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      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>N/A</lei>
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          <isin value="US04351P1012"/>
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        <balance>24318</balance>
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        <curCd>USD</curCd>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
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          <ticker value="AZN "/>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AtriCure Inc.</name>
        <lei>N/A</lei>
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          <ticker value="ATRC "/>
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        <balance>12700</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Avantor Inc.</name>
        <lei>N/A</lei>
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        <cusip>05352A100</cusip>
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          <isin value="US05352A1007"/>
          <ticker value="AVTR "/>
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        <assetCat>EC</assetCat>
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        <name>Axsome Therapeutics Inc.</name>
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        <curCd>USD</curCd>
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        <name>Becton Dickinson and Company</name>
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        <cusip>075887208</cusip>
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          <isin value="US0758872081"/>
          <ticker value="BDX"/>
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        <curCd>USD</curCd>
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        <assetCat>EP</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BeiGene Ltd.</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEIGENE LTD ADR USD.0001</title>
        <cusip>07725L102</cusip>
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          <isin value="US07725L1026"/>
          <ticker value="BGNE "/>
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        <curCd>USD</curCd>
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        <invCountry>CN</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>BioMarin Pharmaceutical Inc.</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
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        <cusip>09061G101</cusip>
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          <isin value="US09061G1013"/>
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        <curCd>USD</curCd>
        <valUSD>1918693.15</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>Biogen Inc.</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
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        <cusip>09062X103</cusip>
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          <isin value="US09062X1037"/>
          <ticker value="BIIB "/>
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        <balance>10529</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>bluebird bio Inc.</name>
        <lei>N/A</lei>
        <title>BLUEBIRD BIO INC COMMON STOCK USD.01</title>
        <cusip>09609G100</cusip>
        <identifiers>
          <isin value="US09609G1004"/>
          <ticker value="BLUE "/>
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        <balance>11834</balance>
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        <curCd>USD</curCd>
        <valUSD>1038433.5</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Blueprint Medicines Corporation</name>
        <lei>N/A</lei>
        <title>BLUEPRINT MEDICINES CORP COMMON STOCK USD.001</title>
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          <isin value="US09627Y1091"/>
          <ticker value="BPMC "/>
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        <curCd>USD</curCd>
        <valUSD>1098548.43</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>Boston Scientific Corporation</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
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          <ticker value="BSX "/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>Bristol-Myers Squibb Company</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>BRISTOL-MYERS SQUIBB CO COMMON STOCK USD.1</title>
        <cusip>110122108</cusip>
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          <isin value="US1101221083"/>
          <ticker value="BMY "/>
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        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4650693.88</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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      <invstOrSec>
        <name>Bristol-Myers Squibb Company</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>CELGENE CORP RIGHT</title>
        <cusip>110122157</cusip>
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          <isin value="US1101221570"/>
          <ticker value="BMY-R "/>
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        <balance>53996</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>162527.96</valUSD>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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        <name>Bruker Corporation</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
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        <cusip>116794108</cusip>
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          <ticker value="BRKR "/>
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        <balance>30002</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1529201.94</valUSD>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Cigna Corporation</name>
        <lei>N/A</lei>
        <title>CIGNA CORP COMMON STOCK USD.01</title>
        <cusip>125523100</cusip>
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          <ticker value="CI "/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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      <invstOrSec>
        <name>Cara Therapeutics Inc.</name>
        <lei>549300COVOY41P0GZ881</lei>
        <title>CARA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>140755109</cusip>
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        <assetCat>EC</assetCat>
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      <invstOrSec>
        <name>Catalent Inc.</name>
        <lei>N/A</lei>
        <title>CATALENT INC COMMON STOCK USD.01</title>
        <cusip>148806102</cusip>
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          <isin value="US1488061029"/>
          <ticker value="CTLT "/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <name>Centene Corporation</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>CENTENE CORP COMMON STOCK USD.001</title>
        <cusip>15135B101</cusip>
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          <ticker value="CNC "/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Constellation Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>CONSTELLATION PHARMACEUTICALS COMMON STOCK USD.0001</title>
        <cusip>210373106</cusip>
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          <ticker value="CNST "/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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      <invstOrSec>
        <name>The Cooper Companies Inc.</name>
        <lei>QJKMVPIGLH7530PCUE20</lei>
        <title>COOPER COS INC/THE COMMON STOCK USD.1</title>
        <cusip>216648402</cusip>
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        <curCd>USD</curCd>
        <valUSD>1874727.15</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>Danaher Corporation</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>DANAHER CORP COMMON STOCK USD.01</title>
        <cusip>235851102</cusip>
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          <ticker value="DHR "/>
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        <balance>36639</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5623353.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Deciphera Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>DECIPHERA PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>24344T101</cusip>
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          <ticker value="DCPH "/>
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        <balance>11218</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>698208.32</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Denali Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DENALI THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
          <ticker value="DNLI "/>
        </identifiers>
        <balance>9400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>163748</valUSD>
        <pctVal>0.0597873354</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DexCom Inc.</name>
        <lei>N/A</lei>
        <title>DEXCOM INC COMMON STOCK USD.001</title>
        <cusip>252131107</cusip>
        <identifiers>
          <isin value="US2521311074"/>
          <ticker value="DXCM "/>
