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        <balance>96837</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <pctVal>2.2204034538</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CVS Health Corporation</name>
        <lei>549300EJG376EN5NQE29</lei>
        <title>CVS HEALTH CORP COMMON STOCK USD.01</title>
        <cusip>126650100</cusip>
        <identifiers>
          <isin value="US1266501006"/>
          <ticker value="CVS US"/>
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        <balance>23810</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2463144.5</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Aktis Oncology Inc.</name>
        <lei>N/A</lei>
        <title>AKTIS ONCOLOGY INC COMMON STOCK</title>
        <cusip>01021M104</cusip>
        <identifiers>
          <isin value="US01021M1045"/>
          <ticker value="AKTS US"/>
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        <balance>6809</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>219454.07</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Alignment Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>ALIGNMENT HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>01625V104</cusip>
        <identifiers>
          <isin value="US01625V1044"/>
          <ticker value="ALHC US"/>
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        <balance>24194</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>576059.14</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Allogene Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>019770106</cusip>
        <identifiers>
          <isin value="US0197701065"/>
          <ticker value="ALLO US"/>
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        <balance>70293</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>146209.44</valUSD>
        <pctVal>0.0581825468</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ALNYLAM PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <ticker value="ALNY US"/>
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        <balance>6050</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1821231.5</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cabaletta Bio Inc.</name>
        <lei>N/A</lei>
        <title>CABALETTA BIO INC COMMON STOCK USD.00001</title>
        <cusip>12674W109</cusip>
        <identifiers>
          <isin value="US12674W1099"/>
          <ticker value="CABA US"/>
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        <balance>37200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>115692</valUSD>
        <pctVal>0.0460384446</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cardinal Health Inc.</name>
        <lei>CCU46N3GJMF4OK4N7U60</lei>
        <title>CARDINAL HEALTH INC COMMON STOCK</title>
        <cusip>14149Y108</cusip>
        <identifiers>
          <isin value="US14149Y1082"/>
          <ticker value="CAH US"/>
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        <balance>11552</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2744293.12</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Alto Neuroscience Inc.</name>
        <lei>N/A</lei>
        <title>ALTO NEUROSCIENCE INC COMMON STOCK USD.0001</title>
        <cusip>02157Q109</cusip>
        <identifiers>
          <isin value="US02157Q1094"/>
          <ticker value="ANRO US"/>
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        <balance>5900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>155701</valUSD>
        <pctVal>0.0619596157</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Alumis Inc.</name>
        <lei>N/A</lei>
        <title>ALUMIS INC COMMON STOCK USD.0001</title>
        <cusip>022307102</cusip>
        <identifiers>
          <isin value="US0223071020"/>
          <ticker value="ALMS US"/>
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        <balance>13208</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>371673.12</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Caris Life Sciences Inc.</name>
        <lei>N/A</lei>
        <title>CARIS LIFE SCIENCES INC COMMON STOCK USD.001</title>
        <cusip>142152107</cusip>
        <identifiers>
          <isin value="US1421521071"/>
          <ticker value="CAI US"/>
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        <balance>2964</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>52818.48</valUSD>
        <pctVal>0.0210185723</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Celcuity Inc.</name>
        <lei>N/A</lei>
        <title>CELCUITY INC COMMON STOCK USD.001</title>
        <cusip>15102K100</cusip>
        <identifiers>
          <isin value="US15102K1007"/>
          <ticker value="CELC US"/>
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        <balance>1265</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>132344.3</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cencora Inc.</name>
        <lei>AI8GXW8LG5WK7E9UD086</lei>
        <title>CENCORA INC COMMON STOCK USD.01</title>
        <cusip>03073E105</cusip>
        <identifiers>
          <isin value="US03073E1055"/>
          <ticker value="COR US"/>
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        <balance>1504</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>425601.92</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Amgen Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
        <title>AMGEN INC COMMON STOCK USD.0001</title>
        <cusip>031162100</cusip>
        <identifiers>
          <isin value="US0311621009"/>
          <ticker value="AMGN US"/>
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        <balance>13193</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4777449.16</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Celldex Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CELLDEX THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
          <ticker value="CLDX US"/>
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        <balance>12093</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>449980.53</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Corvus Pharmaceuticals Inc.</name>
        <lei>549300I3AVJ8F75NCX65</lei>
        <title>CORVUS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>221015100</cusip>
        <identifiers>
          <isin value="US2210151005"/>
