<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/nport" xmlns:com="http://www.sec.gov/edgar/common" xmlns:ncom="http://www.sec.gov/edgar/nportcommon" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <headerData>
    <submissionType>NPORT-P</submissionType>
    <isConfidential>false</isConfidential>
    <filerInfo>

      <filer>
        <issuerCredentials>
          <cik>0000756913</cik>
          <ccc>XXXXXXXX</ccc>
        </issuerCredentials>
      </filer>


      <seriesClassInfo>
        <seriesId>S000008239</seriesId>
        <classId>C000022443</classId>
        <classId>C000022444</classId>
        <classId>C000022442</classId>
      </seriesClassInfo>


    </filerInfo>
  </headerData>
  <formData>
    <genInfo>
      <regName>John Hancock Variable Insurance Trust</regName>
      <regFileNumber>811-04146</regFileNumber>
      <regCik>0000756913</regCik>
      <regLei>Z5DUWKEPW78QKD87GA06</regLei>
      <regStreet1>200 Berkeley Street</regStreet1>
      <regCity>Boston</regCity>
      <regStateConditional regCountry="US" regState="US-MA"/>
      <regZipOrPostalCode>02116</regZipOrPostalCode>
      <regPhone>617-543-9634</regPhone>
      <seriesName>Health Sciences Trust</seriesName>
      <seriesId>S000008239</seriesId>
      <seriesLei>K5HWWGQWUOYDF5BZA919</seriesLei>
      <repPdEnd>2024-12-31</repPdEnd>
      <repPdDate>2024-03-31</repPdDate>
      <isFinalFiling>N</isFinalFiling>
    </genInfo>
    <fundInfo>
      <totAssets>276772410.320000000000</totAssets>
      <totLiabs>398834.700000000000</totLiabs>
      <netAssets>276373575.620000000000</netAssets>
      <assetsAttrMiscSec>0.000000000000</assetsAttrMiscSec>
      <assetsInvested>0.000000000000</assetsInvested>
      <amtPayOneYrBanksBorr>0.000000000000</amtPayOneYrBanksBorr>
      <amtPayOneYrCtrldComp>0.000000000000</amtPayOneYrCtrldComp>
      <amtPayOneYrOthAffil>0.000000000000</amtPayOneYrOthAffil>
      <amtPayOneYrOther>0.000000000000</amtPayOneYrOther>
      <amtPayAftOneYrBanksBorr>0.000000000000</amtPayAftOneYrBanksBorr>
      <amtPayAftOneYrCtrldComp>0.000000000000</amtPayAftOneYrCtrldComp>
      <amtPayAftOneYrOthAffil>0.000000000000</amtPayAftOneYrOthAffil>
      <amtPayAftOneYrOther>0.000000000000</amtPayAftOneYrOther>
      <delayDeliv>0.000000000000</delayDeliv>
      <standByCommit>0.000000000000</standByCommit>
      <liquidPref>0.000000000000</liquidPref>
      <cshNotRptdInCorD>380.440000000000</cshNotRptdInCorD>
      <isNonCashCollateral>N</isNonCashCollateral>
      <returnInfo>
        <monthlyTotReturns>
          <monthlyTotReturn classId="C000022442" rtn1="2.160000000000" rtn2="4.350000000000" rtn3="1.600000000000"/>
          <monthlyTotReturn classId="C000022443" rtn1="2.130000000000" rtn2="4.340000000000" rtn3="1.600000000000"/>
          <monthlyTotReturn classId="C000022444" rtn1="2.130000000000" rtn2="4.320000000000" rtn3="1.580000000000"/>
        </monthlyTotReturns>
        <othMon1 netRealizedGain="5159235.94" netUnrealizedAppr="596890.41"/>
        <othMon2 netRealizedGain="4374981.52" netUnrealizedAppr="7267740.08"/>
        <othMon3 netRealizedGain="2604310.63" netUnrealizedAppr="1603297.49"/>
      </returnInfo>
      <mon1Flow redemption="3004403.510000000000" reinvestment="0.000000000000" sales="610222.230000000000"/>
      <mon2Flow redemption="4803966.08" reinvestment="0" sales="364255.3"/>
      <mon3Flow redemption="1768496.860000000000" reinvestment="0.000000000000" sales="279007.770000000000"/>

    </fundInfo>
    <invstOrSecs>
      <invstOrSec>
        <name>Ocular Therapeutix Inc.</name>
        <lei>N/A</lei>
        <title>OCULAR THERAPEUTIX INC COMMON STOCK USD.0001</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
          <ticker value="OCUL US"/>
        </identifiers>
        <balance>8400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76440</valUSD>
        <pctVal>0.0276582158</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Orchestra Biomed Holdings Inc.</name>
        <lei>N/A</lei>
        <title>ORCHESTRA BIOMED HOLDINGS INC COMMON STOCK USD.0001</title>
        <cusip>68572M106</cusip>
        <identifiers>
          <isin value="US68572M1062"/>
          <ticker value="OBIO US"/>
        </identifiers>
        <balance>13354</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70375.58</valUSD>
        <pctVal>0.0254639322</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORIC Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ORIC PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>68622P109</cusip>
        <identifiers>
          <isin value="US68622P1093"/>
          <ticker value="ORIC US"/>
        </identifiers>
        <balance>22600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>310750</valUSD>
        <pctVal>0.1124383904</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Oscar Health Inc.</name>
        <lei>N/A</lei>
        <title>OSCAR HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>687793109</cusip>
        <identifiers>
          <isin value="US6877931096"/>
          <ticker value="OSCR US"/>
        </identifiers>
        <balance>41174</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>612257.38</valUSD>
        <pctVal>0.2215325321</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Beam Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
          <ticker value="BEAM US"/>
        </identifiers>
        <balance>16900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>558376</valUSD>
        <pctVal>0.2020366812</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Becton Dickinson and Company</name>
        <lei>ICE2EP6D98PQUILVRZ91</lei>
        <title>BECTON DICKINSON + CO COMMON STOCK USD1.0</title>
        <cusip>075887109</cusip>
        <identifiers>
          <isin value="US0758871091"/>
          <ticker value="BDX US"/>
        </identifiers>
        <balance>12211</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3021611.95</valUSD>
        <pctVal>1.0933071091</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BeiGene Ltd.</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEIGENE LTD ADR USD.0001</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
          <ticker value="BGNE US"/>
        </identifiers>
        <balance>11885</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1858695.15</valUSD>
        <pctVal>0.6725299790</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bicycle Therapeutics PLC</name>
        <lei>N/A</lei>
        <title>BICYCLE THERAPEUTICS PLC ADR USD.01</title>
        <cusip>088786108</cusip>
        <identifiers>
          <isin value="US0887861088"/>
          <ticker value="BCYC US"/>
        </identifiers>
        <balance>10444</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>260055.6</valUSD>
        <pctVal>0.0940956817</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pacific Biosciences of California Inc.</name>
        <lei>N/A</lei>
        <title>PACIFIC BIOSCI OF CALIFORNIA COMMON STOCK USD.0001</title>
        <cusip>69404D108</cusip>
        <identifiers>
          <isin value="US69404D1081"/>
          <ticker value="PACB US"/>
        </identifiers>
        <balance>36531</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>136991.25</valUSD>
        <pctVal>0.0495674196</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Penumbra Inc.</name>
        <lei>549300RGE06P3ECANU72</lei>
        <title>PENUMBRA INC COMMON STOCK USD.001</title>
        <cusip>70975L107</cusip>
        <identifiers>
          <isin value="US70975L1070"/>
          <ticker value="PEN US"/>
        </identifiers>
        <balance>13567</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3027883.06</valUSD>
        <pctVal>1.0955761792</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sonova Holding AG</name>
        <lei>N/A</lei>
        <title>SONOVA HOLDING AG COMMON STOCK CHF.05</title>
        <cusip>715603908</cusip>
        <identifiers>
          <isin value="CH0012549785"/>
          <ticker value="SOON SW"/>
        </identifiers>
        <balance>1721</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.90185"/>
        <valUSD>498389.57</valUSD>
        <pctVal>0.1803318457</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pliant Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PLIANT THERAPEUTICS INC COMMON STOCK</title>
        <cusip>729139105</cusip>
        <identifiers>
          <isin value="US7291391057"/>
          <ticker value="PLRX US"/>
        </identifiers>
        <balance>13685</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>203906.5</valUSD>
        <pctVal>0.0737793038</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Praxis Precision Medicines Inc.</name>
        <lei>N/A</lei>
        <title>PRAXIS PRECISION MEDICINES INC COMMON STOCK USD.0001</title>
        <cusip>74006W207</cusip>
        <identifiers>
          <isin value="US74006W2070"/>
          <ticker value="PRAX US"/>
        </identifiers>
        <balance>3700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>225774</valUSD>
        <pctVal>0.0816916015</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prelude Therapeutics Incorporated</name>
        <lei>N/A</lei>
        <title>PRELUDE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>74065P101</cusip>
        <identifiers>
          <isin value="US74065P1012"/>
          <ticker value="PRLD US"/>
        </identifiers>
        <balance>17428</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82608.72</valUSD>
        <pctVal>0.0298902382</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prime Medicine Inc.</name>
        <lei>N/A</lei>
        <title>PRIME MEDICINE INC COMMON STOCK USD.00001</title>
        <cusip>74168J101</cusip>
        <identifiers>
          <isin value="US74168J1016"/>
          <ticker value="PRME US"/>
        </identifiers>
        <balance>17113</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>119791</valUSD>
        <pctVal>0.0433438688</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROCEPT BioRobotics Corporation</name>
        <lei>N/A</lei>
        <title>PROCEPT BIOROBOTICS CORP COMMON STOCK USD.00001</title>
        <cusip>74276L105</cusip>
        <identifiers>
          <isin value="US74276L1052"/>
          <ticker value="PRCT US"/>
        </identifiers>
        <balance>14216</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>702554.72</valUSD>
        <pctVal>0.2542047366</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Protagonist Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
