cusip>37148K100</cusip>
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          <isin value="US37148K1007"/>
          <ticker value="GBIO US"/>
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        <curCd>USD</curCd>
        <valUSD>39953.52</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Geron Corporation</name>
        <lei>N/A</lei>
        <title>GERON CORP COMMON STOCK USD.001</title>
        <cusip>374163103</cusip>
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          <isin value="US3741631036"/>
          <ticker value="GERN US"/>
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        <balance>51065</balance>
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        <curCd>USD</curCd>
        <valUSD>180770.1</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Ginkgo Bioworks Holdings Inc.</name>
        <lei>N/A</lei>
        <title>GINKGO BIOWORKS HOLDINGS INC COMMON STOCK USD.0001</title>
        <cusip>37611X209</cusip>
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          <isin value="US37611X2099"/>
          <ticker value="DNA US"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>HCA Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>HCA HEALTHCARE INC COMMON STOCK USD.01</title>
        <cusip>40412C101</cusip>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Hologic Inc.</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>HOLOGIC INC COMMON STOCK USD.01</title>
        <cusip>436440101</cusip>
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          <isin value="US4364401012"/>
          <ticker value="HOLX US"/>
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        <balance>10463</balance>
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        <curCd>USD</curCd>
        <valUSD>754277.67</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Humana Inc.</name>
        <lei>N/A</lei>
        <title>HUMANA INC COMMON STOCK USD.1666666</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
          <ticker value="HUM US"/>
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        <balance>1859</balance>
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        <curCd>USD</curCd>
        <valUSD>471646.89</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IGM Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IGM BIOSCIENCES INC COMMON STOCK USD.01</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
          <ticker value="IGMS US"/>
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        <balance>17676</balance>
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        <curCd>USD</curCd>
        <valUSD>108000.36</valUSD>
        <pctVal>0.0457987832</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sana Biotechnology Inc.</name>
        <lei>N/A</lei>
        <title>SANA BIOTECHNOLOGY INC COMMON STOCK USD.0001</title>
        <cusip>799566104</cusip>
        <identifiers>
          <isin value="US7995661045"/>
          <ticker value="SANA US"/>
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        <balance>54773</balance>
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        <curCd>USD</curCd>
        <valUSD>89279.99</valUSD>
        <pctVal>0.0378601970</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sanofi</name>
        <lei>549300E9PC51EN656011</lei>
        <title>SANOFI SA ADR</title>
        <cusip>80105N105</cusip>
        <identifiers>
          <isin value="US80105N1054"/>
          <ticker value="SNY US"/>
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        <balance>50603</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2440582.69</valUSD>
        <pctVal>1.0349568968</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corporation</name>
        <lei>N/A</lei>
        <title>SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK US"/>
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        <balance>40306</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1742025.32</valUSD>
        <pctVal>0.7387256850</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GeneDx Holdings Corp.</name>
        <lei>N/A</lei>
        <title>GENEDX HOLDINGS CORP GENEDX HOLDINGS CORP</title>
        <cusip>81663L119</cusip>
        <identifiers>
          <isin value="US81663L1199"/>
          <ticker value="WGSWW"/>
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        <balance>4862</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>777.92</valUSD>
        <pctVal>0.0003298858</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GeneDx Holdings Corp.</name>
        <lei>N/A</lei>
        <title>GENEDX HOLDINGS CORP COMMON STOCK USD.0001</title>
        <cusip>81663L200</cusip>
        <identifiers>
          <isin value="US81663L2007"/>
          <ticker value="WGS US"/>
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        <balance>918</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70557.48</valUSD>
        <pctVal>0.0299207033</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Septerna Inc.</name>
        <lei>N/A</lei>
        <title>SEPTERNA INC COMMON STOCK USD.001</title>
        <cusip>81734D104</cusip>
        <identifiers>
          <isin value="US81734D1046"/>
          <ticker value="SEPN US"/>
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        <balance>7588</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>173765.2</valUSD>
        <pctVal>0.0736871129</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Soleno Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SOLENO THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>834203309</cusip>
        <identifiers>
          <isin value="US8342033094"/>
          <ticker value="SLNO US"/>
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        <balance>8750</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>393312.5</valUSD>
        <pctVal>0.1667886469</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>SomaLogic Inc.</name>
        <lei>N/A</lei>
        <title>SOMALOGIC INC WARRANTS CALL EXP 31AUG26</title>
        <cusip>83444K113</cusip>
        <identifiers>
          <isin value="US83444K1135"/>
          <ticker value="SLGCW"/>
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        <balance>2050</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>207.05</valUSD>
