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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Generation Bio Co.</name>
        <lei>N/A</lei>
        <title>GENERATION BIO CO COMMON STOCK USD.0001</title>
        <cusip>37148K100</cusip>
        <identifiers>
          <isin value="US37148K1007"/>
          <ticker value="GBIO "/>
        </identifiers>
        <balance>37692</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>162075.6</valUSD>
        <pctVal>0.0611117753</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ginkgo Bioworks Holdings Inc.</name>
        <lei>N/A</lei>
        <title>SOARING EAGLE ACQUISITION CO COMMON STOCK USD.0001</title>
        <cusip>37611X100</cusip>
        <identifiers>
          <isin value="US37611X1000"/>
          <ticker value="DNA US"/>
        </identifiers>
        <balance>78858</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>104881.14</valUSD>
        <pctVal>0.0395461912</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gossamer Bio Inc.</name>
        <lei>N/A</lei>
        <title>GOSSAMER BIO INC COMMON STOCK USD.0001</title>
        <cusip>38341P102</cusip>
        <identifiers>
          <isin value="US38341P1021"/>
          <ticker value="GOSS US"/>
        </identifiers>
        <balance>7366</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9281.16</valUSD>
        <pctVal>0.0034995284</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Guardant Health Inc.</name>
        <lei>N/A</lei>
        <title>GUARDANT HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
          <ticker value="GH "/>
        </identifiers>
        <balance>20231</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>474214.64</valUSD>
        <pctVal>0.1788060542</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HCA Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>HCA HEALTHCARE INC COMMON STOCK USD.01</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
          <ticker value="HCA "/>
        </identifiers>
        <balance>11185</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2949260.8</valUSD>
        <pctVal>1.1120400806</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Hologic Inc.</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>HOLOGIC INC COMMON STOCK USD.01</title>
        <cusip>436440101</cusip>
        <identifiers>
          <isin value="US4364401012"/>
          <ticker value="HOLX "/>
        </identifiers>
        <balance>31791</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2565533.7</valUSD>
        <pctVal>0.9673530067</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Humana Inc.</name>
        <lei>N/A</lei>
        <title>HUMANA INC COMMON STOCK USD.166</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
          <ticker value="HUM "/>
        </identifiers>
        <balance>10525</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5109466.5</valUSD>
        <pctVal>1.9265612381</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IGM Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IGM BIOSCIENCES INC COMMON STOCK USD.01</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
          <ticker value="IGMS "/>
        </identifiers>
        <balance>8499</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>116776.26</valUSD>
        <pctVal>0.0440313320</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>iRhythm Technologies Inc.</name>
        <lei>549300FJI72RJGDQS384</lei>
        <title>IRHYTHM TECHNOLOGIES INC COMMON STOCK USD.001</title>
        <cusip>450056106</cusip>
        <identifiers>
          <isin value="US4500561067"/>
          <ticker value="IRTC "/>
        </identifiers>
        <balance>3404</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>422198.12</valUSD>
        <pctVal>0.1591928497</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Illumina Inc.</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>ILLUMINA INC COMMON STOCK USD.01</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
          <ticker value="ILMN "/>
        </identifiers>
        <balance>5631</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1309489.05</valUSD>
        <pctVal>0.4937523018</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immuneering Corporation</name>
        <lei>N/A</lei>
        <title>IMMUNEERING CORP COMMON STOCK USD.001</title>
        <cusip>45254E107</cusip>
        <identifiers>
          <isin value="US45254E1073"/>
          <ticker value="IMRX US"/>
        </identifiers>
        <balance>29676</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>288153.96</valUSD>
        <pctVal>0.1086505313</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunocore Holdings PLC</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC ADR GBP.0001</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
          <ticker value="IMCR US"/>
        </identifiers>
        <balance>19425</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>960372</valUSD>
        <pctVal>0.3621151972</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunovant Inc.</name>
        <lei>N/A</lei>
        <title>IMMUNOVANT INC COMMON STOCK USD.0001</title>
        <cusip>45258J102</cusip>
        <identifiers>
          <isin value="US45258J1025"/>
          <ticker value="IMVT "/>
        </identifiers>
        <balance>5800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>89958</valUSD>
        <pctVal>0.0339193135</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Inari Medical Inc.</name>
        <lei>N/A</lei>
        <title>INARI MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>45332Y109</cusip>
        <identifiers>
          <isin value="US45332Y1091"/>
          <ticker value="NARI "/>
        </identifiers>
        <balance>10846</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>669632.04</valUSD>
        <pctVal>0.2524895959</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Incyte Corporation</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP COMMON STOCK USD.001</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
          <ticker value="INCY "/>
        </identifiers>
        <balance>15173</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1096552.71</valUSD>
        <pctVal>0.4134631173</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rapid Micro Biosystems Inc.</name>
        <lei>N/A</lei>
        <title>RAPID MICRO BIOSYSTEMS INC COMMON STOCK USD.01</title>
        <cusip>75340L104</cusip>
        <identifiers>
          <isin value="US75340L1044"/>
          <ticker value="RPID US"/>
        </identifiers>
        <balance>15325</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20075.75</valUSD>
        <pctVal>0.0075697065</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insmed Incorporated</name>
        <lei>N/A</lei>
        <title>INSMED INC COMMON STOCK USD.01</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <ticker value="INSM "/>
        </identifiers>
        <balance>46329</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>789909.45</valUSD>
        <pctVal>0.2978410619</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Insulet Corporation</name>
        <lei>549300TZTYD2PYN92D43</lei>
        <title>INSULET CORP COMMON STOCK USD.001</title>
        <cusip>45784P101</cusip>
        <identifiers>
          <isin value="US45784P1012"/>
          <ticker value="PODD "/>
        </identifiers>
        <balance>7679</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2449293.84</valUSD>
        <pctVal>0.9235239281</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAPT Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RAPT THERAPEUTICS INC COMMON STOCK</title>
        <cusip>75382E109</cusip>
        <identifiers>
          <isin value="US75382E1091"/>
          <ticker value="RAPT "/>
        </identifiers>
        <balance>15712</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>288315.2</valUSD>
        <pctVal>0.1087113280</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Reata Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>REATA PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75615P103</cusip>
        <identifiers>
          <isin value="US75615P1030"/>
          <ticker value="RETA "/>
        </identifiers>
        <balance>2025</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>184113</valUSD>
        <pctVal>0.0694211361</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intellia Therapeutics Inc.</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
          <ticker value="NTLA "/>
        </identifiers>
        <balance>7787</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>290221.49</valUSD>
        <pctVal>0.1094301084</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Genmab A/S</name>
        <lei>N/A</lei>
        <title>GENMAB A/S COMMON STOCK DKK1.0</title>
        <cusip>459573903</cusip>