          <ticker value="PTGX US"/>
        </identifiers>
        <balance>15253</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>441269.29</valUSD>
        <pctVal>0.1596640667</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAPT Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RAPT THERAPEUTICS INC COMMON STOCK</title>
        <cusip>75382E109</cusip>
        <identifiers>
          <isin value="US75382E1091"/>
          <ticker value="RAPT US"/>
        </identifiers>
        <balance>6612</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>59375.76</valUSD>
        <pctVal>0.0214838773</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc.</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
          <ticker value="REGN US"/>
        </identifiers>
        <balance>7768</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7476622.32</valUSD>
        <pctVal>2.7052594675</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Relay Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RELAY THERAPEUTICS INC COMMON STOCK</title>
        <cusip>75943R102</cusip>
        <identifiers>
          <isin value="US75943R1023"/>
          <ticker value="RLAY US"/>
        </identifiers>
        <balance>49181</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>408202.3</valUSD>
        <pctVal>0.1476994677</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Repligen Corporation</name>
        <lei>54930006QJ0T5AUO1E71</lei>
        <title>REPLIGEN CORP COMMON STOCK USD.01</title>
        <cusip>759916109</cusip>
        <identifiers>
          <isin value="US7599161095"/>
          <ticker value="RGEN US"/>
        </identifiers>
        <balance>5299</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>974592.08</valUSD>
        <pctVal>0.3526357677</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Replimune Group Inc.</name>
        <lei>N/A</lei>
        <title>REPLIMUNE GROUP INC COMMON STOCK USD.001</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
          <ticker value="REPL US"/>
        </identifiers>
        <balance>29973</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>244879.41</valUSD>
        <pctVal>0.0886044946</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</name>
        <lei>N/A</lei>
        <title>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</title>
        <cusip>76105Y109</cusip>
        <identifiers>
          <isin value="US76105Y1091"/>
          <ticker value="76105Y109010"/>
        </identifiers>
        <balance>952298.77</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>952298.77</valUSD>
        <pctVal>0.3445693995</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Revolution Medicines Inc.</name>
        <lei>N/A</lei>
        <title>REVOLUTION MEDICINES INC COMMON STOCK</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
          <ticker value="RVMD US"/>
        </identifiers>
        <balance>28781</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>927611.63</valUSD>
        <pctVal>0.3356368741</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Revolution Medicines Inc.</name>
        <lei>N/A</lei>
        <title>REVOLUTION MEDICINES INC WARRANTS CALL EXP 14NOV28</title>
        <cusip>76155X118</cusip>
        <identifiers>
          <isin value="US76155X1182"/>
          <ticker value="RVMDW"/>
        </identifiers>
        <balance>4502</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>720.32</valUSD>
        <pctVal>0.0002606327</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rhythm Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>RHYTHM PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
          <ticker value="RYTM US"/>
        </identifiers>
        <balance>4739</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>205340.87</valUSD>
        <pctVal>0.0742983006</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc.</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
          <ticker value="RCKT US"/>
        </identifiers>
        <balance>17202</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>463421.88</valUSD>
        <pctVal>0.1676795182</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>State Street Bank and Trust Company</name>
        <lei>571474TGEMMWANRLN572</lei>
        <title>SCC GOVERMENT MM GVXX 20301231 00001.0000000000</title>
        <cusip>7839989D1</cusip>
        <identifiers>
          <ticker value="7839989D1010"/>
        </identifiers>
        <balance>581314.41</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>581314.41</valUSD>
        <pctVal>0.2103364653</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics Inc.</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
          <ticker value="SAGE US"/>
        </identifiers>
        <balance>16074</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>301226.76</valUSD>
        <pctVal>0.1089926051</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sana Biotechnology Inc.</name>
        <lei>N/A</lei>
        <title>SANA BIOTECHNOLOGY INC COMMON STOCK USD.0001</title>
        <cusip>799566104</cusip>
        <identifiers>
          <isin value="US7995661045"/>
          <ticker value="SANA US"/>
        </identifiers>
        <balance>54773</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>547730</valUSD>
        <pctVal>0.1981846487</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SAREPTA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
          <ticker value="SRPT US"/>
        </identifiers>
        <balance>5857</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>758247.22</valUSD>
        <pctVal>0.2743559033</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Voyager Therapeutics Inc.</name>
        <lei>54930082S4XVR0ZWCC74</lei>
        <title>VOYAGER THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>92915B106</cusip>
        <identifiers>
          <isin value="US92915B1061"/>
          <ticker value="VYGR US"/>
        </identifiers>
        <balance>15964</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>148624.84</valUSD>
        <pctVal>0.0537767909</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ALX Oncology Holdings Inc.</name>
        <lei>N/A</lei>
        <title>ALX ONCOLOGY HOLDINGS INC COMMON STOCK USD.001</title>
        <cusip>00166B105</cusip>
        <identifiers>
          <isin value="US00166B1052"/>
          <ticker value="ALXO US"/>
        </identifiers>
        <balance>9800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>109270</valUSD>
        <pctVal>0.0395370649</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AbbVie Inc.</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC COMMON STOCK USD.01</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
          <ticker value="ABBV US"/>
        </identifiers>
        <balance>7657</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1394339.7</valUSD>
        <pctVal>0.5045126680</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acadia Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ACADIA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
          <ticker value="ACAD US"/>
        </identifiers>
        <balance>18341</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>339125.09</valUSD>
        <pctVal>0.1227053235</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acumen Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ACUMEN PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>00509G209</cusip>
        <identifiers>
          <isin value="US00509G2093"/>
          <ticker value="ABOS US"/>
        </identifiers>
        <balance>15500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>62775</valUSD>
        <pctVal>0.0227138213</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Spyre Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SPYRE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>00773J202</cusip>
        <identifiers>
          <isin value="US00773J2024"/>
          <ticker value="SYRE US"/>
        </identifiers>
        <balance>6330</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>240096.9</valUSD>
        <pctVal>0.0868740434</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agilent Technologies Inc.</name>
        <lei>QUIX8Y7A2WP0XRMW7G29</lei>
        <title>AGILENT TECHNOLOGIES INC COMMON STOCK USD.01</title>
        <cusip>00846U101</cusip>
        <identifiers>
          <isin value="US00846U1016"/>
          <ticker value="A US"/>
        </identifiers>
        <balance>20582</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2994886.82</valUSD>
        <pctVal>1.0836371796</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>AGIOS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
          <ticker value="AGIO US"/>
        </identifiers>
        <balance>16527</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>483249.48</valUSD>
        <pctVal>0.1748537207</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>agilon health Inc.</name>
        <lei>N/A</lei>
        <title>AGILON HEALTH INC COMMON STOCK USD.01</title>
        <cusip>00857U107</cusip>
        <identifiers>
          <isin value="US00857U1079"/>
          <ticker value="AGL US"/>
        </identifiers>
        <balance>42556</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>259591.6</valUSD>
        <pctVal>0.0939277930</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akero Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>AKERO THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>00973Y108</cusip>
        <identifiers>
          <isin value="US00973Y1082"/>
          <ticker value="AKRO US"/>
        </identifiers>
        <balance>15591</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>393828.66</valUSD>
        <pctVal>0.1424986666</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alector Inc.</name>
        <lei>N/A</lei>
        <title>ALECTOR INC COMMON STOCK USD.0001</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
          <ticker value="ALEC US"/>
        </identifiers>
        <balance>12104</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>72866.08</valUSD>
        <pctVal>0.0263650676</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
          <ticker value="ALLO US"/>
        </identifiers>
        <balance>51354</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>229552.38</valUSD>
        <pctVal>0.0830587293</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ALNYLAM PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <ticker value="ALNY US"/>
