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        <valUSD>248526.59</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>FibroGen Inc.</name>
        <lei>549300Q914ULWWY95822</lei>
        <title>FIBROGEN INC COMMON STOCK USD.01</title>
        <cusip>31572Q808</cusip>
        <identifiers>
          <isin value="US31572Q8087"/>
          <ticker value="FGEN "/>
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        <balance>18847</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>696962.06</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Forty Seven Inc.</name>
        <lei>N/A</lei>
        <title>FORTY SEVEN INC COMMON STOCK USD.0001</title>
        <cusip>34983P104</cusip>
        <identifiers>
          <isin value="US34983P1049"/>
          <ticker value="FTSV "/>
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        <balance>5322</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>34167.24</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>GW Pharmaceuticals PLC</name>
        <lei>N/A</lei>
        <title>GW PHARMACEUTICALS PLC ADR</title>
        <cusip>36197T103</cusip>
        <identifiers>
          <isin value="US36197T1034"/>
          <ticker value="GWPH "/>
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        <balance>3977</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>457474.31</valUSD>
        <pctVal>0.1711002159</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>G1 Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>G1 THERAPEUTICS INC COMMON STOCK</title>
        <cusip>3621LQ109</cusip>
        <identifiers>
          <isin value="US3621LQ1099"/>
          <ticker value="GTHX "/>
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        <balance>12307</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>280353.46</valUSD>
        <pctVal>0.1048551503</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>General Electric Company</name>
        <lei>3C7474T6CDKPR9K6YT90</lei>
        <title>GENERAL ELECTRIC CO COMMON STOCK USD.06</title>
        <cusip>369604103</cusip>
        <identifiers>
          <isin value="US3696041033"/>
          <ticker value="GE "/>
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        <balance>97200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>868968</valUSD>
        <pctVal>0.3250031951</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Genmab A/S</name>
        <lei>N/A</lei>
        <title>GENMAB A/S ADR</title>
        <cusip>372303206</cusip>
        <identifiers>
          <isin value="US3723032062"/>
          <ticker value="GMAB "/>
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        <balance>10918</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>221198.68</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>GenMark Diagnostics Inc.</name>
        <lei>N/A</lei>
        <title>GENMARK DIAGNOSTICS INC COMMON STOCK USD.0001</title>
        <cusip>372309104</cusip>
        <identifiers>
          <isin value="US3723091043"/>
          <ticker value="GNMK "/>
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        <balance>51460</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>311847.6</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Global Blood Therapeutics Inc.</name>
        <lei>549300U4G0QKK99GRT15</lei>
        <title>GLOBAL BLOOD THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>37890U108</cusip>
        <identifiers>
          <isin value="US37890U1088"/>
          <ticker value="GBT "/>
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        <balance>18037</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>875155.24</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Guardant Health Inc.</name>
        <lei>N/A</lei>
        <title>GUARDANT HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
          <ticker value="GH "/>
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        <balance>6194</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>395363.02</valUSD>
        <pctVal>0.1478699385</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>HCA Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>HCA HEALTHCARE INC COMMON STOCK USD.01</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
          <ticker value="HCA "/>
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        <balance>43943</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5291616.06</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>HTG Molecular Diagnostics Inc.</name>
        <lei>5493001QFG6NIN60NK56</lei>
        <title>HTG MOLECULAR DIAGNOSTICS INC COMMON STOCK USD.001</title>
        <cusip>40434H104</cusip>
        <identifiers>
          <isin value="US40434H1041"/>
          <ticker value="HTGM "/>
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        <balance>34959</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23772.12</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Hologic Inc.</name>
        <lei>549300DYP6F5ZJL0LB74</lei>
        <title>HOLOGIC INC COMMON STOCK USD.01</title>
        <cusip>436440101</cusip>
        <identifiers>
          <isin value="US4364401012"/>
          <ticker value="HOLX "/>
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        <balance>74600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3766554</valUSD>
        <pctVal>1.4087309138</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Homology Medicines Inc.</name>
        <lei>N/A</lei>
        <title>HOMOLOGY MEDICINES INC COMMON STOCK USD.0001</title>
        <cusip>438083107</cusip>
        <identifiers>
          <isin value="US4380831077"/>
          <ticker value="FIXX "/>
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        <balance>18462</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>334162.2</valUSD>
        <pctVal>0.1249801865</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Humana Inc.</name>
        <lei>N/A</lei>
        <title>HUMANA INC COMMON STOCK USD.166</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
          <ticker value="HUM "/>
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        <balance>14089</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3602134.63</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ICU Medical Inc.</name>
        <lei>N/A</lei>
        <title>ICU MEDICAL INC COMMON STOCK USD.1</title>
        <cusip>44930G107</cusip>
        <identifiers>
          <isin value="US44930G1076"/>
          <ticker value="ICUI "/>
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        <balance>6225</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>993510</valUSD>
        <pctVal>0.3715832164</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IGM Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IGM BIOSCIENCES INC COMMON STOCK USD.01</title>
        <cusip>449585108</cusip>
        <identifiers>
          <isin value="US4495851085"/>
          <ticker value="IGMS "/>
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        <balance>7954</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>141183.5</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>iRhythm Technologies Inc.</name>
        <lei>549300FJI72RJGDQS384</lei>
        <title>IRHYTHM TECHNOLOGIES INC COMMON STOCK USD.001</title>
        <cusip>450056106</cusip>
        <identifiers>
          <isin value="US4500561067"/>
          <ticker value="IRTC "/>
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        <balance>6282</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>465559.02</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IDEXX Laboratories Inc.</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX LABORATORIES INC COMMON STOCK USD.1</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
          <ticker value="IDXX "/>
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        <balance>900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>244737</valUSD>
        <pctVal>0.0915342187</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Illumina Inc.</name>
        <lei>SQ95QG8SR5Q56LSNF682</lei>
        <title>ILLUMINA INC COMMON STOCK USD.01</title>
        <cusip>452327109</cusip>
        <identifiers>
          <isin value="US4523271090"/>
          <ticker value="ILMN "/>
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        <balance>5026</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1529009.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Immunomedics Inc.</name>
        <lei>5493007ZU7DDO8PSIM59</lei>
        <title>IMMUNOMEDICS INC COMMON STOCK USD.01</title>
        <cusip>452907108</cusip>
        <identifiers>
          <isin value="US4529071080"/>
          <ticker value="IMMU "/>
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        <balance>38038</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>504383.88</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Incyte Corporation</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP COMMON STOCK USD.001</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
          <ticker value="INCY "/>
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        <balance>31784</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2359326.32</valUSD>
        <pctVal>0.8824129224</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Insmed Incorporated</name>
        <lei>N/A</lei>
        <title>INSMED INC COMMON STOCK USD.01</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <ticker value="INSM "/>
