NPORT-P false 0000756913 XXXXXXXX S000008239 C000022443 C000022444 C000022442 John Hancock Variable Insurance Trust 811-04146 0000756913 Z5DUWKEPW78QKD87GA06 200 Berkeley Street Boston 02116 617-663-4497 Health Sciences Trust S000008239 K5HWWGQWUOYDF5BZA919 2020-12-31 2020-03-31 N 234029029.270000000000 210820.530000000000 233818208.740000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 0.000000000000 80147.780000000000 N Exelixis Inc. N/A 30161Q104 74518 NS USD 1283199.96 0.5488024080 Long EC CORP US N 1 N N N Incyte Corporation 549300Z4WN6JVZ3T4680 45337C102 43224 NS USD 3165293.52 1.3537412407 Long EC CORP US N 1 N N N Radius Health Inc. 549300EV6I2M6E0YVT27 750469207 13791 NS USD 179283 0.0766762353 Long EC CORP US N 1 N N N RAPT Therapeutics Inc. N/A 75382E109 9295 NS USD 197704.65 0.0845548561 Long EC CORP US N 1 N N N Reata Pharmaceuticals Inc. N/A 75615P103 4504 NS USD 650107.36 0.2780396632 Long EC CORP US N 1 N N N Regeneron Pharmaceuticals Inc. 549300RCBFWIRX3HYQ56 75886F107 9591 NS USD 4683189.39 2.0029190264 Long EC CORP US N 1 N N N REGENXBIO Inc. 549300EOES47LATSET33 75901B107 6700 NS USD 216946 0.0927840484 Long EC CORP US N 1 N N N Repligen Corporation 54930006QJ0T5AUO1E71 759916109 1226 NS USD 118358.04 0.0506196847 Long EC CORP US N 1 N N N ROWE T PRICE GOV RES FD 20340919 00000.0000000000 N/A 76105Y109 6836448.25 NS USD 6836448.25 2.9238305634 Long STIV RF US N 1 N N N Revolution Medicines Inc. N/A 76155X100 2388 NS USD 52321.08 0.0223768201 Long EC CORP US N 1 N N N Rocket Pharmaceuticals Inc. 549300R7VV82YUIN4Y93 77313F106 16955 NS USD 236522.25 0.1011564716 Long EC CORP US N 1 N N N SSC GOVERNMENT MM GVMXX N/A 7839989D1 575431.98 NS USD 575431.98 0.2461022959 Long STIV RF US N 1 N N N Sage Therapeutics Inc 5493000JX4BJS9W6CN35 78667J108 14712 NS USD 422528.64 0.1807081845 Long EC CORP US N 1 N N N Sarepta Therapeutics Inc. N/A 803607100 11368 NS USD 1112017.76 0.4755907446 Long EC CORP US N 1 N N N Elanco Animal Health Incorporated N/A 28414H202 1315 NS USD 54099.1 0.0231372485 Long EP CORP US N 1 N N N Insmed Incorporated N/A 457669307 18917 NS USD 303239.51 0.1296902887 Long EC CORP US N 1 N N N Insulet Corporation 549300TZTYD2PYN92D43 45784P101 6900 NS USD 1143192 0.4889234274 Long EC CORP US N 1 N N N Intercept Pharmaceuticals Inc. N/A 45845P108 5247 NS USD 330351.12 0.1412854550 Long EC CORP US N 1 N N N Intra-Cellular Therapies Inc. N/A 46116X101 11549 NS USD 177508.13 0.0759171542 Long EC CORP US N 1 N N N Intuitive Surgical Inc. 54930052SRG011710797 46120E602 17410 NS USD 8621606.1 3.6873116711 Long EC CORP US N 1 N N N Ionis Pharmaceuticals Inc. 549300SI4ZGLG0BLUZ92 462222100 15470 NS USD 731421.6 0.3128163559 Long EC CORP US N 1 N N N Iovance Biotherapeutics Inc. 549300220Z2GHH33XL82 462260100 47614 NS USD 1425325.09 0.6095868657 Long EC CORP US N 1 N N N Kadmon Holdings Inc. N/A 48283N106 50254 NS USD 210564.26 0.0900546887 Long EC CORP US N 1 N N N Karuna Therapeutics Inc. N/A 48576A100 9447 NS USD 