        </identifiers>
        <balance>24426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3650465.7</valUSD>
        <pctVal>1.3208446907</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alpine Immune Sciences Inc.</name>
        <lei>5493000845S6RLSDWJ40</lei>
        <title>ALPINE IMMUNE SCIENCES INC COMMON STOCK USD.001</title>
        <cusip>02083G100</cusip>
        <identifiers>
          <isin value="US02083G1004"/>
          <ticker value="ALPN US"/>
        </identifiers>
        <balance>15233</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>603836.12</valUSD>
        <pctVal>0.2184854752</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bruker Corporation</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
        <title>BRUKER CORP COMMON STOCK USD.01</title>
        <cusip>116794108</cusip>
        <identifiers>
          <isin value="US1167941087"/>
          <ticker value="BRKR US"/>
        </identifiers>
        <balance>9654</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>906896.76</valUSD>
        <pctVal>0.3281416315</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>C4 Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>C4 THERAPEUTICS INC COMMON STOCK</title>
        <cusip>12529R107</cusip>
        <identifiers>
          <isin value="US12529R1077"/>
          <ticker value="CCCC US"/>
        </identifiers>
        <balance>14300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>116831</valUSD>
        <pctVal>0.0422728547</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>The Cigna Group</name>
        <lei>N/A</lei>
        <title>CIGNA GROUP/THE COMMON STOCK USD.01</title>
        <cusip>125523100</cusip>
        <identifiers>
          <isin value="US1255231003"/>
          <ticker value="CI US"/>
        </identifiers>
        <balance>14280</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5186353.2</valUSD>
        <pctVal>1.8765734707</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cabaletta Bio Inc.</name>
        <lei>N/A</lei>
        <title>CABALETTA BIO INC COMMON STOCK USD.00001</title>
        <cusip>12674W109</cusip>
        <identifiers>
          <isin value="US12674W1099"/>
          <ticker value="CABA US"/>
        </identifiers>
        <balance>9787</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>166966.22</valUSD>
        <pctVal>0.0604132358</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cardinal Health Inc.</name>
        <lei>CCU46N3GJMF4OK4N7U60</lei>
        <title>CARDINAL HEALTH INC COMMON STOCK</title>
        <cusip>14149Y108</cusip>
        <identifiers>
          <isin value="US14149Y1082"/>
          <ticker value="CAH US"/>
        </identifiers>
        <balance>13773</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1541198.7</valUSD>
        <pctVal>0.5576505267</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cargo Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CARGO THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>14179K101</cusip>
        <identifiers>
          <isin value="US14179K1016"/>
          <ticker value="CRGX US"/>
        </identifiers>
        <balance>32453</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>724350.96</valUSD>
        <pctVal>0.2620912504</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Celldex Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CELLDEX THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
          <ticker value="CLDX US"/>
        </identifiers>
        <balance>25830</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1084085.1</valUSD>
        <pctVal>0.3922535277</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centene Corporation</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>CENTENE CORP COMMON STOCK USD.001</title>
        <cusip>15135B101</cusip>
        <identifiers>
          <isin value="US15135B1017"/>
          <ticker value="CNC US"/>
        </identifiers>
        <balance>21742</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1706312.16</valUSD>
        <pctVal>0.6173933800</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Guardant Health Inc.</name>
        <lei>N/A</lei>
        <title>GUARDANT HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
          <ticker value="GH US"/>
        </identifiers>
        <balance>15795</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>325850.85</valUSD>
        <pctVal>0.1179023173</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HCA Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>HCA HEALTHCARE INC COMMON STOCK USD.01</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
          <ticker value="HCA US"/>
        </identifiers>
        <balance>9189</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3064807.17</valUSD>
        <pctVal>1.1089363964</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Haemonetics Corporation</name>
        <lei>549300ZEL6TXZS6F5F95</lei>
        <title>HAEMONETICS CORP COMMON STOCK USD.01</title>
        <cusip>405024100</cusip>
        <identifiers>
          <isin value="US4050241003"/>
          <ticker value="HAE US"/>
        </identifiers>
        <balance>2600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>221910</valUSD>
        <pctVal>0.0802934939</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Hologic Inc.</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>HOLOGIC INC COMMON STOCK USD.01</title>
        <cusip>436440101</cusip>
        <identifiers>
          <isin value="US4364401012"/>
          <ticker value="HOLX US"/>
        </identifiers>
        <balance>23161</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1805631.56</valUSD>
        <pctVal>0.6533300284</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Humana Inc.</name>
        <lei>N/A</lei>
        <title>HUMANA INC COMMON STOCK USD.1666666</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
          <ticker value="HUM US"/>
        </identifiers>
        <balance>4150</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1438888</valUSD>
        <pctVal>0.5206315389</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IGM Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IGM BIOSCIENCES INC COMMON STOCK USD.01</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
          <ticker value="IGMS US"/>
        </identifiers>
        <balance>17234</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>166308.1</valUSD>
        <pctVal>0.0601751089</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEAYA Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IDEAYA BIOSCIENCES INC COMMON STOCK</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
          <ticker value="IDYA US"/>
        </identifiers>
        <balance>20344</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>892694.72</valUSD>
        <pctVal>0.3230029202</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immuneering Corporation</name>
        <lei>N/A</lei>
        <title>IMMUNEERING CORP COMMON STOCK USD.001</title>
        <cusip>45254E107</cusip>
        <identifiers>
          <isin value="US45254E1073"/>
          <ticker value="IMRX US"/>
        </identifiers>
        <balance>29676</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>85763.64</valUSD>
        <pctVal>0.0310317800</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunome Inc.</name>
        <lei>N/A</lei>
        <title>IMMUNOME INC COMMON STOCK</title>
        <cusip>45257U108</cusip>
        <identifiers>
          <isin value="US45257U1088"/>
          <ticker value="IMNM US"/>
        </identifiers>
        <balance>29019</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>716188.92</valUSD>
        <pctVal>0.2591379868</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunocore Holdings PLC</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC ADR GBP.0001</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
          <ticker value="IMCR US"/>
        </identifiers>
        <balance>21610</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1404650</valUSD>
        <pctVal>0.5082432345</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunocore Holdings PLC</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC SR UNSECURED 144A 02/30 2.5</title>
        <cusip>45258DAA3</cusip>
        <identifiers>
          <isin value="US45258DAA37"/>
          <ticker value="IMCR"/>
        </identifiers>
        <balance>277000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>288606.3</valUSD>
        <pctVal>0.1044261556</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <debtSec>
          <maturityDt>2030-02-01</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>2.500000000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
          <isMandatoryConvrtbl>N</isMandatoryConvrtbl>
          <isContngtConvrtbl>N</isContngtConvrtbl>
          <dbtSecRefInstruments>
            <dbtSecRefInstrument>
              <name>Immunocore Holdings PLC</name>
              <title>Immunocore Holdings PLC</title>
              <curCd>USD</curCd>
              <identifiers>
                <isin value="US45258D1054"/>
                <ticker value="IMCR"/>
                <other otherDesc="BLOOMBERG" value="EQ0000000089216579"/>
              </identifiers>
            </dbtSecRefInstrument>
          </dbtSecRefInstruments>
          <currencyInfos>
            <currencyInfo convRatio="10.560100000000" curCd="USD"/>
          </currencyInfos>
          <delta>XXXX</delta>
        </debtSec>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunovant Inc.</name>
        <lei>N/A</lei>
        <title>IMMUNOVANT INC COMMON STOCK USD.0001</title>
        <cusip>45258J102</cusip>
        <identifiers>
          <isin value="US45258J1025"/>
          <ticker value="IMVT US"/>
        </identifiers>
        <balance>11095</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>358479.45</valUSD>
        <pctVal>0.1297082940</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centessa Pharmaceuticals PLC</name>
        <lei>N/A</lei>
        <title>CENTESSA PHARMACEUTICALS PLC ADR USD.0001</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
          <ticker value="CNTA US"/>
        </identifiers>
        <balance>26313</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>297336.9</valUSD>
        <pctVal>0.1075851406</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CG Oncology Inc.</name>
        <lei>N/A</lei>