        </identifiers>
        <balance>10810</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2364579.4</valUSD>
        <pctVal>0.8633504025</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Dicerna Pharmaceuticals Inc.</name>
        <lei>549300CTZMJMPH28WN39</lei>
        <title>DICERNA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>253031108</cusip>
        <identifiers>
          <isin value="US2530311081"/>
          <ticker value="DRNA "/>
        </identifiers>
        <balance>26978</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>594325.34</valUSD>
        <pctVal>0.2169988547</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Elanco Animal Health Incorporated</name>
        <lei>N/A</lei>
        <title>ELANCO ANIMAL HEALTH INC COMMON STOCK</title>
        <cusip>28414H103</cusip>
        <identifiers>
          <isin value="US28414H1032"/>
          <ticker value="ELAN "/>
        </identifiers>
        <balance>22308</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>656970.6</valUSD>
        <pctVal>0.2398717641</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Enanta Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ENANTA PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>29251M106</cusip>
        <identifiers>
          <isin value="US29251M1062"/>
          <ticker value="ENTA "/>
        </identifiers>
        <balance>9923</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>613042.94</valUSD>
        <pctVal>0.2238329865</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Envista Holdings Corporation</name>
        <lei>N/A</lei>
        <title>ENVISTA HOLDINGS CORP COMMON STOCK</title>
        <cusip>29415F104</cusip>
        <identifiers>
          <isin value="US29415F1049"/>
          <ticker value="NVST "/>
        </identifiers>
        <balance>51704.52</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1532522.06</valUSD>
        <pctVal>0.5595513255</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Epizyme Inc.</name>
        <lei>549300TNFWF88O4U4605</lei>
        <title>EPIZYME INC COMMON STOCK USD.0001</title>
        <cusip>29428V104</cusip>
        <identifiers>
          <isin value="US29428V1044"/>
          <ticker value="EPZM "/>
        </identifiers>
        <balance>11913</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>293059.8</valUSD>
        <pctVal>0.1070013958</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exact Sciences Corporation</name>
        <lei>N/A</lei>
        <title>EXACT SCIENCES CORP COMMON STOCK USD.01</title>
        <cusip>30063P105</cusip>
        <identifiers>
          <isin value="US30063P1057"/>
          <ticker value="EXAS "/>
        </identifiers>
        <balance>24802</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2293688.96</valUSD>
        <pctVal>0.8374670298</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exagen Inc.</name>
        <lei>N/A</lei>
        <title>EXAGEN INC COMMON STOCK USD.001</title>
        <cusip>30068X103</cusip>
        <identifiers>
          <isin value="US30068X1037"/>
          <ticker value="XGN "/>
        </identifiers>
        <balance>9151</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>232435.4</valUSD>
        <pctVal>0.0848663387</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Exelixis Inc.</name>
        <lei>N/A</lei>
        <title>EXELIXIS INC COMMON STOCK USD.001</title>
        <cusip>30161Q104</cusip>
        <identifiers>
          <isin value="US30161Q1040"/>
          <ticker value="EXEL "/>
        </identifiers>
        <balance>40317</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>710385.54</valUSD>
        <pctVal>0.2593745179</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Fate Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>FATE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>31189P102</cusip>
        <identifiers>
          <isin value="US31189P1021"/>
          <ticker value="FATE "/>
        </identifiers>
        <balance>10703</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>209457.71</valUSD>
        <pctVal>0.0764767714</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>FibroGen Inc.</name>
        <lei>549300Q914ULWWY95822</lei>
        <title>FIBROGEN INC COMMON STOCK USD.01</title>
        <cusip>31572Q808</cusip>
        <identifiers>
          <isin value="US31572Q8087"/>
          <ticker value="FGEN "/>
        </identifiers>
        <balance>15647</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>671099.83</valUSD>
        <pctVal>0.2450305997</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Forty Seven Inc.</name>
        <lei>N/A</lei>
        <title>FORTY SEVEN INC COMMON STOCK USD.0001</title>
        <cusip>34983P104</cusip>
        <identifiers>
          <isin value="US34983P1049"/>
          <ticker value="FTSV "/>
        </identifiers>
        <balance>5289</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>208227.93</valUSD>
        <pctVal>0.0760277566</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GW Pharmaceuticals plc</name>
        <lei>N/A</lei>
        <title>GW PHARMACEUTICALS PLC ADR</title>
        <cusip>36197T103</cusip>
        <identifiers>
          <isin value="US36197T1034"/>
          <ticker value="GWPH "/>
        </identifiers>
        <balance>5377</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>562219.12</valUSD>
        <pctVal>0.2052762972</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>G1 Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>G1 THERAPEUTICS INC COMMON STOCK</title>
        <cusip>3621LQ109</cusip>
        <identifiers>
          <isin value="US3621LQ1099"/>
          <ticker value="GTHX "/>
        </identifiers>
        <balance>10107</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>267128.01</valUSD>
        <pctVal>0.0975332336</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>General Electric Company</name>
        <lei>3C7474T6CDKPR9K6YT90</lei>
        <title>GENERAL ELECTRIC CO COMMON STOCK USD.06</title>
        <cusip>369604103</cusip>
        <identifiers>
          <isin value="US3696041033"/>
          <ticker value="GE "/>
        </identifiers>
        <balance>93200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1040112</valUSD>
        <pctVal>0.3797635697</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GenMark Diagnostics Inc.</name>
        <lei>N/A</lei>
        <title>GENMARK DIAGNOSTICS INC COMMON STOCK USD.0001</title>
        <cusip>372309104</cusip>
        <identifiers>
          <isin value="US3723091043"/>
          <ticker value="GNMK "/>
        </identifiers>
        <balance>34260</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>164790.6</valUSD>
        <pctVal>0.0601680074</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Global Blood Therapeutics Inc.</name>
        <lei>549300U4G0QKK99GRT15</lei>
        <title>GLOBAL BLOOD THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>37890U108</cusip>
        <identifiers>
          <isin value="US37890U1088"/>
          <ticker value="GBT "/>
        </identifiers>
        <balance>23537</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1870956.13</valUSD>
        <pctVal>0.6831196821</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Guardant Health Inc.</name>
        <lei>N/A</lei>
        <title>GUARDANT HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
          <ticker value="GH "/>
        </identifiers>
        <balance>6194</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>483999.16</valUSD>
        <pctVal>0.1767167851</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>HCA Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>HCA HEALTHCARE INC COMMON STOCK USD.01</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
          <ticker value="HCA "/>
        </identifiers>
        <balance>35932</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5311108.92</valUSD>
        <pctVal>1.9391812447</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Hologic Inc.</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>HOLOGIC INC COMMON STOCK USD.01</title>
        <cusip>436440101</cusip>
        <identifiers>
          <isin value="US4364401012"/>
          <ticker value="HOLX "/>
        </identifiers>
        <balance>61100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3190031</valUSD>
        <pctVal>1.1647376053</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Homology Medicines Inc.</name>
        <lei>N/A</lei>
        <title>HOMOLOGY MEDICINES INC COMMON STOCK USD.0001</title>
        <cusip>438083107</cusip>
        <identifiers>
          <isin value="US4380831077"/>
          <ticker value="FIXX "/>
        </identifiers>
        <balance>16642</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>344489.4</valUSD>
        <pctVal>0.1257792664</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Humana Inc.</name>
        <lei>N/A</lei>
        <title>HUMANA INC COMMON STOCK USD.166</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
          <ticker value="HUM "/>
        </identifiers>
        <balance>12489</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4577468.28</valUSD>