          <ticker value="CRVS US"/>
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        <balance>12231</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>182731.14</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Crinetics Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>CRINETICS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
          <ticker value="CRNX US"/>
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        <balance>17929</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>670903.18</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cullinan Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CULLINAN THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>230031106</cusip>
        <identifiers>
          <isin value="US2300311063"/>
          <ticker value="CGEM US"/>
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        <balance>15200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>276792</valUSD>
        <pctVal>0.1101465370</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Elevance Health Inc.</name>
        <lei>8MYN82XMYQH89CTMTH67</lei>
        <title>ELEVANCE HEALTH INC COMMON STOCK USD.01</title>
        <cusip>036752103</cusip>
        <identifiers>
          <isin value="US0367521038"/>
          <ticker value="ELV US"/>
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        <balance>10582</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4092376.86</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Apogee Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>APOGEE THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>03770N101</cusip>
        <identifiers>
          <isin value="US03770N1019"/>
          <ticker value="APGE US"/>
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        <balance>2744</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>364211.12</valUSD>
        <pctVal>0.1449340790</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>argenx SE</name>
        <lei>N/A</lei>
        <title>ARGENX SE ADR</title>
        <cusip>04016X101</cusip>
        <identifiers>
          <isin value="US04016X1019"/>
          <ticker value="ARGX US"/>
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        <balance>1694</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1571642.38</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Arrowhead Pharmaceuticals Inc.</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>ARROWHEAD PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
          <ticker value="ARWR US"/>
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        <balance>3693</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>301016.43</valUSD>
        <pctVal>0.1197864004</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>N/A</lei>
        <title>ASCENDIS PHARMA A/S COMMON STOCK DKK1.0</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="DK0060615755"/>
          <ticker value="ASND US"/>
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        <balance>3830</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1021537.6</valUSD>
        <pctVal>0.4065104087</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Atrium Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ATRIUM THERAPEUTICS INC COMMON STOCK</title>
        <cusip>04965N104</cusip>
        <identifiers>
          <isin value="US04965N1046"/>
          <ticker value="RNA US"/>
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        <balance>14900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>200405</valUSD>
        <pctVal>0.0797491139</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aura Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AURA BIOSCIENCES INC COMMON STOCK USD.00001</title>
        <cusip>05153U107</cusip>
        <identifiers>
          <isin value="US05153U1079"/>
          <ticker value="AURA US"/>
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        <balance>5147</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36543.7</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avalo Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>AVALO THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>05338F306</cusip>
        <identifiers>
          <isin value="US05338F3064"/>
          <ticker value="AVTX US"/>
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        <balance>10308</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>190491.84</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Avalyn Pharma Inc.</name>
        <lei>N/A</lei>
        <title>AVALYN PHARMA INC COMMON STOCK USD.001</title>
        <cusip>05348Y105</cusip>
        <identifiers>
          <isin value="US05348Y1055"/>
          <ticker value="AVLN US"/>
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        <balance>8201</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>269976.92</valUSD>
        <pctVal>0.1074345458</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Axsome Therapeutics Inc.</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
          <ticker value="AXSM US"/>
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        <balance>3166</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>774941.82</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Bicara Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BICARA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>055477103</cusip>
        <identifiers>
          <isin value="US0554771032"/>
          <ticker value="BCAX US"/>
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        <balance>11952</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>354854.88</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Beam Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
          <ticker value="BEAM US"/>
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        <balance>18748</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>643431.36</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Belite Bio Inc</name>
        <lei>N/A</lei>
        <title>BELITE BIO INC ADR USD.0001</title>
        <cusip>07782B104</cusip>
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          <isin value="US07782B1044"/>
          <ticker value="BLTE US"/>
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        <balance>1800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>277173</valUSD>