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        <balance>24817</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>437771.88</valUSD>
        <pctVal>0.1637312994</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Insulet Corporation</name>
        <lei>549300TZTYD2PYN92D43</lei>
        <title>INSULET CORP COMMON STOCK USD.001</title>
        <cusip>45784P101</cusip>
        <identifiers>
          <isin value="US45784P1012"/>
          <ticker value="PODD "/>
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        <balance>9600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1583328</valUSD>
        <pctVal>0.5921813680</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Integer Holdings Corporation</name>
        <lei>549300SUD2ED5XG6X569</lei>
        <title>INTEGER HOLDINGS CORP COMMON STOCK USD.001</title>
        <cusip>45826H109</cusip>
        <identifiers>
          <isin value="US45826H1095"/>
          <ticker value="ITGR "/>
        </identifiers>
        <balance>4000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>302240</valUSD>
        <pctVal>0.1130409471</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Intercept Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>INTERCEPT PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>45845P108</cusip>
        <identifiers>
          <isin value="US45845P1084"/>
          <ticker value="ICPT "/>
        </identifiers>
        <balance>3547</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>235378.92</valUSD>
        <pctVal>0.0880341981</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Intuitive Surgical Inc.</name>
        <lei>54930052SRG011710797</lei>
        <title>INTUITIVE SURGICAL INC COMMON STOCK USD.001</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
          <ticker value="ISRG "/>
        </identifiers>
        <balance>27201</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14686635.93</valUSD>
        <pctVal>5.4929567063</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc.</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
          <ticker value="IONS "/>
        </identifiers>
        <balance>16770</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1004690.7</valUSD>
        <pctVal>0.3757649161</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Iovance Biotherapeutics Inc.</name>
        <lei>549300220Z2GHH33XL82</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC COMMON STOCK USD.000041666</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
          <ticker value="IOVA "/>
        </identifiers>
        <balance>63234</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1150858.8</valUSD>
        <pctVal>0.4304333268</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Karuna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KARUNA THERAPEUTICS INC COMMON STOCK</title>
        <cusip>48576A100</cusip>
        <identifiers>
          <isin value="US48576A1007"/>
          <ticker value="KRTX "/>
        </identifiers>
        <balance>8436</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>137675.52</valUSD>
        <pctVal>0.0514920962</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Kodiak Sciences Inc.</name>
        <lei>N/A</lei>
        <title>KODIAK SCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>50015M109</cusip>
        <identifiers>
          <isin value="US50015M1099"/>
          <ticker value="KOD "/>
        </identifiers>
        <balance>6072</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>87315.36</valUSD>
        <pctVal>0.0326568654</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Krystal Biotech Inc.</name>
        <lei>N/A</lei>
        <title>KRYSTAL BIOTECH INC COMMON STOCK USD.00001</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
          <ticker value="KRYS "/>
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        <balance>7889</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>273945.53</valUSD>
        <pctVal>0.1024585169</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bayer AG</name>
        <lei>549300J4U55H3WP1XT59</lei>
        <title>BAYER AG COMMON STOCK</title>
        <cusip>506921907</cusip>
        <identifiers>
          <isin value="DE000BAY0017"/>
          <ticker value="BAYN "/>
        </identifiers>
        <balance>14769</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.917473"/>
        <valUSD>1040521</valUSD>
        <pctVal>0.3891658261</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lantheus Holdings Inc.</name>
        <lei>N/A</lei>
        <title>LANTHEUS HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
          <ticker value="LNTH "/>
        </identifiers>
        <balance>22144</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>555039.36</valUSD>
        <pctVal>0.2075905734</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly and Company</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO COMMON STOCK</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY "/>
        </identifiers>
        <balance>25250</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2823707.5</valUSD>
        <pctVal>1.0560963806</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Masimo Corporation</name>
        <lei>549300Q4A8JK0PIYCU29</lei>
        <title>MASIMO CORP COMMON STOCK USD.001</title>
        <cusip>574795100</cusip>
        <identifiers>
          <isin value="US5747951003"/>
          <ticker value="MASI "/>
        </identifiers>
        <balance>2300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>342217</valUSD>
        <pctVal>0.1279927666</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Menlo Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MENLO THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>586858102</cusip>
        <identifiers>
          <isin value="US5868581027"/>
          <ticker value="MNLO "/>
        </identifiers>
        <balance>9800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>43904</valUSD>
        <pctVal>0.0164205590</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Merck and Co. Inc.</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK and CO INC COMMON STOCK USD.5</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
          <ticker value="MRK "/>
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        <balance>56917</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4791273.06</valUSD>
        <pctVal>1.7919866477</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</name>
        <lei>N/A</lei>
        <title>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</title>
        <cusip>76105Y109</cusip>
        <identifiers>
          <isin value="US76105Y1091"/>
          <ticker value="76105Y109010"/>
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        <balance>1821530.7</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1821530.7</valUSD>
        <pctVal>0.6812716896</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SSC GOVERNMENT MM GVMXX</name>
        <lei>N/A</lei>
        <title>SSC GOVERNMENT MM GVMXX</title>
        <cusip>7839989D1</cusip>
        <identifiers>
          <ticker value="7839989D1010"/>
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        <balance>532028.62</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>532028.62</valUSD>
        <pctVal>0.1989843140</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Mettler-Toledo International Inc.</name>
        <lei>5493000BD5GJNUDIUG10</lei>
        <title>METTLER-TOLEDO INTERNATIONAL I COMMON STOCK USD.01</title>
        <cusip>592688105</cusip>
        <identifiers>
          <isin value="US5926881054"/>
          <ticker value="MTD "/>
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        <balance>1496</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1053782.4</valUSD>
        <pctVal>0.3941257296</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Milestone Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MILESTONE PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>59935V107</cusip>
        <identifiers>
          <isin value="CA59935V1076"/>
          <ticker value="MIST "/>
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        <balance>12804</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>221509.2</valUSD>
        <pctVal>0.0828467766</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Minerva Neurosciences Inc.</name>
        <lei>54930017PANCHC5LYH79</lei>
        <title>MINERVA NEUROSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>603380106</cusip>
        <identifiers>
          <isin value="US6033801068"/>
          <ticker value="NERV "/>
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        <balance>19876</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>154039</valUSD>
        <pctVal>0.0576122103</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Mirati Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MIRATI THERAPEUTICS INC COMMON STOCK</title>
        <cusip>60468T105</cusip>
        <identifiers>
          <isin value="US60468T1051"/>
          <ticker value="MRTX "/>
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        <balance>11100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>864801</valUSD>
        <pctVal>0.3234446932</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Moderna Inc.</name>
        <lei>N/A</lei>
        <title>MODERNA INC COMMON STOCK USD.0001</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
          <ticker value="MRNA "/>