        <pctVal>1.6713158722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ICU Medical Inc.</name>
        <lei>N/A</lei>
        <title>ICU MEDICAL INC COMMON STOCK USD.1</title>
        <cusip>44930G107</cusip>
        <identifiers>
          <isin value="US44930G1076"/>
          <ticker value="ICUI "/>
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        <balance>4325</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>809294</valUSD>
        <pctVal>0.2954877729</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IGM Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IGM BIOSCIENCES INC COMMON STOCK USD.01</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
          <ticker value="IGMS "/>
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        <balance>7954</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>303524.64</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>iRhythm Technologies Inc.</name>
        <lei>549300FJI72RJGDQS384</lei>
        <title>IRHYTHM TECHNOLOGIES INC COMMON STOCK USD.001</title>
        <cusip>450056106</cusip>
        <identifiers>
          <isin value="US4500561067"/>
          <ticker value="IRTC "/>
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        <balance>6282</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>427741.38</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Illumina Inc.</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>ILLUMINA INC COMMON STOCK USD.01</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
          <ticker value="ILMN "/>
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        <balance>3426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1136541.24</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Immunomedics Inc.</name>
        <lei>5493007ZU7DDO8PSIM59</lei>
        <title>IMMUNOMEDICS INC COMMON STOCK USD.01</title>
        <cusip>452907108</cusip>
        <identifiers>
          <isin value="US4529071080"/>
          <ticker value="IMMU "/>
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        <balance>26669</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>564316.04</valUSD>
        <pctVal>0.2060419203</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Incyte Corporation</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP COMMON STOCK USD.001</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
          <ticker value="INCY "/>
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        <balance>28184</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2461026.88</valUSD>
        <pctVal>0.8985651095</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Insmed Incorporated</name>
        <lei>N/A</lei>
        <title>INSMED INC COMMON STOCK USD.01</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <ticker value="INSM "/>
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        <balance>17417</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>415917.96</valUSD>
        <pctVal>0.1518591163</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Insulet Corporation</name>
        <lei>549300TZTYD2PYN92D43</lei>
        <title>INSULET CORP COMMON STOCK USD.001</title>
        <cusip>45784P101</cusip>
        <identifiers>
          <isin value="US45784P1012"/>
          <ticker value="PODD "/>
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        <balance>6700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1147040</valUSD>
        <pctVal>0.4188049028</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>INTERCEPT PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>45845P108</cusip>
        <identifiers>
          <isin value="US45845P1084"/>
          <ticker value="ICPT "/>
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        <balance>5247</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>650208.24</valUSD>
        <pctVal>0.2374027050</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Intra-Cellular Therapies Inc.</name>
        <lei>N/A</lei>
        <title>INTRA-CELLULAR THERAPIES INC COMMON STOCK USD.0001</title>
        <cusip>46116X101</cusip>
        <identifiers>
          <isin value="US46116X1019"/>
          <ticker value="ITCI "/>
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        <balance>9700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>332807</valUSD>
        <pctVal>0.1215138123</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc.</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
          <ticker value="IONS "/>
        </identifiers>
        <balance>12770</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>771435.7</valUSD>
        <pctVal>0.2816650277</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Iovance Biotherapeutics Inc.</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC COMMON STOCK USD.000041666</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
          <ticker value="IOVA "/>
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        <balance>52314</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1448051.52</valUSD>
        <pctVal>0.5287096144</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kadmon Holdings Inc.</name>
        <lei>N/A</lei>
        <title>KADMON HOLDINGS INC COMMON STOCK USD.001</title>
        <cusip>48283N106</cusip>
        <identifiers>
          <isin value="US48283N1063"/>
          <ticker value="KDMN "/>
        </identifiers>
        <balance>37754</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>171025.62</valUSD>
        <pctVal>0.0624445252</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Karuna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KARUNA THERAPEUTICS INC COMMON STOCK</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
          <ticker value="KRTX "/>
        </identifiers>
        <balance>9447</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>711736.98</valUSD>
        <pctVal>0.2598679529</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Kodiak Sciences Inc.</name>
        <lei>N/A</lei>
        <title>KODIAK SCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>50015M109</cusip>
        <identifiers>
          <isin value="US50015M1099"/>
          <ticker value="KOD "/>
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        <balance>24033</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1729174.35</valUSD>
        <pctVal>0.6313526081</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Krystal Biotech Inc.</name>
        <lei>N/A</lei>
        <title>KRYSTAL BIOTECH INC COMMON STOCK USD.00001</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
          <ticker value="KRYS "/>
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        <balance>7889</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>436892.82</valUSD>
        <pctVal>0.1595174144</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Bayer AG</name>
        <lei>549300J4U55H3WP1XT59</lei>
        <title>BAYER AG COMMON STOCK</title>
        <cusip>506921907</cusip>
        <identifiers>
          <isin value="DE000BAY0017"/>
          <ticker value="BAYN "/>
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        <balance>13412</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.891504"/>
        <valUSD>1090349.9</valUSD>
        <pctVal>0.3981063292</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Lantheus Holdings Inc.</name>
        <lei>N/A</lei>
        <title>LANTHEUS HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
          <ticker value="LNTH "/>
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        <balance>22144</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>454173.44</valUSD>
        <pctVal>0.1658268791</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Eli Lilly and Company</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO COMMON STOCK</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY "/>
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        <balance>35950</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4724908.5</valUSD>
        <pctVal>1.7251489442</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MorphoSys AG</name>
        <lei>N/A</lei>
        <title>MORPHOSYS AG COMMON STOCK</title>
        <cusip>553100900</cusip>
        <identifiers>
          <isin value="DE0006632003"/>
          <ticker value="MOR "/>
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        <balance>2100</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.891504"/>
        <valUSD>297067.38</valUSD>
        <pctVal>0.1084646352</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Evotec SE</name>
        <lei>N/A</lei>
        <title>EVOTEC SE COMMON STOCK</title>
        <cusip>581191905</cusip>
        <identifiers>
          <isin value="DE0005664809"/>
          <ticker value="EVT "/>
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        <balance>14308</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.891504"/>
        <valUSD>368881.64</valUSD>
        <pctVal>0.1346853112</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sartorius AG</name>
        <lei>N/A</lei>
        <title>SARTORIUS AG PREFERENCE</title>
        <cusip>584332902</cusip>
        <identifiers>