        <identifiers>
          <isin value="DK0010272202"/>
          <ticker value="GMAB "/>
        </identifiers>
        <balance>3953</balance>
        <units>NS</units>
        <currencyConditional curCd="DKK" exchangeRt="6.86935"/>
        <valUSD>1494254.83</valUSD>
        <pctVal>0.5634195733</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intuitive Surgical Inc.</name>
        <lei>54930052SRG011710797</lei>
        <title>INTUITIVE SURGICAL INC COMMON STOCK USD.001</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
          <ticker value="ISRG "/>
        </identifiers>
        <balance>30461</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7781871.67</valUSD>
        <pctVal>2.9342109042</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc.</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
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          <isin value="US4622221004"/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc.</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Relay Therapeutics Inc.</name>
        <lei>N/A</lei>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Voyager Therapeutics Inc.</name>
        <lei>54930082S4XVR0ZWCC74</lei>
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      <invstOrSec>
        <name>Warby Parker Inc.</name>
        <lei>N/A</lei>
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      <invstOrSec>
        <name>Relmada Therapeutics Inc.</name>
        <lei>N/A</lei>
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        <name>Repligen Corporation</name>
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        <fairValLevel>1</fairValLevel>
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        <name>ACERTA FUTURE PAYMENTS PP TC30M7746</name>
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      <invstOrSec>
        <name>Royalty Pharma plc</name>
        <lei>N/A</lei>
        <title>ROYALTY PHARMA PLC COMMON STOCK</title>
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          <ticker value="RPRX "/>
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      <invstOrSec>
        <name>Replimune Group Inc.</name>
        <lei>N/A</lei>
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        <cusip>76029N106</cusip>
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          <isin value="US76029N1063"/>
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        <fairValLevel>1</fairValLevel>
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        <name>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</name>
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        <title>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</title>
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          <ticker value="76105Y109010"/>
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        <assetCat>STIV</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Revolution Medicines Inc.</name>
        <lei>N/A</lei>
        <title>REVOLUTION MEDICINES INC COMMON STOCK</title>
        <cusip>76155X100</cusip>
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          <isin value="US76155X1000"/>
          <ticker value="RVMD "/>
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        <curCd>USD</curCd>
        <valUSD>623396.46</valUSD>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Bicycle Therapeutics PLC</name>
        <lei>N/A</lei>
        <title>BICYCLE THERAPEUTICS PLC ADR USD.01</title>
        <cusip>088786108</cusip>
        <identifiers>
          <isin value="US0887861088"/>
          <ticker value="BCYC US"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>BioMarin Pharmaceutical Inc.</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BIOMARIN PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>09061G101</cusip>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>Biogen Inc.</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC COMMON STOCK USD.0005</title>
        <cusip>09062X103</cusip>
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          <ticker value="BIIB "/>
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        <assetCat>EC</assetCat>
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      <invstOrSec>
        <name>Blueprint Medicines Corporation</name>
        <lei>N/A</lei>
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        <cusip>09627Y109</cusip>
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          <ticker value="BPMC "/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <name>Boston Scientific Corporation</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
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        <cusip>101137107</cusip>
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          <isin value="US1011371077"/>
          <ticker value="BSX "/>
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        <curCd>USD</curCd>
        <valUSD>899089.13</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>Bruker Corporation</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
        <title>BRUKER CORP COMMON STOCK USD.01</title>
        <cusip>116794108</cusip>
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          <ticker value="BRKR "/>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>ShockWave Medical Inc.</name>
        <lei>N/A</lei>
        <title>SHOCKWAVE MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>82489T104</cusip>
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          <ticker value="SWAV "/>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>SomaLogic Inc.</name>
        <lei>N/A</lei>
        <title>SOMALOGIC INC WTS CALL EXP 31AUG26</title>
        <cusip>83444K113</cusip>
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          <ticker value="SLGCW"/>
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        <assetCat>EC</assetCat>
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      <invstOrSec>
        <name>SpringWorks Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SPRINGWORKS THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>85205L107</cusip>
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          <ticker value="SWTX "/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>STERIS plc</name>
        <lei>N/A</lei>
        <title>STERIS PLC COMMON STOCK USD75.0</title>
        <cusip>859152100</cusip>
        <identifiers>
          <isin value="IE00BFY8C754"/>
          <ticker value="STE "/>
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        <balance>3891</balance>
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        <curCd>USD</curCd>
        <valUSD>744270.48</valUSD>
        <pctVal>0.2806325587</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Stoke Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STOKE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>86150R107</cusip>
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          <isin value="US86150R1077"/>
          <ticker value="STOK "/>
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        <balance>8627</balance>
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        <curCd>USD</curCd>
        <valUSD>71862.91</valUSD>
        <pctVal>0.0270964291</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>STRYKER CORP COMMON STOCK USD.1</title>
        <cusip>863667101</cusip>
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          <ticker value="SYK "/>
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        <balance>25723</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7343144.81</valUSD>
        <pctVal>2.7687857737</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Structure Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STRUCTURE THERAPEUTICS INC ADR USD.0001</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
          <ticker value="GPCR US"/>
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        <balance>6882</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>163722.78</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Surgery Partners Inc.</name>
        <lei>549300LC82HG33S19I03</lei>
        <title>SURGERY PARTNERS INC COMMON STOCK USD.01</title>
        <cusip>86881A100</cusip>
        <identifiers>
          <isin value="US86881A1007"/>
          <ticker value="SGRY "/>
        </identifiers>
        <balance>12704</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>437906.88</valUSD>
        <pctVal>0.1651159511</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Teleflex Incorporated</name>
        <lei>UUL85LWXB4NGSWWXIQ25</lei>
        <title>TELEFLEX INC COMMON STOCK USD1.0</title>
        <cusip>879369106</cusip>
        <identifiers>
          <isin value="US8793691069"/>
          <ticker value="TFX "/>
        </identifiers>