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        <balance>7348</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>116980.16</valUSD>
        <pctVal>0.0437518134</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molina Healthcare Inc.</name>
        <lei>549300NQQCEQ46YHZ591</lei>
        <title>MOLINA HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>60855R100</cusip>
        <identifiers>
          <isin value="US60855R1005"/>
          <ticker value="MOH "/>
        </identifiers>
        <balance>15009</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1646787.48</valUSD>
        <pctVal>0.6159158827</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Momenta Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MOMENTA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>60877T100</cusip>
        <identifiers>
          <isin value="US60877T1007"/>
          <ticker value="MNTA "/>
        </identifiers>
        <balance>18439</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>238969.44</valUSD>
        <pctVal>0.0893770905</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Chugai Pharmaceutical Co. Ltd.</name>
        <lei>N/A</lei>
        <title>CHUGAI PHARMACEUTICAL CO LTD COMMON STOCK</title>
        <cusip>619640006</cusip>
        <identifiers>
          <isin value="JP3519400000"/>
          <ticker value="4519 "/>
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        <balance>18800</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="108.125"/>
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        <pctVal>0.5494837482</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>MyoKardia Inc.</name>
        <lei>549300OLNNNZ1NI9UY54</lei>
        <title>MYOKARDIA INC COMMON STOCK USD.0001</title>
        <cusip>62857M105</cusip>
        <identifiers>
          <isin value="US62857M1053"/>
          <ticker value="MYOK "/>
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        <balance>17145</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>894111.75</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Natera Inc.</name>
        <lei>N/A</lei>
        <title>NATERA INC COMMON STOCK USD.0001</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
          <ticker value="NTRA "/>
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        <balance>5800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>190240</valUSD>
        <pctVal>0.0711517661</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Nektar Therapeutics</name>
        <lei>N/A</lei>
        <title>NEKTAR THERAPEUTICS COMMON STOCK USD.0001</title>
        <cusip>640268108</cusip>
        <identifiers>
          <isin value="US6402681083"/>
          <ticker value="NKTR "/>
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        <balance>13200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>240438</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Neoleukin Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>NEOLEUKIN THERAPEUTICS INC COMMON STOCK</title>
        <cusip>64049K104</cusip>
        <identifiers>
          <isin value="US64049K1043"/>
          <ticker value="NLTX"/>
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        <balance>7366</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>20993.1</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Neurocrine Biosciences Inc.</name>
        <lei>549300FECER0XBN49756</lei>
        <title>NEUROCRINE BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>64125C109</cusip>
        <identifiers>
          <isin value="US64125C1099"/>
          <ticker value="NBIX "/>
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        <balance>32664</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2943353.04</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Nevro Corp.</name>
        <lei>N/A</lei>
        <title>NEVRO CORP COMMON STOCK USD.001</title>
        <cusip>64157F103</cusip>
        <identifiers>
          <isin value="US64157F1030"/>
          <ticker value="NVRO "/>
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        <balance>15640</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1344570.8</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>NuVasive Inc.</name>
        <lei>549300C5ZB4NZ6TWM881</lei>
        <title>NUVASIVE INC COMMON STOCK USD.001</title>
        <cusip>670704105</cusip>
        <identifiers>
          <isin value="US6707041058"/>
          <ticker value="NUVA "/>
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        <balance>2900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>183802</valUSD>
        <pctVal>0.0687438862</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Odonate Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ODONATE THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>676079106</cusip>
        <identifiers>
          <isin value="US6760791060"/>
          <ticker value="ODT "/>
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        <balance>9305</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>242209.15</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Orchard Therapeutics PLC</name>
        <lei>N/A</lei>
        <title>ORCHARD THERAPEUTICS PLC ADR</title>
        <cusip>68570P101</cusip>
        <identifiers>
          <isin value="US68570P1012"/>
          <ticker value="ORTX "/>
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        <balance>25331</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>300932.28</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PRA Health Sciences Inc.</name>
        <lei>549300R1HR1VWWHIAK47</lei>
        <title>PRA HEALTH SCIENCES INC COMMON STOCK USD.01</title>
        <cusip>69354M108</cusip>
        <identifiers>
          <isin value="US69354M1080"/>
          <ticker value="PRAH "/>
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        <balance>8600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>853378</valUSD>
        <pctVal>0.3191723707</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PTC Therapeutics Inc.</name>
        <lei>549300UJLWOIWFDGB318</lei>
        <title>PTC THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>69366J200</cusip>
        <identifiers>
          <isin value="US69366J2006"/>
          <ticker value="PTCT "/>
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        <balance>25787</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>872116.34</valUSD>
        <pctVal>0.3261807075</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Patterson Companies Inc.</name>
        <lei>YM48Q2087CUE26GWEK09</lei>
        <title>PATTERSON COS INC COMMON STOCK USD.01</title>
        <cusip>703395103</cusip>
        <identifiers>
          <isin value="US7033951036"/>
          <ticker value="PDCO "/>
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        <balance>3386</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>60338.52</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      <invstOrSec>
        <name>Penumbra Inc.</name>
        <lei>549300RGE06P3ECANU72</lei>
        <title>PENUMBRA INC COMMON STOCK USD.001</title>
        <cusip>70975L107</cusip>
        <identifiers>
          <isin value="US70975L1070"/>
          <ticker value="PEN "/>
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        <balance>8929</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1200861.21</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Novartis AG</name>
        <lei>5493007HIVTX6SY6XD66</lei>
        <title>NOVARTIS AG COMMON STOCK CHF.5</title>
        <cusip>710306903</cusip>
        <identifiers>
          <isin value="CH0012005267"/>
          <ticker value="NOVN "/>
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        <balance>32561</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.99805"/>
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        <pctVal>1.0569050924</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Roche Holding AG</name>
        <lei>N/A</lei>
        <title>ROCHE HOLDING AG COMMON STOCK</title>
        <cusip>711038901</cusip>
        <identifiers>
          <isin value="CH0012032048"/>
          <ticker value="ROG "/>
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        <balance>11199</balance>
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        <currencyConditional curCd="CHF" exchangeRt="0.99805"/>
        <valUSD>3260750.65</valUSD>
        <pctVal>1.2195551272</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Pfizer Inc.</name>
        <lei>765LHXWGK1KXCLTFYQ30</lei>
        <title>PFIZER INC COMMON STOCK USD.05</title>
        <cusip>717081103</cusip>
        <identifiers>
          <isin value="US7170811035"/>
          <ticker value="PFE "/>
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        <balance>80411</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2889167.23</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>PhaseBio Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>PHASEBIO PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>717224109</cusip>
        <identifiers>
          <isin value="US7172241090"/>
          <ticker value="PHAS "/>
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        <balance>15205</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>63404.85</valUSD>
        <pctVal>0.0237140825</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Wuxi Biologics (Cayman) Inc.</name>
        <lei>N/A</lei>
        <title>WUXI BIOLOGICS CAYMAN INC COMMON STOCK USD.000025</title>
        <cusip>BZ3C3R901</cusip>
        <identifiers>