        <title>CG ONCOLOGY INC COMMON STOCK</title>
        <cusip>156944100</cusip>
        <identifiers>
          <isin value="US1569441009"/>
          <ticker value="CGON US"/>
        </identifiers>
        <balance>14001</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>614643.9</valUSD>
        <pctVal>0.2223960444</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Charles River Laboratories International Inc.</name>
        <lei>549300BSQ0R4UZ5KX287</lei>
        <title>CHARLES RIVER LABORATORIES INT COMMON STOCK USD.01</title>
        <cusip>159864107</cusip>
        <identifiers>
          <isin value="US1598641074"/>
          <ticker value="CRL US"/>
        </identifiers>
        <balance>4275</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1158311.25</valUSD>
        <pctVal>0.4191107082</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Enovis Corporation</name>
        <lei>N/A</lei>
        <title>ENOVIS CORP COMMON STOCK USD.001</title>
        <cusip>194014502</cusip>
        <identifiers>
          <isin value="US1940145022"/>
          <ticker value="ENOV US"/>
        </identifiers>
        <balance>4037</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>252110.65</valUSD>
        <pctVal>0.0912209676</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Corbus Pharmaceuticals Holdings Inc.</name>
        <lei>N/A</lei>
        <title>CORBUS PHARMACEUTICALS HOLDING COMMON STOCK USD.0001</title>
        <cusip>21833P301</cusip>
        <identifiers>
          <isin value="US21833P3010"/>
          <ticker value="CRBP US"/>
        </identifiers>
        <balance>2500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>98100</valUSD>
        <pctVal>0.0354954340</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Crinetics Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>CRINETICS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
          <ticker value="CRNX US"/>
        </identifiers>
        <balance>18414</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>861959.34</valUSD>
        <pctVal>0.3118819656</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cytokinetics Incorporated</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC COMMON STOCK USD.001</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
          <ticker value="CYTK US"/>
        </identifiers>
        <balance>8539</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>598669.29</valUSD>
        <pctVal>0.2166159658</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Incyte Corporation</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP COMMON STOCK USD.001</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
          <ticker value="INCY US"/>
        </identifiers>
        <balance>7518</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>428300.46</valUSD>
        <pctVal>0.1549715667</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insmed Incorporated</name>
        <lei>N/A</lei>
        <title>INSMED INC COMMON STOCK USD.01</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <ticker value="INSM US"/>
        </identifiers>
        <balance>40225</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1091304.25</valUSD>
        <pctVal>0.3948656262</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Danaher Corporation</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>DANAHER CORP COMMON STOCK USD.01</title>
        <cusip>235851102</cusip>
        <identifiers>
          <isin value="US2358511028"/>
          <ticker value="DHR US"/>
        </identifiers>
        <balance>32928</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8222780.16</valUSD>
        <pctVal>2.9752410814</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Day One Biopharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>DAY ONE BIOPHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>23954D109</cusip>
        <identifiers>
          <isin value="US23954D1090"/>
          <ticker value="DAWN US"/>
        </identifiers>
        <balance>1141</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>18849.32</valUSD>
        <pctVal>0.0068202323</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Denali Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DENALI THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
          <ticker value="DNLI US"/>
        </identifiers>
        <balance>18220</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>373874.4</valUSD>
        <pctVal>0.1352786348</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DexCom Inc.</name>
        <lei>N/A</lei>
        <title>DEXCOM INC COMMON STOCK USD.001</title>
        <cusip>252131107</cusip>
        <identifiers>
          <isin value="US2521311074"/>
          <ticker value="DXCM US"/>
        </identifiers>
        <balance>14449</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2004076.3</valUSD>
        <pctVal>0.7251331085</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Disc Medicine Inc.</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC COMMON STOCK USD.0001</title>
        <cusip>254604101</cusip>
        <identifiers>
          <isin value="US2546041011"/>
          <ticker value="IRON US"/>
        </identifiers>
        <balance>3902</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>242938.52</valUSD>
        <pctVal>0.0879022242</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Dyne Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DYNE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>26818M108</cusip>
        <identifiers>
          <isin value="US26818M1080"/>
          <ticker value="DYN US"/>
        </identifiers>
        <balance>8500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>241315</valUSD>
        <pctVal>0.0873147874</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Edwards Lifesciences Corporation</name>
        <lei>YA13X31F3V31L8TMPR58</lei>
        <title>EDWARDS LIFESCIENCES CORP COMMON STOCK USD1.0</title>
        <cusip>28176E108</cusip>
        <identifiers>
          <isin value="US28176E1082"/>
          <ticker value="EW US"/>
        </identifiers>
        <balance>38567</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3685462.52</valUSD>
        <pctVal>1.3335075583</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Entrada Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ENTRADA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>29384C108</cusip>
        <identifiers>
          <isin value="US29384C1080"/>
          <ticker value="TRDA US"/>
        </identifiers>
        <balance>11625</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>164726.25</valUSD>
        <pctVal>0.0596027495</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exact Sciences Corporation</name>
        <lei>N/A</lei>
        <title>EXACT SCIENCES CORP COMMON STOCK USD.01</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
          <ticker value="EXAS US"/>
        </identifiers>
        <balance>16241</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1121603.46</valUSD>
        <pctVal>0.4058287618</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exelixis Inc.</name>
        <lei>N/A</lei>
        <title>EXELIXIS INC COMMON STOCK USD.001</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
          <ticker value="EXEL US"/>
        </identifiers>
        <balance>19678</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>466958.94</valUSD>
        <pctVal>0.1689593294</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>EyePoint Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>EYEPOINT PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>30233G209</cusip>
        <identifiers>
          <isin value="US30233G2093"/>
          <ticker value="EYPT US"/>
        </identifiers>
        <balance>15686</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>324229.62</valUSD>
        <pctVal>0.1173157091</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fate Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>FATE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
          <ticker value="FATE US"/>
        </identifiers>
        <balance>6900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50646</valUSD>
        <pctVal>0.0183251962</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Inspire Medical Systems Inc.</name>
        <lei>N/A</lei>
        <title>INSPIRE MEDICAL SYSTEMS INC COMMON STOCK USD.001</title>
        <cusip>457730109</cusip>
        <identifiers>
          <isin value="US4577301090"/>
          <ticker value="INSP US"/>
        </identifiers>
        <balance>3360</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>721694.4</valUSD>
        <pctVal>0.2611300297</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insulet Corporation</name>
        <lei>549300TZTYD2PYN92D43</lei>
        <title>INSULET CORP COMMON STOCK USD.001</title>
        <cusip>45784P101</cusip>
        <identifiers>
          <isin value="US45784P1012"/>
          <ticker value="PODD US"/>
        </identifiers>
        <balance>3405</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>583617</valUSD>
        <pctVal>0.2111696094</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intellia Therapeutics Inc.</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
          <ticker value="NTLA US"/>
        </identifiers>
        <balance>5309</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>146050.59</valUSD>
        <pctVal>0.0528453524</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intuitive Surgical Inc.</name>
        <lei>54930052SRG011710797</lei>
        <title>INTUITIVE SURGICAL INC COMMON STOCK USD.001</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
          <ticker value="ISRG US"/>
        </identifiers>
        <balance>29170</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11641455.3</valUSD>
        <pctVal>4.2122172042</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Generation Bio Co.</name>
        <lei>N/A</lei>
        <title>GENERATION BIO CO COMMON STOCK USD.0001</title>
        <cusip>37148K100</cusip>
        <identifiers>
          <isin value="US37148K1007"/>
          <ticker value="GBIO US"/>
        </identifiers>
        <balance>37692</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>153406.44</valUSD>
        <pctVal>0.0555069129</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Geron Corporation</name>
        <lei>N/A</lei>
        <title>GERON CORP COMMON STOCK USD.001</title>
