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        <valUSD>731560.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>Cigna Corporation</name>
        <lei>N/A</lei>
        <title>CIGNA CORP COMMON STOCK USD.01</title>
        <cusip>125523100</cusip>
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          <isin value="US1255231003"/>
          <ticker value="CI "/>
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        <balance>26466</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6274294.62</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CM Life Sciences III Inc.</name>
        <lei>N/A</lei>
        <title>CM LIFE SCIENCES III INC UNIT USD.0001</title>
        <cusip>125841205</cusip>
        <identifiers>
          <isin value="US1258412055"/>
          <ticker value="CMLTU US"/>
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        <balance>22514</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>246528.3</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CM Life Sciences II Inc.</name>
        <lei>N/A</lei>
        <title>CM LIFE SCIENCES II INC UNIT USD.0001</title>
        <cusip>125842203</cusip>
        <identifiers>
          <isin value="US1258422039"/>
          <ticker value="CMIIU US"/>
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        <balance>10251</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>137875.95</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Cara Therapeutics Inc.</name>
        <lei>549300COVOY41P0GZ881</lei>
        <title>CARA THERAPEUTICS INC COMMON STOCK USD.001</title>
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          <isin value="US1407551092"/>
          <ticker value="CARA "/>
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        <balance>9133</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>130327.91</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Catalent Inc.</name>
        <lei>N/A</lei>
        <title>CATALENT INC COMMON STOCK USD.01</title>
        <cusip>148806102</cusip>
        <identifiers>
          <isin value="US1488061029"/>
          <ticker value="CTLT "/>
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        <balance>14481</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1565685.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Celldex Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CELLDEX THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
          <ticker value="CLDX "/>
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        <balance>6300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>210672</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Centene Corporation</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>CENTENE CORP COMMON STOCK USD.001</title>
        <cusip>15135B101</cusip>
        <identifiers>
          <isin value="US15135B1017"/>
          <ticker value="CNC "/>
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        <balance>82925</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6047720.25</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Centessa Pharmaceuticals PLC</name>
        <lei>N/A</lei>
        <title>CENTESSA PHARMACEUTICALS PLC ADR USD.0001</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
          <ticker value="CNTA US"/>
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        <balance>18009</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>399979.89</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cerevel Therapeutics Holdings Inc.</name>
        <lei>N/A</lei>
        <title>CEREVEL THERAPEUTICS HOLDING CEREVEL THERAPEUTICS HO CW27</title>
        <cusip>15678U102</cusip>
        <identifiers>
          <isin value="US15678U1025"/>
          <ticker value="CEREW"/>
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        <balance>3748</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53446.48</valUSD>
        <pctVal>0.0157960762</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cerevel Therapeutics Holdings Inc.</name>
        <lei>N/A</lei>
        <title>CEREVEL THERAPEUTICS HOLDING COMMON STOCK USD.0001</title>
        <cusip>15678U128</cusip>
        <identifiers>
          <isin value="US15678U1280"/>
          <ticker value="CERE "/>
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        <balance>11246</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>288122.52</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Certara Inc.</name>
        <lei>N/A</lei>
        <title>CERTARA INC COMMON STOCK USD.01</title>
        <cusip>15687V109</cusip>
        <identifiers>
          <isin value="US15687V1098"/>
          <ticker value="CERT "/>
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        <balance>15731</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>445659.23</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Chimerix Inc.</name>
        <lei>N/A</lei>
        <title>CHIMERIX INC COMMON STOCK USD.001</title>
        <cusip>16934W106</cusip>
        <identifiers>
          <isin value="US16934W1062"/>
          <ticker value="CMRX "/>
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        <balance>25949</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>207592</valUSD>
        <pctVal>0.0613536954</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>CM Life Sciences Inc.</name>
        <lei>N/A</lei>
        <title>CM LIFE SCIENCES INC UNIT</title>
        <cusip>18978W208</cusip>
        <identifiers>
          <isin value="US18978W2089"/>
          <ticker value="CMLFU "/>
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        <balance>14588</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>238732.62</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>The Cooper Companies Inc.</name>
        <lei>QJKMVPIGLH7530PCUE20</lei>
        <title>COOPER COS INC/THE COMMON STOCK USD.1</title>
        <cusip>216648402</cusip>
        <identifiers>
          <isin value="US2166484020"/>
          <ticker value="COO "/>
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        <balance>3858</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1528809.66</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Danaher Corporation</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>DANAHER CORP COMMON STOCK USD.01</title>
        <cusip>235851102</cusip>
        <identifiers>
          <isin value="US2358511028"/>
          <ticker value="DHR "/>
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        <balance>43522</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11679563.92</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Day One Biopharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>DAY ONE BIOPHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>23954D109</cusip>
        <identifiers>
          <isin value="US23954D1090"/>
          <ticker value="DAWN US"/>
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        <balance>8112</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>184710.24</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Deciphera Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>DECIPHERA PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>24344T101</cusip>
        <identifiers>
          <isin value="US24344T1016"/>
          <ticker value="DCPH "/>
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        <balance>3307</balance>
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        <curCd>USD</curCd>
        <valUSD>121069.27</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Denali Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DENALI THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
          <ticker value="DNLI "/>
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        <balance>28929</balance>
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        <curCd>USD</curCd>
        <valUSD>2269190.76</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>DENTSPLY SIRONA Inc.</name>
        <lei>9NHEHR1SOZCYXDO8HO28</lei>
        <title>DENTSPLY SIRONA INC COMMON STOCK USD.01</title>
        <cusip>24906P109</cusip>
        <identifiers>
          <isin value="US24906P1093"/>
          <ticker value="XRAY "/>
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        <balance>12942</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>818710.92</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Design Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DESIGN THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>25056L103</cusip>
        <identifiers>
          <isin value="US25056L1035"/>
          <ticker value="DSGN US"/>
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        <balance>14731</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>292999.59</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Dexcom Inc.</name>
        <lei>N/A</lei>
        <title>DEXCOM INC COMMON STOCK USD.001</title>
        <cusip>252131107</cusip>
        <identifiers>
          <isin value="US2521311074"/>
          <ticker value="DXCM "/>
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        <balance>5303</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2264381</valUSD>
        <pctVal>0.6692364929</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Dicerna Pharmaceuticals Inc.</name>
        <lei>549300CTZMJMPH28WN39</lei>
        <title>DICERNA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>253031108</cusip>
        <identifiers>
          <isin value="US2530311081"/>
          <ticker value="DRNA "/>
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        <balance>12078</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>450750.96</valUSD>
        <pctVal>0.1332191851</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Doximity Inc.</name>
        <lei>N/A</lei>
        <title>DOXIMITY INC COMMON STOCK USD.001</title>
        <cusip>26622P107</cusip>
        <identifiers>
          <isin value="US26622P1075"/>
          <ticker value="DOCS US"/>
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        <balance>10171</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>591952.2</valUSD>
        <pctVal>0.1749511298</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Dynamics Special Purpose Corp.</name>
        <lei>N/A</lei>
        <title>DYNAMICS SPECIAL PURPOSE CORP COMMON STOCK USD.0001</title>
        <cusip>268010105</cusip>
        <identifiers>
          <isin value="US2680101050"/>
          <ticker value="DYNS US"/>
        </identifiers>
        <balance>18789</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>186762.66</valUSD>
        <pctVal>0.0551975960</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Elanco Animal Health Incorporated</name>
        <lei>N/A</lei>
        <title>ELANCO ANIMAL HEALTH INC COMMON STOCK</title>
        <cusip>28414H103</cusip>
        <identifiers>
          <isin value="US28414H1032"/>
          <ticker value="ELAN "/>
        </identifiers>
        <balance>19393</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>672743.17</valUSD>
        <pctVal>0.1988288542</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Enanta Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ENANTA PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>29251M106</cusip>