680184 0.2909029214 Long EC CORP US N 1 N N N Karyopharm Therapeutics Inc. 549300J1VANRCNTYST87 48576U106 11086 NS USD 212962.06 0.0910801862 Long EC CORP US N 1 N N N Kodiak Sciences Inc. N/A 50015M109 21733 NS USD 1036664.1 0.4433632888 Long EC CORP US N 1 N N N Krystal Biotech Inc. N/A 501147102 5189 NS USD 224372.36 0.0959601740 Long EC CORP US N 1 N N N Bayer AG 549300J4U55H3WP1XT59 506921907 13777 NS 789400.63 0.3376129833 Long EC CORP DE N 2 N N N Lantheus Holdings Inc. N/A 516544103 19644 NS USD 250657.44 0.1072018477 Long EC CORP US N 1 N N N Eli Lilly and Company FRDRIPF3EKNDJ2CQJL29 532457108 39450 NS USD 5472504 2.3404952204 Long EC CORP US N 1 N N N MorphoSys AG N/A 553100900 4007 NS 385815.05 0.1650064176 Long EC CORP DE N 2 N N N Evotec SE N/A 581191905 26952 NS 585122.76 0.2502468748 Long EC CORP DE N 2 N N N McKesson Corporation 549300WZWOM80UCFSF54 58155Q103 3700 NS USD 500462 0.2140389334 Long EC CORP US N 1 N N N Merck and Co. Inc. 4YV9Y5M8S0BRK1RP0397 58933Y105 51516 NS USD 3963641.04 1.6951806540 Long EC CORP US N 1 N N N Mettler-Toledo International Inc. 5493000BD5GJNUDIUG10 592688105 1086 NS USD 749893.86 0.3207166217 Long EC CORP US N 1 N N N Milestone Pharmaceuticals Inc. N/A 59935V107 8804 NS USD 16199.36 0.0069281858 Long EC CORP CA N 1 N N N Minerva Neurosciences Inc. 54930017PANCHC5LYH79 603380106 14976 NS USD 90155.52 0.0385579551 Long EC CORP US N 1 N N N Mirati Therapeutics Inc. N/A 60468T105 8395 NS USD 645323.65 0.2759937532 Long EC CORP US N 1 N N N Moderna Inc. N/A 60770K107 5400 NS USD 161730 0.0691691211 Long EC CORP US N 1 N N N Molina Healthcare Inc. 549300NQQCEQ46YHZ591 60855R100 11909 NS USD 1663806.39 0.7115811891 Long EC CORP US N 1 N N N Momenta Pharmaceuticals Inc. N/A 60877T100 20165 NS USD 548488 0.2345788221 Long EC CORP US N 1 N N N Chugai Pharmaceutical Co. Ltd. N/A 619640006 15800 NS 1827993.14 0.7818010196 Long EC CORP JP N 2 N N N MyoKardia Inc. 549300OLNNNZ1NI9UY54 62857M105 14745 NS USD 691245.6 0.2956337762 Long EC CORP US N 1 N N N Eisai Co. Ltd. N/A 630720001 13800 NS 1009433.93 0.4317174165 Long EC CORP JP N 2 N N N Nektar Therapeutics N/A 640268108 14400 NS USD 257040 0.1099315581 Long EC CORP US N 1 N N N Neurocrine Biosciences Inc. 549300FECER0XBN49756 64125C109 22515 NS USD 1948673.25 0.8334138134 Long EC CORP US N 1 N N N Nevro Corp. N/A 64157F103 13240 NS USD 1323735.2 0.5661386284 Long EC CORP US N 1 N N N Odonate Therapeutics Inc. N/A 676079106 9305 NS USD 256911.05 0.1098764084 Long EC CORP US N 1 N N N Option Care Health Inc. 549300DI3Q5ACSYJRI17 68404L201 9759 NS USD 92417.73 0.0395254632 Long EC CORP US N 1 N N N Schrodinger Inc. N/A 80810D103 4954 NS USD 213616.48 0.0913600704 Long EC CORP US N 1 N N N Roche Holding AG N/A 711038901 9711 NS 3124435.19 1.3362668403 Long EC CORP CH N 2 N N N PhaseBio Pharmaceuticals Inc. N/A 717224109 15205 NS USD 50328.55 0.0215246495 Long EC CORP US N 1 N N N Phreesia Inc. N/A 71944F106 6466 NS USD 135979.98 0.0581562834 Long EC CORP