          <isin value="DE0007165631"/>
          <ticker value="SRT3 "/>
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        <balance>5386</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.891504"/>
        <valUSD>1151321.14</valUSD>
        <pctVal>0.4203680239</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Merck and Co. Inc.</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK and CO INC COMMON STOCK USD.5</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
          <ticker value="MRK "/>
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        <balance>58816</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5349315.2</valUSD>
        <pctVal>1.9531310436</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mettler-Toledo International Inc.</name>
        <lei>5493000BD5GJNUDIUG10</lei>
        <title>METTLER-TOLEDO INTERNATIONAL I COMMON STOCK USD.01</title>
        <cusip>592688105</cusip>
        <identifiers>
          <isin value="US5926881054"/>
          <ticker value="MTD "/>
        </identifiers>
        <balance>1196</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>948762.88</valUSD>
        <pctVal>0.3464103656</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Milestone Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MILESTONE PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>59935V107</cusip>
        <identifiers>
          <isin value="CA59935V1076"/>
          <ticker value="MIST "/>
        </identifiers>
        <balance>12804</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>204992.04</valUSD>
        <pctVal>0.0748462751</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirati Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MIRATI THERAPEUTICS INC COMMON STOCK</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
          <ticker value="MRTX "/>
        </identifiers>
        <balance>9200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1185512</valUSD>
        <pctVal>0.4328517209</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molina Healthcare Inc.</name>
        <lei>549300NQQCEQ46YHZ591</lei>
        <title>MOLINA HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>60855R100</cusip>
        <identifiers>
          <isin value="US60855R1005"/>
          <ticker value="MOH "/>
        </identifiers>
        <balance>12809</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1738053.21</valUSD>
        <pctVal>0.6345944393</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Momenta Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MOMENTA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>60877T100</cusip>
        <identifiers>
          <isin value="US60877T1007"/>
          <ticker value="MNTA "/>
        </identifiers>
        <balance>20165</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>397855.45</valUSD>
        <pctVal>0.1452641696</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Chugai Pharmaceutical Co. Ltd.</name>
        <lei>N/A</lei>
        <title>CHUGAI PHARMACEUTICAL CO LTD COMMON STOCK</title>
        <cusip>619640006</cusip>
        <identifiers>
          <isin value="JP3519400000"/>
          <ticker value="4519 "/>
        </identifiers>
        <balance>20700</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="108.655"/>
        <valUSD>1906371.32</valUSD>
        <pctVal>0.6960504039</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MyoKardia Inc.</name>
        <lei>549300OLNNNZ1NI9UY54</lei>
        <title>MYOKARDIA INC COMMON STOCK USD.0001</title>
        <cusip>62857M105</cusip>
        <identifiers>
          <isin value="US62857M1053"/>
          <ticker value="MYOK "/>
        </identifiers>
        <balance>14745</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1074689.33</valUSD>
        <pctVal>0.3923883739</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eisai Co. Ltd.</name>
        <lei>N/A</lei>
        <title>EISAI CO LTD COMMON STOCK</title>
        <cusip>630720001</cusip>
        <identifiers>
          <isin value="JP3160400002"/>
          <ticker value="4523 "/>
        </identifiers>
        <balance>7700</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="108.655"/>
        <valUSD>576159.79</valUSD>
        <pctVal>0.2103662861</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nektar Therapeutics</name>
        <lei>N/A</lei>
        <title>NEKTAR THERAPEUTICS COMMON STOCK USD.0001</title>
        <cusip>640268108</cusip>
        <identifiers>
          <isin value="US6402681083"/>
          <ticker value="NKTR "/>
        </identifiers>
        <balance>9600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>207216</valUSD>
        <pctVal>0.0756582828</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Neurocrine Biosciences Inc.</name>
        <lei>549300FECER0XBN49756</lei>
        <title>NEUROCRINE BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
          <ticker value="NBIX "/>
        </identifiers>
        <balance>29764</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3199332.36</valUSD>
        <pctVal>1.1681336989</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nevro Corp.</name>
        <lei>N/A</lei>
        <title>NEVRO CORP COMMON STOCK USD.001</title>
        <cusip>64157F103</cusip>
        <identifiers>
          <isin value="US64157F1030"/>
          <ticker value="NVRO "/>
        </identifiers>
        <balance>12640</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1485705.6</valUSD>
        <pctVal>0.5424577952</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NuVasive Inc.</name>
        <lei>549300C5ZB4NZ6TWM881</lei>
        <title>NUVASIVE INC COMMON STOCK USD.001</title>
        <cusip>670704105</cusip>
        <identifiers>
          <isin value="US6707041058"/>
          <ticker value="NUVA "/>
        </identifiers>
        <balance>2400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>185616</valUSD>
        <pctVal>0.0677717349</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Odonate Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ODONATE THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>676079106</cusip>
        <identifiers>
          <isin value="US6760791060"/>
          <ticker value="ODT "/>
        </identifiers>
        <balance>9305</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>301947.25</valUSD>
        <pctVal>0.1102463634</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Orchard Therapeutics plc</name>
        <lei>N/A</lei>
        <title>ORCHARD THERAPEUTICS PLC ADR</title>
        <cusip>68570P101</cusip>
        <identifiers>
          <isin value="US68570P1012"/>
          <ticker value="ORTX "/>
        </identifiers>
        <balance>25331</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>348301.25</valUSD>
        <pctVal>0.1271710412</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PRA Health Sciences Inc.</name>
        <lei>549300R1HR1VWWHIAK47</lei>
        <title>PRA HEALTH SCIENCES INC COMMON STOCK USD.01</title>
        <cusip>69354M108</cusip>
        <identifiers>
          <isin value="US69354M1080"/>
          <ticker value="PRAH "/>
        </identifiers>
        <balance>7608</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>845629.2</valUSD>
        <pctVal>0.3087544069</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PTC Therapeutics Inc.</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
          <ticker value="PTCT "/>
        </identifiers>
        <balance>23228</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1115640.84</valUSD>
        <pctVal>0.4073405056</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Astellas Pharma Inc.</name>
        <lei>N/A</lei>
        <title>ASTELLAS PHARMA INC COMMON STOCK</title>
        <cusip>698538006</cusip>
        <identifiers>
          <isin value="JP3942400007"/>
          <ticker value="4503 "/>
        </identifiers>
        <balance>59300</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="108.655"/>
        <valUSD>1012249.95</valUSD>
        <pctVal>0.3695906349</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>The Pennant Group Inc.</name>
        <lei>N/A</lei>
        <title>PENNANT GROUP INC/THE COMMON STOCK USD.001</title>
        <cusip>70805E109</cusip>
        <identifiers>
          <isin value="US70805E1091"/>
          <ticker value="PNTG "/>
        </identifiers>
        <balance>11681</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>386290.67</valUSD>
        <pctVal>0.1410416607</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Penumbra Inc.</name>
        <lei>549300RGE06P3ECANU72</lei>
        <title>PENUMBRA INC COMMON STOCK USD.001</title>
        <cusip>70975L107</cusip>
        <identifiers>
          <isin value="US70975L1070"/>
          <ticker value="PEN "/>
        </identifiers>
        <balance>7729</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1269642.83</valUSD>
        <pctVal>0.4635693977</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novartis AG</name>
        <lei>5493007HIVTX6SY6XD66</lei>
        <title>NOVARTIS AG COMMON STOCK CHF.5</title>
        <cusip>710306903</cusip>
        <identifiers>
          <isin value="CH0012005267"/>