          <isin value="KYG970081090"/>
          <ticker value="2269 "/>
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        <balance>26500</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.8377"/>
        <valUSD>270217.84</valUSD>
        <pctVal>0.1010643216</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Alkermes Public Limited Company</name>
        <lei>549300YHRMYLL071E243</lei>
        <title>ALKERMES PLC COMMON STOCK USD.01</title>
        <cusip>G01767105</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
          <ticker value="ALKS "/>
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        <balance>25833</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>504001.83</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Myovant Sciences Ltd.</name>
        <lei>N/A</lei>
        <title>MYOVANT SCIENCES LTD COMMON STOCK USD.000017727</title>
        <cusip>G637AM102</cusip>
        <identifiers>
          <isin value="BMG637AM1024"/>
          <ticker value="MYOV "/>
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        <balance>17476</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>90875.2</valUSD>
        <pctVal>0.0339882831</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Novocure Limited</name>
        <lei>N/A</lei>
        <title>NOVOCURE LTD COMMON STOCK</title>
        <cusip>G6674U108</cusip>
        <identifiers>
          <isin value="JE00BYSS4X48"/>
          <ticker value="NVCR "/>
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        <balance>15976</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1194685.28</valUSD>
        <pctVal>0.4468248925</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Perrigo Company Public Limited Company</name>
        <lei>549300IFOQS6R1QLY196</lei>
        <title>PERRIGO CO PLC COMMON STOCK EUR.001</title>
        <cusip>G97822103</cusip>
        <identifiers>
          <isin value="IE00BGH1M568"/>
          <ticker value="PRGO "/>
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        <balance>2100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>117369</valUSD>
        <pctVal>0.0438972436</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CRISPR Therapeutics AG</name>
        <lei>N/A</lei>
        <title>CRISPR THERAPEUTICS AG COMMON STOCK CHF.03</title>
        <cusip>H17182108</cusip>
        <identifiers>
          <isin value="CH0334081137"/>
          <ticker value="CRSP "/>
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        <balance>5900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>241841</valUSD>
        <pctVal>0.0904510842</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>WaVe Life Sciences Ltd.</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD COMMON STOCK</title>
        <cusip>Y95308105</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
          <ticker value="WVE "/>
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        <balance>5114</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>104990.42</valUSD>
        <pctVal>0.0392675242</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AnaptysBio Inc.</name>
        <lei>N/A</lei>
        <title>ANAPTYSBIO INC COMMON STOCK USD.001</title>
        <cusip>032724106</cusip>
        <identifiers>
          <isin value="US0327241065"/>
          <ticker value="ANAB "/>
        </identifiers>
        <balance>5306</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>185656.94</valUSD>
        <pctVal>0.0694376533</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Anthem Inc.</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>ANTHEM INC COMMON STOCK USD.01</title>
        <cusip>036752103</cusip>
        <identifiers>
          <isin value="US0367521038"/>
          <ticker value="ANTM "/>
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        <balance>18234</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4377983.4</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Apellis Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>APELLIS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>03753U106</cusip>
        <identifiers>
          <isin value="US03753U1060"/>
          <ticker value="APLS "/>
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        <balance>8535</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>205608.15</valUSD>
        <pctVal>0.0768996162</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>argenx SE</name>
        <lei>N/A</lei>
        <title>ARGENX SE ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
          <ticker value="ARGX "/>
        </identifiers>
        <balance>19240</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2192590.4</valUSD>
        <pctVal>0.8200519301</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AbbVie Inc.</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC COMMON STOCK USD.01</title>
        <cusip>00287Y109</cusip>
        <identifiers>
          <isin value="US00287Y1091"/>
          <ticker value="ABBV "/>
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        <balance>49520</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3749654.4</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ArQule Inc.</name>
        <lei>N/A</lei>
        <title>ARQULE INC COMMON STOCK USD.01</title>
        <cusip>04269E107</cusip>
        <identifiers>
          <isin value="US04269E1073"/>
          <ticker value="ARQL "/>
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        <balance>7400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>53058</valUSD>
        <pctVal>0.0198442515</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>N/A</lei>
        <title>ASCENDIS PHARMA A/S ADR DKK1.0</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
          <ticker value="ASND "/>
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        <balance>29018</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2795013.76</valUSD>
        <pctVal>1.0453646193</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ABIOMED Inc.</name>
        <lei>5493001EZN4ZTB4Z5887</lei>
        <title>ABIOMED INC COMMON STOCK USD.01</title>
        <cusip>003654100</cusip>
        <identifiers>
          <isin value="US0036541003"/>
          <ticker value="ABMD "/>
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        <balance>3000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>533670</valUSD>
        <pctVal>0.1995982075</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Acadia Healthcare Company Inc.</name>
        <lei>5493005CW985Y9D0NC11</lei>
        <title>ACADIA HEALTHCARE CO INC COMMON STOCK USD.01</title>
        <cusip>00404A109</cusip>
        <identifiers>
          <isin value="US00404A1097"/>
          <ticker value="ACHC "/>
        </identifiers>
        <balance>15493</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>481522.44</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ACADIA Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ACADIA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>004225108</cusip>
        <identifiers>
          <isin value="US0042251084"/>
          <ticker value="ACAD "/>
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        <balance>76498</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2753163.02</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Acceleron Pharma Inc.</name>
        <lei>N/A</lei>
        <title>ACCELERON PHARMA INC COMMON STOCK USD.001</title>
        <cusip>00434H108</cusip>
        <identifiers>
          <isin value="US00434H1086"/>
          <ticker value="XLRN "/>
        </identifiers>
        <balance>22927</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>905845.77</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Adaptive Biotechnologies Corporation</name>
        <lei>N/A</lei>
        <title>ADAPTIVE BIOTECHNOLOGIES CORP COMMON STOCK</title>
        <cusip>00650F109</cusip>
        <identifiers>
          <isin value="US00650F1093"/>
          <ticker value="ADPT "/>
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        <balance>7752</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>239536.8</valUSD>
        <pctVal>0.0895892891</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Adverum Biotechnologies Inc.</name>
        <lei>N/A</lei>
        <title>ADVERUM BIOTECHNOLOGIES INC COMMON STOCK USD.0001</title>
        <cusip>00773U108</cusip>
        <identifiers>
          <isin value="US00773U1088"/>
          <ticker value="ADVM "/>
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        <balance>23500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>128075</valUSD>
        <pctVal>0.0479014005</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Agilent Technologies Inc.</name>
        <lei>QUIX8Y7A2WP0XRMW7G29</lei>
        <title>AGILENT TECHNOLOGIES INC COMMON STOCK USD.01</title>
        <cusip>00846U101</cusip>
        <identifiers>
          <isin value="US00846U1016"/>
          <ticker value="A "/>
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        <balance>64607</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4950834.41</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>AGIOS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
          <ticker value="AGIO "/>
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        <balance>13437</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>435358.8</valUSD>
        <pctVal>0.1628287820</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC ADR</title>
        <cusip>046353108</cusip>