        <pctVal>0.0000878019</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>SpringWorks Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SPRINGWORKS THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
          <ticker value="SWTX US"/>
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        <balance>15295</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>552608.35</valUSD>
        <pctVal>0.2343398670</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>STRYKER CORP COMMON STOCK USD.1</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
          <ticker value="SYK US"/>
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        <balance>27504</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9902815.2</valUSD>
        <pctVal>4.1994016147</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Structure Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STRUCTURE THERAPEUTICS INC ADR USD.0001</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
          <ticker value="GPCR US"/>
        </identifiers>
        <balance>13377</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>362784.24</valUSD>
        <pctVal>0.1538427904</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Summit Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SUMMIT THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>86627T108</cusip>
        <identifiers>
          <isin value="US86627T1088"/>
          <ticker value="SMMT US"/>
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        <balance>94143</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1679981.84</valUSD>
        <pctVal>0.7124154404</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX US"/>
        </identifiers>
        <balance>14246</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5736864.2</valUSD>
        <pctVal>2.4327826278</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Tarsus Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>TARSUS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>87650L103</cusip>
        <identifiers>
          <isin value="US87650L1035"/>
          <ticker value="TARS US"/>
        </identifiers>
        <balance>7103</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>393293.11</valUSD>
        <pctVal>0.1667804243</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>10x Genomics Inc.</name>
        <lei>N/A</lei>
        <title>10X GENOMICS INC COMMON STOCK USD.00001</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
          <ticker value="TXG US"/>
        </identifiers>
        <balance>20634</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>296304.24</valUSD>
        <pctVal>0.1256511890</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Viridian Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>VIRIDIAN THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>92790C104</cusip>
        <identifiers>
          <isin value="US92790C1045"/>
          <ticker value="VRDN US"/>
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        <balance>5400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>103518</valUSD>
        <pctVal>0.0438979873</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Voyager Therapeutics Inc.</name>
        <lei>54930082S4XVR0ZWCC74</lei>
        <title>VOYAGER THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>92915B106</cusip>
        <identifiers>
          <isin value="US92915B1061"/>
          <ticker value="VYGR US"/>
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        <balance>15964</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>90515.88</valUSD>
        <pctVal>0.0383842902</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Tenet Healthcare Corporation</name>
        <lei>0W9AIBT6U6ADJ2I8HK17</lei>
        <title>TENET HEALTHCARE CORP COMMON STOCK USD.05</title>
        <cusip>88033G407</cusip>
        <identifiers>
          <isin value="US88033G4073"/>
          <ticker value="THC US"/>
        </identifiers>
        <balance>12141</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1532558.43</valUSD>
        <pctVal>0.6498988637</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Teva Pharmaceutical Industries Limited</name>
        <lei>549300BAFGM4RC74ZJ94</lei>
        <title>TEVA PHARMACEUTICAL INDUSTRIES ADR</title>
        <cusip>881624209</cusip>
        <identifiers>
          <isin value="US8816242098"/>
          <ticker value="TEVA US"/>
        </identifiers>
        <balance>26278</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>579167.12</valUSD>
        <pctVal>0.2456024161</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Xencor Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC COMMON STOCK USD.01</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <ticker value="XNCR US"/>
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        <balance>15279</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>351111.42</valUSD>
        <pctVal>0.1488927981</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Zai Lab Limited</name>
        <lei>N/A</lei>
        <title>ZAI LAB LTD ADR USD.00006</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
          <ticker value="ZLAB US"/>
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        <balance>35437</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>928095.03</valUSD>
        <pctVal>0.3935692719</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ZENTALIS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
          <ticker value="ZNTL US"/>
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        <balance>26102</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>79089.06</valUSD>
        <pctVal>0.0335386170</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sensorion</name>
        <lei>N/A</lei>
        <title>SENSORION SA COMMON STOCK EUR.1</title>
        <cusip>BWSW4N905</cusip>
        <identifiers>
          <isin value="FR0012596468"/>
          <ticker value="ALSEN FP"/>
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        <balance>182870</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.965391"/>
        <valUSD>120068.89</valUSD>