        <identifiers>
          <isin value="US29251M1062"/>
          <ticker value="ENTA "/>
        </identifiers>
        <balance>131</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5765.31</valUSD>
        <pctVal>0.0017039340</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Envista Holdings Corporation</name>
        <lei>N/A</lei>
        <title>ENVISTA HOLDINGS CORP COMMON STOCK</title>
        <cusip>29415F104</cusip>
        <identifiers>
          <isin value="US29415F1049"/>
          <ticker value="NVST "/>
        </identifiers>
        <balance>38924</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1681906.04</valUSD>
        <pctVal>0.4970863559</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exact Sciences Corporation</name>
        <lei>N/A</lei>
        <title>EXACT SCIENCES CORP COMMON STOCK USD.01</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
          <ticker value="EXAS "/>
        </identifiers>
        <balance>27175</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3378124.25</valUSD>
        <pctVal>0.9984026653</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exelixis Inc.</name>
        <lei>N/A</lei>
        <title>EXELIXIS INC COMMON STOCK USD.001</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
          <ticker value="EXEL "/>
        </identifiers>
        <balance>102725</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1871649.5</valUSD>
        <pctVal>0.5531649256</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>atai Life Sciences N.V.</name>
        <lei>N/A</lei>
        <title>ATAI LIFE SCIENCES NV COMMON STOCK EUR.16</title>
        <cusip>00211V106</cusip>
        <identifiers>
          <isin value="NL0015000DX5"/>
          <ticker value="ATAI US"/>
        </identifiers>
        <balance>9726</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>179931</valUSD>
        <pctVal>0.0531785028</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AbbVie Inc.</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC COMMON STOCK USD.01</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
          <ticker value="ABBV "/>
        </identifiers>
        <balance>51094</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5755228.16</valUSD>
        <pctVal>1.7009543490</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ACADIA Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ACADIA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
          <ticker value="ACAD "/>
        </identifiers>
        <balance>26408</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>644091.12</valUSD>
        <pctVal>0.1903607574</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acceleron Pharma Inc.</name>
        <lei>N/A</lei>
        <title>ACCELERON PHARMA INC COMMON STOCK USD.001</title>
        <cusip>00434H108</cusip>
        <identifiers>
          <isin value="US00434H1086"/>
          <ticker value="XLRN "/>
        </identifiers>
        <balance>26083</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3273155.67</valUSD>
        <pctVal>0.9673792623</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Accolade Inc.</name>
        <lei>N/A</lei>
        <title>ACCOLADE INC COMMON STOCK</title>
        <cusip>00437E102</cusip>
        <identifiers>
          <isin value="US00437E1029"/>
          <ticker value="ACCD "/>
        </identifiers>
        <balance>8870</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>481729.7</valUSD>
        <pctVal>0.1423749338</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Adaptive Biotechnologies Corporation</name>
        <lei>N/A</lei>
        <title>ADAPTIVE BIOTECHNOLOGIES CORP COMMON STOCK</title>
        <cusip>00650F109</cusip>
        <identifiers>
          <isin value="US00650F1093"/>
          <ticker value="ADPT "/>
        </identifiers>
        <balance>21224</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>867212.64</valUSD>
        <pctVal>0.2563041934</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agilent Technologies Inc.</name>
        <lei>QUIX8Y7A2WP0XRMW7G29</lei>
        <title>AGILENT TECHNOLOGIES INC COMMON STOCK USD.01</title>
        <cusip>00846U101</cusip>
        <identifiers>
          <isin value="US00846U1016"/>
          <ticker value="A "/>
        </identifiers>
        <balance>39844</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5889341.64</valUSD>
        <pctVal>1.7405915103</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>AGIOS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
          <ticker value="AGIO "/>
        </identifiers>
        <balance>9938</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>547683.18</valUSD>
        <pctVal>0.1618674466</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agiliti Inc.</name>
        <lei>N/A</lei>
        <title>AGILITI INC COMMON STOCK</title>
        <cusip>00848J104</cusip>
        <identifiers>
          <isin value="US00848J1043"/>
          <ticker value="AGTI US"/>
        </identifiers>
        <balance>28434</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>621851.58</valUSD>
        <pctVal>0.1837878743</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agilon Health Inc.</name>
        <lei>N/A</lei>
        <title>AGILON HEALTH INC COMMON STOCK USD.01</title>
        <cusip>00857U107</cusip>
        <identifiers>
          <isin value="US00857U1079"/>
          <ticker value="AGL US"/>
        </identifiers>
        <balance>17672</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>716953.04</valUSD>
        <pctVal>0.2118950557</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Akero Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>AKERO THERAPEUTICS INC COMMON STOCK</title>
        <cusip>00973Y108</cusip>
        <identifiers>
          <isin value="US00973Y1082"/>
          <ticker value="AKRO "/>
        </identifiers>
        <balance>4936</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>122462.16</valUSD>
        <pctVal>0.0361936205</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akoya Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AKOYA BIOSCIENCES INC COMMON STOCK USD.00001</title>
        <cusip>00974H104</cusip>
        <identifiers>
          <isin value="US00974H1041"/>
          <ticker value="AKYA US"/>
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        <balance>7645</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>147854.3</valUSD>
        <pctVal>0.0436982527</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alector Inc.</name>
        <lei>N/A</lei>
        <title>ALECTOR INC COMMON STOCK USD.0001</title>
        <cusip>014442107</cusip>
        <identifiers>
          <isin value="US0144421072"/>
          <ticker value="ALEC "/>
        </identifiers>
        <balance>16204</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>337529.32</valUSD>
        <pctVal>0.0997565950</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alignment Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>ALIGNMENT HEALTHCARE INC COMMON STOCK</title>
        <cusip>01625V104</cusip>
        <identifiers>
          <isin value="US01625V1044"/>
          <ticker value="ALHC US"/>
        </identifiers>
        <balance>46816</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1094089.92</valUSD>
        <pctVal>0.3233576421</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Allogene Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
          <ticker value="ALLO "/>
        </identifiers>
        <balance>19856</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>517844.48</valUSD>
        <pctVal>0.1530486361</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ALNYLAM PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <ticker value="ALNY "/>
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        <balance>19267</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3266141.84</valUSD>
        <pctVal>0.9653063289</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amedisys Inc.</name>
        <lei>N/A</lei>
        <title>AMEDISYS INC COMMON STOCK USD.001</title>
        <cusip>023436108</cusip>
        <identifiers>
          <isin value="US0234361089"/>
          <ticker value="AMED "/>
        </identifiers>
        <balance>3532</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>865092.76</valUSD>
        <pctVal>0.2556776641</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amgen Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC COMMON STOCK USD.0001</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
          <ticker value="AMGN "/>
        </identifiers>
        <balance>15508</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3780075</valUSD>
        <pctVal>1.1171989767</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amicus Therapeutics Inc.</name>
        <lei>549300MRD1SMUTNBPQ53</lei>
        <title>AMICUS THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>03152W109</cusip>
        <identifiers>
          <isin value="US03152W1099"/>
          <ticker value="FOLD "/>
        </identifiers>
        <balance>7300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>70372</valUSD>
        <pctVal>0.0207984038</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Annexon Inc.</name>
        <lei>N/A</lei>
        <title>ANNEXON INC COMMON STOCK</title>
        <cusip>03589W102</cusip>
        <identifiers>
          <isin value="US03589W1027"/>
          <ticker value="ANNX "/>
        </identifiers>
        <balance>8751</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>196985.01</valUSD>
        <pctVal>0.0582188056</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Anthem Inc.</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>ANTHEM INC COMMON STOCK USD.01</title>
        <cusip>036752103</cusip>
        <identifiers>
          <isin value="US0367521038"/>
          <ticker value="ANTM "/>
        </identifiers>
        <balance>14282</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5452867.6</valUSD>
        <pctVal>1.6115918606</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>APELLIS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
          <ticker value="APLS "/>
        </identifiers>
        <balance>27125</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1714300</valUSD>
        <pctVal>0.5066603720</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
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      <invstOrSec>
        <name>Ardelyx Inc.</name>
        <lei>549300F542QR4SXHCY32</lei>
        <title>ARDELYX INC COMMON STOCK USD.000001</title>
        <cusip>039697107</cusip>
        <identifiers>
          <isin value="US0396971071"/>
          <ticker value="ARDX "/>
        </identifiers>
        <balance>22814</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>172930.12</valUSD>
        <pctVal>0.0511093968</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arcutis Biotherapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ARCUTIS BIOTHERAPEUTICS INC COMMON STOCK</title>
        <cusip>03969K108</cusip>
        <identifiers>
          <isin value="US03969K1088"/>
          <ticker value="ARQT "/>
        </identifiers>