        <cusip>374163103</cusip>
        <identifiers>
          <isin value="US3741631036"/>
          <ticker value="GERN US"/>
        </identifiers>
        <balance>24900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82170</valUSD>
        <pctVal>0.0297314965</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ginkgo Bioworks Holdings Inc.</name>
        <lei>N/A</lei>
        <title>GINKGO BIOWORKS HOLDINGS INC COMMON STOCK USD.0001</title>
        <cusip>37611X100</cusip>
        <identifiers>
          <isin value="US37611X1000"/>
          <ticker value="DNA US"/>
        </identifiers>
        <balance>78858</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>91475.28</valUSD>
        <pctVal>0.0330984175</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gossamer Bio Inc.</name>
        <lei>N/A</lei>
        <title>GOSSAMER BIO INC COMMON STOCK USD.0001</title>
        <cusip>38341P102</cusip>
        <identifiers>
          <isin value="US38341P1021"/>
          <ticker value="GOSS US"/>
        </identifiers>
        <balance>45188</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53321.84</valUSD>
        <pctVal>0.0192933930</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kyverna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYVERNA THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>501976104</cusip>
        <identifiers>
          <isin value="US5019761049"/>
          <ticker value="KYTX US"/>
        </identifiers>
        <balance>7329</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>182052.36</valUSD>
        <pctVal>0.0658718402</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lantheus Holdings Inc.</name>
        <lei>N/A</lei>
        <title>LANTHEUS HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
          <ticker value="LNTH US"/>
        </identifiers>
        <balance>8245</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>513168.8</valUSD>
        <pctVal>0.1856794011</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc.</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
          <ticker value="IONS US"/>
        </identifiers>
        <balance>17154</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>743625.9</valUSD>
        <pctVal>0.2690654844</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Iovance Biotherapeutics Inc.</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC COMMON STOCK USD.000041666</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
          <ticker value="IOVA US"/>
        </identifiers>
        <balance>59007</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>874483.74</valUSD>
        <pctVal>0.3164136579</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Legend Biotech Corporation</name>
        <lei>N/A</lei>
        <title>LEGEND BIOTECH CORP ADR</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
          <ticker value="LEGN US"/>
        </identifiers>
        <balance>21441</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1202625.69</valUSD>
        <pctVal>0.4351449618</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly and Company</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO COMMON STOCK</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY US"/>
        </identifiers>
        <balance>35261</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>27431647.56</valUSD>
        <pctVal>9.9255681367</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IQVIA Holdings Inc.</name>
        <lei>N/A</lei>
        <title>IQVIA HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>46266C105</cusip>
        <identifiers>
          <isin value="US46266C1053"/>
          <ticker value="IQV US"/>
        </identifiers>
        <balance>4324</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1093496.36</valUSD>
        <pctVal>0.3956587954</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Krystal Biotech Inc.</name>
        <lei>N/A</lei>
        <title>KRYSTAL BIOTECH INC COMMON STOCK USD.00001</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
          <ticker value="KRYS US"/>
        </identifiers>
        <balance>7208</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1282519.44</valUSD>
        <pctVal>0.4640528448</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Longboard Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>LONGBOARD PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>54300N103</cusip>
        <identifiers>
          <isin value="US54300N1037"/>
          <ticker value="LBPH US"/>
        </identifiers>
        <balance>16599</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>358538.4</valUSD>
        <pctVal>0.1297296238</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lyell Immunopharma Inc.</name>
        <lei>N/A</lei>
        <title>LYELL IMMUNOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>55083R104</cusip>
        <identifiers>
          <isin value="US55083R1041"/>
          <ticker value="LYEL US"/>
        </identifiers>
        <balance>95825</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>213689.75</valUSD>
        <pctVal>0.0773191683</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MacroGenics Inc.</name>
        <lei>5493001KJQUA83L8MH79</lei>
        <title>MACROGENICS INC COMMON STOCK USD.01</title>
        <cusip>556099109</cusip>
        <identifiers>
          <isin value="US5560991094"/>
          <ticker value="MGNX US"/>
        </identifiers>
        <balance>24089</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>354590.08</valUSD>
        <pctVal>0.1283010068</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MADRIGAL PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
          <ticker value="MDGL US"/>
        </identifiers>
        <balance>5350</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1428664</valUSD>
        <pctVal>0.5169321983</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kymera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC COMMON STOCK</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
          <ticker value="KYMR US"/>
        </identifiers>
        <balance>23246</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>934489.2</valUSD>
        <pctVal>0.3381253790</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Icon Public Limited Company</name>
        <lei>N/A</lei>
        <title>ICON PLC COMMON STOCK EUR.06</title>
        <cusip>G4705A100</cusip>
        <identifiers>
          <isin value="IE0005711209"/>
          <ticker value="ICLR US"/>
        </identifiers>
        <balance>4602</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1546041.9</valUSD>
        <pctVal>0.5594029373</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>McKesson Corporation</name>
        <lei>549300WZWOM80UCFSF54</lei>
        <title>MCKESSON CORP COMMON STOCK USD.01</title>
        <cusip>58155Q103</cusip>
        <identifiers>
          <isin value="US58155Q1031"/>
          <ticker value="MCK US"/>
        </identifiers>
        <balance>2435</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1307229.75</valUSD>
        <pctVal>0.4729937539</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sartorius AG</name>
        <lei>N/A</lei>
        <title>SARTORIUS AG PREFERENCE</title>
        <cusip>584332902</cusip>
        <identifiers>
          <isin value="DE0007165631"/>
          <ticker value="SRT3 GR"/>
        </identifiers>
        <balance>1984</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.926913"/>
        <valUSD>787866.5</valUSD>
        <pctVal>0.2850730205</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>West Pharmaceutical Services Inc.</name>
        <lei>5493007NKRGM1RJQ1P16</lei>
        <title>WEST PHARMACEUTICAL SERVICES I COMMON STOCK USD.25</title>
        <cusip>955306105</cusip>
        <identifiers>
          <isin value="US9553061055"/>
          <ticker value="WST US"/>
        </identifiers>
        <balance>4588</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1815517.48</valUSD>
        <pctVal>0.6569070418</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC COMMON STOCK USD.01</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <ticker value="XNCR US"/>
        </identifiers>
        <balance>16855</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>373001.15</valUSD>
        <pctVal>0.1349626675</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NovoCure Limited</name>
        <lei>N/A</lei>
        <title>NOVOCURE LTD COMMON STOCK</title>
        <cusip>G6674U108</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
          <ticker value="NVCR US"/>
        </identifiers>
        <balance>34614</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>541016.82</valUSD>
        <pctVal>0.1957556249</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prothena Corporation Public Limited Company</name>
        <lei>N/A</lei>
        <title>PROTHENA CORP PLC COMMON STOCK USD.01</title>
        <cusip>G72800108</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
          <ticker value="PRTA US"/>
        </identifiers>
        <balance>15394</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>381309.38</valUSD>
        <pctVal>0.1379688268</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zai Lab Limited</name>
        <lei>N/A</lei>
        <title>ZAI LAB LTD ADR USD.00006</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
          <ticker value="ZLAB US"/>
        </identifiers>
        <balance>27277</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>436977.54</valUSD>
        <pctVal>0.1581111867</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ZENTALIS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
          <ticker value="ZNTL US"/>
        </identifiers>
        <balance>25143</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>396253.68</valUSD>
        <pctVal>0.1433761094</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roivant Sciences Ltd.</name>
        <lei>N/A</lei>
        <title>ROIVANT SCIENCES LTD COMMON STOCK</title>
        <cusip>G76279101</cusip>
        <identifiers>
          <isin value="BMG762791017"/>
          <ticker value="ROIV US"/>
        </identifiers>
        <balance>16493</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>173836.22</valUSD>
        <pctVal>0.0628990017</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRISPR Therapeutics AG</name>
        <lei>N/A</lei>
        <title>CRISPR THERAPEUTICS AG COMMON STOCK CHF.03</title>