        <pctVal>0.1102981520</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Natera Inc.</name>
        <lei>N/A</lei>
        <title>NATERA INC COMMON STOCK</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
          <ticker value="NTRA US"/>
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        <balance>13829</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3753882.05</valUSD>
        <pctVal>1.4938188532</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Novo Nordisk A/S</name>
        <lei>549300DAQ1CVT6CXN342</lei>
        <title>NOVO NORDISK A/S ADR</title>
        <cusip>670100205</cusip>
        <identifiers>
          <isin value="US6701002056"/>
          <ticker value="NVO US"/>
        </identifiers>
        <balance>16597</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>795660.18</valUSD>
        <pctVal>0.3166248065</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Nurix Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>NURIX THERAPEUTICS INC COMMON STOCK</title>
        <cusip>67080M103</cusip>
        <identifiers>
          <isin value="US67080M1036"/>
          <ticker value="NRIX US"/>
        </identifiers>
        <balance>26683</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>647329.58</valUSD>
        <pctVal>0.2575981658</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Ocular Therapeutix Inc.</name>
        <lei>N/A</lei>
        <title>OCULAR THERAPEUTIX INC COMMON STOCK USD.0001</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
          <ticker value="OCUL US"/>
        </identifiers>
        <balance>31700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>311294</valUSD>
        <pctVal>0.1238762539</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Odyssey Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ODYSSEY THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>67613T104</cusip>
        <identifiers>
          <isin value="US67613T1043"/>
          <ticker value="ODTX US"/>
        </identifiers>
        <balance>7899</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>147790.29</valUSD>
        <pctVal>0.0588116298</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Olema Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>OLEMA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>68062P106</cusip>
        <identifiers>
          <isin value="US68062P1066"/>
          <ticker value="OLMA US"/>
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        <balance>11411</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>142751.61</valUSD>
        <pctVal>0.0568065388</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>ORIC Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ORIC PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>68622P109</cusip>
        <identifiers>
          <isin value="US68622P1093"/>
          <ticker value="ORIC US"/>
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        <balance>38512</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>417084.96</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cytokinetics Incorporated</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC COMMON STOCK USD.001</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
          <ticker value="CYTK US"/>
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        <balance>8740</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>744560.6</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Danaher Corporation</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>DANAHER CORP COMMON STOCK USD.01</title>
        <cusip>235851102</cusip>
        <identifiers>
          <isin value="US2358511028"/>
          <ticker value="DHR US"/>
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        <balance>19883</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3787313.84</valUSD>
        <pctVal>1.5071226911</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Definium Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DEFINIUM THERAPEUTICS INC COMMON STOCK</title>
        <cusip>24477V105</cusip>
        <identifiers>
          <isin value="CA24477V1058"/>
          <ticker value="DFTX US"/>
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        <balance>28472</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1339322.88</valUSD>
        <pctVal>0.5329698009</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Denali Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DENALI THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
          <ticker value="DNLI US"/>
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        <balance>9512</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>244648.64</valUSD>
        <pctVal>0.0973554166</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Dianthus Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DIANTHUS THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>252828108</cusip>
        <identifiers>
          <isin value="US2528281080"/>
          <ticker value="DNTH US"/>
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        <balance>9421</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>918359.08</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Disc Medicine Inc.</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC COMMON STOCK USD.0001</title>
        <cusip>254604101</cusip>
        <identifiers>
          <isin value="US2546041011"/>
          <ticker value="IRON US"/>
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        <balance>3047</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>222857.58</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Oruka Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ORUKA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>687604108</cusip>
        <identifiers>
          <isin value="US6876041087"/>
          <ticker value="ORKA US"/>
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        <balance>9920</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>944086.4</valUSD>
        <pctVal>0.3756894981</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Palvella Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PALVELLA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>697947109</cusip>
        <identifiers>
          <isin value="US6979471090"/>
          <ticker value="PVLA US"/>