        <balance>5800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>158282</valUSD>
        <pctVal>0.0467801534</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>argenx SE</name>
        <lei>N/A</lei>
        <title>ARGENX SE ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
          <ticker value="ARGX "/>
        </identifiers>
        <balance>15031</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4525383.17</valUSD>
        <pctVal>1.3374743746</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Arvinas Inc.</name>
        <lei>N/A</lei>
        <title>ARVINAS INC COMMON STOCK USD.001</title>
        <cusip>04335A105</cusip>
        <identifiers>
          <isin value="US04335A1051"/>
          <ticker value="ARVN "/>
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        <balance>11123</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>856471</valUSD>
        <pctVal>0.2531295079</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>N/A</lei>
        <title>ASCENDIS PHARMA A/S ADR DKK1.0</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
          <ticker value="ASND "/>
        </identifiers>
        <balance>13323</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1752640.65</valUSD>
        <pctVal>0.5179919289</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Repligen Corporation</name>
        <lei>54930006QJ0T5AUO1E71</lei>
        <title>REPLIGEN CORP COMMON STOCK USD.01</title>
        <cusip>759916109</cusip>
        <identifiers>
          <isin value="US7599161095"/>
          <ticker value="RGEN "/>
        </identifiers>
        <balance>2042</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>407624.04</valUSD>
        <pctVal>0.1204730489</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Repare Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>REPARE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>760273102</cusip>
        <identifiers>
          <isin value="US7602731025"/>
          <ticker value="RPTX US"/>
        </identifiers>
        <balance>6100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>190198</valUSD>
        <pctVal>0.0562129087</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Royalty Pharma plc</name>
        <lei>N/A</lei>
        <title>ROYALTY PHARMA PLC COMMON STOCK</title>
        <cusip>76028H209</cusip>
        <identifiers>
          <isin value="GB00BMVP7Y09"/>
          <ticker value="RPRX "/>
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        <balance>31749</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1301391.51</valUSD>
        <pctVal>0.3846255070</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Replimune Group Inc.</name>
        <lei>N/A</lei>
        <title>REPLIMUNE GROUP INC COMMON STOCK USD.001</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
          <ticker value="REPL "/>
        </identifiers>
        <balance>19371</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>744233.82</valUSD>
        <pctVal>0.2199578744</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</name>
        <lei>N/A</lei>
        <title>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</title>
        <cusip>76105Y109</cusip>
        <identifiers>
          <isin value="US76105Y1091"/>
          <ticker value="76105Y109010"/>
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        <balance>1719070.25</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1719070.25</valUSD>
        <pctVal>0.5080702166</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Revolution Healthcare Acquisition Corp.</name>
        <lei>N/A</lei>
        <title>REVOLUTION HEALTHCARE ACQUISIT UNIT USD.0001</title>
        <cusip>76155Y207</cusip>
        <identifiers>
          <isin value="US76155Y2072"/>
          <ticker value="REVHU US"/>
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        <balance>31883</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>319786.49</valUSD>
        <pctVal>0.0945127119</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc.</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
          <ticker value="RCKT "/>
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        <balance>18898</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>836992.42</valUSD>
        <pctVal>0.2473726249</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>State Street Bank and Trust Company</name>
        <lei>571474TGEMMWANRLN572</lei>
        <title>SSC GOVERNMENT MM GVMXX</title>
        <cusip>7839989D1</cusip>
        <identifiers>
          <ticker value="7839989D1010"/>
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        <balance>591829.78</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>591829.78</valUSD>
        <pctVal>0.1749149487</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics Inc.</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
          <ticker value="SAGE "/>
        </identifiers>
        <balance>7877</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>447492.37</valUSD>
        <pctVal>0.1322561107</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sana Biotechnology Inc.</name>
        <lei>N/A</lei>
        <title>SANA BIOTECHNOLOGY INC COMMON STOCK USD.0001</title>
        <cusip>799566104</cusip>
        <identifiers>
          <isin value="US7995661045"/>
          <ticker value="SANA US"/>
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        <balance>7446</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>146388.36</valUSD>
        <pctVal>0.0432649950</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SAREPTA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
          <ticker value="SRPT "/>
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        <balance>6268</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>487274.32</valUSD>
        <pctVal>0.1440136430</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corporation</name>
        <lei>N/A</lei>
        <title>SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK "/>
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        <balance>15362</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>443961.8</valUSD>
        <pctVal>0.1312126528</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Schrodinger Inc.</name>
        <lei>N/A</lei>
        <title>SCHRODINGER INC/UNITED STATES COMMON STOCK USD.01</title>
        <cusip>80810D103</cusip>
        <identifiers>
          <isin value="US80810D1037"/>
          <ticker value="SDGR "/>
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        <balance>4954</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>374571.94</valUSD>
        <pctVal>0.1107045199</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Seagen Inc.</name>
        <lei>N/A</lei>
        <title>SEAGEN INC COMMON STOCK USD.001</title>
        <cusip>81181C104</cusip>
        <identifiers>
          <isin value="US81181C1045"/>
          <ticker value="SGEN "/>
        </identifiers>
        <balance>17739</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2800633.32</valUSD>
        <pctVal>0.8277255555</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Seer Inc.</name>
        <lei>N/A</lei>
        <title>SEER INC COMMON STOCK USD.00001</title>
        <cusip>81578P106</cusip>
        <identifiers>
          <isin value="US81578P1066"/>
          <ticker value="SEER "/>
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        <balance>49727</balance>
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        <curCd>USD</curCd>
        <valUSD>1630051.06</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Seres Therapeutics Inc.</name>
        <lei>549300GMXBE5NUWISF13</lei>
        <title>SERES THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>81750R102</cusip>
        <identifiers>
          <isin value="US81750R1023"/>
          <ticker value="MCRB "/>
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        <balance>9002</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>214697.7</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ShockWave Medical Inc.</name>
        <lei>N/A</lei>
        <title>SHOCKWAVE MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>82489T104</cusip>
        <identifiers>
          <isin value="US82489T1043"/>
          <ticker value="SWAV "/>
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        <balance>15493</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2939486.89</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Solid Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>SOLID BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>83422E105</cusip>
        <identifiers>
          <isin value="US83422E1055"/>
          <ticker value="SLDB US"/>
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        <balance>27976</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>102392.16</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>SpringWorks Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SPRINGWORKS THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>85205L107</cusip>
        <identifiers>
          <isin value="US85205L1070"/>
          <ticker value="SWTX "/>
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        <balance>5481</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>451689.21</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>STERIS plc</name>
        <lei>N/A</lei>
        <title>STERIS PLC COMMON STOCK USD75.0</title>
        <cusip>859152100</cusip>
        <identifiers>
          <isin value="IE00BFY8C754"/>
          <ticker value="STE "/>
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        <balance>2900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>598270</valUSD>
        <pctVal>0.1768183520</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Stoke Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STOKE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>86150R107</cusip>
        <identifiers>
          <isin value="US86150R1077"/>
          <ticker value="STOK "/>
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        <balance>8627</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>290384.82</valUSD>
        <pctVal>0.0858230653</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>STRYKER CORP COMMON STOCK USD.1</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
          <ticker value="SYK "/>
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        <balance>30619</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7952672.87</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Surgery Partners Inc.</name>
        <lei>549300LC82HG33S19I03</lei>
        <title>SURGERY PARTNERS INC COMMON STOCK USD.01</title>
        <cusip>86881A100</cusip>
        <identifiers>
          <isin value="US86881A1007"/>
          <ticker value="SGRY "/>
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        <balance>14903</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>992837.86</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Syndax Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>SYNDAX PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>87164F105</cusip>
        <identifiers>
          <isin value="US87164F1057"/>
          <ticker value="SNDX "/>