        <balance>5490</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1390671.9</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Tenaya Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>TENAYA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>87990A106</cusip>
        <identifiers>
          <isin value="US87990A1060"/>
          <ticker value="TNYA US"/>
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        <balance>24566</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70013.1</valUSD>
        <pctVal>0.0263989449</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>10x Genomics Inc.</name>
        <lei>N/A</lei>
        <title>10X GENOMICS INC COMMON STOCK</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
          <ticker value="TXG "/>
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        <balance>23415</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1306322.85</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Thermo Fisher Scientific Inc.</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO "/>
        </identifiers>
        <balance>25516</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14706656.92</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Theseus Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>THESEUS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>88369M101</cusip>
        <identifiers>
          <isin value="US88369M1018"/>
          <ticker value="THRX US"/>
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        <balance>20251</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>179828.88</valUSD>
        <pctVal>0.0678057777</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>2Seventy Bio Inc.</name>
        <lei>N/A</lei>
        <title>2SEVENTY BIO INC COMMON STOCK USD.0001</title>
        <cusip>901384107</cusip>
        <identifiers>
          <isin value="US9013841070"/>
          <ticker value="TSVT US"/>
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        <balance>8100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82620</valUSD>
        <pctVal>0.0311524676</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Twist Bioscience Corporation</name>
        <lei>N/A</lei>
        <title>TWIST BIOSCIENCE CORP COMMON STOCK USD.00001</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
          <ticker value="TWST "/>
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        <balance>8130</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>122600.4</valUSD>
        <pctVal>0.0462273661</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc.</name>
        <lei>N/A</lei>
        <title>ULTRAGENYX PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
          <ticker value="RARE "/>
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        <balance>22615</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>906861.5</valUSD>
        <pctVal>0.3419386768</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>UnitedHealth Group Incorporated</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC COMMON STOCK USD.01</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNHN "/>
        </identifiers>
        <balance>41959</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19829403.81</valUSD>
        <pctVal>7.4768198900</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Veeva Systems Inc.</name>
        <lei>549300YZEXPDB92M2F02</lei>
        <title>VEEVA SYSTEMS INC COMMON STOCK USD.00001</title>
        <cusip>922475108</cusip>
        <identifiers>
          <isin value="US9224751084"/>
          <ticker value="VEEV "/>
        </identifiers>
        <balance>9746</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1791217.34</valUSD>
        <pctVal>0.6753914320</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Ventyx Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>VENTYX BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>92332V107</cusip>
        <identifiers>
          <isin value="US92332V1070"/>
          <ticker value="VTYX US"/>
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        <balance>14580</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>488430</valUSD>
        <pctVal>0.1841660583</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX "/>
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        <balance>21827</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6877032.89</valUSD>
        <pctVal>2.5930349086</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Viatris Inc</name>
        <lei>N/A</lei>
        <title>VIATRIS INC COMMON STOCK</title>
        <cusip>92556V106</cusip>
        <identifiers>
          <isin value="US92556V1061"/>
          <ticker value="VTRS "/>
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        <balance>28380</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>273015.6</valUSD>
        <pctVal>0.1029425034</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>West Pharmaceutical Services Inc.</name>
        <lei>5493007NKRGM1RJQ1P16</lei>
        <title>WEST PHARMACEUTICAL SERVICES I COMMON STOCK USD.25</title>
        <cusip>955306105</cusip>
        <identifiers>
          <isin value="US9553061055"/>
          <ticker value="WST "/>
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        <balance>6488</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2247897.36</valUSD>
        <pctVal>0.8475859311</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Wuxi Biologics (Cayman) Inc.</name>
        <lei>N/A</lei>
        <title>WUXI BIOLOGICS CAYMAN INC COMMON STOCK USD.00001</title>
        <cusip>967JXD907</cusip>
        <identifiers>
          <isin value="KYG970081173"/>
          <ticker value="2269"/>
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        <balance>57500</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.8499"/>
        <valUSD>354312.58</valUSD>
        <pctVal>0.1335961167</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Xencor Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC COMMON STOCK USD.01</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <ticker value="XNCR "/>
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        <balance>16855</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>470085.95</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Zai Lab Limited</name>
        <lei>N/A</lei>
        <title>ZAI LAB LTD ADR USD.00006</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
          <ticker value="ZLAB "/>
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        <balance>17127</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>569644.02</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ZENTALIS PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
          <ticker value="ZNTL "/>
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        <balance>15240</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>262128</valUSD>
        <pctVal>0.0988372552</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Zimmer Biomet Holdings Inc.</name>
        <lei>2P2YLDVPES3BXQ1FRB91</lei>
        <title>ZIMMER BIOMET HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>98956P102</cusip>
        <identifiers>
          <isin value="US98956P1021"/>
          <ticker value="ZBH "/>
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        <balance>10862</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1403370.4</valUSD>
        <pctVal>0.5291509427</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zoetis Inc.</name>
        <lei>549300HD9Q1LOC9KLJ48</lei>
        <title>ZOETIS INC COMMON STOCK USD.01</title>
        <cusip>98978V103</cusip>
        <identifiers>
          <isin value="US98978V1035"/>
          <ticker value="ZTS "/>
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        <balance>7306</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1216010.64</valUSD>
        <pctVal>0.4585055923</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Daiichi Sankyo Company Limited</name>
        <lei>N/A</lei>
        <title>DAIICHI SANKYO CO LTD COMMON STOCK</title>
        <cusip>B0J7D9901</cusip>
        <identifiers>
          <isin value="JP3475350009"/>
          <ticker value="4568 "/>
        </identifiers>
        <balance>62300</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="132.775"/>
        <valUSD>2272556.7</valUSD>
        <pctVal>0.8568839133</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc.</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
          <ticker value="RCKT "/>
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        <balance>9847</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>168679.11</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>State Street Bank and Trust Company</name>
        <lei>571474TGEMMWANRLN572</lei>
        <title>SSC GOVERNMENT MM GVMXX</title>
        <cusip>7839989D1</cusip>
        <identifiers>
          <ticker value="7839989D1010"/>