        <pctVal>0.0509165808</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Thermo Fisher Scientific Inc.</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO US"/>
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        <balance>20893</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10869165.39</valUSD>
        <pctVal>4.6091934230</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes Public Limited Company</name>
        <lei>549300YHRMYLL071E243</lei>
        <title>ALKERMES PLC COMMON STOCK USD.01</title>
        <cusip>G01767105</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
          <ticker value="ALKS US"/>
        </identifiers>
        <balance>26399</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>759235.24</valUSD>
        <pctVal>0.3219623540</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Ltd.</name>
        <lei>N/A</lei>
        <title>BIOHAVEN LTD COMMON STOCK</title>
        <cusip>G1110E107</cusip>
        <identifiers>
          <isin value="VGG1110E1079"/>
          <ticker value="BHVN US"/>
        </identifiers>
        <balance>35415</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1322750.25</valUSD>
        <pctVal>0.5609273145</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Helix Acquisition Corp. II</name>
        <lei>N/A</lei>
        <title>HELIX ACQUISITION CORP II COMMON STOCK USD.0001</title>
        <cusip>G4444H101</cusip>
        <identifiers>
          <isin value="KYG4444H1011"/>
          <ticker value="HLXB US"/>
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        <balance>16298</balance>
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        <curCd>USD</curCd>
        <valUSD>171129</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Icon Public Limited Company</name>
        <lei>N/A</lei>
        <title>ICON PLC COMMON STOCK EUR.06</title>
        <cusip>G4705A100</cusip>
        <identifiers>
          <isin value="IE0005711209"/>
          <ticker value="ICLR US"/>
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        <balance>2199</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>461152.29</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>NovoCure Limited</name>
        <lei>N/A</lei>
        <title>NOVOCURE LTD COMMON STOCK</title>
        <cusip>G6674U108</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
          <ticker value="NVCR US"/>
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        <balance>25659</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>764638.2</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Prothena Corporation Public Limited Company</name>
        <lei>N/A</lei>
        <title>PROTHENA CORP PLC COMMON STOCK USD.01</title>
        <cusip>G72800108</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
          <ticker value="PRTA US"/>
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        <balance>14694</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>203511.9</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UroGen Pharma Ltd.</name>
        <lei>N/A</lei>
        <title>UROGEN PHARMA LTD COMMON STOCK USD.01</title>
        <cusip>M96088105</cusip>
        <identifiers>
          <isin value="IL0011407140"/>
          <ticker value="URGN US"/>
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        <balance>5500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58575</valUSD>
        <pctVal>0.0248393961</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Immatics N.V.</name>
        <lei>N/A</lei>
        <title>IMMATICS NV COMMON STOCK</title>
        <cusip>N44445109</cusip>
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          <isin value="NL0015285941"/>
          <ticker value="IMTX US"/>
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        <balance>27090</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>192609.9</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Merus N.V.</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>MERUS NV COMMON STOCK EUR.05</title>
        <cusip>N5749R100</cusip>
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          <isin value="NL0011606264"/>
          <ticker value="MRUS US"/>
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        <balance>8767</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>368652.35</valUSD>
        <pctVal>0.1563312293</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Pharvaris N.V.</name>
        <lei>N/A</lei>
        <title>PHARVARIS NV COMMON STOCK EUR.12</title>
        <cusip>N69605108</cusip>
        <identifiers>
          <isin value="NL00150005Y4"/>
          <ticker value="PHVS US"/>
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        <balance>9988</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>191469.96</valUSD>
        <pctVal>0.0811950181</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Wave Life Sciences Ltd.</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD COMMON STOCK</title>
        <cusip>Y95308105</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
          <ticker value="WVE US"/>
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        <balance>39868</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>493167.16</valUSD>
        <pctVal>0.2091331532</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cencora Inc.</name>
        <lei>AI8GXW8LG5WK7E9UD086</lei>
        <title>CENCORA INC COMMON STOCK USD.01</title>
        <cusip>03073E105</cusip>
        <identifiers>
          <isin value="US03073E1055"/>
          <ticker value="COR US"/>
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        <balance>3377</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>758744.36</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Amgen Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC COMMON STOCK USD.0001</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
          <ticker value="AMGN US"/>
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        <balance>13811</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3599699.04</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AnaptysBio Inc.</name>
        <lei>N/A</lei>
        <title>ANAPTYSBIO INC COMMON STOCK USD.001</title>
        <cusip>032724106</cusip>
        <identifiers>
          <isin value="US0327241065"/>