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        <balance>3173</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>484897.86</valUSD>
        <pctVal>0.1929601291</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Dyne Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DYNE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>26818M108</cusip>
        <identifiers>
          <isin value="US26818M1080"/>
          <ticker value="DYN US"/>
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        <balance>2500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>55525</valUSD>
        <pctVal>0.0220956042</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Edwards Lifesciences Corporation</name>
        <lei>YA13X31F3V31L8TMPR58</lei>
        <title>EDWARDS LIFESCIENCES CORP COMMON STOCK USD1.0</title>
        <cusip>28176E108</cusip>
        <identifiers>
          <isin value="US28176E1082"/>
          <ticker value="EW US"/>
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        <balance>17285</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1563601.1</valUSD>
        <pctVal>0.6222190178</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Parabilis Medicines Inc.</name>
        <lei>N/A</lei>
        <title>PARABILIS MEDICINES INC COMMON STOCK USD.0001</title>
        <cusip>698955101</cusip>
        <identifiers>
          <isin value="US6989551014"/>
          <ticker value="PBLS US"/>
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        <balance>10131</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>277285.47</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Sonova Holding AG</name>
        <lei>N/A</lei>
        <title>SONOVA HOLDING AG COMMON STOCK CHF.05</title>
        <cusip>715603908</cusip>
        <identifiers>
          <isin value="CH0012549785"/>
          <ticker value="SOON SW"/>
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        <balance>1684</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.808"/>
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        <pctVal>0.1590507088</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
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        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Praxis Precision Medicines Inc.</name>
        <lei>N/A</lei>
        <title>PRAXIS PRECISION MEDICINES INC COMMON STOCK USD.0001</title>
        <cusip>74006W207</cusip>
        <identifiers>
          <isin value="US74006W2070"/>
          <ticker value="PRAX US"/>
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        <balance>3079</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1030818.41</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Procept Biorobotics Corporation</name>
        <lei>N/A</lei>
        <title>PROCEPT BIOROBOTICS CORP COMMON STOCK USD.00001</title>
        <cusip>74276L105</cusip>
        <identifiers>
          <isin value="US74276L1052"/>
          <ticker value="PRCT US"/>
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        <balance>7988</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>180369.04</valUSD>
        <pctVal>0.0717760092</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Protagonist Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PROTAGONIST THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>74366E102</cusip>
        <identifiers>
          <isin value="US74366E1029"/>
          <ticker value="PTGX US"/>
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        <balance>18396</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2254981.68</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Quest Diagnostics Incorporated</name>
        <lei>8MCWUBXQ0WE04KMXBX50</lei>
        <title>QUEST DIAGNOSTICS INC COMMON STOCK USD.01</title>
        <cusip>74834L100</cusip>
        <identifiers>
          <isin value="US74834L1008"/>
          <ticker value="DGX US"/>
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        <balance>1100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>233145</valUSD>
        <pctVal>0.0927776611</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Eikon Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>EIKON THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>282564103</cusip>
        <identifiers>
          <isin value="US2825641036"/>
          <ticker value="EIKN US"/>
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        <balance>7211</balance>
        <units>NS</units>
        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Climb Bio Inc.</name>
        <lei>N/A</lei>
        <title>CLIMB BIO INC COMMON STOCK</title>
        <cusip>28658R106</cusip>
        <identifiers>
          <isin value="US28658R1068"/>
          <ticker value="CLYM US"/>
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        <balance>36100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>470744</valUSD>
        <pctVal>0.1873277458</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Rapport Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RAPPORT THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>75383L102</cusip>
        <identifiers>
          <isin value="US75383L1026"/>
          <ticker value="RAPP US"/>
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        <balance>11835</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>493164.45</valUSD>
        <pctVal>0.1962497338</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Regeneron Pharmaceuticals Inc.</name>
        <lei>549300RCBFWIRX3HYQ56</lei>
        <title>REGENERON PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>75886F107</cusip>
        <identifiers>
          <isin value="US75886F1075"/>
          <ticker value="REGN US"/>
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        <balance>1214</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>756977.56</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Relay Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>RELAY THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>75943R102</cusip>
        <identifiers>
          <isin value="US75943R1023"/>
          <ticker value="RLAY US"/>
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        <balance>37964</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>710306.44</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Royalty Pharma plc</name>