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        <balance>628482.24</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>628482.24</valUSD>
        <pctVal>0.2369737667</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sage Therapeutics Inc.</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
          <ticker value="SAGE "/>
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        <balance>12342</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>517870.32</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sana Biotechnology Inc.</name>
        <lei>N/A</lei>
        <title>SANA BIOTECHNOLOGY INC COMMON STOCK USD.0001</title>
        <cusip>799566104</cusip>
        <identifiers>
          <isin value="US7995661045"/>
          <ticker value="SANA US"/>
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        <balance>30507</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>99757.89</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sarepta Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SAREPTA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
          <ticker value="SRPT "/>
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        <balance>11619</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1601446.77</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Scholar Rock Holding Corporation</name>
        <lei>N/A</lei>
        <title>SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK "/>
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        <balance>37540</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>300320</valUSD>
        <pctVal>0.1132378245</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Schrodinger Inc.</name>
        <lei>N/A</lei>
        <title>SCHRODINGER INC/UNITED STATES COMMON STOCK USD.01</title>
        <cusip>80810D103</cusip>
        <identifiers>
          <isin value="US80810D1037"/>
          <ticker value="SDGR "/>
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        <balance>6200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>163246</valUSD>
        <pctVal>0.0615530831</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Seagen Inc.</name>
        <lei>N/A</lei>
        <title>SEAGEN INC COMMON STOCK USD.001</title>
        <cusip>81181C104</cusip>
        <identifiers>
          <isin value="US81181C1045"/>
          <ticker value="SGEN "/>
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        <balance>16258</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3291757.26</valUSD>
        <pctVal>1.2411808439</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Seer Inc.</name>
        <lei>N/A</lei>
        <title>SEER INC COMMON STOCK USD.00001</title>
        <cusip>81578P106</cusip>
        <identifiers>
          <isin value="US81578P1066"/>
          <ticker value="SEER "/>
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        <balance>19716</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76103.76</valUSD>
        <pctVal>0.0286954722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GeneDX Holdings Corp.</name>
        <lei>N/A</lei>
        <title>SEMA4 HLDGS CORP WTS COMMON STOCK USD.0001</title>
        <cusip>81663L101</cusip>
        <identifiers>
          <isin value="US81663L1017"/>
          <ticker value="SMFR US"/>
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        <balance>30292</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11056.58</valUSD>
        <pctVal>0.0041689633</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>GeneDX Holdings Corp.</name>
        <lei>N/A</lei>
        <title>SEMA4 HLDGS CORP WTS CALL EXP 22JUL26</title>
        <cusip>81663L119</cusip>
        <identifiers>
          <isin value="US81663L1199"/>
          <ticker value="SMFRW"/>
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        <balance>4862</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>89.95</valUSD>
        <pctVal>0.0000339163</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SENTI BIOSCIENCES INC COMMON STOCK USD.0001</name>
        <lei>N/A</lei>
        <title>SENTI BIOSCIENCES INC COMMON STOCK</title>
        <cusip>81726A100</cusip>
        <identifiers>
          <isin value="US81726A1007"/>
          <ticker value="SNTI"/>
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        <balance>18789</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22171.02</valUSD>
        <pctVal>0.0083597432</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Aadi Bioscience Inc.</name>
        <lei>N/A</lei>
        <title>AADI BIOSCIENCE INC COMMON STOCK USD.0001</title>
        <cusip>00032Q104</cusip>
        <identifiers>
          <isin value="US00032Q1040"/>
          <ticker value="AADI US"/>
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        <balance>5700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41268</valUSD>
        <pctVal>0.0155603974</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AbbVie Inc.</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC COMMON STOCK USD.01</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
          <ticker value="ABBV "/>
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        <balance>28406</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4527064.22</valUSD>
        <pctVal>1.7069622530</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Acadia Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ACADIA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
          <ticker value="ACAD "/>
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        <balance>28578</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>537837.96</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Adaptive Biotechnologies Corporation</name>
        <lei>N/A</lei>
        <title>ADAPTIVE BIOTECHNOLOGIES CORP COMMON STOCK</title>
        <cusip>00650F109</cusip>
        <identifiers>
          <isin value="US00650F1093"/>
          <ticker value="ADPT "/>
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        <balance>25114</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>221756.62</valUSD>
        <pctVal>0.0836149348</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ALNYLAM PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <ticker value="ALNY "/>
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        <balance>24562</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4920259.84</valUSD>
        <pctVal>1.8552195007</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Ambrx Biopharma Inc.</name>
        <lei>N/A</lei>
        <title>AMBRX BIOPHARMA INC ADR USD.0001</title>
        <cusip>02290A102</cusip>
        <identifiers>
          <isin value="US02290A1025"/>
          <ticker value="AMAM US"/>
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        <balance>2700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24084</valUSD>
        <pctVal>0.0090810461</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Legend Biotech Corporation</name>
        <lei>N/A</lei>
        <title>LEGEND BIOTECH CORP ADR</title>
        <cusip>52490G102</cusip>
        <identifiers>
          <isin value="US52490G1022"/>
          <ticker value="LEGN US"/>
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        <balance>14689</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>708303.58</valUSD>
        <pctVal>0.2670709793</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>LIANBIO ADR USD.0001</name>
        <lei>N/A</lei>
        <title>LIANBIO ADR USD.0001</title>
        <cusip>53000N108</cusip>
        <identifiers>
          <isin value="US53000N1081"/>
          <ticker value="LIAN US"/>
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        <balance>38982</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76014.9</valUSD>
        <pctVal>0.0286619669</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly and Company</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO COMMON STOCK</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY "/>
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        <balance>28596</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9820438.32</valUSD>
        <pctVal>3.7028671796</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Longboard Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>LONGBOARD PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>54300N103</cusip>
        <identifiers>
          <isin value="US54300N1037"/>
          <ticker value="LBPH US"/>
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        <balance>6452</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25356.36</valUSD>
        <pctVal>0.0095607986</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Lyell Immunopharma Inc.</name>
        <lei>N/A</lei>
        <title>LYELL IMMUNOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>55083R104</cusip>