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        <balance>6400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>109888</valUSD>
        <pctVal>0.0324773347</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Teleflex Incorporated</name>
        <lei>UUL85LWXB4NGSWWXIQ25</lei>
        <title>TELEFLEX INC COMMON STOCK USD1.0</title>
        <cusip>879369106</cusip>
        <identifiers>
          <isin value="US8793691069"/>
          <ticker value="TFX "/>
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        <balance>6780</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2724136.2</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>10x Genomics Inc.</name>
        <lei>N/A</lei>
        <title>10X GENOMICS INC COMMON STOCK</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
          <ticker value="TXG "/>
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        <balance>9307</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1822496.74</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>TG Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>TG THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>88322Q108</cusip>
        <identifiers>
          <isin value="US88322Q1085"/>
          <ticker value="TGTX "/>
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        <balance>5171</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>200583.09</valUSD>
        <pctVal>0.0592822161</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Thermo Fisher Scientific Inc.</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO "/>
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        <balance>25077</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12650594.19</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Translate Bio Inc.</name>
        <lei>N/A</lei>
        <title>TRANSLATE BIO INC COMMON STOCK USD.001</title>
        <cusip>89374L104</cusip>
        <identifiers>
          <isin value="US89374L1044"/>
          <ticker value="TBIO "/>
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        <balance>13393</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>368843.22</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Turning Point Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>TURNING POINT THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>90041T108</cusip>
        <identifiers>
          <isin value="US90041T1088"/>
          <ticker value="TPTX "/>
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        <balance>8840</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>689696.8</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Twist Bioscience Corporation</name>
        <lei>N/A</lei>
        <title>TWIST BIOSCIENCE CORP COMMON STOCK USD.00001</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
          <ticker value="TWST "/>
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        <balance>7977</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1062935.25</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc.</name>
        <lei>N/A</lei>
        <title>ULTRAGENYX PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
          <ticker value="RARE "/>
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        <balance>26048</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2483676.8</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Unitedhealth Group Incorporated</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC COMMON STOCK USD.01</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNHN "/>
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        <balance>51699</balance>
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        <curCd>USD</curCd>
        <valUSD>20702347.56</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Veeva Systems Inc.</name>
        <lei>549300YZEXPDB92M2F02</lei>
        <title>VEEVA SYSTEMS INC COMMON STOCK USD.00001</title>
        <cusip>922475108</cusip>
        <identifiers>
          <isin value="US9224751084"/>
          <ticker value="VEEV "/>
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        <balance>10139</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3152722.05</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX "/>
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        <balance>38112</balance>
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        <curCd>USD</curCd>
        <valUSD>7684522.56</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Verve Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>VERVE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>92539P101</cusip>
        <identifiers>
          <isin value="US92539P1012"/>
          <ticker value="VERV US"/>
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        <balance>4213</balance>
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        <curCd>USD</curCd>
        <valUSD>253833.25</valUSD>
        <pctVal>0.0750202700</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>Acerta Pharma B.V.</name>
        <lei>N/A</lei>
        <title>ACERTA PHARMA BV CLASS B PP COMMON STOCK</title>
        <cusip>928WSA908</cusip>
        <identifiers>
          <ticker value="928WSA908"/>
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        <balance>4276305</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>611511.62</valUSD>
        <pctVal>0.1807319051</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Waters Corporation</name>
        <lei>5T547R1474YC9HOD8Q74</lei>
        <title>WATERS CORP COMMON STOCK USD.01</title>
        <cusip>941848103</cusip>
        <identifiers>
          <isin value="US9418481035"/>
          <ticker value="WAT "/>
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        <balance>1000</balance>
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        <curCd>USD</curCd>
        <valUSD>345610</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DOXIMITY CLASS B LOCKUP TC7B7IA05</name>
        <lei>N/A</lei>
        <title>DOXIMITY CLASS B LOCKUP TC7B7IA05</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Custodian Identifier" value="942XMRII8"/>
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        <balance>63222</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3412806.57</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>West Pharmaceutical Services Inc.</name>
        <lei>5493007NKRGM1RJQ1P16</lei>
        <title>WEST PHARMACEUTICAL SERVICES I COMMON STOCK USD.25</title>
        <cusip>955306105</cusip>
        <identifiers>
          <isin value="US9553061055"/>
          <ticker value="WST "/>
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        <balance>10799</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3877920.9</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>Wuxi Biologics (Cayman) Inc.</name>
        <lei>N/A</lei>
        <title>WUXI BIOLOGICS CAYMAN INC COMMON STOCK USD.00001</title>
        <cusip>967JXD907</cusip>
        <identifiers>
          <isin value="KYG970081173"/>
          <ticker value="2269"/>
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        <balance>57500</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.7643"/>
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        <pctVal>0.3111666098</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Warby Parker Retail Inc.</name>
        <lei>N/A</lei>
        <title>JAND INCDBA WARBY PARKER SER SER D CVT PRFD STK PRIV PLCMT</title>
        <cusip>976CZA905</cusip>
        <identifiers>
          <ticker value="976CZA905"/>
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        <balance>33198</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>814366.86</valUSD>
        <pctVal>0.2406856538</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Xencor Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC COMMON STOCK USD.01</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <ticker value="XNCR "/>
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        <balance>19055</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>657206.95</valUSD>
        <pctVal>0.1942371334</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Zai Lab Limited</name>
        <lei>N/A</lei>
        <title>ZAI LAB LTD ADR USD.00006</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
          <ticker value="ZLAB "/>
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        <balance>6989</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1236983.11</valUSD>
        <pctVal>0.3655896416</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Zentalis Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ZENTALIS PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>98943L107</cusip>
        <identifiers>
          <isin value="US98943L1070"/>
          <ticker value="ZNTL "/>
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        <balance>14394</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>765760.8</valUSD>
        <pctVal>0.2263201609</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Zimmer Biomet Holdings Inc.</name>
        <lei>2P2YLDVPES3BXQ1FRB91</lei>
        <title>ZIMMER BIOMET HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>98956P102</cusip>
        <identifiers>
          <isin value="US98956P1021"/>
          <ticker value="ZBH "/>
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        <balance>7044</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1132816.08</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Zymeworks Inc.</name>
        <lei>N/A</lei>
        <title>ZYMEWORKS INC COMMON STOCK</title>
        <cusip>98985W102</cusip>
        <identifiers>
          <isin value="CA98985W1023"/>
          <ticker value="ZYME "/>
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        <balance>6823</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>236689.87</valUSD>
        <pctVal>0.0699535540</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zeneca Inc.</name>
        <lei>N/A</lei>
        <title>Zeneca Inc. Contingent Value COMMON STOCK</title>
        <cusip>ACI06HJ35</cusip>
        <identifiers>
          <ticker value="ACI06HJ35"/>
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        <balance>13151</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8087.87</valUSD>
        <pctVal>0.0023903653</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WARBY PARKER INC.</name>
        <lei>N/A</lei>
        <title>JAND INC. CLASS A COMMON SH COMMON STOCK</title>
        <cusip>ACI0CG2S3</cusip>
        <identifiers>
          <ticker value="ACI0CG2S3"/>
        </identifiers>
        <balance>14867</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>364696.43</valUSD>
        <pctVal>0.1077858186</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alcon Inc.</name>
        <lei>N/A</lei>
        <title>ALCON INC COMMON STOCK CHF.04</title>
        <cusip>ACI198PY5</cusip>
        <identifiers>
          <isin value="CH0432492467"/>
          <ticker value="ALC "/>
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        <balance>10952</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.92525"/>
        <valUSD>768145.94</valUSD>