        <identifiers>
          <isin value="US0463531089"/>
          <ticker value="AZN "/>
        </identifiers>
        <balance>95600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4260892</valUSD>
        <pctVal>1.5936185385</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AtriCure Inc.</name>
        <lei>N/A</lei>
        <title>ATRICURE INC COMMON STOCK USD.001</title>
        <cusip>04963C209</cusip>
        <identifiers>
          <isin value="US04963C2098"/>
          <ticker value="ATRC "/>
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        <balance>12700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>316738</valUSD>
        <pctVal>0.1184633520</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Aimmune Therapeutics Inc.</name>
        <lei>549300WDF7T2EVBC1877</lei>
        <title>AIMMUNE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>00900T107</cusip>
        <identifiers>
          <isin value="US00900T1079"/>
          <ticker value="AIMT "/>
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        <balance>27035</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>566112.9</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Akero Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>AKERO THERAPEUTICS INC COMMON STOCK</title>
        <cusip>00973Y108</cusip>
        <identifiers>
          <isin value="US00973Y1082"/>
          <ticker value="AKRO "/>
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        <balance>4103</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>93343.25</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Audentes Therapeutics Inc.</name>
        <lei>549300PZYT0QC9UNJF13</lei>
        <title>AUDENTES THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>05070R104</cusip>
        <identifiers>
          <isin value="US05070R1041"/>
          <ticker value="BOLD "/>
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        <balance>4574</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>128483.66</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Autolus Therapeutics plc</name>
        <lei>N/A</lei>
        <title>AUTOLUS THERAPEUTICS PLC ADR GBP.0000001</title>
        <cusip>05280R100</cusip>
        <identifiers>
          <isin value="US05280R1005"/>
          <ticker value="AUTL "/>
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        <balance>6426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>79810.92</valUSD>
        <pctVal>0.0298501257</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Alexion Pharmaceuticals Inc.</name>
        <lei>M1YXUUZR0EIMU8T0EM75</lei>
        <title>ALEXION PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>015351109</cusip>
        <identifiers>
          <isin value="US0153511094"/>
          <ticker value="ALXN "/>
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        <balance>36831</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3607228.14</valUSD>
        <pctVal>1.3491413621</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Allakos Inc.</name>
        <lei>N/A</lei>
        <title>ALLAKOS INC COMMON STOCK USD.001</title>
        <cusip>01671P100</cusip>
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          <isin value="US01671P1003"/>
          <ticker value="ALLK "/>
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        <balance>5714</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>449291.82</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Avantor Inc.</name>
        <lei>N/A</lei>
        <title>AVANTOR INC COMMON STOCK USD.01</title>
        <cusip>05352A100</cusip>
        <identifiers>
          <isin value="US05352A1007"/>
          <ticker value="AVTR "/>
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        <balance>102304</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1503868.8</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>AVROBIO Inc.</name>
        <lei>N/A</lei>
        <title>AVROBIO INC COMMON STOCK USD.0001</title>
        <cusip>05455M100</cusip>
        <identifiers>
          <isin value="US05455M1009"/>
          <ticker value="AVRO "/>
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        <balance>6374</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>90000.88</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Axsome Therapeutics Inc.</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
          <ticker value="AXSM "/>
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        <balance>13000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>263120</valUSD>
        <pctVal>0.0984096546</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Becton Dickinson and Company</name>
        <lei>ICE2EP6D98PQUILVRZ91</lei>
        <title>BECTON DICKINSON AND CO COMMON STOCK USD1.0</title>
        <cusip>075887109</cusip>
        <identifiers>
          <isin value="US0758871091"/>
          <ticker value="BDX "/>
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        <balance>53406</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13509581.76</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BeiGene Ltd.</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEIGENE LTD ADR USD.0001</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
          <ticker value="BGNE "/>
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        <balance>6382</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>781539.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BioMarin Pharmaceutical Inc.</name>
        <lei>NSLL8ITTRR0J5HEMR848</lei>
        <title>BIOMARIN PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>09061G101</cusip>
        <identifiers>
          <isin value="US09061G1013"/>
          <ticker value="BMRN "/>
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        <balance>27193</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1832808.2</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Allergan Public Limited Company</name>
        <lei>N/A</lei>
        <title>ALLERGAN PLC COMMON STOCK USD.0033</title>
        <cusip>018490102</cusip>
        <identifiers>
          <isin value="IE00BY9D5467"/>
          <ticker value="AGN "/>
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        <balance>13167</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2215874.43</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Allogene Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
          <ticker value="ALLO "/>
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        <balance>7797</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>212507.24</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Biogen Inc.</name>
        <lei>W8J5WZB5IY3K0NDQT671</lei>
        <title>BIOGEN INC COMMON STOCK USD.0005</title>
        <cusip>09062X103</cusip>
        <identifiers>
          <isin value="US09062X1037"/>
          <ticker value="BIIB "/>
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        <balance>9329</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2171977.78</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>bluebird bio Inc.</name>
        <lei>N/A</lei>
        <title>BLUEBIRD BIO INC COMMON STOCK USD.01</title>
        <cusip>09609G100</cusip>
        <identifiers>
          <isin value="US09609G1004"/>
          <ticker value="BLUE "/>
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        <balance>12554</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1152708.28</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Blueprint Medicines Corporation</name>
        <lei>N/A</lei>
        <title>BLUEPRINT MEDICINES CORP COMMON STOCK USD.001</title>
        <cusip>09627Y109</cusip>
        <identifiers>
          <isin value="US09627Y1091"/>
          <ticker value="BPMC "/>
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        <balance>18113</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1330762.11</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC COMMON STOCK USD.25</title>
        <cusip>098952906</cusip>
        <identifiers>
          <isin value="GB0009895292"/>
          <ticker value="AZN "/>
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        <balance>304</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.813306"/>
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        <pctVal>0.0101520936</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Phreesia Inc.</name>
        <lei>N/A</lei>
        <title>PHREESIA INC COMMON STOCK USD.001</title>
        <cusip>71944F106</cusip>
        <identifiers>
          <isin value="US71944F1066"/>
          <ticker value="PHR "/>
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        <balance>6466</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>156735.84</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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        <name>Boston Scientific Corporation</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>BOSTON SCIENTIFIC CORP COMMON STOCK USD.01</title>
        <cusip>101137107</cusip>
        <identifiers>
          <isin value="US1011371077"/>
          <ticker value="BSX "/>
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        <balance>7800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>317382</valUSD>
        <pctVal>0.1187042147</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Bristol-Myers Squibb Company</name>
        <lei>HLYYNH7UQUORYSJQCN42</lei>
        <title>BRISTOL-MYERS SQUIBB CO COMMON STOCK USD.1</title>