        <identifiers>
          <isin value="US55083R1041"/>
          <ticker value="LYEL US"/>
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        <balance>41100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>96996</valUSD>
        <pctVal>0.0365730422</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Masimo Corporation</name>
        <lei>549300Q4A8JK0PIYCU29</lei>
        <title>MASIMO CORP COMMON STOCK USD.001</title>
        <cusip>574795100</cusip>
        <identifiers>
          <isin value="US5747951003"/>
          <ticker value="MASI "/>
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        <balance>1472</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>271642.88</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Evotec SE</name>
        <lei>N/A</lei>
        <title>EVOTEC SE COMMON STOCK</title>
        <cusip>581191905</cusip>
        <identifiers>
          <isin value="DE0005664809"/>
          <ticker value="EVT "/>
        </identifiers>
        <balance>12592</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.922084"/>
        <valUSD>265969.04</valUSD>
        <pctVal>0.1002855470</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>McKesson Corporation</name>
        <lei>549300WZWOM80UCFSF54</lei>
        <title>MCKESSON CORP COMMON STOCK USD.01</title>
        <cusip>58155Q103</cusip>
        <identifiers>
          <isin value="US58155Q1031"/>
          <ticker value="MCK "/>
        </identifiers>
        <balance>2082</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>741296.1</valUSD>
        <pctVal>0.2795110472</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sartorius AG</name>
        <lei>N/A</lei>
        <title>SARTORIUS AG PREFERENCE</title>
        <cusip>584332902</cusip>
        <identifiers>
          <isin value="DE0007165631"/>
          <ticker value="SRT3 "/>
        </identifiers>
        <balance>4251</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.922084"/>
        <valUSD>1791610.44</valUSD>
        <pctVal>0.6755396532</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Merck and Co. Inc.</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK and CO INC COMMON STOCK USD.5</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
          <ticker value="MRK "/>
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        <balance>88326</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9397003.14</valUSD>
        <pctVal>3.5432078875</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Mettler-Toledo International Inc.</name>
        <lei>5493000BD5GJNUDIUG10</lei>
        <title>METTLER-TOLEDO INTERNATIONAL I COMMON STOCK USD.01</title>
        <cusip>592688105</cusip>
        <identifiers>
          <isin value="US5926881054"/>
          <ticker value="MTD "/>
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        <balance>914</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1398611.94</valUSD>
        <pctVal>0.5273567310</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Mirati Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MIRATI THERAPEUTICS INC COMMON STOCK</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
          <ticker value="MRTX "/>
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        <balance>13166</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>489511.88</valUSD>
        <pctVal>0.1845739890</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Moderna Inc.</name>
        <lei>N/A</lei>
        <title>MODERNA INC COMMON STOCK USD.0001</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
          <ticker value="MRNA "/>
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        <balance>10217</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1569126.86</valUSD>
        <pctVal>0.5916506129</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molina Healthcare Inc.</name>
        <lei>549300NQQCEQ46YHZ591</lei>
        <title>MOLINA HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>60855R100</cusip>
        <identifiers>
          <isin value="US60855R1005"/>
          <ticker value="MOH "/>
        </identifiers>
        <balance>13060</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3493419.4</valUSD>
        <pctVal>1.3172190099</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Eisai Co. Ltd.</name>
        <lei>N/A</lei>
        <title>EISAI CO LTD COMMON STOCK</title>
        <cusip>630720001</cusip>
        <identifiers>
          <isin value="JP3160400002"/>
          <ticker value="4523 "/>
        </identifiers>
        <balance>7300</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="132.775"/>
        <valUSD>414636.98</valUSD>
        <pctVal>0.1563418673</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurocrine Biosciences Inc.</name>
        <lei>549300FECER0XBN49756</lei>
        <title>NEUROCRINE BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
          <ticker value="NBIX "/>
        </identifiers>
        <balance>6883</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>696697.26</valUSD>
        <pctVal>0.2626947326</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Nevro Corp.</name>
        <lei>N/A</lei>
        <title>NEVRO CORP COMMON STOCK USD.001</title>
        <cusip>64157F103</cusip>
        <identifiers>
          <isin value="US64157F1030"/>
          <ticker value="NVRO "/>
        </identifiers>
        <balance>4519</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>163361.85</valUSD>
        <pctVal>0.0615967651</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novo Nordisk A/S</name>
        <lei>549300DAQ1CVT6CXN342</lei>
        <title>NOVO-NORDISK A/S</title>
        <cusip>670100205</cusip>
        <identifiers>
          <isin value="IE00BZ12WP82"/>
          <ticker value="NVO"/>
        </identifiers>
        <balance>7037</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1119868.18</valUSD>
        <pctVal>0.4222543836</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Nuvalent Inc.</name>
        <lei>N/A</lei>
        <title>NUVALENT INC COMMON STOCK USD.0001</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
          <ticker value="NUVL US"/>
        </identifiers>
        <balance>5848</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>152574.32</valUSD>
        <pctVal>0.0575292491</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Nuvation Bio Inc.</name>
        <lei>N/A</lei>
        <title>NUVATION BIO INC COMMON STOCK USD.0001</title>
        <cusip>67080N101</cusip>
        <identifiers>
          <isin value="US67080N1019"/>
          <ticker value="NUVB US"/>
        </identifiers>
        <balance>10300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>17098</valUSD>
        <pctVal>0.0064469244</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Olink Holding AB</name>
        <lei>N/A</lei>
        <title>OLINK HOLDING AB ADR</title>
        <cusip>680710100</cusip>
        <identifiers>
          <isin value="US6807101000"/>
          <ticker value="OLK US"/>
        </identifiers>
        <balance>39426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>888267.78</valUSD>
        <pctVal>0.3349277804</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Option Care Health Inc.</name>
        <lei>549300DI3Q5ACSYJRI17</lei>
        <title>OPTION CARE HEALTH INC COMMON STOCK USD.0001</title>
        <cusip>68404L201</cusip>
        <identifiers>
          <isin value="US68404L2016"/>
          <ticker value="OPCH "/>
        </identifiers>
        <balance>13198</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>419300.46</valUSD>
        <pctVal>0.1581002661</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Orchestra Biomed Holdings Inc.</name>
        <lei>N/A</lei>
        <title>ORCHESTRA BIOMED HOLDINGS INC COMMON STOCK USD.0001</title>
        <cusip>68572M106</cusip>
        <identifiers>
          <isin value="US68572M1062"/>
          <ticker value="OBIO"/>
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        <balance>13354</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>261337.78</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PTC Therapeutics Inc.</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
          <ticker value="PTCT "/>
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        <balance>7783</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>377008.52</valUSD>
        <pctVal>0.1421537848</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Agilent Technologies Inc.</name>
        <lei>QUIX8Y7A2WP0XRMW7G29</lei>
        <title>AGILENT TECHNOLOGIES INC COMMON STOCK USD.01</title>
        <cusip>00846U101</cusip>
        <identifiers>
          <isin value="US00846U1016"/>
          <ticker value="A "/>
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        <balance>37144</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5138500.96</valUSD>