        <pctVal>0.2270250876</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Abcam plc</name>
        <lei>N/A</lei>
        <title>ABCAM PLC COMMON STOCK GBP.002</title>
        <cusip>B67746907</cusip>
        <identifiers>
          <isin value="GB00B6774699"/>
          <ticker value="ABC "/>
        </identifiers>
        <balance>35266</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.722909"/>
        <valUSD>674393.43</valUSD>
        <pctVal>0.1993165876</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Alkermes Public Limited Company</name>
        <lei>549300YHRMYLL071E243</lei>
        <title>ALKERMES PLC COMMON STOCK USD.01</title>
        <cusip>G01767105</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
          <ticker value="ALKS "/>
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        <balance>3287</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>80597.24</valUSD>
        <pctVal>0.0238204676</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BCLS Acquisition Corp.</name>
        <lei>N/A</lei>
        <title>BCLS ACQUISITION CORP COMMON STOCK USD.0001</title>
        <cusip>G0904B105</cusip>
        <identifiers>
          <isin value="KYG0904B1059"/>
          <ticker value="BLSA "/>
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        <balance>12029</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>126665.37</valUSD>
        <pctVal>0.0374358767</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eucrates Biomedical Acquisition Corp.</name>
        <lei>N/A</lei>
        <title>EUCRATES BIOMEDICAL ACQUISITIO UNIT</title>
        <cusip>G3141W114</cusip>
        <identifiers>
          <isin value="VGG3141W1142"/>
          <ticker value="EUCRU "/>
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        <balance>11914</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>121403.66</valUSD>
        <pctVal>0.0358807814</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Frontier Acquisition Corp.</name>
        <lei>N/A</lei>
        <title>FRONTIER ACQUISITION CORP UNIT USD.0001</title>
        <cusip>G36826116</cusip>
        <identifiers>
          <isin value="KYG368261163"/>
          <ticker value="FRONU US"/>
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        <balance>12607</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>126070</valUSD>
        <pctVal>0.0372599155</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Health Sciences Acquisitions Corporation 2</name>
        <lei>N/A</lei>
        <title>HEALTH SCIENCES ACQUISITIONS C COMMON STOCK USD.0001</title>
        <cusip>G4411D109</cusip>
        <identifiers>
          <isin value="KYG4411D1097"/>
          <ticker value="HSAQ "/>
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        <balance>13354</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>136210.8</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Helix Acquisition Corp.</name>
        <lei>N/A</lei>
        <title>HELIX ACQUISITION CORP COMMON STOCK USD.0001</title>
        <cusip>G4444C102</cusip>
        <identifiers>
          <isin value="KYG4444C1024"/>
          <ticker value="HLXA "/>
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        <balance>12247</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>126511.51</valUSD>
        <pctVal>0.0373904035</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MeiraGTx Holdings plc</name>
        <lei>N/A</lei>
        <title>MEIRAGTX HOLDINGS PLC COMMON STOCK USD.00001</title>
        <cusip>G59665102</cusip>
        <identifiers>
          <isin value="KYG596651029"/>
          <ticker value="MGTX "/>
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        <balance>10086</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>156333</valUSD>
        <pctVal>0.0462041276</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lantheus Holdings Inc.</name>
        <lei>N/A</lei>
        <title>LANTHEUS HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
          <ticker value="LNTH "/>
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        <balance>18633</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>515016.12</valUSD>
        <pctVal>0.1522127159</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly and Company</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO COMMON STOCK</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY "/>
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        <balance>51965</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11927006.8</valUSD>
        <pctVal>3.5250199511</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Longboard Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>LONGBOARD PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>54300N103</cusip>
        <identifiers>
          <isin value="US54300N1037"/>
          <ticker value="LBPH US"/>
        </identifiers>
        <balance>9824</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>89594.88</valUSD>
        <pctVal>0.0264797149</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lyell Immunopharma Inc.</name>
        <lei>N/A</lei>
        <title>LYELL IMMUNOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>55083R104</cusip>
        <identifiers>
          <isin value="US55083R1041"/>
          <ticker value="LYEL US"/>
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        <balance>15406</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>250193.44</valUSD>
        <pctVal>0.0739445263</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NovoCure Limited</name>
        <lei>N/A</lei>
        <title>NOVOCURE LTD COMMON STOCK</title>
        <cusip>G6674U108</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
          <ticker value="NVCR "/>
        </identifiers>
        <balance>11724</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2600617.68</valUSD>
        <pctVal>0.7686110489</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ortho Clinical Diagnostics Holdings plc</name>
        <lei>N/A</lei>
        <title>ORTHO CLINICAL DIAGNOSTICS HOL COMMON STOCK USD.00001</title>
        <cusip>G6829J107</cusip>
        <identifiers>
          <isin value="GB00BMDNH979"/>
          <ticker value="OCDX US"/>
        </identifiers>
        <balance>58896</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1260963.36</valUSD>
        <pctVal>0.3726769906</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prothena Corporation Public Limited Company</name>
        <lei>N/A</lei>
        <title>PROTHENA CORP PLC COMMON STOCK USD.01</title>
        <cusip>G72800108</cusip>
        <identifiers>
          <isin value="IE00B91XRN20"/>
          <ticker value="PRTA "/>
        </identifiers>
        <balance>18560</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>954169.6</valUSD>
        <pctVal>0.2820042726</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ADC Therapeutics SA</name>
        <lei>N/A</lei>
        <title>ADC THERAPEUTICS SA COMMON STOCK USD.00001</title>
        <cusip>H0036K147</cusip>
        <identifiers>
          <isin value="CH0499880968"/>
          <ticker value="ADCT "/>
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        <balance>18726</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>455978.1</valUSD>
        <pctVal>0.1347640633</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Maravai LifeSciences Holdings Inc.</name>
        <lei>N/A</lei>
        <title>MARAVAI LIFESCIENCES HOLDINGS COMMON STOCK USD.01</title>
        <cusip>56600D107</cusip>
        <identifiers>
          <isin value="US56600D1072"/>
          <ticker value="MRVI US"/>
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        <balance>12522</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>522543.06</valUSD>
        <pctVal>0.1544372987</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MaxCyte Inc.</name>
        <lei>N/A</lei>
        <title>MAXCYTE INC COMMON STOCK NPV</title>
        <cusip>57777K106</cusip>
        <identifiers>
          <isin value="US57777K1060"/>
          <ticker value="MXCT LN"/>
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        <balance>11231</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.722909"/>
        <valUSD>139467.78</valUSD>
        <pctVal>0.0412196216</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CRISPR Therapeutics AG</name>
        <lei>N/A</lei>
        <title>CRISPR THERAPEUTICS AG COMMON STOCK CHF.03</title>
        <cusip>H17182108</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
          <ticker value="CRSP "/>
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        <balance>4952</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>801679.28</valUSD>
        <pctVal>0.2369358468</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>uniQure N.V.</name>
        <lei>N/A</lei>
        <title>UNIQURE NV COMMON STOCK EUR.05</title>
        <cusip>N90064101</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
          <ticker value="QURE "/>
        </identifiers>
        <balance>10600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>326480</valUSD>
        <pctVal>0.0964909749</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>F-Star Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>F-STAR THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>30315R107</cusip>
        <identifiers>
          <isin value="US30315R1077"/>
          <ticker value="FSTX US"/>
        </identifiers>
        <balance>12596</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>108199.64</valUSD>
        <pctVal>0.0319783409</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FS Development Corp. II</name>
        <lei>N/A</lei>
        <title>FS DEVELOPMENT CORP II COMMON STOCK USD.0001</title>
        <cusip>30318F100</cusip>
        <identifiers>
          <isin value="US30318F1003"/>
          <ticker value="FSII US"/>
        </identifiers>
        <balance>10438</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>104380</valUSD>
        <pctVal>0.0308494485</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fate Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>FATE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
          <ticker value="FATE "/>
        </identifiers>
        <balance>18357</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1593204.03</valUSD>
        <pctVal>0.4708705282</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Freshpet Inc.</name>
        <lei>549300S4ZK8ZQ6HNPN59</lei>
        <title>FRESHPET INC COMMON STOCK USD.001</title>
        <cusip>358039105</cusip>
        <identifiers>
          <isin value="US3580391056"/>
          <ticker value="FRPT "/>
        </identifiers>
        <balance>200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32592</valUSD>
        <pctVal>0.0096325467</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Generation Bio Co.</name>
        <lei>N/A</lei>
        <title>GENERATION BIO CO COMMON STOCK USD.0001</title>
        <cusip>37148K100</cusip>
        <identifiers>
          <isin value="US37148K1007"/>
          <ticker value="GBIO "/>
        </identifiers>
        <balance>29400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>790860</valUSD>
        <pctVal>0.2337382149</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Global Blood Therapeutics Inc.</name>