          <ticker value="ANAB US"/>
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        <balance>6400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>84736</valUSD>
        <pctVal>0.0359332663</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Annexon Inc.</name>
        <lei>N/A</lei>
        <title>ANNEXON INC COMMON STOCK</title>
        <cusip>03589W102</cusip>
        <identifiers>
          <isin value="US03589W1027"/>
          <ticker value="ANNX US"/>
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        <balance>22109</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>113419.17</valUSD>
        <pctVal>0.0480966913</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Biogen Inc.</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC COMMON STOCK USD.0005</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
          <ticker value="BIIB US"/>
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        <balance>3550</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>542866</valUSD>
        <pctVal>0.2302085125</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Bio-Techne Corporation</name>
        <lei>N/A</lei>
        <title>BIO-TECHNE CORP COMMON STOCK USD.01</title>
        <cusip>09073M104</cusip>
        <identifiers>
          <isin value="US09073M1045"/>
          <ticker value="TECH US"/>
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        <balance>14800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1066044</valUSD>
        <pctVal>0.4520681043</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BioNTech SE</name>
        <lei>N/A</lei>
        <title>BIONTECH SE ADR</title>
        <cusip>09075V102</cusip>
        <identifiers>
          <isin value="US09075V1026"/>
          <ticker value="BNTX US"/>
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        <balance>4276</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>487250.2</valUSD>
        <pctVal>0.2066239989</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Blueprint Medicines Corporation</name>
        <lei>N/A</lei>
        <title>BLUEPRINT MEDICINES CORP COMMON STOCK USD.001</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
          <ticker value="BPMC US"/>
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        <balance>30911</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2696057.42</valUSD>
        <pctVal>1.1432938669</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Boston Scientific Corporation</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>BOSTON SCIENTIFIC CORP COMMON STOCK USD.01</title>
        <cusip>101137107</cusip>
        <identifiers>
          <isin value="US1011371077"/>
          <ticker value="BSX US"/>
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        <balance>67030</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5987119.6</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>BrightSpring Health Services Inc.</name>
        <lei>N/A</lei>
        <title>BRIGHTSPRING HEALTH SERVICES I COMMON STOCK USD100.0</title>
        <cusip>10950A106</cusip>
        <identifiers>
          <isin value="US10950A1060"/>
          <ticker value="BTSG US"/>
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        <balance>41337</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>703969.11</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Bruker Corporation</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
        <title>BRUKER CORP COMMON STOCK USD.01</title>
        <cusip>116794108</cusip>
        <identifiers>
          <isin value="US1167941087"/>
          <ticker value="BRKR US"/>
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        <balance>6177</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>362095.74</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>The Cigna Group</name>
        <lei>N/A</lei>
        <title>CIGNA GROUP/THE COMMON STOCK USD.01</title>
        <cusip>125523100</cusip>
        <identifiers>
          <isin value="US1255231003"/>
          <ticker value="CI US"/>
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        <balance>11419</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3153242.66</valUSD>
        <pctVal>1.3371684769</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cabaletta Bio Inc.</name>
        <lei>N/A</lei>
        <title>CABALETTA BIO INC COMMON STOCK USD.00001</title>
        <cusip>12674W109</cusip>
        <identifiers>
          <isin value="US12674W1099"/>
          <ticker value="CABA US"/>
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        <balance>9787</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22216.49</valUSD>
        <pctVal>0.0094211557</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cardinal Health Inc.</name>
        <lei>CCU46N3GJMF4OK4N7U60</lei>
        <title>CARDINAL HEALTH INC COMMON STOCK</title>
        <cusip>14149Y108</cusip>
        <identifiers>
          <isin value="US14149Y1082"/>
          <ticker value="CAH US"/>
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        <balance>7011</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>829190.97</valUSD>
        <pctVal>0.3516278783</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CARGO Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CARGO THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>14179K101</cusip>
        <identifiers>
          <isin value="US14179K1016"/>
          <ticker value="CRGX US"/>
        </identifiers>
        <balance>27782</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>400616.44</valUSD>
        <pctVal>0.1698859659</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Celldex Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CELLDEX THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
          <ticker value="CLDX US"/>
        </identifiers>
        <balance>14960</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>378039.2</valUSD>
        <pctVal>0.1603118300</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centene Corporation</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>CENTENE CORP COMMON STOCK USD.001</title>
        <cusip>15135B101</cusip>
        <identifiers>
          <isin value="US15135B1017"/>
          <ticker value="CNC US"/>