        <cusip>H17182108</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
          <ticker value="CRSP US"/>
        </identifiers>
        <balance>1842</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>125550.72</valUSD>
        <pctVal>0.0454279031</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zimmer Biomet Holdings Inc.</name>
        <lei>2P2YLDVPES3BXQ1FRB91</lei>
        <title>ZIMMER BIOMET HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>98956P102</cusip>
        <identifiers>
          <isin value="US98956P1021"/>
          <ticker value="ZBH US"/>
        </identifiers>
        <balance>11105</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1465637.9</valUSD>
        <pctVal>0.5303104310</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zoetis Inc.</name>
        <lei>549300HD9Q1LOC9KLJ48</lei>
        <title>ZOETIS INC COMMON STOCK USD.01</title>
        <cusip>98978V103</cusip>
        <identifiers>
          <isin value="US98978V1035"/>
          <ticker value="ZTS US"/>
        </identifiers>
        <balance>8944</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1513414.24</valUSD>
        <pctVal>0.5475973007</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UroGen Pharma Ltd.</name>
        <lei>N/A</lei>
        <title>UROGEN PHARMA LTD COMMON STOCK USD.01</title>
        <cusip>M96088105</cusip>
        <identifiers>
          <isin value="IL0011407140"/>
          <ticker value="URGN US"/>
        </identifiers>
        <balance>5800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87000</valUSD>
        <pctVal>0.0314791310</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immatics N.V.</name>
        <lei>N/A</lei>
        <title>IMMATICS NV COMMON STOCK</title>
        <cusip>N44445109</cusip>
        <identifiers>
          <isin value="NL0015285941"/>
          <ticker value="IMTX US"/>
        </identifiers>
        <balance>35390</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>371948.9</valUSD>
        <pctVal>0.1345819329</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Daiichi Sankyo Company Limited</name>
        <lei>N/A</lei>
        <title>DAIICHI SANKYO CO LTD COMMON STOCK</title>
        <cusip>B0J7D9901</cusip>
        <identifiers>
          <isin value="JP3475350009"/>
          <ticker value="4568 JP"/>
        </identifiers>
        <balance>20100</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="151.38"/>
        <valUSD>639559.35</valUSD>
        <pctVal>0.2314111791</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pharming Group N.V.</name>
        <lei>N/A</lei>
        <title>PHARMING GROUP NV COMMON STOCK EUR.01</title>
        <cusip>B8RC74902</cusip>
        <identifiers>
          <isin value="NL0010391025"/>
          <ticker value="PHARM NA"/>
        </identifiers>
        <balance>188255</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.926913"/>
        <valUSD>206899.07</valUSD>
        <pctVal>0.0748621027</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Siemens Healthineers AG</name>
        <lei>N/A</lei>
        <title>SIEMENS HEALTHINEERS AG COMMON STOCK</title>
        <cusip>BD594Y909</cusip>
        <identifiers>
          <isin value="DE000SHL1006"/>
          <ticker value="SHL GR"/>
        </identifiers>
        <balance>7018</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.926913"/>
        <valUSD>429203.67</valUSD>
        <pctVal>0.1552983743</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merus N.V.</name>
        <lei>549300W8GPUWU8QNU293</lei>
        <title>MERUS NV COMMON STOCK EUR.05</title>
        <cusip>N5749R100</cusip>
        <identifiers>
          <isin value="NL0011606264"/>
          <ticker value="MRUS US"/>
        </identifiers>
        <balance>14335</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>645505.05</valUSD>
        <pctVal>0.2335625063</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pharvaris B.V.</name>
        <lei>N/A</lei>
        <title>PHARVARIS NV COMMON STOCK EUR.12</title>
        <cusip>N69605108</cusip>
        <identifiers>
          <isin value="NL00150005Y4"/>
          <ticker value="PHVS US"/>
        </identifiers>
        <balance>14671</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>339046.81</valUSD>
        <pctVal>0.1226769995</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Wave Life Sciences Ltd.</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD COMMON STOCK</title>
        <cusip>Y95308105</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
          <ticker value="WVE US"/>
        </identifiers>
        <balance>28947</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>178602.99</valUSD>
        <pctVal>0.0646237578</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc.</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BIOMARIN PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
          <ticker value="BMRN US"/>
        </identifiers>
        <balance>14769</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1289924.46</valUSD>
        <pctVal>0.4667321965</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biogen Inc.</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC COMMON STOCK USD.0005</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
          <ticker value="BIIB US"/>
        </identifiers>
        <balance>7038</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1517603.94</valUSD>
        <pctVal>0.5491132561</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bio-Techne Corporation</name>
        <lei>N/A</lei>
        <title>BIO-TECHNE CORP COMMON STOCK USD.01</title>
        <cusip>09073M104</cusip>
        <identifiers>
          <isin value="US09073M1045"/>
          <ticker value="TECH US"/>
        </identifiers>
        <balance>18702</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1316433.78</valUSD>
        <pctVal>0.4763240397</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Blueprint Medicines Corporation</name>
        <lei>N/A</lei>
        <title>BLUEPRINT MEDICINES CORP COMMON STOCK USD.001</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
          <ticker value="BPMC US"/>
        </identifiers>
        <balance>37765</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3582387.9</valUSD>
        <pctVal>1.2962121621</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Boston Scientific Corporation</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>BOSTON SCIENTIFIC CORP COMMON STOCK USD.01</title>
        <cusip>101137107</cusip>
        <identifiers>
          <isin value="US1011371077"/>
          <ticker value="BSX US"/>
        </identifiers>
        <balance>42010</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2877264.9</valUSD>
        <pctVal>1.0410781470</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BrightSpring Health Services Inc.</name>
        <lei>N/A</lei>
        <title>BRIGHTSPRING HEALTH SERVICES I COMMON STOCK USD100.0</title>
        <cusip>10950A106</cusip>
        <identifiers>
          <isin value="US10950A1060"/>
          <ticker value="BTSG US"/>
        </identifiers>
        <balance>20237</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>219976.19</valUSD>
        <pctVal>0.0795937852</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merck and Co. Inc.</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK and CO INC COMMON STOCK USD.5</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
          <ticker value="MRK US"/>
        </identifiers>
        <balance>85275</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11252036.25</valUSD>
        <pctVal>4.0713140628</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mereo BioPharma Group plc</name>
        <lei>N/A</lei>
        <title>MEREO BIOPHARMA GROUP PLC ADR</title>
        <cusip>589492107</cusip>
        <identifiers>
          <isin value="US5894921072"/>
          <ticker value="MREO US"/>
        </identifiers>
        <balance>28300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>93390</valUSD>
        <pctVal>0.0337912189</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirum Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MIRUM PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>604749101</cusip>
        <identifiers>
          <isin value="US6047491013"/>
          <ticker value="MIRM US"/>
        </identifiers>
        <balance>7791</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>195709.92</valUSD>
        <pctVal>0.0708135427</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molina Healthcare Inc.</name>
        <lei>549300NQQCEQ46YHZ591</lei>
        <title>MOLINA HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>60855R100</cusip>
        <identifiers>
          <isin value="US60855R1005"/>
          <ticker value="MOH US"/>
        </identifiers>
        <balance>10122</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4158421.26</valUSD>
        <pctVal>1.5046377899</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Monte Rosa Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
          <ticker value="GLUE US"/>
        </identifiers>
        <balance>27152</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>191421.6</valUSD>
        <pctVal>0.0692619038</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MoonLake Immunotherapeutics</name>
        <lei>N/A</lei>
        <title>MOONLAKE IMMUNOTHERAPEUTICS COMMON STOCK USD.0001</title>
        <cusip>61559X104</cusip>
        <identifiers>
          <isin value="KY61559X1045"/>
          <ticker value="MLTX US"/>
        </identifiers>
        <balance>18787</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>943671.01</valUSD>
        <pctVal>0.3414476250</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Morphic Holding Inc.</name>
        <lei>N/A</lei>
        <title>MORPHIC HOLDING INC COMMON STOCK USD.0001</title>
        <cusip>61775R105</cusip>
        <identifiers>
          <isin value="US61775R1059"/>
          <ticker value="MORF US"/>
        </identifiers>
        <balance>15168</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>533913.6</valUSD>
        <pctVal>0.1931854733</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Chugai Pharmaceutical Co. Ltd.</name>
        <lei>N/A</lei>
        <title>CHUGAI PHARMACEUTICAL CO LTD COMMON STOCK</title>
        <cusip>619640006</cusip>
        <identifiers>
          <isin value="JP3519400000"/>
          <ticker value="4519 JP"/>
        </identifiers>