        <lei>549300U4G0QKK99GRT15</lei>
        <title>GLOBAL BLOOD THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>37890U108</cusip>
        <identifiers>
          <isin value="US37890U1088"/>
          <ticker value="GBT "/>
        </identifiers>
        <balance>6332</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>221746.64</valUSD>
        <pctVal>0.0655370910</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Guardant Health Inc.</name>
        <lei>N/A</lei>
        <title>GUARDANT HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
          <ticker value="GH "/>
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        <balance>13940</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1731208.6</valUSD>
        <pctVal>0.5116576989</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>HCA Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>HCA HEALTHCARE INC COMMON STOCK USD.01</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
          <ticker value="HCA "/>
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        <balance>20376</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4212534.24</valUSD>
        <pctVal>1.2450120545</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Hologic Inc.</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>HOLOGIC INC COMMON STOCK USD.01</title>
        <cusip>436440101</cusip>
        <identifiers>
          <isin value="US4364401012"/>
          <ticker value="HOLX "/>
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        <balance>47489</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3168466.08</valUSD>
        <pctVal>0.9364383146</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Humana Inc.</name>
        <lei>N/A</lei>
        <title>HUMANA INC COMMON STOCK USD.166</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
          <ticker value="HUM "/>
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        <balance>14022</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6207819.84</valUSD>
        <pctVal>1.8347175579</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ICU Medical Inc.</name>
        <lei>N/A</lei>
        <title>ICU MEDICAL INC COMMON STOCK USD.1</title>
        <cusip>44930G107</cusip>
        <identifiers>
          <isin value="US44930G1076"/>
          <ticker value="ICUI "/>
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        <balance>425</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87465</valUSD>
        <pctVal>0.0258502301</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>IGM Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IGM BIOSCIENCES INC COMMON STOCK USD.01</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
          <ticker value="IGMS "/>
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        <balance>5782</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>481062.4</valUSD>
        <pctVal>0.1421777137</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>iRhythm Technologies Inc.</name>
        <lei>549300FJI72RJGDQS384</lei>
        <title>IRHYTHM TECHNOLOGIES INC COMMON STOCK USD.001</title>
        <cusip>450056106</cusip>
        <identifiers>
          <isin value="US4500561067"/>
          <ticker value="IRTC "/>
        </identifiers>
        <balance>4332</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>287428.2</valUSD>
        <pctVal>0.0849492380</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEAYA Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IDEAYA BIOSCIENCES INC COMMON STOCK</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
          <ticker value="IDYA "/>
        </identifiers>
        <balance>9100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>191009</valUSD>
        <pctVal>0.0564525993</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immunocore Holdings PLC</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC ADR GBP.0001</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
          <ticker value="IMCR US"/>
        </identifiers>
        <balance>5762</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>225006.1</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Inari Medical Inc.</name>
        <lei>N/A</lei>
        <title>INARI MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>45332Y109</cusip>
        <identifiers>
          <isin value="US45332Y1091"/>
          <ticker value="NARI "/>
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        <balance>3430</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>319950.4</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Incyte Corporation</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP COMMON STOCK USD.001</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
          <ticker value="INCY "/>
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        <balance>45661</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3841459.93</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Insmed Incorporated</name>
        <lei>N/A</lei>
        <title>INSMED INC COMMON STOCK USD.01</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <ticker value="INSM "/>
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        <balance>41482</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1180577.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Innovage Holding Corp.</name>
        <lei>N/A</lei>
        <title>INNOVAGE HOLDING CORP COMMON STOCK USD.001</title>
        <cusip>45784A104</cusip>
        <identifiers>
          <isin value="US45784A1043"/>
          <ticker value="INNV US"/>
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        <balance>7668</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>163405.08</valUSD>
        <pctVal>0.0482942767</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Insulet Corporation</name>
        <lei>549300TZTYD2PYN92D43</lei>
        <title>INSULET CORP COMMON STOCK USD.001</title>
        <cusip>45784P101</cusip>
        <identifiers>
          <isin value="US45784P1012"/>
          <ticker value="PODD "/>
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        <balance>5879</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1613844.29</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Intellia Therapeutics Inc.</name>
        <lei>5493002T5BCPE5DZC723</lei>
        <title>INTELLIA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>45826J105</cusip>
        <identifiers>
          <isin value="US45826J1051"/>
          <ticker value="NTLA "/>
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        <balance>9445</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1529239.95</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Genmab A/S</name>
        <lei>N/A</lei>
        <title>GENMAB A/S COMMON STOCK DKK1.0</title>
        <cusip>459573903</cusip>
        <identifiers>
          <isin value="DK0010272202"/>
          <ticker value="GMAB "/>
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        <balance>3907</balance>
        <units>NS</units>
        <currencyConditional curCd="DKK" exchangeRt="6.27125"/>
        <valUSD>1600863.87</valUSD>
        <pctVal>0.4731343895</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Intuitive Surgical Inc.</name>
        <lei>54930052SRG011710797</lei>
        <title>INTUITIVE SURGICAL INC COMMON STOCK USD.001</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
          <ticker value="ISRG "/>
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        <balance>13392</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12315818.88</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Invitae Corporation</name>
        <lei>549300MYI59DZW1WIX92</lei>
        <title>INVITAE CORP COMMON STOCK USD.0001</title>
        <cusip>46185L103</cusip>
        <identifiers>
          <isin value="US46185L1035"/>
          <ticker value="NVTA "/>
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        <balance>17144</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>578267.12</valUSD>
        <pctVal>0.1709065124</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc.</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
          <ticker value="IONS "/>
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        <balance>22470</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>896328.3</valUSD>
        <pctVal>0.2649093099</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Iovance Biotherapeutics Inc.</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC COMMON STOCK USD.000041666</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
          <ticker value="IOVA "/>
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        <balance>26336</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>685262.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IVERIC bio Inc.</name>
        <lei>549300GZXI59U71XPM70</lei>
        <title>IVERIC BIO INC COMMON STOCK USD.001</title>
        <cusip>46583P102</cusip>
        <identifiers>
          <isin value="US46583P1021"/>
          <ticker value="ISEE "/>
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        <balance>37581</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>237136.11</valUSD>
        <pctVal>0.0700854400</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Merck KGaA</name>
        <lei>N/A</lei>
        <title>MERCK KGAA COMMON STOCK</title>
        <cusip>474184900</cusip>
        <identifiers>
          <isin value="DE0006599905"/>
          <ticker value="MRK "/>
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        <balance>8432</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.843348"/>
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        <pctVal>0.4781693103</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Karuna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KARUNA THERAPEUTICS INC COMMON STOCK</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
          <ticker value="KRTX "/>
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        <balance>7771</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>885816.29</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Kinnate Biopharma Inc.</name>
        <lei>N/A</lei>
        <title>KINNATE BIOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>49705R105</cusip>
        <identifiers>
          <isin value="US49705R1059"/>
          <ticker value="KNTE "/>
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        <balance>9888</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>230192.64</valUSD>
        <pctVal>0.0680333014</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Kodiak Sciences Inc.</name>
        <lei>N/A</lei>
        <title>KODIAK SCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>50015M109</cusip>
        <identifiers>
          <isin value="US50015M1099"/>
          <ticker value="KOD "/>
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        <balance>21111</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1963323</valUSD>
        <pctVal>0.5802589754</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Kronos Bio Inc.</name>
        <lei>N/A</lei>
        <title>KRONOS BIO INC COMMON STOCK</title>