        <pctVal>1.9375088909</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>AGIOS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
          <ticker value="AGIO "/>
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        <balance>9085</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>208682.45</valUSD>
        <pctVal>0.0786852246</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Agilon Health Inc.</name>
        <lei>N/A</lei>
        <title>AGILON HEALTH INC COMMON STOCK USD.01</title>
        <cusip>00857U107</cusip>
        <identifiers>
          <isin value="US00857U1079"/>
          <ticker value="AGL US"/>
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        <balance>28856</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>685330</valUSD>
        <pctVal>0.2584086251</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Akero Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>AKERO THERAPEUTICS INC COMMON STOCK</title>
        <cusip>00973Y108</cusip>
        <identifiers>
          <isin value="US00973Y1082"/>
          <ticker value="AKRO "/>
        </identifiers>
        <balance>12068</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>461721.68</valUSD>
        <pctVal>0.1740954934</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alector Inc.</name>
        <lei>N/A</lei>
        <title>ALECTOR INC COMMON STOCK USD.0001</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
          <ticker value="ALEC "/>
        </identifiers>
        <balance>11904</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>73685.76</valUSD>
        <pctVal>0.0277837479</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alignment Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>ALIGNMENT HEALTHCARE INC COMMON STOCK</title>
        <cusip>01625V104</cusip>
        <identifiers>
          <isin value="US01625V1044"/>
          <ticker value="ALHC US"/>
        </identifiers>
        <balance>25979</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>165226.44</valUSD>
        <pctVal>0.0622998223</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allakos Inc.</name>
        <lei>N/A</lei>
        <title>ALLAKOS INC COMMON STOCK USD.001</title>
        <cusip>01671P100</cusip>
        <identifiers>
          <isin value="US01671P1003"/>
          <ticker value="ALLK "/>
        </identifiers>
        <balance>19563</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87055.35</valUSD>
        <pctVal>0.0328248483</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
          <ticker value="ALLO "/>
        </identifiers>
        <balance>37654</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>186010.76</valUSD>
        <pctVal>0.0701367002</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AmerisourceBergen Corporation</name>
        <lei>AI8GXW8LG5WK7E9UD086</lei>
        <title>AMERISOURCEBERGEN CORP COMMON STOCK USD.01</title>
        <cusip>03073E105</cusip>
        <identifiers>
          <isin value="US03073E1055"/>
          <ticker value="ABC "/>
        </identifiers>
        <balance>3923</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>628111.53</valUSD>
        <pctVal>0.2368339878</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Elevance Health Inc.</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>ANTHEM INC COMMON STOCK USD.01</title>
        <cusip>036752103</cusip>
        <identifiers>
          <isin value="US0367521038"/>
          <ticker value="ANTM "/>
        </identifiers>
        <balance>18232</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8383255.92</valUSD>
        <pctVal>3.1609671782</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>APELLIS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
          <ticker value="APLS "/>
        </identifiers>
        <balance>27708</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1827619.68</valUSD>
        <pctVal>0.6891171972</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Monte Rosa Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
          <ticker value="GLUE US"/>
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        <balance>27152</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>211514.08</valUSD>
        <pctVal>0.0797529112</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MoonLake Immunotherapeutics</name>
        <lei>N/A</lei>
        <title>MOONLAKE IMMUNOTHERAPEUTICS COMMON STOCK USD.0001</title>
        <cusip>61559X104</cusip>
        <identifiers>
          <isin value="KY61559X1045"/>
          <ticker value="MLTX US"/>
        </identifiers>
        <balance>11486</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>245685.54</valUSD>
        <pctVal>0.0926375069</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Morphic Holding Inc.</name>
        <lei>N/A</lei>
        <title>MORPHIC HOLDING INC COMMON STOCK USD.0001</title>
        <cusip>61775R105</cusip>
        <identifiers>
          <isin value="US61775R1059"/>
          <ticker value="MORF "/>
        </identifiers>
        <balance>6189</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>232953.96</valUSD>
        <pctVal>0.0878369727</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>C4 Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>C4 THERAPEUTICS INC COMMON STOCK</title>
        <cusip>12529R107</cusip>
        <identifiers>
          <isin value="US12529R1077"/>
          <ticker value="CCCC "/>
        </identifiers>
        <balance>19141</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>60102.74</valUSD>
        <pctVal>0.0226621721</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>The Cigna Group</name>
        <lei>N/A</lei>
        <title>CIGNA CORP COMMON STOCK USD.01</title>
        <cusip>125523100</cusip>
        <identifiers>
          <isin value="US1255231003"/>
          <ticker value="CI "/>
        </identifiers>
        <balance>11681</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2984845.93</valUSD>
        <pctVal>1.1254577108</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Catalent Inc.</name>
        <lei>N/A</lei>
        <title>CATALENT INC COMMON STOCK USD.01</title>
        <cusip>148806102</cusip>
        <identifiers>
          <isin value="US1488061029"/>
          <ticker value="CTLT "/>
        </identifiers>
        <balance>15927</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1046563.17</valUSD>
        <pctVal>0.3946142002</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Celldex Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CELLDEX THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
          <ticker value="CLDX "/>
        </identifiers>
        <balance>12361</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>444748.78</valUSD>
        <pctVal>0.1676957389</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Centene Corporation</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>CENTENE CORP COMMON STOCK USD.001</title>
        <cusip>15135B101</cusip>
        <identifiers>
          <isin value="US15135B1017"/>
          <ticker value="CNC "/>
        </identifiers>
        <balance>37596</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2376443.16</valUSD>
        <pctVal>0.8960550532</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centessa Pharmaceuticals PLC</name>
        <lei>N/A</lei>
        <title>CENTESSA PHARMACEUTICALS PLC ADR USD.0001</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
          <ticker value="CNTA US"/>
        </identifiers>
        <balance>18009</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>69334.65</valUSD>
        <pctVal>0.0261431304</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cerevel Therapeutics Holdings Inc.</name>
        <lei>N/A</lei>
        <title>CEREVEL THERAPEUTICS HOLDING COMMON STOCK USD.0001</title>
        <cusip>15678U128</cusip>
        <identifiers>
          <isin value="US15678U1280"/>
          <ticker value="CERE "/>
        </identifiers>
        <balance>30338</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>739943.82</valUSD>
        <pctVal>0.2790011603</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Certara Inc.</name>
        <lei>N/A</lei>
        <title>CERTARA INC COMMON STOCK USD.01</title>
        <cusip>15687V109</cusip>
        <identifiers>
          <isin value="US15687V1098"/>
          <ticker value="CERT "/>
        </identifiers>
        <balance>12799</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>308583.89</valUSD>
        <pctVal>0.1163537839</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Charles River Laboratories International Inc.</name>
        <lei>549300BSQ0R4UZ5KX287</lei>
        <title>CHARLES RIVER LABORATORIES INT COMMON STOCK USD.01</title>
        <cusip>159864107</cusip>
        <identifiers>
          <isin value="US1598641074"/>
          <ticker value="CRL US"/>