US N 1 N N N Lonza Group AG 549300EFW4H2TCZ71055 733337901 1949 NS 801670.04 0.3428603975 Long EC CORP CH N 2 N N N Principia Biopharma Inc. N/A 74257L108 7778 NS USD 461857.64 0.1975285169 Long EC CORP US N 1 N N N Progenics Pharmaceuticals Inc. N/A 743187106 28500 NS USD 108300 0.0463180351 Long EC CORP US N 1 N N N Puma Biotechnology Inc. N/A 74587V107 16200 NS USD 136728 0.0584761986 Long EC CORP US N 1 N N N Quanterix Corporation N/A 74766Q101 18700 NS USD 343519 0.1469171293 Long EC CORP US N 1 N N N Quidel Corporation 549300X2FQ6S98OQLQ46 74838J101 14329 NS USD 1401519.49 0.5994056227 Long EC CORP US N 1 N N N Applied Therapeutics Inc. N/A 03828A101 600 NS USD 19614 0.0083885682 Long EC CORP US N 1 N N N Bruker Corporation LEBZ6VLQ6I8XB1NHVY15 116794108 26802 NS USD 961119.72 0.4110542653 Long EC CORP US N 1 N N N Sartorius AG N/A 584332902 4418 NS 1056236.06 0.4517338772 Long EP CORP DE N 2 N N N Warby Parker Retail Inc. N/A 976CZA905 33198 NS USD 495646.14 0.2119792734 Long EP CORP US Y 3 N N N Doximity Inc. N/A ACI087LQ1 31611 NS USD 449192.31 0.1921117745 Long EP CORP US Y 3 N N N WaVe Life Sciences Ltd. 54930070006GPKFYZ813 Y95308105 6914 NS USD 64784.18 0.0277070722 Long EC CORP US N 1 N N N Becton Dickinson and Company ICE2EP6D98PQUILVRZ91 075887208 9988 NS USD 522172.64 0.2233241982 Long EP CORP US N 1 N N N Orchard Therapeutics plc N/A 68570P101 13631 NS USD 102641.43 0.0438979627 Long EC CORP GB N 1 N N N PRA Health Sciences Inc. 549300R1HR1VWWHIAK47 69354M108 7608 NS USD 631768.32 0.2701963732 Long EC CORP US N 1 N N N PPD Inc. N/A 69355F102 15758 NS USD 280649.98 0.1200291378 Long EC CORP US N 1 N N N PTC Therapeutics Inc. 549300UJLWOIWFDGB318 69366J200 8905 NS USD 397252.05 0.1698978245 Long EC CORP US N 1 N N N Astellas Pharma Inc. N/A 698538006 46300 NS 713360.68 0.3050920131 Long EC CORP JP N 2 N N N Passage Bio Inc. N/A 702712100 3328 NS USD 52416 0.0224174158 Long EC CORP US N 1 N N N The Pennant Group Inc. N/A 70805E109 11735 NS USD 166167.6 0.0710670058 Long EC CORP US N 1 N N N Penumbra Inc. 549300RGE06P3ECANU72 70975L107 7229 NS USD 1166254.57 0.4987868893 Long EC CORP US N 1 N N N Novartis AG 5493007HIVTX6SY6XD66 710306903 19847 NS 1637353.27 0.7002676476 Long EC CORP CH N 2 N N N Fate Therapeutics Inc. N/A 31189P102 10703 NS USD 237713.63 0.1016660042 Long EC CORP US N 1 N N N FibroGen Inc. 549300Q914ULWWY95822 31572Q808 15647 NS USD 543733.25 0.2325452979 Long EC CORP US N 1 N N N GW Pharmaceuticals plc N/A 36197T103 4077 NS USD 357022.89 0.1526925092 Long EC CORP GB N 1 N N N G1 Therapeutics Inc. N/A 3621LQ109 7707 NS USD 84931.14 0.0363235782 Long EC CORP US N 1 N N N General Electric Company 3C7474T6CDKPR9K6YT90 369604103 120600 NS USD 957564 0.4095335454 Long EC CORP US N 1 N N N GenMark Diagnostics Inc. N/A 372309104 34260 NS USD 141151.2 0.0603679246 Long EC CORP US N 1 N N N Global Blood Therapeutics Inc. 549300U4G0QKK99GRT15 37890U108 19532 NS USD 997889.88 0.4267802261 Long EC CORP US N 1 N N N