        <cusip>110122108</cusip>
        <identifiers>
          <isin value="US1101221083"/>
          <ticker value="BMY "/>
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        <balance>80252</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4069578.92</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Bruker Corporation</name>
        <lei>LEBZ6VLQ6I8XB1NHVY15</lei>
        <title>BRUKER CORP COMMON STOCK USD.01</title>
        <cusip>116794108</cusip>
        <identifiers>
          <isin value="US1167941087"/>
          <ticker value="BRKR "/>
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        <balance>36502</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1603532.86</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Cigna Corporation</name>
        <lei>N/A</lei>
        <title>CIGNA CORP COMMON STOCK USD.01</title>
        <cusip>125523100</cusip>
        <identifiers>
          <isin value="US1255231003"/>
          <ticker value="CI "/>
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        <balance>30686</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4657827.94</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Cara Therapeutics Inc.</name>
        <lei>549300COVOY41P0GZ881</lei>
        <title>CARA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>140755109</cusip>
        <identifiers>
          <isin value="US1407551092"/>
          <ticker value="CARA "/>
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        <balance>27699</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>506337.72</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Lonza Group AG</name>
        <lei>549300EFW4H2TCZ71055</lei>
        <title>LONZA GROUP AG COMMON STOCK CHF1.0</title>
        <cusip>733337901</cusip>
        <identifiers>
          <isin value="CH0013841017"/>
          <ticker value="LONN "/>
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        <balance>1641</balance>
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        <currencyConditional curCd="CHF" exchangeRt="0.99805"/>
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        <pctVal>0.2077000688</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Principia Biopharma Inc.</name>
        <lei>N/A</lei>
        <title>PRINCIPIA BIOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>74257L108</cusip>
        <identifiers>
          <isin value="US74257L1089"/>
          <ticker value="PRNB "/>
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        <balance>6362</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>179662.88</valUSD>
        <pctVal>0.0671958116</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Progenics Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>PROGENICS PHARMACEUTICALS INC COMMON STOCK USD.0013</title>
        <cusip>743187106</cusip>
        <identifiers>
          <isin value="US7431871067"/>
          <ticker value="PGNX "/>
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        <balance>39900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>201694.5</valUSD>
        <pctVal>0.0754358698</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Puma Biotechnology Inc.</name>
        <lei>N/A</lei>
        <title>PUMA BIOTECHNOLOGY INC COMMON STOCK USD.0001</title>
        <cusip>74587V107</cusip>
        <identifiers>
          <isin value="US74587V1070"/>
          <ticker value="PBYI "/>
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        <balance>11400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>122721</valUSD>
        <pctVal>0.0458989481</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Quanterix Corporation</name>
        <lei>N/A</lei>
        <title>QUANTERIX CORP COMMON STOCK USD.001</title>
        <cusip>74766Q101</cusip>
        <identifiers>
          <isin value="US74766Q1013"/>
          <ticker value="QTRX "/>
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        <balance>18700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>410652</valUSD>
        <pctVal>0.1535881783</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Quidel Corporation</name>
        <lei>549300X2FQ6S98OQLQ46</lei>
        <title>QUIDEL CORP COMMON STOCK USD.001</title>
        <cusip>74838J101</cusip>
        <identifiers>
          <isin value="US74838J1016"/>
          <ticker value="QDEL "/>
        </identifiers>
        <balance>20729</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1271724.15</valUSD>
        <pctVal>0.4756382422</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Radius Health Inc.</name>
        <lei>549300EV6I2M6E0YVT27</lei>
        <title>RADIUS HEALTH INC COMMON STOCK USD.0001</title>
        <cusip>750469207</cusip>
        <identifiers>
          <isin value="US7504692077"/>
          <ticker value="RDUS "/>
        </identifiers>
        <balance>13400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>345050</valUSD>
        <pctVal>0.1290523385</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Reata Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>REATA PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75615P103</cusip>
        <identifiers>
          <isin value="US75615P1030"/>
          <ticker value="RETA "/>
        </identifiers>
        <balance>7677</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>616386.33</valUSD>
        <pctVal>0.2305349871</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc.</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
          <ticker value="REGN "/>
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        <balance>12158</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3372629.2</valUSD>
        <pctVal>1.2613988847</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>REGENXBIO Inc.</name>
        <lei>549300EOES47LATSET33</lei>
        <title>REGENXBIO INC COMMON STOCK USD.0001</title>
        <cusip>75901B107</cusip>
        <identifiers>
          <isin value="US75901B1070"/>
          <ticker value="RGNX "/>
        </identifiers>
        <balance>10900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>388040</valUSD>
        <pctVal>0.1451310518</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Rhythm Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>RHYTHM PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
          <ticker value="RYTM "/>
        </identifiers>
        <balance>7891</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>170366.69</valUSD>
        <pctVal>0.0637189386</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Rocket Pharmaceuticals Inc.</name>
        <lei>549300R7VV82YUIN4Y93</lei>
        <title>ROCKET PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>77313F106</cusip>
        <identifiers>
          <isin value="US77313F1066"/>
          <ticker value="RCKT "/>
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        <balance>15540</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>181041</valUSD>
        <pctVal>0.0677112431</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ALNYLAM PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <ticker value="ALNY "/>
        </identifiers>
        <balance>19200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1544064</valUSD>
        <pctVal>0.5774962179</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Amarin Corporation plc</name>
        <lei>N/A</lei>
        <title>AMARIN CORP PLC ADR GBP.1</title>
        <cusip>023111206</cusip>
        <identifiers>
          <isin value="US0231112063"/>
          <ticker value="AMRN "/>
        </identifiers>
        <balance>44258</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>670951.28</valUSD>
        <pctVal>0.2509428538</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sage Therapeutics Inc.</name>
        <lei>5493000JX4BJS9W6CN35</lei>
        <title>SAGE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>78667J108</cusip>
        <identifiers>
          <isin value="US78667J1088"/>
          <ticker value="SAGE "/>
        </identifiers>
        <balance>37712</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5290616.48</valUSD>
        <pctVal>1.9787463523</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sarepta Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SAREPTA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>803607100</cusip>
        <identifiers>
          <isin value="US8036071004"/>
          <ticker value="SRPT "/>
        </identifiers>
        <balance>22968</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1729949.76</valUSD>
        <pctVal>0.6470194523</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Amedisys Inc.</name>
        <lei>N/A</lei>
        <title>AMEDISYS INC COMMON STOCK USD.001</title>
        <cusip>023436108</cusip>
        <identifiers>
          <isin value="US0234361089"/>
          <ticker value="AMED "/>
        </identifiers>
        <balance>4400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>576444</valUSD>
        <pctVal>0.2155961345</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Amgen Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC COMMON STOCK USD.0001</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
          <ticker value="AMGN "/>
        </identifiers>
        <balance>31500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6095565</valUSD>
        <pctVal>2.2798055869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Scholar Rock Holding Corporation</name>
        <lei>N/A</lei>
        <title>SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK "/>