        </identifiers>
        <balance>7094</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1431711.08</valUSD>
        <pctVal>0.5398370008</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>The Cooper Companies Inc.</name>
        <lei>QJKMVPIGLH7530PCUE20</lei>
        <title>COOPER COS INC/THE COMMON STOCK USD.1</title>
        <cusip>216648402</cusip>
        <identifiers>
          <isin value="US2166484020"/>
          <ticker value="COO "/>
        </identifiers>
        <balance>2239</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>835953.04</valUSD>
        <pctVal>0.3152021300</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>QuidelOrtho Corporation</name>
        <lei>N/A</lei>
        <title>QUIDELORTHO CORP COMMON STOCK USD.001</title>
        <cusip>219798105</cusip>
        <identifiers>
          <isin value="US2197981051"/>
          <ticker value="QDEL US"/>
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        <balance>6701</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>596992.09</valUSD>
        <pctVal>0.2251001783</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cytokinetics Incorporated</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC COMMON STOCK USD.001</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
          <ticker value="CYTK "/>
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        <balance>9236</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>325014.84</valUSD>
        <pctVal>0.1225491923</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DICE Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DICE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>23345J104</cusip>
        <identifiers>
          <isin value="US23345J1043"/>
          <ticker value="DICE US"/>
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        <balance>13895</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>398091.75</valUSD>
        <pctVal>0.1501033689</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Danaher Corporation</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>DANAHER CORP COMMON STOCK USD.01</title>
        <cusip>235851102</cusip>
        <identifiers>
          <isin value="US2358511028"/>
          <ticker value="DHR "/>
        </identifiers>
        <balance>31757</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8004034.28</valUSD>
        <pctVal>3.0179789205</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Day One Biopharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>DAY ONE BIOPHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>23954D109</cusip>
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          <isin value="US23954D1090"/>
          <ticker value="DAWN US"/>
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        <balance>12941</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>173021.17</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>Deciphera Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>DECIPHERA PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>24344T101</cusip>
        <identifiers>
          <isin value="US24344T1016"/>
          <ticker value="DCPH "/>
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        <balance>9900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>152955</valUSD>
        <pctVal>0.0576727872</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Denali Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DENALI THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
          <ticker value="DNLI "/>
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        <balance>21163</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>487595.52</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>DENTSPLY SIRONA Inc.</name>
        <lei>9NHEHR1SOZCYXDO8HO28</lei>
        <title>DENTSPLY SIRONA INC COMMON STOCK USD.01</title>
        <cusip>24906P109</cusip>
        <identifiers>
          <isin value="US24906P1093"/>
          <ticker value="XRAY "/>
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        <balance>6800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>267104</valUSD>
        <pctVal>0.1007134919</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>DexCom Inc.</name>
        <lei>N/A</lei>
        <title>DEXCOM INC COMMON STOCK USD.001</title>
        <cusip>252131107</cusip>
        <identifiers>
          <isin value="US2521311074"/>
          <ticker value="DXCM "/>
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        <balance>20556</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2388196.08</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Iovance Biotherapeutics Inc.</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC COMMON STOCK USD.000041666</title>
        <cusip>462260100</cusip>
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          <isin value="US4622601007"/>
          <ticker value="IOVA "/>
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        <balance>34648</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>211699.28</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IQVIA Holdings Inc.</name>
        <lei>N/A</lei>
        <title>IQVIA HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>46266C105</cusip>
        <identifiers>
          <isin value="US46266C1053"/>
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        <balance>3562</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>708446.18</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>IVERIC bio Inc.</name>
        <lei>549300GZXI59U71XPM70</lei>
        <title>IVERIC BIO INC COMMON STOCK USD.001</title>
        <cusip>46583P102</cusip>
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          <isin value="US46583P1021"/>
          <ticker value="ISEE "/>
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        <balance>47467</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1154872.11</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Karuna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KARUNA THERAPEUTICS INC COMMON STOCK</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
          <ticker value="KRTX "/>
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        <balance>10733</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1949542.12</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Keros Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KEROS THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>492327101</cusip>
        <identifiers>
          <isin value="US4923271013"/>
          <ticker value="KROS US"/>
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        <balance>5200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>222040</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Kymera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC COMMON STOCK</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
          <ticker value="KYMR "/>
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        <balance>17197</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>509547.11</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Lantheus Holdings Inc.</name>
        <lei>N/A</lei>
        <title>LANTHEUS HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
          <ticker value="LNTH "/>
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        <balance>5086</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>419900.16</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Ardelyx Inc.</name>
        <lei>549300F542QR4SXHCY32</lei>
        <title>ARDELYX INC COMMON STOCK USD.000001</title>
        <cusip>039697107</cusip>
        <identifiers>
          <isin value="US0396971071"/>
          <ticker value="ARDX US"/>
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        <balance>35200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>168608</valUSD>
        <pctVal>0.0635748639</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Arcus Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>ARCUS BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>03969F109</cusip>
        <identifiers>
          <isin value="US03969F1093"/>
          <ticker value="RCUS "/>
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        <balance>8005</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>146011.2</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>argenx SE</name>
        <lei>N/A</lei>
        <title>ARGENX SE ADR</title>
        <cusip>04016X101</cusip>
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          <isin value="US04016X1019"/>
          <ticker value="ARGX "/>
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        <balance>11150</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4154267</valUSD>
        <pctVal>1.5663963693</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Arvinas Inc.</name>