        <lei>N/A</lei>
        <title>ROYALTY PHARMA PLC COMMON STOCK</title>
        <cusip>76028H209</cusip>
        <identifiers>
          <isin value="GB00BMVP7Y09"/>
          <ticker value="RPRX US"/>
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        <balance>45659</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2560100.13</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</name>
        <lei>N/A</lei>
        <title>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</title>
        <cusip>76105Y109</cusip>
        <identifiers>
          <isin value="US76105Y1091"/>
          <ticker value="76105Y109010"/>
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        <balance>1757300.28</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1757300.28</valUSD>
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        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Revolution Medicines Inc.</name>
        <lei>N/A</lei>
        <title>REVOLUTION MEDICINES INC COMMON STOCK</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
          <ticker value="RVMD US"/>
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        <balance>10986</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2057458.08</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Revolution Medicines Inc.</name>
        <lei>N/A</lei>
        <title>REVOLUTION MEDICINES INC WARRANTS CALL EXP 17DEC26</title>
        <cusip>76155X118</cusip>
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          <isin value="US76155X1182"/>
          <ticker value="RVMDW"/>
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        <balance>4502</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>42318.8</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Rhythm Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>RHYTHM PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>76243J105</cusip>
        <identifiers>
          <isin value="US76243J1051"/>
          <ticker value="RYTM US"/>
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        <balance>5825</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>646749.75</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>State Street Bank and Trust Company</name>
        <lei>571474TGEMMWANRLN572</lei>
        <title>SCC GOVERMENT MM GVXX 20301231 00001.0000000000</title>
        <cusip>7839989D1</cusip>
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        <curCd>USD</curCd>
        <valUSD>482174</valUSD>
        <pctVal>0.1918761970</pctVal>
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        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Xenon Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>XENON PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>98420N105</cusip>
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          <isin value="CA98420N1050"/>
          <ticker value="XENE US"/>
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        <balance>1300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>78468</valUSD>
        <pctVal>0.0312255356</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CA</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Encompass Health Corporation</name>
        <lei>549300FVRPM9DRQZRG64</lei>
        <title>ENCOMPASS HEALTH CORP COMMON STOCK USD.01</title>
        <cusip>29261A100</cusip>
        <identifiers>
          <isin value="US29261A1007"/>
          <ticker value="EHC US"/>
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        <balance>3941</balance>
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        <curCd>USD</curCd>
        <valUSD>398356.28</valUSD>
        <pctVal>0.1585217952</pctVal>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Enliven Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>29337E102</cusip>
        <identifiers>
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          <ticker value="ELVN US"/>
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        <curCd>USD</curCd>
        <valUSD>722730.75</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Entrada Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ENTRADA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>29384C108</cusip>
        <identifiers>
          <isin value="US29384C1080"/>
          <ticker value="TRDA US"/>
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        <balance>11642</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>85685.12</valUSD>
        <pctVal>0.0340975145</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Erasca Inc.</name>
        <lei>N/A</lei>
        <title>ERASCA INC COMMON STOCK USD.0001</title>
        <cusip>29479A108</cusip>
        <identifiers>
          <isin value="US29479A1088"/>
          <ticker value="ERAS US"/>
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        <balance>57241</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1048655.12</valUSD>
        <pctVal>0.4173015476</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Evommune Inc.</name>
        <lei>N/A</lei>
        <title>EVOMMUNE INC COMMON STOCK USD.0001</title>
        <cusip>30054Y107</cusip>
        <identifiers>
          <isin value="US30054Y1073"/>
          <ticker value="EVMN US"/>
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        <balance>8201</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>108991.29</valUSD>
        <pctVal>0.0433719658</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

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          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
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      <invstOrSec>
        <name>GE HealthCare Technologies Inc.</name>
        <lei>N/A</lei>
        <title>GE HEALTHCARE TECHNOLOGIES INC COMMON STOCK USD.01</title>
        <cusip>36266G107</cusip>
        <identifiers>
          <isin value="US36266G1076"/>
          <ticker value="GEHC US"/>
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        <balance>1000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>64010</valUSD>
        <pctVal>0.0254721229</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Generate Biomedicines Inc.</name>
        <lei>N/A</lei>
        <title>GENERATE BIOMEDICINES INC COMMON STOCK</title>
        <cusip>370920100</cusip>