        </identifiers>
        <balance>5587</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>50003.65</valUSD>
        <pctVal>0.0187018924</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Seattle Genetics Inc.</name>
        <lei>N/A</lei>
        <title>SEATTLE GENETICS INC COMMON STOCK USD.001</title>
        <cusip>812578102</cusip>
        <identifiers>
          <isin value="US8125781026"/>
          <ticker value="SGEN "/>
        </identifiers>
        <balance>24875</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2124325</valUSD>
        <pctVal>0.7945199507</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Shockwave Medical Inc.</name>
        <lei>N/A</lei>
        <title>SHOCKWAVE MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>82489T104</cusip>
        <identifiers>
          <isin value="US82489T1043"/>
          <ticker value="SWAV "/>
        </identifiers>
        <balance>4275</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>127950.75</valUSD>
        <pctVal>0.0478549297</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SI-BONE Inc.</name>
        <lei>N/A</lei>
        <title>SI-BONE INC COMMON STOCK USD.0001</title>
        <cusip>825704109</cusip>
        <identifiers>
          <isin value="US8257041090"/>
          <ticker value="SIBN "/>
        </identifiers>
        <balance>5610</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>99128.7</valUSD>
        <pctVal>0.0370751791</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Silk Road Medical Inc.</name>
        <lei>N/A</lei>
        <title>SILK ROAD MEDICAL INC COMMON STOCK USD.001</title>
        <cusip>82710M100</cusip>
        <identifiers>
          <isin value="US82710M1009"/>
          <ticker value="SILK "/>
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        <balance>1823</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>59302.19</valUSD>
        <pctVal>0.0221796444</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>SmileDirectClub Inc.</name>
        <lei>N/A</lei>
        <title>SMILEDIRECTCLUB INC COMMON STOCK</title>
        <cusip>83192H106</cusip>
        <identifiers>
          <isin value="US83192H1068"/>
          <ticker value="SDC "/>
        </identifiers>
        <balance>10843</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>150500.84</valUSD>
        <pctVal>0.0562889012</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stemline Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STEMLINE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>85858C107</cusip>
        <identifiers>
          <isin value="US85858C1071"/>
          <ticker value="STML "/>
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        <balance>2239</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23307.99</valUSD>
        <pctVal>0.0087174340</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Stoke Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STOKE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>86150R107</cusip>
        <identifiers>
          <isin value="US86150R1077"/>
          <ticker value="STOK "/>
        </identifiers>
        <balance>7038</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>151246.62</valUSD>
        <pctVal>0.0565678308</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>STRYKER CORP COMMON STOCK USD.1</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
          <ticker value="SYK "/>
        </identifiers>
        <balance>42641</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9223248.3</valUSD>
        <pctVal>3.4495921220</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tandem Diabetes Care Inc.</name>
        <lei>549300JEPFOD0K4D3I05</lei>
        <title>TANDEM DIABETES CARE INC COMMON STOCK</title>
        <cusip>875372203</cusip>
        <identifiers>
          <isin value="US8753722037"/>
          <ticker value="TNDM "/>
        </identifiers>
        <balance>4700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>277206</valUSD>
        <pctVal>0.1036779671</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Teladoc Health Inc.</name>
        <lei>N/A</lei>
        <title>TELADOC HEALTH INC COMMON STOCK USD.001</title>
        <cusip>87918A105</cusip>
        <identifiers>
          <isin value="US87918A1051"/>
          <ticker value="TDOC "/>
        </identifiers>
        <balance>5500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>372460</valUSD>
        <pctVal>0.1393039675</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Teleflex Incorporated</name>
        <lei>UUL85LWXB4NGSWWXIQ25</lei>
        <title>TELEFLEX INC COMMON STOCK USD1.0</title>
        <cusip>879369106</cusip>
        <identifiers>
          <isin value="US8793691069"/>
          <ticker value="TFX "/>
        </identifiers>
        <balance>7935</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2695916.25</valUSD>
        <pctVal>1.0083011055</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>10X Genomics Inc.</name>
        <lei>N/A</lei>
        <title>10X GENOMICS INC COMMON STOCK</title>
        <cusip>88025U109</cusip>
        <identifiers>
          <isin value="US88025U1097"/>
          <ticker value="TXG "/>
        </identifiers>
        <balance>3636</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>183254.4</valUSD>
        <pctVal>0.0685390780</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Thermo Fisher Scientific Inc.</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO "/>
        </identifiers>
        <balance>36900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10747863</valUSD>
        <pctVal>4.0198140967</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Tricida Inc.</name>
        <lei>N/A</lei>
        <title>TRICIDA INC COMMON STOCK</title>
        <cusip>89610F101</cusip>
        <identifiers>
          <isin value="US89610F1012"/>
          <ticker value="TCDA "/>
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        <balance>29591</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>913474.17</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Turning Point Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>TURNING POINT THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>90041T108</cusip>
        <identifiers>
          <isin value="US90041T1088"/>
          <ticker value="TPTX "/>
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        <balance>6518</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>245076.8</valUSD>
        <pctVal>0.0916613075</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Ultragenyx Pharmaceutical Inc.</name>
        <lei>N/A</lei>
        <title>ULTRAGENYX PHARMACEUTICAL INC COMMON STOCK USD.001</title>
        <cusip>90400D108</cusip>
        <identifiers>
          <isin value="US90400D1081"/>
          <ticker value="RARE "/>
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        <balance>20405</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>872925.9</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Unitedhealth Group Incorporated</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC COMMON STOCK USD.01</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNHN "/>
        </identifiers>
        <balance>62090</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>13493398.8</valUSD>
        <pctVal>5.0466734371</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Veeva Systems Inc.</name>
        <lei>549300YZEXPDB92M2F02</lei>
        <title>VEEVA SYSTEMS INC COMMON STOCK USD.00001</title>
        <cusip>922475108</cusip>
        <identifiers>
          <isin value="US9224751084"/>
          <ticker value="VEEV "/>
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        <balance>1200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>183228</valUSD>
        <pctVal>0.0685292041</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX "/>
        </identifiers>
        <balance>61466</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10413569.72</valUSD>
        <pctVal>3.8947848849</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Acerta Pharma B.V.</name>
        <lei>N/A</lei>
        <title>ACERTA PHARMA BV CLASS B PP COMMON STOCK</title>
        <cusip>928WSA908</cusip>
        <identifiers>
          <ticker value="928WSA908"/>
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        <balance>4276305</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>391281.91</valUSD>
        <pctVal>0.1463435604</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Becton Dickinson and Company</name>
        <lei>ICE2EP6D98PQUILVRZ91</lei>
        <title>BECTON DICKINSON AND CO PREFERRED STOCK 05/20 6.125</title>
        <cusip>075887208</cusip>
        <identifiers>
          <isin value="US0758872081"/>
          <ticker value="BDX"/>
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        <balance>9988</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>618357.08</valUSD>
        <pctVal>0.2312720684</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sartorius AG</name>
        <lei>N/A</lei>
        <title>SARTORIUS AG PREFERENCE</title>
        <cusip>584332902</cusip>
        <identifiers>
          <isin value="DE0007165631"/>
          <ticker value="SRT3 "/>
        </identifiers>
        <balance>4998</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.917473"/>
        <valUSD>911186.67</valUSD>
        <pctVal>0.3407934229</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Warby Parker Retail Inc.</name>
        <lei>N/A</lei>