Gritstone Oncology Inc. N/A 39868T105 5800 NS USD 33756 0.0144368568 Long EC CORP US N 1 N N N Exact Sciences Corporation N/A 30063P105 26102 NS USD 1513916 0.6474756642 Long EC CORP US N 1 N N N Guardant Health Inc. N/A 40131M109 6194 NS USD 431102.4 0.1843750332 Long EC CORP US N 1 N N N HCA Healthcare Inc. N/A 40412C101 33083 NS USD 2972507.55 1.2712900189 Long EC CORP US N 1 N N N HTG Molecular Diagnostics Inc. 5493001QFG6NIN60NK56 40434H104 34959 NS USD 11361.68 0.0048591938 Long EC CORP US N 1 N N N Hologic Inc. 549300DYP6F5ZJL0LB74 436440101 55000 NS USD 1930500 0.8256414290 Long EC CORP US N 1 N N N Homology Medicines Inc. N/A 438083107 14662 NS USD 227847.48 0.0974464227 Long EC CORP US N 1 N N N Humana Inc. N/A 444859102 15561 NS USD 4886465.22 2.0898565797 Long EC CORP US N 1 N N N ICU Medical Inc. N/A 44930G107 3925 NS USD 791947.25 0.3387021286 Long EC CORP US N 1 N N N IGM Biosciences Inc. N/A 449585108 7954 NS USD 446617.1 0.1910104018 Long EC CORP US N 1 N N N iRhythm Technologies Inc. 549300FJI72RJGDQS384 450056106 6282 NS USD 511040.7 0.2185632602 Long EC CORP US N 1 N N N Immunomedics Inc. 5493007ZU7DDO8PSIM59 452907108 24269 NS USD 327146.12 0.1399147319 Long EC CORP US N 1 N N N Ardelyx Inc. 549300F542QR4SXHCY32 039697107 22814 NS USD 129697.59 0.0554694139 Long EC CORP US N 1 N N N Arcutis Biotherapeutics Inc. N/A 03969K108 4960 NS USD 147808 0.0632149227 Long EC CORP US N 1 N N N argenx SE N/A 04016X101 13329 NS USD 1755829.17 0.7509377390 Long EC CORP NL N 1 N N N Arvinas Inc. N/A 04335A105 1100 NS USD 44330 0.0189591736 Long EC CORP US N 1 N N N Ascendis Pharma A/S N/A 04351P101 21118 NS USD 2378097.98 1.0170713362 Long EC CORP DK N 1 N N N Assembly Biosciences Inc. N/A 045396108 6774 NS USD 100458.42 0.0429643271 Long EC CORP US N 1 N N N AstraZeneca PLC PY6ZZQWO2IZFZC3IOL08 046353108 81108 NS USD 3622283.28 1.5491878496 Long EC CORP GB N 1 N N N AtriCure Inc. N/A 04963C209 12700 NS USD 426593 0.1824464409 Long EC CORP US N 1 N N N Avantor Inc. N/A 05352A100 81304 NS USD 1015486.96 0.4343061926 Long EC CORP US N 1 N N N AVROBIO Inc. N/A 05455M100 5977 NS USD 93002.12 0.0397753967 Long EC CORP US N 1 N N N Axsome Therapeutics Inc. 549300EXGR0XLRJEIB95 05464T104 6121 NS USD 360098.43 0.1540078645 Long EC CORP US N 1 N N N Beam Therapeutics Inc. N/A 07373V105 2325 NS USD 41850 0.0178985205 Long EC CORP US N 1 N N N Becton Dickinson and Company ICE2EP6D98PQUILVRZ91 075887109 34808 NS USD 7997834.16 3.4205352111 Long EC CORP US N 1 N N N BeiGene Ltd. 549300JFUK6FRD5MH739 07725L102 5423 NS USD 667625.53 0.2855318812 Long EC CORP CN N 1 N N N BELLUS Health Inc. N/A 07987C204 10094 NS USD 100738.12 0.0430839499 Long EC CORP CA N 1 N N N BioMarin Pharmaceutical Inc. NSLL8ITTRR0J5HEMR848 09061G101 17093 NS USD 1444358.5 0.6177271256 Long EC CORP US N 1 N N N Biogen Inc. W8J5WZB5IY3K0NDQT671 09062X103 14690 NS USD 4647622.2 1.9877075550 Long EC CORP US N 1 N N N bluebird bio Inc. N/A 09609G100 9834 NS USD 451970.64 0.1933000182 