        <identifiers>
          <isin value="US3709201004"/>
          <ticker value="GENB US"/>
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        <balance>19277</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>325202.99</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>CONTRA GENERATION BIO COMMON STOCK</name>
        <lei>N/A</lei>
        <title>CONTRA GENERATION BIO COMMON STOCK</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Custodian Identifier" value="371CVR010"/>
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        <balance>3769</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3952.55</valUSD>
        <pctVal>0.0015728767</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Gilead Sciences Inc.</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC COMMON STOCK USD.001</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
          <ticker value="GILD US"/>
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        <balance>58630</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7407314.2</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Crescent Biopharma Inc.</name>
        <lei>N/A</lei>
        <title>CRESCENT BIOPHARMA INC COMMON STOCK USD.001</title>
        <cusip>38000Q201</cusip>
        <identifiers>
          <isin value="KYG2545C1042"/>
          <ticker value="CBIO US"/>
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        <balance>5959</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>107262</valUSD>
        <pctVal>0.0426838126</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IDEAYA Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IDEAYA BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
          <ticker value="IDYA US"/>
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        <balance>16018</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>596990.86</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Immuneering Corporation</name>
        <lei>N/A</lei>
        <title>IMMUNEERING CORP COMMON STOCK USD.001</title>
        <cusip>45254E107</cusip>
        <identifiers>
          <isin value="US45254E1073"/>
          <ticker value="IMRX US"/>
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        <balance>11995</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>59855.05</valUSD>
        <pctVal>0.0238187031</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Immunome Inc.</name>
        <lei>N/A</lei>
        <title>IMMUNOME INC COMMON STOCK USD.0001</title>
        <cusip>45257U108</cusip>
        <identifiers>
          <isin value="US45257U1088"/>
          <ticker value="IMNM US"/>
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        <balance>24087</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>510403.53</valUSD>
        <pctVal>0.2031098489</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Immunocore Holdings plc</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC ADR GBP.0001</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
          <ticker value="IMCR US"/>
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        <balance>13301</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>422306.75</valUSD>
        <pctVal>0.1680526390</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Immunocore Holdings plc</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC SR UNSECURED 02/30 2.5</title>
        <cusip>45258DAB1</cusip>
        <identifiers>
          <isin value="US45258DAB10"/>
          <ticker value="IMCR"/>
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        <balance>277000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>253455</valUSD>
        <pctVal>0.1008598172</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <debtSec>
          <maturityDt>2030-02-01</maturityDt>
          <couponKind>Fixed</couponKind>
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          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
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          <isMandatoryConvrtbl>N</isMandatoryConvrtbl>
          <isContngtConvrtbl>N</isContngtConvrtbl>
          <dbtSecRefInstruments>
            <dbtSecRefInstrument>
              <name>Immunocore Holdings PLC</name>
              <title>Immunocore Holdings PLC</title>
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                <isin value="US45258D1054"/>
                <ticker value="IMCR"/>
                <other otherDesc="BLOOMBERG" value="EQ0000000089216579"/>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Immix Biopharma Inc.</name>
        <lei>N/A</lei>
        <title>IMMIX BIOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>45258H106</cusip>
        <identifiers>
          <isin value="US45258H1068"/>
          <ticker value="IMMX US"/>
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        <balance>27992</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>288597.52</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Incyte Corporation</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP COMMON STOCK USD.001</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
          <ticker value="INCY US"/>
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        <balance>2663</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>301877.68</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Insmed Incorporated</name>
        <lei>N/A</lei>
        <title>INSMED INC COMMON STOCK USD.01</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <ticker value="INSM US"/>
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        <balance>12082</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1288182.84</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Inspire Medical Systems Inc.</name>
        <lei>N/A</lei>
        <title>INSPIRE MEDICAL SYSTEMS INC COMMON STOCK USD.001</title>
        <cusip>457730109</cusip>
        <identifiers>
          <isin value="US4577301090"/>
          <ticker value="INSP US"/>
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        <balance>2800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>124908</valUSD>
        <pctVal>0.0497058573</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Intuitive Surgical Inc.</name>
        <lei>54930052SRG011710797</lei>
        <title>INTUITIVE SURGICAL INC COMMON STOCK USD.001</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