        <title>JAND INCDBA WARBY PARKER SER SER D CVT PRFD STK PRIV PLCMT</title>
        <cusip>976CZA905</cusip>
        <identifiers>
          <ticker value="976CZA905"/>
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        <balance>33198</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>548762.94</valUSD>
        <pctVal>0.2052431262</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Doximity Inc.</name>
        <lei>N/A</lei>
        <title>Doximity Inc. PREFERRED STOCK</title>
        <cusip>ACI087LQ1</cusip>
        <identifiers>
          <ticker value="ACI087LQ1"/>
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        <balance>31611</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>182395.47</valUSD>
        <pctVal>0.0682178291</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>WellCare Health Plans Inc.</name>
        <lei>N/A</lei>
        <title>WELLCARE HEALTH PLANS INC COMMON STOCK USD.01</title>
        <cusip>94946T106</cusip>
        <identifiers>
          <isin value="US94946T1060"/>
          <ticker value="WCG "/>
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        <balance>3357</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>870033.69</valUSD>
        <pctVal>0.3254017744</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>West Pharmaceutical Services Inc.</name>
        <lei>5493007NKRGM1RJQ1P16</lei>
        <title>WEST PHARMACEUTICAL SERVICES I COMMON STOCK USD.25</title>
        <cusip>955306105</cusip>
        <identifiers>
          <isin value="US9553061055"/>
          <ticker value="WST "/>
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        <balance>15260</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2164173.2</valUSD>
        <pctVal>0.8094235977</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Wright Medical Group N.V.</name>
        <lei>549300JGCCQ1HTDOXU32</lei>
        <title>WRIGHT MEDICAL GROUP NV COMMON STOCK USD.03</title>
        <cusip>98235T107</cusip>
        <identifiers>
          <isin value="NL0011327523"/>
          <ticker value="WMGI "/>
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        <balance>39325</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>811274.75</valUSD>
        <pctVal>0.3034253113</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC COMMON STOCK USD.01</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <ticker value="XNCR "/>
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        <balance>26934</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>908483.82</valUSD>
        <pctVal>0.3397825285</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Y-mAbs Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>Y-MABS THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>984241109</cusip>
        <identifiers>
          <isin value="US9842411095"/>
          <ticker value="YMAB "/>
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        <balance>8652</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>225471.12</valUSD>
        <pctVal>0.0843285764</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Zai Lab Limited</name>
        <lei>N/A</lei>
        <title>ZAI LAB LTD ADR USD.00006</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
          <ticker value="ZLAB "/>
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        <balance>3797</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>122832.95</valUSD>
        <pctVal>0.0459408186</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Zealand Pharma A/S</name>
        <lei>549300ITBB1ULBL4CZ12</lei>
        <title>ZEALAND PHARMA A/S ADR</title>
        <cusip>98920Y304</cusip>
        <identifiers>
          <isin value="US98920Y3045"/>
          <ticker value="ZEAL "/>
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        <balance>2282</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>57871.52</valUSD>
        <pctVal>0.0216445587</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Zimmer Biomet Holdings Inc.</name>
        <lei>2P2YLDVPES3BXQ1FRB91</lei>
        <title>ZIMMER BIOMET HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>98956P102</cusip>
        <identifiers>
          <isin value="US98956P1021"/>
          <ticker value="ZBH "/>
        </identifiers>
        <balance>7750</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1063842.5</valUSD>
        <pctVal>0.3978883131</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zogenix Inc.</name>
        <lei>54930089H3HF4C32SK78</lei>
        <title>ZOGENIX INC COMMON STOCK USD.001</title>
        <cusip>98978L204</cusip>
        <identifiers>
          <isin value="US98978L2043"/>
          <ticker value="ZGNX "/>
        </identifiers>
        <balance>8800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>352352</valUSD>
        <pctVal>0.1317833635</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zoetis Inc.</name>
        <lei>549300HD9Q1LOC9KLJ48</lei>
        <title>ZOETIS INC COMMON STOCK USD.01</title>
        <cusip>98978V103</cusip>
        <identifiers>
          <isin value="US98978V1035"/>
          <ticker value="ZTS "/>
        </identifiers>
        <balance>400</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>49836</valUSD>
        <pctVal>0.0186391895</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zymeworks Inc.</name>
        <lei>N/A</lei>
        <title>ZYMEWORKS INC COMMON STOCK</title>
        <cusip>98985W102</cusip>
        <identifiers>
          <isin value="CA98985W1023"/>
          <ticker value="ZYME "/>
        </identifiers>
        <balance>11869</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>294351.2</valUSD>
        <pctVal>0.1100904527</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zeneca Inc.</name>
        <lei>N/A</lei>
        <title>Zeneca Inc. Contingent Value COMMON STOCK</title>
        <cusip>ACI06HJ35</cusip>
        <identifiers>
          <ticker value="ACI06HJ35"/>
        </identifiers>
        <balance>13151</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8087.87</valUSD>
        <pctVal>0.0030249487</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>JAND Inc</name>
        <lei>N/A</lei>
        <title>JAND INC. CLASS A COMMON SH COMMON STOCK</title>
        <cusip>ACI0CG2S3</cusip>
        <identifiers>
          <ticker value="ACI0CG2S3"/>
        </identifiers>
        <balance>14867</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>245751.51</valUSD>
        <pctVal>0.0919136562</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>Y</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alcon Inc.</name>
        <lei>N/A</lei>
        <title>ALCON INC COMMON STOCK CHF.04</title>
        <cusip>ACI198PY5</cusip>
        <identifiers>
          <isin value="CH0432492467"/>
          <ticker value="ALC "/>
        </identifiers>
        <balance>37308</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.99805"/>
        <valUSD>2176170.57</valUSD>
        <pctVal>0.8139107406</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Galapagos NV</name>
        <lei>549300QKJ78IY0IOV655</lei>
        <title>GALAPAGOS NV COMMON STOCK</title>
        <cusip>B07Q2V905</cusip>
        <identifiers>
          <isin value="BE0003818359"/>
          <ticker value="GLPG "/>
        </identifiers>
        <balance>5341</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.917473"/>
        <valUSD>813725.31</valUSD>
        <pctVal>0.3043418466</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>BE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Daiichi Sankyo Company Limited</name>
        <lei>N/A</lei>
        <title>DAIICHI SANKYO CO LTD COMMON STOCK</title>
        <cusip>B0J7D9901</cusip>
        <identifiers>
          <isin value="JP3475350009"/>
          <ticker value="4568 "/>
        </identifiers>
        <balance>39200</balance>
        <units>NS</units>
        <currencyConditional curCd="JPY" exchangeRt="108.125"/>
        <valUSD>2477023.9</valUSD>
        <pctVal>0.9264330585</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>JP</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>DiaSorin S.p.A.</name>
        <lei>N/A</lei>
        <title>DIASORIN SPA COMMON STOCK EUR1.0</title>
        <cusip>B234WN909</cusip>
        <identifiers>
          <isin value="IT0003492391"/>
          <ticker value="DIA "/>
        </identifiers>
        <balance>6050</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.917473"/>
        <valUSD>703603.9</valUSD>
        <pctVal>0.2631552780</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IT</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Abcam PLC</name>
        <lei>N/A</lei>
        <title>ABCAM PLC COMMON STOCK GBP.002</title>
        <cusip>B67746907</cusip>
        <identifiers>
          <isin value="GB00B6774699"/>
          <ticker value="ABC "/>
        </identifiers>
        <balance>31532</balance>
        <units>NS</units>
        <currencyConditional curCd="GBP" exchangeRt="0.813306"/>
        <valUSD>444346.19</valUSD>
        <pctVal>0.1661901606</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Returns are reported without deduction of sales loads and redemption fees, if applicable." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2019-10-30</ncom:dateSigned>
      <ncom:nameOfApplicant>John Hancock Variable Insurance Trust</ncom:nameOfApplicant>
      <ncom:signature>/s/Salvatore Schiavone</ncom:signature>
      <ncom:signerName>Salvatore Schiavone</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