Long EC CORP US N 1 N N N Blueprint Medicines Corporation N/A 09627Y109 11214 NS USD 655794.72 0.2804720486 Long EC CORP US N 1 N N N Bristol-Myers Squibb Company HLYYNH7UQUORYSJQCN42 110122108 41952 NS USD 2338404.48 1.0000951135 Long EC CORP US N 1 N N N Bristol-Myers Squibb Company HLYYNH7UQUORYSJQCN42 110122157 64896 NS USD 246604.8 0.1054686037 Long EC CORP US N 1 N N N Seattle Genetics Inc. N/A 812578102 28123 NS USD 3244831.74 1.3877583604 Long EC CORP US N 1 N N N Zealand Pharma A/S 549300ITBB1ULBL4CZ12 98920Y304 3482 NS USD 120129 0.0513770936 Long EC CORP DK N 1 N N N Zimmer Biomet Holdings Inc. 2P2YLDVPES3BXQ1FRB91 98956P102 5750 NS USD 581210 0.2485734550 Long EC CORP US N 1 N N N Shockwave Medical Inc. N/A 82489T104 4275 NS USD 141844.5 0.0606644370 Long EC CORP US N 1 N N N Silk Road Medical Inc. N/A 82710M100 1823 NS USD 57388.04 0.0245438712 Long EC CORP US N 1 N N N Stoke Therapeutics Inc. N/A 86150R107 7038 NS USD 161170.2 0.0689297043 Long EC CORP US N 1 N N N Stryker Corporation 5493002F0SC4JTBU5137 863667101 31009 NS USD 5162688.41 2.2079924561 Long EC CORP US N 1 N N N Tandem Diabetes Care Inc. 549300JEPFOD0K4D3I05 875372203 4400 NS USD 283140 0.1210940763 Long EC CORP US N 1 N N N Teladoc Health Inc. N/A 87918A105 2800 NS USD 434028 0.1856262617 Long EC CORP US N 1 N N N Teleflex Incorporated UUL85LWXB4NGSWWXIQ25 879369106 6135 NS USD 1796696.1 0.7684158174 Long EC CORP US N 1 N N N 10X Genomics Inc. N/A 88025U109 4636 NS USD 288915.52 0.1235641662 Long EC CORP US N 1 N N N Thermo Fisher Scientific Inc. HCHV7422L5HDJZCRFL38 883556102 29578 NS USD 8388320.8 3.5875395869 Long EC CORP US N 1 N N N Translate Bio Inc. N/A 89374L104 2800 NS USD 27916 0.0119391899 Long EC CORP US N 1 N N N Tricida Inc. N/A 89610F101 18825 NS USD 414150 0.1771247852 Long EC CORP US N 1 N N N Turning Point Therapeutics Inc. N/A 90041T108 7418 NS USD 331287.88 0.1416860910 Long EC CORP US N 1 N N N Zogenix Inc. 54930089H3HF4C32SK78 98978L204 9122 NS USD 225587.06 0.0964796802 Long EC CORP US N 1 N N N Zymeworks Inc. N/A 98985W102 11723 NS USD 415814.81 0.1778367956 Long EC CORP CA N 1 N N N Zeneca Inc. N/A ACI06HJ35 13151 NS USD 8087.87 0.0034590420 Long EC CORP US N 3 N N N JAND Inc N/A ACI0CG2S3 14867 NS USD 221964.31 0.0949302927 Long EC CORP US Y 3 N N N Alcon Inc. N/A ACI198PY5 32829 NS 1681853.61 0.7192996726 Long EC CORP CH N 2 N N N Galapagos NV 549300QKJ78IY0IOV655 B07Q2V905 4545 NS 892534.82 0.3817216909 Long EC CORP BE N 2 N N N Daiichi Sankyo Company Limited N/A B0J7D9901 23600 NS 1620767.97 0.6931744019 Long EC CORP JP N 2 N N N Ipsen SA 549300M6SGDPB4Z94P11 B0R7JF902 6997 NS 358664.74 0.1533947001 Long EC CORP FR N 2 N N N Ultragenyx Pharmaceutical Inc. N/A 90400D108 18099 NS USD 804138.57 0.3439161451 Long EC CORP US N 1 N N N United Therapeutics Corporation N/A 91307C102 3100 NS USD 293957.5 0.1257205337 Long EC CORP US N 1 N N N Unitedhealth Group Incorporated 549300GHBMY8T5GXDE41 91324P102 53355 NS USD 13305669.9 5.6906046675 