          <ticker value="ISRG US"/>
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        <balance>12535</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4984918.8</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc.</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
          <ticker value="IONS US"/>
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        <balance>9649</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>765069.21</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>Iovance Biotherapeutics Inc.</name>
        <lei>N/A</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC COMMON STOCK USD.000041666</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
          <ticker value="IOVA US"/>
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        <balance>25566</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>106354.56</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>IQVIA Holdings Inc.</name>
        <lei>N/A</lei>
        <title>IQVIA HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>46266C105</cusip>
        <identifiers>
          <isin value="US46266C1053"/>
          <ticker value="IQV US"/>
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        <balance>891</balance>
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        <curCd>USD</curCd>
        <valUSD>172159.02</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>Johnson and Johnson</name>
        <lei>549300G0CFPGEF6X2043</lei>
        <title>JOHNSON and JOHNSON COMMON STOCK USD1.0</title>
        <cusip>478160104</cusip>
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          <isin value="US4781601046"/>
          <ticker value="JNJ US"/>
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        <balance>62593</balance>
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        <curCd>USD</curCd>
        <valUSD>15896744.21</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>Kailera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KAILERA THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>482931102</cusip>
        <identifiers>
          <isin value="US4829311020"/>
          <ticker value="KLRA US"/>
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        <balance>33069</balance>
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        <curCd>USD</curCd>
        <valUSD>728510.07</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Kodiak Sciences Inc.</name>
        <lei>N/A</lei>
        <title>KODIAK SCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>50015M109</cusip>
        <identifiers>
          <isin value="US50015M1099"/>
          <ticker value="KOD US"/>
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        <balance>22414</balance>
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        <curCd>USD</curCd>
        <valUSD>873249.44</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Krystal Biotech Inc.</name>
        <lei>N/A</lei>
        <title>KRYSTAL BIOTECH INC COMMON STOCK USD.00001</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
          <ticker value="KRYS US"/>
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        <balance>3044</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1131363.48</valUSD>
        <pctVal>0.4502144910</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Kymera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
          <ticker value="KYMR US"/>
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        <balance>20464</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2346606.88</valUSD>
        <pctVal>0.9338081356</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kyverna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYVERNA THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>501976104</cusip>
        <identifiers>
          <isin value="US5019761049"/>
          <ticker value="KYTX US"/>
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        <balance>17518</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>156085.38</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly and Company</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO COMMON STOCK</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY US"/>
        </identifiers>
        <balance>29965</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>35940919.95</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Liquidia Corporation</name>
        <lei>N/A</lei>
        <title>LIQUIDIA CORP COMMON STOCK USD.001</title>
        <cusip>53635D202</cusip>
        <identifiers>
          <isin value="US53635D2027"/>
          <ticker value="LQDA US"/>
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        <balance>8111</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>646690.03</valUSD>
        <pctVal>0.2573436635</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MBX Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>MBX BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>55287L101</cusip>
        <identifiers>
          <isin value="US55287L1017"/>
          <ticker value="MBX US"/>
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        <balance>12943</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>714453.6</valUSD>
        <pctVal>0.2843094810</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MADRIGAL PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
          <ticker value="MDGL US"/>
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        <balance>1250</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>671187.5</valUSD>
        <pctVal>0.2670921804</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>MapLight Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MAPLIGHT THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>56565P103</cusip>
        <identifiers>
          <isin value="US56565P1030"/>
          <ticker value="MPLT US"/>
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        <balance>929</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>33295.36</valUSD>
        <pctVal>0.0132495470</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Summit Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SUMMIT THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>86627T108</cusip>
        <identifiers>