          <ticker value="NOVN "/>
        </identifiers>
        <balance>20488</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.9678"/>
        <valUSD>1939999.92</valUSD>
        <pctVal>0.7083288097</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roche Holding AG</name>
        <lei>N/A</lei>
        <title>ROCHE HOLDING AG COMMON STOCK</title>
        <cusip>711038901</cusip>
        <identifiers>
          <isin value="CH0012032048"/>
          <ticker value="ROG "/>
        </identifiers>
        <balance>10104</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.9678"/>
        <valUSD>3283826.81</valUSD>
        <pctVal>1.1989841400</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Phreesia Inc.</name>
        <lei>N/A</lei>
        <title>PHREESIA INC COMMON STOCK USD.001</title>
        <cusip>71944F106</cusip>
        <identifiers>
          <isin value="US71944F1066"/>
          <ticker value="PHR "/>
        </identifiers>
        <balance>6466</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>172254.24</valUSD>
        <pctVal>0.0628931164</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lonza Group AG</name>
        <lei>549300EFW4H2TCZ71055</lei>
        <title>LONZA GROUP AG COMMON STOCK CHF1.0</title>
        <cusip>733337901</cusip>
        <identifiers>
          <isin value="CH0013841017"/>
          <ticker value="LONN "/>
        </identifiers>
        <balance>1949</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.9678"/>
        <valUSD>711009.39</valUSD>
        <pctVal>0.2596022967</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Principia Biopharma Inc.</name>
        <lei>N/A</lei>
        <title>PRINCIPIA BIOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>74257L108</cusip>
        <identifiers>
          <isin value="US74257L1089"/>
          <ticker value="PRNB "/>
        </identifiers>
        <balance>7778</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>426078.84</valUSD>
        <pctVal>0.1555690361</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Progenics Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>PROGENICS PHARMACEUTICALS INC COMMON STOCK USD.0013</title>
        <cusip>743187106</cusip>
        <identifiers>
          <isin value="US7431871067"/>
          <ticker value="PGNX "/>
        </identifiers>
        <balance>36900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>187821</valUSD>
        <pctVal>0.0685768200</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Quanterix Corporation</name>
        <lei>N/A</lei>
        <title>QUANTERIX CORP COMMON STOCK USD.001</title>
        <cusip>74766Q101</cusip>
        <identifiers>
          <isin value="US74766Q1013"/>
          <ticker value="QTRX "/>
        </identifiers>
        <balance>18700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>441881</valUSD>
        <pctVal>0.1613386885</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Quidel Corporation</name>
        <lei>549300X2FQ6S98OQLQ46</lei>
        <title>QUIDEL CORP COMMON STOCK USD.001</title>
        <cusip>74838J101</cusip>
        <identifiers>
          <isin value="US74838J1016"/>
          <ticker value="QDEL "/>
        </identifiers>
        <balance>17829</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1337709.87</valUSD>
        <pctVal>0.4884218964</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Radius Health Inc.</name>
        <lei>549300EV6I2M6E0YVT27</lei>
        <title>RADIUS HEALTH INC COMMON STOCK USD.0001</title>
        <cusip>750469207</cusip>
        <identifiers>
          <isin value="US7504692077"/>
          <ticker value="RDUS "/>
        </identifiers>
        <balance>13791</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>278026.56</valUSD>
        <pctVal>0.1015124899</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>RAPT Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RAPT THERAPEUTICS INC COMMON STOCK</title>
        <cusip>75382E109</cusip>
        <identifiers>
          <isin value="US75382E1091"/>
          <ticker value="RAPT "/>
        </identifiers>
        <balance>8390</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>231647.9</valUSD>
        <pctVal>0.0845788083</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Reata Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>REATA PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75615P103</cusip>
        <identifiers>
          <isin value="US75615P1030"/>
          <ticker value="RETA "/>
        </identifiers>
        <balance>8104</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1656700.72</valUSD>
        <pctVal>0.6048911842</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc.</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
          <ticker value="REGN "/>
        </identifiers>
        <balance>9691</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3638776.68</valUSD>
        <pctVal>1.3285827118</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>REGENXBIO Inc.</name>
        <lei>549300EOES47LATSET33</lei>
        <title>REGENXBIO INC COMMON STOCK USD.0001</title>
        <cusip>75901B107</cusip>
        <identifiers>
          <isin value="US75901B1070"/>
          <ticker value="RGNX "/>
        </identifiers>
        <balance>7500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>307275</valUSD>
        <pctVal>0.1121916206</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</name>
        <lei>N/A</lei>
        <title>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</title>
        <cusip>76105Y109</cusip>
        <identifiers>
          <isin value="US76105Y1091"/>
          <ticker value="76105Y109010"/>
        </identifiers>
        <balance>649003.65</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>649003.65</valUSD>
        <pctVal>0.2369628876</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Rhythm Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>RHYTHM PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
          <ticker value="RYTM "/>
        </identifiers>
        <balance>7891</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>181177.36</valUSD>
        <pctVal>0.0661511078</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc.</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
          <ticker value="RCKT "/>
        </identifiers>
        <balance>19174</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>436400.24</valUSD>
        <pctVal>0.1593375646</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SSC GOVERNMENT MM GVMXX</name>
        <lei>N/A</lei>
        <title>SSC GOVERNMENT MM GVMXX</title>
        <cusip>7839989D1</cusip>
        <identifiers>
          <ticker value="7839989D1010"/>
        </identifiers>
        <balance>500000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>500000</valUSD>
        <pctVal>0.1825589791</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics Inc</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
          <ticker value="SAGE "/>
        </identifiers>
        <balance>22412</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1617922.28</valUSD>
        <pctVal>0.5907324794</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SAREPTA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
          <ticker value="SRPT "/>
        </identifiers>
        <balance>17068</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2202454.72</valUSD>
        <pctVal>0.8041557704</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Seattle Genetics Inc.</name>
        <lei>N/A</lei>
        <title>SEATTLE GENETICS INC COMMON STOCK USD.001</title>
        <cusip>812578102</cusip>
        <identifiers>
          <isin value="US8125781026"/>
          <ticker value="SGEN "/>
        </identifiers>
        <balance>28575</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3264979.5</valUSD>
        <pctVal>1.1921026486</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Shockwave Medical Inc.</name>
        <lei>N/A</lei>
        <title>SHOCKWAVE MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>82489T104</cusip>
        <identifiers>
          <isin value="US82489T1043"/>
          <ticker value="SWAV "/>
        </identifiers>
        <balance>4275</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>187758</valUSD>
        <pctVal>0.0685538176</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Stoke Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STOKE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>86150R107</cusip>
        <identifiers>
          <isin value="US86150R1077"/>
          <ticker value="STOK "/>
        </identifiers>
        <balance>7038</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>199316.16</valUSD>
        <pctVal>0.0727739094</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Tandem Diabetes Care Inc.</name>
        <lei>549300JEPFOD0K4D3I05</lei>
        <title>TANDEM DIABETES CARE INC COMMON STOCK</title>
        <cusip>875372203</cusip>
        <identifiers>
          <isin value="US8753722037"/>
          <ticker value="TNDM "/>
        </identifiers>
        <balance>4400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>262284</valUSD>