        <cusip>50107A104</cusip>
        <identifiers>
          <isin value="US50107A1043"/>
          <ticker value="KRON "/>
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        <balance>7495</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>179505.25</valUSD>
        <pctVal>0.0530526727</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Kymera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC COMMON STOCK</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
          <ticker value="KYMR "/>
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        <balance>8231</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>399203.5</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Evotec SE</name>
        <lei>N/A</lei>
        <title>EVOTEC SE COMMON STOCK</title>
        <cusip>581191905</cusip>
        <identifiers>
          <isin value="DE0005664809"/>
          <ticker value="EVT "/>
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        <balance>18730</balance>
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        <currencyConditional curCd="EUR" exchangeRt="0.843348"/>
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        <pctVal>0.2511173011</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sartorius AG</name>
        <lei>N/A</lei>
        <title>SARTORIUS AG PREFERENCE</title>
        <cusip>584332902</cusip>
        <identifiers>
          <isin value="DE0007165631"/>
          <ticker value="SRT3 "/>
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        <balance>3704</balance>
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        <currencyConditional curCd="EUR" exchangeRt="0.843348"/>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Merck and Co. Inc.</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK and CO INC COMMON STOCK USD.5</title>
        <cusip>58933Y105</cusip>
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          <isin value="US58933Y1055"/>
          <ticker value="MRK "/>
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        <balance>62313</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4846082.01</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Mersana Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MERSANA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>59045L106</cusip>
        <identifiers>
          <isin value="US59045L1061"/>
          <ticker value="MRSN "/>
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        <balance>19088</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>259215.04</valUSD>
        <pctVal>0.0766108549</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Mettler-Toledo International Inc.</name>
        <lei>5493000BD5GJNUDIUG10</lei>
        <title>METTLER-TOLEDO INTERNATIONAL I COMMON STOCK USD.01</title>
        <cusip>592688105</cusip>
        <identifiers>
          <isin value="US5926881054"/>
          <ticker value="MTD "/>
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        <balance>883</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1223255.22</valUSD>
        <pctVal>0.3615323717</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirati Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MIRATI THERAPEUTICS INC COMMON STOCK</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
          <ticker value="MRTX "/>
        </identifiers>
        <balance>11094</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1792013.82</valUSD>
        <pctVal>0.5296286465</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Moderna Inc.</name>
        <lei>N/A</lei>
        <title>MODERNA INC COMMON STOCK USD.0001</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
          <ticker value="MRNA "/>
        </identifiers>
        <balance>24256</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5699674.88</valUSD>
        <pctVal>1.6845356093</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molecular Templates Inc.</name>
        <lei>N/A</lei>
        <title>MOLECULAR TEMPLATES INC COMMON STOCK USD.001</title>
        <cusip>608550109</cusip>
        <identifiers>
          <isin value="US6085501095"/>
          <ticker value="MTEM "/>
        </identifiers>
        <balance>8300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>64906</valUSD>
        <pctVal>0.0191829307</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molina Healthcare Inc.</name>
        <lei>549300NQQCEQ46YHZ591</lei>
        <title>MOLINA HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>60855R100</cusip>
        <identifiers>
          <isin value="US60855R1005"/>
          <ticker value="MOH "/>
        </identifiers>
        <balance>11839</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2995977.34</valUSD>
        <pctVal>0.8854593674</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Monte Rosa Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MONTE ROSA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>61225M102</cusip>
        <identifiers>
          <isin value="US61225M1027"/>
          <ticker value="GLUE US"/>
        </identifiers>
        <balance>9565</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>217125.5</valUSD>
        <pctVal>0.0641713158</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Morphic Holding Inc.</name>
        <lei>N/A</lei>
        <title>MORPHIC HOLDING INC COMMON STOCK USD.0001</title>
        <cusip>61775R105</cusip>
        <identifiers>
          <isin value="US61775R1059"/>
          <ticker value="MORF "/>
        </identifiers>
        <balance>1883</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>108065.37</valUSD>
        <pctVal>0.0319386575</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MultiPlan Corporation</name>
        <lei>N/A</lei>
        <title>MULTIPLAN CORP COMMON STOCK</title>
        <cusip>62548M100</cusip>
        <identifiers>
          <isin value="US62548M1009"/>
          <ticker value="MPLN "/>
        </identifiers>
        <balance>32800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>312256</valUSD>
        <pctVal>0.0922870799</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NGM Biopharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>NGM BIOPHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>62921N105</cusip>
        <identifiers>
          <isin value="US62921N1054"/>
          <ticker value="NGM "/>
        </identifiers>
        <balance>6500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>128180</valUSD>
        <pctVal>0.0378835248</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eisai Co. Ltd.</name>
        <lei>N/A</lei>
        <title>EISAI CO LTD COMMON STOCK</title>
        <cusip>630720001</cusip>
        <identifiers>
          <isin value="JP3160400002"/>
          <ticker value="4523 "/>
        </identifiers>
        <balance>8900</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="111.095"/>
        <valUSD>874667.14</valUSD>
        <pctVal>0.2585073666</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurocrine Biosciences Inc.</name>
        <lei>549300FECER0XBN49756</lei>
        <title>NEUROCRINE BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
          <ticker value="NBIX "/>
        </identifiers>
        <balance>10765</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1047649.8</valUSD>
        <pctVal>0.3096322915</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nevro Corp.</name>
        <lei>N/A</lei>
        <title>NEVRO CORP COMMON STOCK USD.001</title>
        <cusip>64157F103</cusip>
        <identifiers>
          <isin value="US64157F1030"/>
          <ticker value="NVRO "/>
        </identifiers>
        <balance>6140</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1017950.6</valUSD>
        <pctVal>0.3008547102</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novavax Inc.</name>
        <lei>N/A</lei>
        <title>NOVAVAX INC COMMON STOCK USD.01</title>
        <cusip>670002401</cusip>
        <identifiers>
          <isin value="US6700024010"/>
          <ticker value="NVAX"/>
        </identifiers>
        <balance>3075</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>652853.25</valUSD>
        <pctVal>0.1929503999</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nurix Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>NURIX THERAPEUTICS INC COMMON STOCK</title>
        <cusip>67080M103</cusip>
        <identifiers>
          <isin value="US67080M1036"/>
          <ticker value="NRIX "/>
        </identifiers>
        <balance>15120</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>401133.6</valUSD>
        <pctVal>0.1185548031</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Oak Street Health Inc.</name>
        <lei>N/A</lei>
        <title>OAK STREET HEALTH INC COMMON STOCK USD.001</title>
        <cusip>67181A107</cusip>
        <identifiers>
          <isin value="US67181A1079"/>
          <ticker value="OSH "/>
        </identifiers>
        <balance>8398</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>491870.86</valUSD>
        <pctVal>0.1453721478</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Olink Holding AB</name>
        <lei>N/A</lei>
        <title>OLINK HOLDING AB ADR</title>
        <cusip>680710100</cusip>
        <identifiers>
          <isin value="US6807101000"/>
          <ticker value="OLK US"/>
        </identifiers>
        <balance>17122</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>589339.24</valUSD>
        <pctVal>0.1741788710</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Option Care Health Inc.</name>
        <lei>549300DI3Q5ACSYJRI17</lei>
        <title>OPTION CARE HEALTH INC COMMON STOCK USD.0001</title>
        <cusip>68404L201</cusip>
        <identifiers>
          <isin value="US68404L2016"/>
          <ticker value="OPCH "/>
        </identifiers>
        <balance>30023</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>656603.01</valUSD>
        <pctVal>0.1940586393</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Orion Acquisition Corp.</name>
        <lei>N/A</lei>
        <title>ORION ACQUISITION CORP UNIT USD.0001</title>
        <cusip>68626A207</cusip>
        <identifiers>
          <isin value="US68626A2078"/>
          <ticker value="OHPAU US"/>
        </identifiers>
        <balance>12953</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>128493.76</valUSD>
        <pctVal>0.0379762563</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Oscar Health Inc.</name>
        <lei>N/A</lei>
        <title>OSCAR HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>687793109</cusip>
        <identifiers>
          <isin value="US6877931096"/>
          <ticker value="OSCR US"/>
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        <balance>6001</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>129021.5</valUSD>
        <pctVal>0.0381322296</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Outset Medical Inc.</name>
        <lei>N/A</lei>
        <title>OUTSET MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>690145107</cusip>
        <identifiers>
          <isin value="US6901451079"/>
          <ticker value="OM "/>
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        <balance>18326</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>915933.48</valUSD>