Long EC CORP US N 1 N N N Veeva Systems Inc. 549300YZEXPDB92M2F02 922475108 6999 NS USD 1094433.63 0.4680703166 Long EC CORP US N 1 N N N Vertex Pharmaceuticals Incorporated 54930015RAQRRZ5ZGJ91 92532F100 45791 NS USD 10895968.45 4.6600170743 Long EC CORP US N 1 N N N Acerta Pharma B.V. N/A 928WSA908 4276305 NS USD 396841.1 0.1697220683 Long EC CORP US Y 3 N N N West Pharmaceutical Services Inc. 5493007NKRGM1RJQ1P16 955306105 10853 NS USD 1652369.25 0.7066897223 Long EC CORP US N 1 N N N Xencor Inc. 549300V5IF65437JKG30 98401F105 20834 NS USD 622519.92 0.2662409927 Long EC CORP US N 1 N N N X4 Pharmaceuticals Inc. N/A 98420X103 2700 NS USD 27000 0.0115474326 Long EC CORP US N 1 N N N Zai Lab Limited N/A 98887Q104 4374 NS USD 225173.52 0.0963028163 Long EC CORP CN N 1 N N N Wuxi Biologics (Cayman) Inc. N/A BZ3C3R901 21500 NS 274486.81 0.1173932567 Long EC CORP CN N 2 N N N Alkermes Public Limited Company 549300YHRMYLL071E243 G01767105 19633 NS USD 283107.86 0.1210803305 Long EC CORP IE N 1 N N N NovoCure Limited N/A G6674U108 9176 NS USD 617911.84 0.2642701966 Long EC CORP JE N 1 N N N Perrigo Company Public Limited Company 549300IFOQS6R1QLY196 G97822103 267 NS USD 12840.03 0.0054914585 Long EC CORP IE N 1 N N N CRISPR Therapeutics AG N/A H17182108 5214 NS USD 221125.74 0.0945716509 Long EC CORP CH N 1 N N N uniQure N.V. N/A N90064101 3300 NS USD 156585 0.0669686937 Long EC CORP NL N 1 N N N DiaSorin S.p.A. N/A B234WN909 5165 NS 680819.58 0.2911747480 Long EC CORP IT N 2 N N N Abcam plc N/A B67746907 23434 NS 330563.06 0.1413760980 Long EC CORP GB N 2 N N N Scholar Rock Holding Corporation N/A 80706P103 5587 NS USD 67658.57 0.0289363991 Long EC CORP US N 1 N N N Alector Inc. N/A 014442107 8804 NS USD 212440.52 0.0908571326 Long EC CORP US N 1 N N N Alexion Pharmaceuticals Inc. M1YXUUZR0EIMU8T0EM75 015351109 32231 NS USD 2894021.49 1.2377228898 Long EC CORP US N 1 N N N Allakos Inc. N/A 01671P100 2614 NS USD 116296.86 0.0497381537 Long EC CORP US N 1 N N N Allogene Therapeutics Inc. N/A 019770106 7797 NS USD 151573.68 0.0648254389 Long EC CORP US N 1 N N N Alnylam Pharmaceuticals Inc. N/A 02043Q107 24872 NS USD 2707317.2 1.1578726972 Long EC CORP US N 1 N N N Amarin Corporation plc N/A 023111206 61214 NS USD 244856 0.1047206722 Long EC CORP IE N 1 N N N Amedisys Inc. N/A 023436108 4507 NS USD 827214.78 0.3537854406 Long EC CORP US N 1 N N N Amgen Inc. 62QBXGPJ34PQ72Z12S66 031162100 28500 NS USD 5777805 2.4710671727 Long EC CORP US N 1 N N N Anthem Inc. 8MYN82XMYQH89CTMTH67 036752103 12705 NS USD 2884543.2 1.2336691892 Long EC CORP US N 1 N N N Apellis Pharmaceuticals Inc. N/A 03753U106 9472 NS USD 253754.88 0.1085265692 Long EC CORP US N 1 N N N AbbVie Inc. FR5LCKFTG8054YNNRU85 00287Y109 63824 NS USD 4862750.56 2.0797142302 Long EC CORP US N 1 N N N Acadia Healthcare Company Inc. 5493005CW985Y9D0NC11 00404A109 13100 NS USD 240385 0.1028085029 Long EC CORP US N 1 N N N ACADIA Pharmaceuticals Inc. N/A 004225108 58386 NS USD 2466808.5 