        <balance>13100</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="151.38"/>
        <valUSD>500621.55</valUSD>
        <pctVal>0.1811394410</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neumora Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>NEUMORA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>640979100</cusip>
        <identifiers>
          <isin value="US6409791000"/>
          <ticker value="NMRA US"/>
        </identifiers>
        <balance>6400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>88000</valUSD>
        <pctVal>0.0318409601</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurocrine Biosciences Inc.</name>
        <lei>549300FECER0XBN49756</lei>
        <title>NEUROCRINE BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
          <ticker value="NBIX US"/>
        </identifiers>
        <balance>14248</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1965084.16</valUSD>
        <pctVal>0.7110246179</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novo Nordisk A/S</name>
        <lei>549300DAQ1CVT6CXN342</lei>
        <title>NOVO NORDISK A/S ADR</title>
        <cusip>670100205</cusip>
        <identifiers>
          <isin value="US6701002056"/>
          <ticker value="NVO US"/>
        </identifiers>
        <balance>33007</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4238098.8</valUSD>
        <pctVal>1.5334674418</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nuvalent Inc.</name>
        <lei>N/A</lei>
        <title>NUVALENT INC COMMON STOCK USD.0001</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
          <ticker value="NUVL US"/>
        </identifiers>
        <balance>2238</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>168051.42</valUSD>
        <pctVal>0.0608058928</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nuvation Bio Inc.</name>
        <lei>N/A</lei>
        <title>NUVATION BIO INC COMMON STOCK USD.0001</title>
        <cusip>67080N101</cusip>
        <identifiers>
          <isin value="US67080N1019"/>
          <ticker value="NUVB US"/>
        </identifiers>
        <balance>16100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>58604</valUSD>
        <pctVal>0.0212046321</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alto Neuroscience Inc.</name>
        <lei>N/A</lei>
        <title>ALTO NEUROSCIENCE INC COMMON STOCK USD.0001</title>
        <cusip>02157Q109</cusip>
        <identifiers>
          <isin value="US02157Q1094"/>
          <ticker value="ANRO US"/>
        </identifiers>
        <balance>9005</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>138226.75</valUSD>
        <pctVal>0.0500144595</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cencora Inc.</name>
        <lei>AI8GXW8LG5WK7E9UD086</lei>
        <title>CENCORA INC COMMON STOCK USD.01</title>
        <cusip>03073E105</cusip>
        <identifiers>
          <isin value="US03073E1055"/>
          <ticker value="COR US"/>
        </identifiers>
        <balance>3710</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>901492.9</valUSD>
        <pctVal>0.3261863577</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amgen Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC COMMON STOCK USD.0001</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
          <ticker value="AMGN US"/>
        </identifiers>
        <balance>15961</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4538031.52</valUSD>
        <pctVal>1.6419918257</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amylyx Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>AMYLYX PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>03237H101</cusip>
        <identifiers>
          <isin value="US03237H1014"/>
          <ticker value="AMLX US"/>
        </identifiers>
        <balance>15424</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43804.16</valUSD>
        <pctVal>0.0158496195</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AnaptysBio Inc.</name>
        <lei>N/A</lei>
        <title>ANAPTYSBIO INC COMMON STOCK USD.001</title>
        <cusip>032724106</cusip>
        <identifiers>
          <isin value="US0327241065"/>
          <ticker value="ANAB US"/>
        </identifiers>
        <balance>2300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>51796</valUSD>
        <pctVal>0.0187412997</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Annexon Inc.</name>
        <lei>N/A</lei>
        <title>ANNEXON INC COMMON STOCK</title>
        <cusip>03589W102</cusip>
        <identifiers>
          <isin value="US03589W1027"/>
          <ticker value="ANNX US"/>
        </identifiers>
        <balance>18400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>131928</valUSD>
        <pctVal>0.0477353885</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Elevance Health Inc.</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>ELEVANCE HEALTH INC COMMON STOCK USD.01</title>
        <cusip>036752103</cusip>
        <identifiers>
          <isin value="US0367521038"/>
          <ticker value="ELV US"/>
        </identifiers>
        <balance>19091</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9899447.14</valUSD>
        <pctVal>3.5819079729</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>APELLIS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
          <ticker value="APLS US"/>
        </identifiers>
        <balance>25474</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1497361.72</valUSD>
        <pctVal>0.5417890320</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apogee Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
          <ticker value="APGE US"/>
        </identifiers>
        <balance>17772</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1180949.4</valUSD>
        <pctVal>0.4273018494</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcellx Inc.</name>
        <lei>N/A</lei>
        <title>ARCELLX INC COMMON STOCK USD.001</title>
        <cusip>03940C100</cusip>
        <identifiers>
          <isin value="US03940C1009"/>
          <ticker value="ACLX US"/>
        </identifiers>
        <balance>7340</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>510497</valUSD>
        <pctVal>0.1847126661</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ardelyx Inc.</name>
        <lei>549300F542QR4SXHCY32</lei>
        <title>ARDELYX INC COMMON STOCK USD.000001</title>
        <cusip>039697107</cusip>
        <identifiers>
          <isin value="US0396971071"/>
          <ticker value="ARDX US"/>
        </identifiers>
        <balance>54174</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>395470.2</valUSD>
        <pctVal>0.1430926235</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>argenx SE</name>
        <lei>N/A</lei>
        <title>ARGENX SE ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
          <ticker value="ARGX US"/>
        </identifiers>
        <balance>14270</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5618384.4</valUSD>
        <pctVal>2.0328949276</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arvinas Inc.</name>
        <lei>N/A</lei>
        <title>ARVINAS INC COMMON STOCK USD.001</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
          <ticker value="ARVN US"/>
        </identifiers>
        <balance>21005</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>867086.4</valUSD>
        <pctVal>0.3137370851</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>N/A</lei>
        <title>ASCENDIS PHARMA A/S ADR DKK1.0</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
          <ticker value="ASND US"/>
        </identifiers>
        <balance>10972</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1658637.24</valUSD>
        <pctVal>0.6001432070</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC ADR</title>
        <cusip>046353108</cusip>
        <identifiers>
          <isin value="US0463531089"/>
          <ticker value="AZN US"/>
        </identifiers>
        <balance>81976</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5553874</valUSD>
        <pctVal>2.0095531881</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Atara Biotherapeutics Inc.</name>
        <lei>549300WBXUXZRE03MS38</lei>
        <title>ATARA BIOTHERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>046513107</cusip>
        <identifiers>
          <isin value="US0465131078"/>
          <ticker value="ATRA US"/>
        </identifiers>
        <balance>78100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>54201.4</valUSD>
        <pctVal>0.0196116434</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aura Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AURA BIOSCIENCES INC COMMON STOCK USD.00001</title>
        <cusip>05153U107</cusip>
        <identifiers>
          <isin value="US05153U1079"/>
          <ticker value="AURA US"/>
        </identifiers>
        <balance>10426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>81844.1</valUSD>
        <pctVal>0.0296135764</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Autolus Therapeutics plc</name>
        <lei>N/A</lei>
        <title>AUTOLUS THERAPEUTICS PLC ADR GBP.0000001</title>
        <cusip>05280R100</cusip>
        <identifiers>
          <isin value="US05280R1005"/>
          <ticker value="AUTL US"/>
        </identifiers>
        <balance>38928</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>248360.64</valUSD>
        <pctVal>0.0898641049</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avidity Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AVIDITY BIOSCIENCES INC COMMON STOCK</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
          <ticker value="RNA US"/>
        </identifiers>
        <balance>53352</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1361543.04</valUSD>
        <pctVal>0.4926458823</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sensorion</name>
        <lei>N/A</lei>
        <title>SENSORION SA COMMON STOCK EUR.1</title>
        <cusip>BWSW4N905</cusip>
        <identifiers>
          <isin value="FR0012596468"/>
          <ticker value="ALSEN FP"/>
        </identifiers>
        <balance>182870</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.926913"/>
        <valUSD>152224.26</valUSD>
        <pctVal>0.0550791658</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes plc</name>
        <lei>549300YHRMYLL071E243</lei>
        <title>ALKERMES PLC COMMON STOCK USD.01</title>
        <cusip>G01767105</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