        <pctVal>0.0957645986</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Teleflex Incorporated</name>
        <lei>UUL85LWXB4NGSWWXIQ25</lei>
        <title>TELEFLEX INC COMMON STOCK USD1.0</title>
        <cusip>879369106</cusip>
        <identifiers>
          <isin value="US8793691069"/>
          <ticker value="TFX "/>
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        <balance>6435</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2422391.4</valUSD>
        <pctVal>0.8844586019</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>10X Genomics Inc.</name>
        <lei>N/A</lei>
        <title>10X GENOMICS INC COMMON STOCK</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
          <ticker value="TXG "/>
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        <balance>3636</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>277245</valUSD>
        <pctVal>0.1012271283</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tricida Inc.</name>
        <lei>N/A</lei>
        <title>TRICIDA INC COMMON STOCK</title>
        <cusip>89610F101</cusip>
        <identifiers>
          <isin value="US89610F1012"/>
          <ticker value="TCDA "/>
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        <balance>26299</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>992524.26</valUSD>
        <pctVal>0.3623884313</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Turning Point Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>TURNING POINT THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>90041T108</cusip>
        <identifiers>
          <isin value="US90041T1088"/>
          <ticker value="TPTX "/>
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        <balance>7418</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>462067.22</valUSD>
        <pctVal>0.1687090399</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc.</name>
        <lei>N/A</lei>
        <title>ULTRAGENYX PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
          <ticker value="RARE "/>
        </identifiers>
        <balance>16705</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>713470.55</valUSD>
        <pctVal>0.2605009105</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Veeva Systems Inc.</name>
        <lei>549300YZEXPDB92M2F02</lei>
        <title>VEEVA SYSTEMS INC COMMON STOCK USD.00001</title>
        <cusip>922475108</cusip>
        <identifiers>
          <isin value="US9224751084"/>
          <ticker value="VEEV "/>
        </identifiers>
        <balance>4100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>576706</valUSD>
        <pctVal>0.2105657172</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Acerta Pharma B.V.</name>
        <lei>N/A</lei>
        <title>ACERTA PHARMA BV CLASS B PP COMMON STOCK</title>
        <cusip>928WSA908</cusip>
        <identifiers>
          <ticker value="928WSA908"/>
        </identifiers>
        <balance>4276305</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>395985.84</valUSD>
        <pctVal>0.1445815414</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WellCare Health Plans Inc.</name>
        <lei>N/A</lei>
        <title>WELLCARE HEALTH PLANS INC COMMON STOCK USD.01</title>
        <cusip>94946T106</cusip>
        <identifiers>
          <isin value="US94946T1060"/>
          <ticker value="WCG "/>
        </identifiers>
        <balance>2157</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>712262.97</valUSD>
        <pctVal>0.2600600013</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>West Pharmaceutical Services Inc.</name>
        <lei>5493007NKRGM1RJQ1P16</lei>
        <title>WEST PHARMACEUTICAL SERVICES I COMMON STOCK USD.25</title>
        <cusip>955306105</cusip>
        <identifiers>
          <isin value="US9553061055"/>
          <ticker value="WST "/>
        </identifiers>
        <balance>10953</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1646564.49</valUSD>
        <pctVal>0.6011902646</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Warby Parker Retail Inc.</name>
        <lei>N/A</lei>
        <title>JAND INCDBA WARBY PARKER SER SER D CVT PRFD STK PRIV PLCMT</title>
        <cusip>976CZA905</cusip>
        <identifiers>
          <ticker value="976CZA905"/>
        </identifiers>
        <balance>33198</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>602875.68</valUSD>
        <pctVal>0.2201207373</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC COMMON STOCK USD.01</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <ticker value="XNCR "/>
        </identifiers>
        <balance>20834</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>716481.26</valUSD>
        <pctVal>0.2616001747</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zai Lab Limited</name>
        <lei>N/A</lei>
        <title>ZAI LAB LTD ADR USD.00006</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
          <ticker value="ZLAB "/>
        </identifiers>
        <balance>3797</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>157917.23</valUSD>
        <pctVal>0.0576584166</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zimmer Biomet Holdings Inc.</name>
        <lei>2P2YLDVPES3BXQ1FRB91</lei>
        <title>ZIMMER BIOMET HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>98956P102</cusip>
        <identifiers>
          <isin value="US98956P1021"/>
          <ticker value="ZBH "/>
        </identifiers>
        <balance>6550</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>980404</valUSD>
        <pctVal>0.3579631067</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zogenix Inc.</name>
        <lei>54930089H3HF4C32SK78</lei>
        <title>ZOGENIX INC COMMON STOCK USD.001</title>
        <cusip>98978L204</cusip>
        <identifiers>
          <isin value="US98978L2043"/>
          <ticker value="ZGNX "/>
        </identifiers>
        <balance>12583</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>655951.79</valUSD>
        <pctVal>0.2394997782</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zymeworks Inc.</name>
        <lei>N/A</lei>
        <title>ZYMEWORKS INC COMMON STOCK</title>
        <cusip>98985W102</cusip>
        <identifiers>
          <isin value="CA98985W1023"/>
          <ticker value="ZYME "/>
        </identifiers>
        <balance>11869</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>539564.74</valUSD>
        <pctVal>0.1970047762</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Doximity Inc.</name>
        <lei>N/A</lei>
        <title>Doximity Inc. PREFERRED STOCK</title>
        <cusip>ACI087LQ1</cusip>
        <identifiers>
          <ticker value="ACI087LQ1"/>
        </identifiers>
        <balance>31611</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>404620.8</valUSD>
        <pctVal>0.1477343203</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JAND Inc</name>
        <lei>N/A</lei>
        <title>JAND INC. CLASS A COMMON SH COMMON STOCK</title>
        <cusip>ACI0CG2S3</cusip>
        <identifiers>
          <ticker value="ACI0CG2S3"/>
        </identifiers>
        <balance>14867</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>269984.72</valUSD>
        <pctVal>0.0985762697</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alcon Inc.</name>
        <lei>N/A</lei>
        <title>ALCON INC COMMON STOCK CHF.04</title>
        <cusip>ACI198PY5</cusip>
        <identifiers>
          <isin value="CH0432492467"/>
          <ticker value="ALC "/>
        </identifiers>
        <balance>33308</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.9678"/>
        <valUSD>1886618.91</valUSD>
        <pctVal>0.6888384443</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Galapagos NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>GALAPAGOS NV COMMON STOCK</title>
        <cusip>B07Q2V905</cusip>
        <identifiers>
          <isin value="BE0003818359"/>
          <ticker value="GLPG "/>
        </identifiers>
        <balance>4545</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.891504"/>
        <valUSD>946484.87</valUSD>
        <pctVal>0.3455786232</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Daiichi Sankyo Company Limited</name>
        <lei>N/A</lei>
        <title>DAIICHI SANKYO CO LTD COMMON STOCK</title>
        <cusip>B0J7D9901</cusip>
        <identifiers>
          <isin value="JP3475350009"/>
          <ticker value="4568 "/>
        </identifiers>
        <balance>33900</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="108.655"/>
        <valUSD>2238900.05</valUSD>
        <pctVal>0.8174626149</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ipsen SA</name>
        <lei>549300M6SGDPB4Z94P11</lei>
        <title>IPSEN SA COMMON STOCK EUR1.0</title>
        <cusip>B0R7JF902</cusip>
        <identifiers>
          <isin value="FR0010259150"/>
          <ticker value="IPN "/>
        </identifiers>
        <balance>5159</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.891504"/>
        <valUSD>457947.47</valUSD>
        <pctVal>0.1672048452</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DiaSorin S.p.A.</name>
        <lei>N/A</lei>
        <title>DIASORIN SPA COMMON STOCK EUR1.0</title>
        <cusip>B234WN909</cusip>