        <pctVal>0.2707036095</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
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      <invstOrSec>
        <name>PTC Therapeutics Inc.</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
          <ticker value="PTCT "/>
        </identifiers>
        <balance>9074</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>383557.98</valUSD>
        <pctVal>0.1133603388</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Pacific Biosciences of California Inc.</name>
        <lei>N/A</lei>
        <title>PACIFIC BIOSCI OF CALIFORNIA COMMON STOCK USD.0001</title>
        <cusip>69404D108</cusip>
        <identifiers>
          <isin value="US69404D1081"/>
          <ticker value="PACB "/>
        </identifiers>
        <balance>51594</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1804242.18</valUSD>
        <pctVal>0.5332427312</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>The Pennant Group Inc.</name>
        <lei>N/A</lei>
        <title>PENNANT GROUP INC/THE COMMON STOCK USD.001</title>
        <cusip>70805E109</cusip>
        <identifiers>
          <isin value="US70805E1091"/>
          <ticker value="PNTG "/>
        </identifiers>
        <balance>10535</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>430881.5</valUSD>
        <pctVal>0.1273467777</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Penumbra Inc.</name>
        <lei>549300RGE06P3ECANU72</lei>
        <title>PENUMBRA INC COMMON STOCK USD.001</title>
        <cusip>70975L107</cusip>
        <identifiers>
          <isin value="US70975L1070"/>
          <ticker value="PEN "/>
        </identifiers>
        <balance>10493</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2875711.58</valUSD>
        <pctVal>0.8499148917</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roche Holding AG</name>
        <lei>N/A</lei>
        <title>ROCHE HOLDING AG COMMON STOCK</title>
        <cusip>711038901</cusip>
        <identifiers>
          <isin value="CH0012032048"/>
          <ticker value="ROG "/>
        </identifiers>
        <balance>8260</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.92525"/>
        <valUSD>3112680.5</valUSD>
        <pctVal>0.9199509188</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pfizer Inc.</name>
        <lei>765LHXWGK1KXCLTFYQ30</lei>
        <title>PFIZER INC COMMON STOCK USD.05</title>
        <cusip>717081103</cusip>
        <identifiers>
          <isin value="US7170811035"/>
          <ticker value="PFE "/>
        </identifiers>
        <balance>28517</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1116725.72</valUSD>
        <pctVal>0.3300476397</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Phreesia Inc.</name>
        <lei>N/A</lei>
        <title>PHREESIA INC COMMON STOCK USD.001</title>
        <cusip>71944F106</cusip>
        <identifiers>
          <isin value="US71944F1066"/>
          <ticker value="PHR "/>
        </identifiers>
        <balance>21021</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1288587.3</valUSD>
        <pctVal>0.3808412301</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pliant Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PLIANT THERAPEUTICS INC COMMON STOCK</title>
        <cusip>729139105</cusip>
        <identifiers>
          <isin value="US7291391057"/>
          <ticker value="PLRX US"/>
        </identifiers>
        <balance>3471</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>101075.52</valUSD>
        <pctVal>0.0298728114</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lonza Group AG</name>
        <lei>549300EFW4H2TCZ71055</lei>
        <title>LONZA GROUP AG COMMON STOCK CHF1.0</title>
        <cusip>733337901</cusip>
        <identifiers>
          <isin value="CH0013841017"/>
          <ticker value="LONN "/>
        </identifiers>
        <balance>1486</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.92525"/>
        <valUSD>1053509.33</valUSD>
        <pctVal>0.3113640722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Precision BioSciences Inc.</name>
        <lei>N/A</lei>
        <title>PRECISION BIOSCIENCES INC COMMON STOCK</title>
        <cusip>74019P108</cusip>
        <identifiers>
          <isin value="US74019P1084"/>
          <ticker value="DTIL "/>
        </identifiers>
        <balance>9100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>113932</valUSD>
        <pctVal>0.0336725366</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Prelude Therapeutics Incorporated</name>
        <lei>N/A</lei>
        <title>PRELUDE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>74065P101</cusip>
        <identifiers>
          <isin value="US74065P1012"/>
          <ticker value="PRLD "/>
        </identifiers>
        <balance>6738</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>192908.94</valUSD>
        <pctVal>0.0570141255</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Privia Health Group Inc.</name>
        <lei>N/A</lei>
        <title>PRIVIA HEALTH GROUP INC COMMON STOCK USD.01</title>
        <cusip>74276R102</cusip>
        <identifiers>
          <isin value="US74276R1023"/>
          <ticker value="PRVA US"/>
        </identifiers>
        <balance>11503</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>510388.11</valUSD>
        <pctVal>0.1508449103</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Protagonist Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
          <ticker value="PTGX "/>
        </identifiers>
        <balance>14560</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>653452.8</valUSD>
        <pctVal>0.1931275965</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PROGENIC PHARMACEUTICALS INC. COMMON STOCK</name>
        <lei>N/A</lei>
        <title>PROGENIC PHARMACEUTICALS INC. COMMON STOCK</title>
        <cusip>743CVR037</cusip>
        <identifiers>
          <isin value="US743CVR0370"/>
        </identifiers>
        <balance>21900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>935.13</valUSD>
        <pctVal>0.0002763771</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pulmonx Corporation</name>
        <lei>N/A</lei>
        <title>PULMONX CORP COMMON STOCK</title>
        <cusip>745848101</cusip>
        <identifiers>
          <isin value="US7458481014"/>
          <ticker value="LUNG "/>
        </identifiers>
        <balance>3467</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>152964.04</valUSD>
        <pctVal>0.0452084334</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Quantum-Si Incorporated</name>
        <lei>N/A</lei>
        <title>QUANTUM SI INC COMMON STOCK USD.0001</title>
        <cusip>74765K105</cusip>
        <identifiers>
          <isin value="US74765K1051"/>
          <ticker value="QSI US"/>
        </identifiers>
        <balance>31200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>382512</valUSD>
        <pctVal>0.1130512000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Quanterix Corporation</name>
        <lei>N/A</lei>
        <title>QUANTERIX CORP COMMON STOCK USD.001</title>
        <cusip>74766Q101</cusip>
        <identifiers>
          <isin value="US74766Q1013"/>
          <ticker value="QTRX "/>
        </identifiers>
        <balance>13174</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>772786.84</valUSD>
        <pctVal>0.2283967029</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Quidel Corporation</name>
        <lei>549300X2FQ6S98OQLQ46</lei>
        <title>QUIDEL CORP COMMON STOCK USD.001</title>
        <cusip>74838J101</cusip>
        <identifiers>
          <isin value="US74838J1016"/>
          <ticker value="QDEL "/>
        </identifiers>
        <balance>9184</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1176654.08</valUSD>
        <pctVal>0.3477594318</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Radius Health Inc.</name>
        <lei>549300EV6I2M6E0YVT27</lei>
        <title>RADIUS HEALTH INC COMMON STOCK USD.0001</title>
        <cusip>750469207</cusip>
        <identifiers>
          <isin value="US7504692077"/>
          <ticker value="RDUS "/>
        </identifiers>
        <balance>11791</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>215067.84</valUSD>
        <pctVal>0.0635631755</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAPT Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RAPT THERAPEUTICS INC COMMON STOCK</title>
        <cusip>75382E109</cusip>
        <identifiers>
          <isin value="US75382E1091"/>
          <ticker value="RAPT "/>
        </identifiers>
        <balance>13742</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>436858.18</valUSD>
        <pctVal>0.1291131821</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Reata Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>REATA PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75615P103</cusip>
        <identifiers>
          <isin value="US75615P1030"/>
          <ticker value="RETA "/>
        </identifiers>
        <balance>4624</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>654434.72</valUSD>
        <pctVal>0.1934178024</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Recursion Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>RECURSION PHARMACEUTICALS INC COMMON STOCK USD.00001</title>
        <cusip>75629V104</cusip>
        <identifiers>
          <isin value="US75629V1044"/>
          <ticker value="RXRX US"/>
        </identifiers>
        <balance>8914</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>325361</valUSD>
        <pctVal>0.0961602551</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc.</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
          <ticker value="REGN "/>
        </identifiers>
        <balance>8356</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4667160.24</valUSD>
        <pctVal>1.3793765055</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>REGENXBIO Inc.</name>
        <lei>549300EOES47LATSET33</lei>
        <title>REGENXBIO INC COMMON STOCK USD.0001</title>
        <cusip>75901B107</cusip>
        <identifiers>
          <isin value="US75901B1070"/>
          <ticker value="RGNX "/>
        </identifiers>
        <balance>4203</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>163286.55</valUSD>
        <pctVal>0.0482592453</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Relay Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RELAY THERAPEUTICS INC COMMON STOCK</title>
        <cusip>75943R102</cusip>
        <identifiers>
          <isin value="US75943R1023"/>
          <ticker value="RLAY "/>
        </identifiers>
        <balance>5385</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>197037.15</valUSD>
        <pctVal>0.0582342155</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Returns are reported without deduction of sales loads and redemption fees, if applicable." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2021-07-30</ncom:dateSigned>
      <ncom:nameOfApplicant>John Hancock Variable Insurance Trust</ncom:nameOfApplicant>
      <ncom:signature>/s/Salvatore Schiavone</ncom:signature>
      <ncom:signerName>Salvatore Schiavone</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