        </identifiers>
        <balance>13158</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>797111.64</valUSD>
        <pctVal>0.3380242729</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centessa Pharmaceuticals plc</name>
        <lei>N/A</lei>
        <title>CENTESSA PHARMACEUTICALS PLC ADR USD.0001</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
          <ticker value="CNTA US"/>
        </identifiers>
        <balance>67000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1122250</valUSD>
        <pctVal>0.4759028990</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CG Oncology Inc.</name>
        <lei>N/A</lei>
        <title>CG ONCOLOGY INC COMMON STOCK</title>
        <cusip>156944100</cusip>
        <identifiers>
          <isin value="US1569441009"/>
          <ticker value="CGON US"/>
        </identifiers>
        <balance>10462</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>300050.16</valUSD>
        <pctVal>0.1272396890</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>The Cooper Companies Inc.</name>
        <lei>QJKMVPIGLH7530PCUE20</lei>
        <title>COOPER COS INC/THE COMMON STOCK USD.1</title>
        <cusip>216648501</cusip>
        <identifiers>
          <isin value="US2166485019"/>
          <ticker value="COO US"/>
        </identifiers>
        <balance>6338</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>582652.34</valUSD>
        <pctVal>0.2470803633</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Corbus Pharmaceuticals Holdings Inc.</name>
        <lei>N/A</lei>
        <title>CORBUS PHARMACEUTICALS HOLDING COMMON STOCK USD.0001</title>
        <cusip>21833P301</cusip>
        <identifiers>
          <isin value="US21833P3010"/>
          <ticker value="CRBP US"/>
        </identifiers>
        <balance>4300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50740</valUSD>
        <pctVal>0.0215168751</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Crinetics Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>CRINETICS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
          <ticker value="CRNX US"/>
        </identifiers>
        <balance>22394</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1145005.22</valUSD>
        <pctVal>0.4855525093</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cytokinetics Incorporated</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC COMMON STOCK USD.001</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
          <ticker value="CYTK US"/>
        </identifiers>
        <balance>13691</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>644024.64</valUSD>
        <pctVal>0.2731059864</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEAYA Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IDEAYA BIOSCIENCES INC COMMON STOCK</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
          <ticker value="IDYA US"/>
        </identifiers>
        <balance>10437</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>268230.9</valUSD>
        <pctVal>0.1137463693</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEXX Laboratories Inc.</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX LABORATORIES INC COMMON STOCK USD.1</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
          <ticker value="IDXX US"/>
        </identifiers>
        <balance>2336</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>965795.84</valUSD>
        <pctVal>0.4095567299</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immuneering Corporation</name>
        <lei>N/A</lei>
        <title>IMMUNEERING CORP COMMON STOCK USD.001</title>
        <cusip>45254E107</cusip>
        <identifiers>
          <isin value="US45254E1073"/>
          <ticker value="IMRX US"/>
        </identifiers>
        <balance>29676</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>65287.2</valUSD>
        <pctVal>0.0276857810</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunome Inc.</name>
        <lei>N/A</lei>
        <title>IMMUNOME INC COMMON STOCK USD.0001</title>
        <cusip>45257U108</cusip>
        <identifiers>
          <isin value="US45257U1088"/>
          <ticker value="IMNM US"/>
        </identifiers>
        <balance>37567</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>398961.54</valUSD>
        <pctVal>0.1691841867</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vaxcyte Inc.</name>
        <lei>N/A</lei>
        <title>VAXCYTE INC COMMON STOCK USD.001</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
          <ticker value="PCVX US"/>
        </identifiers>
        <balance>20218</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1655045.48</valUSD>
        <pctVal>0.7018408928</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Veeva Systems Inc.</name>
        <lei>549300YZEXPDB92M2F02</lei>
        <title>VEEVA SYSTEMS INC COMMON STOCK USD.00001</title>
        <cusip>922475108</cusip>
        <identifiers>
          <isin value="US9224751084"/>
          <ticker value="VEEV US"/>
        </identifiers>
        <balance>1380</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>290145</valUSD>
        <pctVal>0.1230392931</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
          <ticker value="VERA US"/>
        </identifiers>
        <balance>22680</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>959137.2</valUSD>
        <pctVal>0.4067330577</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Verona Pharma PLC</name>
        <lei>N/A</lei>
        <title>VERONA PHARMA PLC ADR</title>
        <cusip>925050106</cusip>
        <identifiers>
          <isin value="US9250501064"/>
          <ticker value="VRNA US"/>
        </identifiers>
        <balance>27493</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1276774.92</valUSD>
        <pctVal>0.5414309519</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Returns are reported without deduction of sales loads and redemption fees, if applicable." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2025-01-30</ncom:dateSigned>
      <ncom:nameOfApplicant>John Hancock Variable Insurance Trust</ncom:nameOfApplicant>
      <ncom:signature>/s/Salvatore Schiavone</ncom:signature>
      <ncom:signerName>Salvatore Schiavone</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