        <identifiers>
          <isin value="IT0003492391"/>
          <ticker value="DIA "/>
        </identifiers>
        <balance>6689</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.891504"/>
        <valUSD>866278.95</valUSD>
        <pctVal>0.3162940015</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IT</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Abcam plc</name>
        <lei>N/A</lei>
        <title>ABCAM PLC COMMON STOCK GBP.002</title>
        <cusip>B67746907</cusip>
        <identifiers>
          <isin value="GB00B6774699"/>
          <ticker value="ABC "/>
        </identifiers>
        <balance>25909</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.754945"/>
        <valUSD>464955.47</valUSD>
        <pctVal>0.1697635919</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Wuxi Biologics (Cayman) Inc.</name>
        <lei>N/A</lei>
        <title>WUXI BIOLOGICS CAYMAN INC COMMON STOCK USD.000025</title>
        <cusip>BZ3C3R901</cusip>
        <identifiers>
          <isin value="KYG970081090"/>
          <ticker value="2269 "/>
        </identifiers>
        <balance>29500</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.7923"/>
        <valUSD>373630.49</valUSD>
        <pctVal>0.1364192016</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes Public Limited Company</name>
        <lei>549300YHRMYLL071E243</lei>
        <title>ALKERMES PLC COMMON STOCK USD.01</title>
        <cusip>G01767105</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
          <ticker value="ALKS "/>
        </identifiers>
        <balance>19633</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>400513.2</valUSD>
        <pctVal>0.1462345618</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NovoCure Limited</name>
        <lei>N/A</lei>
        <title>NOVOCURE LTD COMMON STOCK</title>
        <cusip>G6674U108</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
          <ticker value="NVCR "/>
        </identifiers>
        <balance>9976</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>840677.52</valUSD>
        <pctVal>0.3069464596</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CRISPR Therapeutics AG</name>
        <lei>N/A</lei>
        <title>CRISPR THERAPEUTICS AG COMMON STOCK CHF.03</title>
        <cusip>H17182108</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
          <ticker value="CRSP "/>
        </identifiers>
        <balance>5214</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>317558.67</valUSD>
        <pctVal>0.1159463732</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Akero Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>AKERO THERAPEUTICS INC COMMON STOCK</title>
        <cusip>00973Y108</cusip>
        <identifiers>
          <isin value="US00973Y1082"/>
          <ticker value="AKRO "/>
        </identifiers>
        <balance>4103</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>91066.09</valUSD>
        <pctVal>0.0332498648</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Assembly Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>ASSEMBLY BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>045396108</cusip>
        <identifiers>
          <isin value="US0453961080"/>
          <ticker value="ASMB "/>
        </identifiers>
        <balance>6774</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>138596.04</valUSD>
        <pctVal>0.0506039031</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Autolus Therapeutics plc</name>
        <lei>N/A</lei>
        <title>AUTOLUS THERAPEUTICS PLC ADR GBP.0000001</title>
        <cusip>05280R100</cusip>
        <identifiers>
          <isin value="US05280R1005"/>
          <ticker value="AUTL "/>
        </identifiers>
        <balance>6426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>84823.2</valUSD>
        <pctVal>0.0309704736</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AVROBIO Inc.</name>
        <lei>N/A</lei>
        <title>AVROBIO INC COMMON STOCK USD.0001</title>
        <cusip>05455M100</cusip>
        <identifiers>
          <isin value="US05455M1009"/>
          <ticker value="AVRO "/>
        </identifiers>
        <balance>4793</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>96483.09</valUSD>
        <pctVal>0.0352277088</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ChemoCentryx Inc.</name>
        <lei>N/A</lei>
        <title>CHEMOCENTRYX INC COMMON STOCK USD.001</title>
        <cusip>16383L106</cusip>
        <identifiers>
          <isin value="US16383L1061"/>
          <ticker value="CCXI "/>
        </identifiers>
        <balance>800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31640</valUSD>
        <pctVal>0.0115523322</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cortexyme Inc.</name>
        <lei>N/A</lei>
        <title>CORTEXYME INC COMMON STOCK USD.001</title>
        <cusip>22053A107</cusip>
        <identifiers>
          <isin value="US22053A1079"/>
          <ticker value="CRTX "/>
        </identifiers>
        <balance>900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50526</valUSD>
        <pctVal>0.0184479500</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gritstone Oncology Inc.</name>
        <lei>N/A</lei>
        <title>GRITSTONE ONCOLOGY INC COMMON STOCK USD.0001</title>
        <cusip>39868T105</cusip>
        <identifiers>
          <isin value="US39868T1051"/>
          <ticker value="GRTS "/>
        </identifiers>
        <balance>3200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28704</valUSD>
        <pctVal>0.0104803459</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HTG Molecular Diagnostics Inc.</name>
        <lei>5493001QFG6NIN60NK56</lei>
        <title>HTG MOLECULAR DIAGNOSTICS INC COMMON STOCK USD.001</title>
        <cusip>40434H104</cusip>
        <identifiers>
          <isin value="US40434H1041"/>
          <ticker value="HTGM "/>
        </identifiers>
        <balance>34959</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>24537.72</valUSD>
        <pctVal>0.0089591622</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Karyopharm Therapeutics Inc.</name>
        <lei>549300J1VANRCNTYST87</lei>
        <title>KARYOPHARM THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>48576U106</cusip>
        <identifiers>
          <isin value="US48576U1060"/>
          <ticker value="KPTI "/>
        </identifiers>
        <balance>1500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>28755</valUSD>
        <pctVal>0.0104989669</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Menlo Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MENLO THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>586858102</cusip>
        <identifiers>
          <isin value="US5868581027"/>
          <ticker value="MNLO "/>
        </identifiers>
        <balance>9800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>45472</valUSD>
        <pctVal>0.0166026438</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Minerva Neurosciences Inc.</name>
        <lei>54930017PANCHC5LYH79</lei>
        <title>MINERVA NEUROSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>603380106</cusip>
        <identifiers>
          <isin value="US6033801068"/>
          <ticker value="NERV "/>
        </identifiers>
        <balance>19876</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>141318.36</valUSD>
        <pctVal>0.0515978711</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Moderna Inc.</name>
        <lei>N/A</lei>
        <title>MODERNA INC COMMON STOCK USD.0001</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
          <ticker value="MRNA "/>
        </identifiers>
        <balance>2184</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42719.04</valUSD>
        <pctVal>0.0155974887</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Option Care Health Inc.</name>
        <lei>549300DI3Q5ACSYJRI17</lei>
        <title>OPTION CARE HEALTH INC COMMON STOCK USD.0001</title>
        <cusip>68404L102</cusip>
        <identifiers>
          <isin value="US68404L1026"/>
          <ticker value="BIOS"/>
        </identifiers>
        <balance>12452</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>46445.96</valUSD>
        <pctVal>0.0169582541</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>PhaseBio Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>PHASEBIO PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>717224109</cusip>
        <identifiers>
          <isin value="US7172241090"/>
          <ticker value="PHAS "/>
        </identifiers>
        <balance>15205</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>92902.55</valUSD>
        <pctVal>0.0339203894</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Puma Biotechnology Inc.</name>
        <lei>N/A</lei>
        <title>PUMA BIOTECHNOLOGY INC COMMON STOCK USD.0001</title>
        <cusip>74587V107</cusip>
        <identifiers>
          <isin value="US74587V1070"/>
          <ticker value="PBYI "/>
        </identifiers>
        <balance>11400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>99750</valUSD>
        <pctVal>0.0364205163</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Relmada Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RELMADA THERAPEUTICS INC COMMON STOCK</title>