          <ticker value="ALKS US"/>
        </identifiers>
        <balance>30647</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>829614.29</valUSD>
        <pctVal>0.3001785855</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Ltd.</name>
        <lei>N/A</lei>
        <title>BIOHAVEN LTD COMMON STOCK</title>
        <cusip>G1110E107</cusip>
        <identifiers>
          <isin value="VGG1110E1079"/>
          <ticker value="BHVN US"/>
        </identifiers>
        <balance>31744</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1736079.36</valUSD>
        <pctVal>0.6281640190</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Helix Acquisition Corp. II</name>
        <lei>N/A</lei>
        <title>HELIX ACQUISITION CORP II COMMON STOCK USD.0001</title>
        <cusip>G4444H101</cusip>
        <identifiers>
          <isin value="KYG4444H1011"/>
          <ticker value="HLXB US"/>
        </identifiers>
        <balance>16298</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>168684.3</valUSD>
        <pctVal>0.0610348872</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corporation</name>
        <lei>N/A</lei>
        <title>SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK US"/>
        </identifiers>
        <balance>37540</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>666710.4</valUSD>
        <pctVal>0.2412352189</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GeneDX Holdings Corp.</name>
        <lei>N/A</lei>
        <title>GENEDX HOLDINGS CORP GENEDX HOLDINGS CORP</title>
        <cusip>81663L119</cusip>
        <identifiers>
          <isin value="US81663L1199"/>
          <ticker value="WGSWW"/>
        </identifiers>
        <balance>4862</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>267.41</valUSD>
        <pctVal>0.0000967567</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GeneDX Holdings Corp.</name>
        <lei>N/A</lei>
        <title>GENEDX HOLDINGS CORP COMMON STOCK USD.0001</title>
        <cusip>81663L200</cusip>
        <identifiers>
          <isin value="US81663L2007"/>
          <ticker value="WGS US"/>
        </identifiers>
        <balance>918</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8381.34</valUSD>
        <pctVal>0.0030326126</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Shockwave Medical Inc.</name>
        <lei>N/A</lei>
        <title>SHOCKWAVE MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>82489T104</cusip>
        <identifiers>
          <isin value="US82489T1043"/>
          <ticker value="SWAV US"/>
        </identifiers>
        <balance>6763</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2202235.69</valUSD>
        <pctVal>0.7968329407</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Soleno Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SOLENO THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>834203309</cusip>
        <identifiers>
          <isin value="US8342033094"/>
          <ticker value="SLNO US"/>
        </identifiers>
        <balance>4621</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>197778.8</valUSD>
        <pctVal>0.0715621237</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SomaLogic Inc.</name>
        <lei>N/A</lei>
        <title>SOMALOGIC INC WARRANTS CALL EXP 31AUG26</title>
        <cusip>83444K113</cusip>
        <identifiers>
          <isin value="US83444K1135"/>
          <ticker value="SLGCW"/>
        </identifiers>
        <balance>2050</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>207.05</valUSD>
        <pctVal>0.0000749167</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SpringWorks Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SPRINGWORKS THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
          <ticker value="SWTX US"/>
        </identifiers>
        <balance>26821</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1320129.62</valUSD>
        <pctVal>0.4776613021</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>STRYKER CORP COMMON STOCK USD.1</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
          <ticker value="SYK US"/>
        </identifiers>
        <balance>28452</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10182117.24</valUSD>
        <pctVal>3.6841862386</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Structure Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STRUCTURE THERAPEUTICS INC ADR USD.0001</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
          <ticker value="GPCR US"/>
        </identifiers>
        <balance>14790</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>633899.4</valUSD>
        <pctVal>0.2293632445</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Surgery Partners Inc.</name>
        <lei>549300LC82HG33S19I03</lei>
        <title>SURGERY PARTNERS INC COMMON STOCK USD.01</title>
        <cusip>86881A100</cusip>
        <identifiers>
          <isin value="US86881A1007"/>
          <ticker value="SGRY US"/>
        </identifiers>
        <balance>16697</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>498071.51</valUSD>
        <pctVal>0.1802167624</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tarsus Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>TARSUS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>87650L103</cusip>
        <identifiers>
          <isin value="US87650L1035"/>
          <ticker value="TARS US"/>
        </identifiers>
        <balance>5028</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>182767.8</valUSD>
        <pctVal>0.0661307072</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Taysha Gene Therapies Inc.</name>
        <lei>N/A</lei>
        <title>TAYSHA GENE THERAPIES INC COMMON STOCK</title>
        <cusip>877619106</cusip>
        <identifiers>
          <isin value="US8776191061"/>
          <ticker value="TSHA US"/>
        </identifiers>
        <balance>17400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49938</valUSD>
        <pctVal>0.0180690212</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Teleflex Incorporated</name>
        <lei>UUL85LWXB4NGSWWXIQ25</lei>
        <title>TELEFLEX INC COMMON STOCK USD1.0</title>
        <cusip>879369106</cusip>
        <identifiers>
          <isin value="US8793691069"/>
          <ticker value="TFX US"/>
        </identifiers>
        <balance>842</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>190435.14</valUSD>
        <pctVal>0.0689049738</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>10x Genomics Inc.</name>
        <lei>N/A</lei>
        <title>10X GENOMICS INC COMMON STOCK</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
          <ticker value="TXG US"/>
        </identifiers>
        <balance>33359</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1251963.27</valUSD>
        <pctVal>0.4529967336</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tenet Healthcare Corporation</name>
        <lei>0W9AIBT6U6ADJ2I8HK17</lei>
        <title>TENET HEALTHCARE CORP COMMON STOCK USD.05</title>
        <cusip>88033G407</cusip>
        <identifiers>
          <isin value="US88033G4073"/>
          <ticker value="THC US"/>
        </identifiers>
        <balance>12579</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1322178.69</valUSD>
        <pctVal>0.4784027153</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Thermo Fisher Scientific Inc.</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO US"/>
        </identifiers>
        <balance>19069</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11083093.49</valUSD>
        <pctVal>4.0101856573</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc.</name>
        <lei>N/A</lei>
        <title>ULTRAGENYX PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
          <ticker value="RARE US"/>
        </identifiers>
        <balance>24805</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1158145.45</valUSD>
        <pctVal>0.4190507169</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>UnitedHealth Group Incorporated</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC COMMON STOCK USD.01</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNH US"/>
        </identifiers>
        <balance>34104</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>16871248.8</valUSD>
        <pctVal>6.1045086391</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vaxcyte Inc.</name>
        <lei>N/A</lei>
        <title>VAXCYTE INC COMMON STOCK USD.001</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
          <ticker value="PCVX US"/>
        </identifiers>
        <balance>15697</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1072262.07</valUSD>
        <pctVal>0.3879756115</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Veeva Systems Inc.</name>
        <lei>549300YZEXPDB92M2F02</lei>
        <title>VEEVA SYSTEMS INC COMMON STOCK USD.00001</title>
        <cusip>922475108</cusip>
        <identifiers>
          <isin value="US9224751084"/>
          <ticker value="VEEV US"/>
        </identifiers>
        <balance>8715</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2019178.35</valUSD>
        <pctVal>0.7305974696</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
          <ticker value="VERA US"/>
        </identifiers>
        <balance>13619</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>587251.28</valUSD>
        <pctVal>0.2124845976</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX US"/>
        </identifiers>
        <balance>14025</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5862590.25</valUSD>
        <pctVal>2.1212557086</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Viatris Inc</name>
        <lei>N/A</lei>
        <title>VIATRIS INC COMMON STOCK</title>
        <cusip>92556V106</cusip>
        <identifiers>
          <isin value="US92556V1061"/>
          <ticker value="VTRS US"/>
        </identifiers>
        <balance>25298</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>302058.12</valUSD>
        <pctVal>0.1092934154</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Returns are reported without deduction of sales loads and redemption fees, if applicable." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2024-04-30</ncom:dateSigned>
      <ncom:nameOfApplicant>John Hancock Variable Insurance Trust</ncom:nameOfApplicant>
      <ncom:signature>/s/Salvatore Schiavone</ncom:signature>
      <ncom:signerName>Salvatore Schiavone</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