        <lei>N/A</lei>
        <title>ARVINAS INC COMMON STOCK USD.001</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
          <ticker value="ARVN "/>
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        <balance>11123</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>303880.36</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>N/A</lei>
        <title>ASCENDIS PHARMA A/S ADR DKK1.0</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
          <ticker value="ASND "/>
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        <balance>15465</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1658157.3</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC ADR</title>
        <cusip>046353108</cusip>
        <identifiers>
          <isin value="US0463531089"/>
          <ticker value="AZN "/>
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        <balance>135716</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9420047.56</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Aura Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AURA BIOSCIENCES INC COMMON STOCK USD.00001</title>
        <cusip>05153U107</cusip>
        <identifiers>
          <isin value="US05153U1079"/>
          <ticker value="AURA US"/>
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        <balance>10426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>96753.28</valUSD>
        <pctVal>0.0364815229</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Avantor Inc.</name>
        <lei>N/A</lei>
        <title>AVANTOR INC COMMON STOCK USD.01</title>
        <cusip>05352A100</cusip>
        <identifiers>
          <isin value="US05352A1007"/>
          <ticker value="AVTR "/>
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        <balance>69769</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1474916.66</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Avidity Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AVIDITY BIOSCIENCES INC COMMON STOCK</title>
        <cusip>05370A108</cusip>
        <identifiers>
          <isin value="US05370A1088"/>
          <ticker value="RNA "/>
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        <balance>34922</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>536052.7</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Baxter International Inc.</name>
        <lei>J5OIVXX3P24RJRW5CK77</lei>
        <title>BAXTER INTERNATIONAL INC COMMON STOCK USD1.0</title>
        <cusip>071813109</cusip>
        <identifiers>
          <isin value="US0718131099"/>
          <ticker value="BAX "/>
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        <balance>11600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>470496</valUSD>
        <pctVal>0.1774039141</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Becton Dickinson and Company</name>
        <lei>ICE2EP6D98PQUILVRZ91</lei>
        <title>BECTON DICKINSON AND CO COMMON STOCK USD1.0</title>
        <cusip>075887109</cusip>
        <identifiers>
          <isin value="US0758871091"/>
          <ticker value="BDX "/>
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        <balance>20337</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5034220.98</valUSD>
        <pctVal>1.8981893714</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BeiGene Ltd.</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEIGENE LTD ADR USD.0001</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
          <ticker value="BGNE "/>
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        <balance>6134</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1322061.02</valUSD>
        <pctVal>0.4984926539</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pacific Biosciences of California Inc.</name>
        <lei>N/A</lei>
        <title>PACIFIC BIOSCI OF CALIFORNIA COMMON STOCK USD.0001</title>
        <cusip>69404D108</cusip>
        <identifiers>
          <isin value="US69404D1081"/>
          <ticker value="PACB "/>
        </identifiers>
        <balance>54894</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>635672.52</valUSD>
        <pctVal>0.2396849137</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Penumbra Inc.</name>
        <lei>549300RGE06P3ECANU72</lei>
        <title>PENUMBRA INC COMMON STOCK USD.001</title>
        <cusip>70975L107</cusip>
        <identifiers>
          <isin value="US70975L1070"/>
          <ticker value="PEN "/>
        </identifiers>
        <balance>12452</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3470247.88</valUSD>
        <pctVal>1.3084820210</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roche Holding AG</name>
        <lei>N/A</lei>
        <title>ROCHE HOLDING AG COMMON STOCK</title>
        <cusip>711038901</cusip>
        <identifiers>
          <isin value="CH0012032048"/>
          <ticker value="ROG "/>
        </identifiers>
        <balance>6560</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.91495"/>
        <valUSD>1874470.54</valUSD>
        <pctVal>0.7067826522</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pfizer Inc.</name>
        <lei>765LHXWGK1KXCLTFYQ30</lei>
        <title>PFIZER INC COMMON STOCK USD.05</title>
        <cusip>717081103</cusip>
        <identifiers>
          <isin value="US7170811035"/>
          <ticker value="PFE "/>
        </identifiers>
        <balance>130543</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5326154.4</valUSD>
        <pctVal>2.0082649754</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pliant Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PLIANT THERAPEUTICS INC COMMON STOCK</title>
        <cusip>729139105</cusip>
        <identifiers>
          <isin value="US7291391057"/>
          <ticker value="PLRX US"/>
        </identifiers>
        <balance>11373</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>302521.8</valUSD>
        <pctVal>0.1140680291</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prelude Therapeutics Incorporated</name>
        <lei>N/A</lei>
        <title>PRELUDE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>74065P101</cusip>
        <identifiers>
          <isin value="US74065P1012"/>
          <ticker value="PRLD "/>
        </identifiers>
        <balance>7294</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>41575.8</valUSD>
        <pctVal>0.0156764556</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prime Medicine Inc.</name>
        <lei>N/A</lei>
        <title>PRIME MEDICINE INC COMMON STOCK USD.00001</title>
        <cusip>74168J101</cusip>
        <identifiers>
          <isin value="US74168J1016"/>
          <ticker value="PRME US"/>
        </identifiers>
        <balance>12784</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>157243.2</valUSD>
        <pctVal>0.0592896840</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROCEPT BioRobotics Corporation</name>
        <lei>N/A</lei>
        <title>PROCEPT BIOROBOTICS CORP COMMON STOCK USD.00001</title>
        <cusip>74276L105</cusip>
        <identifiers>
          <isin value="US74276L1052"/>
          <ticker value="PRCT US"/>
        </identifiers>
        <balance>12845</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>364798</valUSD>
        <pctVal>0.1375497200</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prometheus Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>PROMETHEUS BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>74349U108</cusip>
        <identifiers>
          <isin value="US74349U1088"/>
          <ticker value="RXDX US"/>
        </identifiers>
        <balance>7699</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>826256.68</valUSD>
        <pctVal>0.3115460474</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Protagonist Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
          <ticker value="PTGX "/>
        </identifiers>
        <balance>5600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>128800</valUSD>
        <pctVal>0.0485649700</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROGENIC PHARMACEUTICALS INC. COMMON STOCK</name>
        <lei>N/A</lei>
        <title>PROGENIC PHARMACEUTICALS INC. COMMON STOCK</title>
        <cusip>743CVR037</cusip>
        <identifiers>
          <isin value="US743CVR0370"/>
        </identifiers>
        <balance>21900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25204.71</valUSD>
        <pctVal>0.0095036179</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Returns are reported without deduction of sales loads and redemption fees, if applicable." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2023-04-28</ncom:dateSigned>
      <ncom:nameOfApplicant>John Hancock Variable Insurance Trust</ncom:nameOfApplicant>
      <ncom:signature>/s/Salvatore Schiavone</ncom:signature>
      <ncom:signerName>Salvatore Schiavone</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