        <cusip>75955J402</cusip>
        <identifiers>
          <isin value="US75955J4022"/>
          <ticker value="RLMD "/>
        </identifiers>
        <balance>2109</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>82251</valUSD>
        <pctVal>0.0300313172</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corporation</name>
        <lei>N/A</lei>
        <title>SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK "/>
        </identifiers>
        <balance>5587</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>73636.66</valUSD>
        <pctVal>0.0268860669</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SI-BONE Inc.</name>
        <lei>N/A</lei>
        <title>SI-BONE INC COMMON STOCK USD.0001</title>
        <cusip>825704109</cusip>
        <identifiers>
          <isin value="US8257041090"/>
          <ticker value="SIBN "/>
        </identifiers>
        <balance>5610</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>120615</valUSD>
        <pctVal>0.0440387025</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Silk Road Medical Inc.</name>
        <lei>N/A</lei>
        <title>SILK ROAD MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>82710M100</cusip>
        <identifiers>
          <isin value="US82710M1009"/>
          <ticker value="SILK "/>
        </identifiers>
        <balance>1823</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>73612.74</valUSD>
        <pctVal>0.0268773333</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SmileDirectClub Inc.</name>
        <lei>N/A</lei>
        <title>SMILEDIRECTCLUB INC COMMON STOCK</title>
        <cusip>83192H106</cusip>
        <identifiers>
          <isin value="US83192H1068"/>
          <ticker value="SDC "/>
        </identifiers>
        <balance>6427</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>56171.98</valUSD>
        <pctVal>0.0205093986</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Supernus Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>SUPERNUS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>868459108</cusip>
        <identifiers>
          <isin value="US8684591089"/>
          <ticker value="SUPN "/>
        </identifiers>
        <balance>601</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14255.72</valUSD>
        <pctVal>0.0052050194</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Translate Bio Inc.</name>
        <lei>N/A</lei>
        <title>TRANSLATE BIO INC COMMON STOCK USD.001</title>
        <cusip>89374L104</cusip>
        <identifiers>
          <isin value="US89374L1044"/>
          <ticker value="TBIO "/>
        </identifiers>
        <balance>2800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>22792</valUSD>
        <pctVal>0.0083217685</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zealand Pharma A/S</name>
        <lei>549300ITBB1ULBL4CZ12</lei>
        <title>ZEALAND PHARMA A/S ADR</title>
        <cusip>98920Y304</cusip>
        <identifiers>
          <isin value="US98920Y3045"/>
          <ticker value="ZEAL "/>
        </identifiers>
        <balance>3482</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>115602.4</valUSD>
        <pctVal>0.0422085123</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zeneca Inc.</name>
        <lei>N/A</lei>
        <title>Zeneca Inc. Contingent Value COMMON STOCK</title>
        <cusip>ACI06HJ35</cusip>
        <identifiers>
          <ticker value="ACI06HJ35"/>
        </identifiers>
        <balance>13151</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8087.87</valUSD>
        <pctVal>0.0029530266</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Otsuka Holdings Co. Ltd.</name>
        <lei>N/A</lei>
        <title>OTSUKA HOLDINGS CO LTD COMMON STOCK</title>
        <cusip>B5LTM9909</cusip>
        <identifiers>
          <isin value="JP3188220002"/>
          <ticker value="4578 "/>
        </identifiers>
        <balance>2900</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="108.655"/>
        <valUSD>129265.28</valUSD>
        <pctVal>0.0471970751</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Myovant Sciences Ltd.</name>
        <lei>N/A</lei>
        <title>MYOVANT SCIENCES LTD COMMON STOCK USD.000017727</title>
        <cusip>G637AM102</cusip>
        <identifiers>
          <isin value="BMG637AM1024"/>
          <ticker value="MYOV "/>
        </identifiers>
        <balance>169</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2622.88</valUSD>
        <pctVal>0.0009576606</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Perrigo Company Public Limited Company</name>
        <lei>549300IFOQS6R1QLY196</lei>
        <title>PERRIGO CO PLC COMMON STOCK EUR.001</title>
        <cusip>G97822103</cusip>
        <identifiers>
          <isin value="IE00BGH1M568"/>
          <ticker value="PRGO "/>
        </identifiers>
        <balance>267</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13793.22</valUSD>
        <pctVal>0.0050361523</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Qiagen N.V.</name>
        <lei>54930036WK3GMCN17Z57</lei>
        <title>QIAGEN NV COMMON STOCK EUR.01</title>
        <cusip>N72482123</cusip>
        <identifiers>
          <isin value="NL0012169213"/>
          <ticker value="QGEN "/>
        </identifiers>
        <balance>4600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>155480</valUSD>
        <pctVal>0.0567685401</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>uniQure N.V.</name>
        <lei>N/A</lei>
        <title>UNIQURE NV COMMON STOCK EUR.05</title>
        <cusip>N90064101</cusip>
        <identifiers>
          <isin value="NL0010696654"/>
          <ticker value="QURE "/>
        </identifiers>
        <balance>1500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>107490</valUSD>
        <pctVal>0.0392465293</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>WaVe Life Sciences Ltd.</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD COMMON STOCK</title>
        <cusip>Y95308105</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
          <ticker value="WVE "/>
        </identifiers>
        <balance>5914</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47400.71</valUSD>
        <pctVal>0.0173068505</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amgen Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC COMMON STOCK USD.0001</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
          <ticker value="AMGN "/>
        </identifiers>
        <balance>27600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6653532</valUSD>
        <pctVal>2.4293240187</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Becton Dickinson and Company</name>
        <lei>ICE2EP6D98PQUILVRZ91</lei>
        <title>BECTON DICKINSON AND CO COMMON STOCK USD1.0</title>
        <cusip>075887109</cusip>
        <identifiers>
          <isin value="US0758871091"/>
          <ticker value="BDX "/>
        </identifiers>
        <balance>41808</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11370521.76</valUSD>
        <pctVal>4.1515816888</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intuitive Surgical Inc.</name>
        <lei>54930052SRG011710797</lei>
        <title>INTUITIVE SURGICAL INC COMMON STOCK USD.001</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
          <ticker value="ISRG "/>
        </identifiers>
        <balance>21660</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12804309</valUSD>
        <pctVal>4.6750831583</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>STRYKER CORP COMMON STOCK USD.1</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
          <ticker value="SYK "/>
        </identifiers>
        <balance>33309</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6992891.46</valUSD>
        <pctVal>2.5532302518</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Thermo Fisher Scientific Inc.</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO "/>
        </identifiers>
        <balance>32100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10428327</valUSD>
        <pctVal>3.8075694618</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Unitedhealth Group Incorporated</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC COMMON STOCK USD.01</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNHN "/>
        </identifiers>
        <balance>50019</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14704585.62</valUSD>
        <pctVal>5.3689082779</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX "/>
        </identifiers>
        <balance>52257</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>11441670.15</valUSD>
        <pctVal>4.1775592436</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Returns are reported without deduction of sales loads and redemption fees, if applicable." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2020-01-30</ncom:dateSigned>
      <ncom:nameOfApplicant>John Hancock Variable Insurance Trust</ncom:nameOfApplicant>
      <ncom:signature>/s/Salvatore Schiavone</ncom:signature>
      <ncom:signerName>Salvatore Schiavone</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