1.0550112899 Long EC CORP US N 1 N N N Acceleron Pharma Inc. N/A 00434H108 24727 NS USD 2222215.49 0.9504030939 Long EC CORP US N 1 N N N Adaptive Biotechnologies Corporation N/A 00650F109 12272 NS USD 340916.16 0.1458039397 Long EC CORP US N 1 N N N Adverum Biotechnologies Inc. N/A 00773U108 25397 NS USD 248128.69 0.1061203451 Long EC CORP US N 1 N N N Agilent Technologies Inc. QUIX8Y7A2WP0XRMW7G29 00846U101 49271 NS USD 3528789.02 1.5092019732 Long EC CORP US N 1 N N N Agios Pharmaceuticals Inc. N/A 00847X104 11637 NS USD 412880.76 0.1765819532 Long EC CORP US N 1 N N N Aimmune Therapeutics Inc. 549300WDF7T2EVBC1877 00900T107 24335 NS USD 350910.7 0.1500784314 Long EC CORP US N 1 N N N Akero Therapeutics Inc. N/A 00973Y108 4103 NS USD 86983.6 0.0372013799 Long EC CORP US N 1 N N N Cigna Corporation N/A 125523100 26886 NS USD 4763661.48 2.0373355461 Long EC CORP US N 1 N N N Cara Therapeutics Inc. 549300COVOY41P0GZ881 140755109 19833 NS USD 261993.93 0.1120502682 Long EC CORP US N 1 N N N Cardinal Health Inc. CCU46N3GJMF4OK4N7U60 14149Y108 9500 NS USD 455430 0.1947795266 Long EC CORP US N 1 N N N Catalent Inc. N/A 148806102 14481 NS USD 752287.95 0.3217405326 Long EC CORP US N 1 N N N Centene Corporation 549300Z7JJ4TQSQGT333 15135B101 91247 NS USD 5420984.27 2.3184611238 Long EC CORP US N 1 N N N ChemoCentryx Inc. N/A 16383L106 3962 NS USD 159193.16 0.0680841586 Long EC CORP US N 1 N N N Constellation Pharmaceuticals Inc. N/A 210373106 6600 NS USD 207438 0.0887176414 Long EC CORP US N 1 N N N The Cooper Companies Inc. QJKMVPIGLH7530PCUE20 216648402 5258 NS USD 1449472.86 0.6199144488 Long EC CORP US N 1 N N N Cortexyme Inc. N/A 22053A107 1200 NS USD 54732 0.0234079289 Long EC CORP US N 1 N N N Cyclerion Therapeutics Inc. N/A 23255M105 8100 NS USD 21465 0.0091802089 Long EC CORP US N 1 N N N Danaher Corporation S4BKK9OTCEWQ3YHPFM11 235851102 36839 NS USD 5098885.99 2.1807052656 Long EC CORP US N 1 N N N Deciphera Pharmaceuticals Inc. N/A 24344T101 11218 NS USD 461845.06 0.1975231367 Long EC CORP US N 1 N N N Denali Therapeutics Inc. N/A 24823R105 11675 NS USD 204429.25 0.0874308511 Long EC CORP US N 1 N N N DexCom Inc. N/A 252131107 9210 NS USD 2479976.7 1.0606431011 Long EC CORP US N 1 N N N Dicerna Pharmaceuticals Inc. 549300CTZMJMPH28WN39 253031108 24778 NS USD 455171.86 0.1946691246 Long EC CORP US N 1 N N N Elanco Animal Health Incorporated N/A 28414H103 22308 NS USD 499476.12 0.2136172896 Long EC CORP US N 1 N N N Enanta Pharmaceuticals Inc. N/A 29251M106 9923 NS USD 510339.89 0.2182635359 Long EC CORP US N 1 N N N Envista Holdings Corporation N/A 29415F104 52904 NS USD 790385.76 0.3380343063 Long EC CORP US N 1 N N N Epizyme Inc. 549300TNFWF88O4U4605 29428V104 14713 NS USD 228198.63 0.0975966035 Long EC CORP US N 1 N N N Esperion Therapeutics Inc. 549300OFU56UKEWVUS92 29664W105 2800 NS USD 88284 0.0377575384 Long EC CORP US N 1 N N N 2020-04-30 John Hancock Variable Insurance Trust /s/Salvatore Schiavone Salvatore Schiavone Treasurer XXXX