          <isin value="US86627T1088"/>
          <ticker value="SMMT US"/>
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        <balance>56004</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>815978.28</valUSD>
        <pctVal>0.3247101860</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tango Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>TANGO THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>87583X109</cusip>
        <identifiers>
          <isin value="US87583X1090"/>
          <ticker value="TNGX US"/>
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        <balance>31026</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>969872.76</valUSD>
        <pctVal>0.3859509156</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tarsus Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>TARSUS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>87650L103</cusip>
        <identifiers>
          <isin value="US87650L1035"/>
          <ticker value="TARS US"/>
        </identifiers>
        <balance>3689</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>232185.66</valUSD>
        <pctVal>0.0923959016</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tectonic Therapeutic Inc.</name>
        <lei>N/A</lei>
        <title>TECTONIC THERAPEUTIC INC COMMON STOCK USD.0001</title>
        <cusip>878972108</cusip>
        <identifiers>
          <isin value="US8789721086"/>
          <ticker value="TECX US"/>
        </identifiers>
        <balance>756</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>25987.5</valUSD>
        <pctVal>0.0103414590</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tenax Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>TENAX THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>88032L605</cusip>
        <identifiers>
          <isin value="US88032L6056"/>
          <ticker value="TENX US"/>
        </identifiers>
        <balance>9723</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>141469.65</valUSD>
        <pctVal>0.0562963960</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tenet Healthcare Corporation</name>
        <lei>0W9AIBT6U6ADJ2I8HK17</lei>
        <title>TENET HEALTHCARE CORP COMMON STOCK USD.05</title>
        <cusip>88033G407</cusip>
        <identifiers>
          <isin value="US88033G4073"/>
          <ticker value="THC US"/>
        </identifiers>
        <balance>13342</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2496021.36</valUSD>
        <pctVal>0.9932660952</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Teva Pharmaceutical Industries Limited</name>
        <lei>549300BAFGM4RC74ZJ94</lei>
        <title>TEVA PHARMACEUTICAL INDUSTRIES ADR</title>
        <cusip>881624209</cusip>
        <identifiers>
          <isin value="US8816242098"/>
          <ticker value="TEVA US"/>
        </identifiers>
        <balance>17600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>596288</valUSD>
        <pctVal>0.2372866927</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Thermo Fisher Scientific Inc.</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO US"/>
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        <balance>13365</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6700676.4</valUSD>
        <pctVal>2.6664654356</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Twist Bioscience Corporation</name>
        <lei>N/A</lei>
        <title>TWIST BIOSCIENCE CORP COMMON STOCK USD.00001</title>
        <cusip>90184D100</cusip>
        <identifiers>
          <isin value="US90184D1000"/>
          <ticker value="TWST US"/>
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        <balance>12300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1265424</valUSD>
        <pctVal>0.5035624997</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Tyra Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>TYRA BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>90240B106</cusip>
        <identifiers>
          <isin value="US90240B1061"/>
          <ticker value="TYRA US"/>
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        <balance>7500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>239550</valUSD>
        <pctVal>0.0953264651</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
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      <invstOrSec>
        <name>United Therapeutics Corporation</name>
        <lei>N/A</lei>
        <title>UNITED THERAPEUTICS CORP COMMON STOCK USD.01</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
          <ticker value="UTHR US"/>
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        <balance>2145</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1162225.35</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>UnitedHealth Group Incorporated</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC COMMON STOCK USD.01</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNH US"/>
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        <balance>35965</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14948132.95</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Vaxcyte Inc.</name>
        <lei>N/A</lei>
        <title>VAXCYTE INC COMMON STOCK USD.001</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
          <ticker value="PCVX US"/>
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        <balance>9298</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>540492.74</valUSD>
        <pctVal>0.2150835413</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Veeva Systems Inc.</name>
        <lei>549300YZEXPDB92M2F02</lei>
        <title>VEEVA SYSTEMS INC COMMON STOCK USD.00001</title>
        <cusip>922475108</cusip>
        <identifiers>
          <isin value="US9224751084"/>
          <ticker value="VEEV US"/>
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        <balance>2000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>354940</valUSD>
        <pctVal>0.1412447319</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Vera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
          <ticker value="VERA US"/>
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        <balance>18078</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>775726.98</valUSD>
        <pctVal>0.3086925940</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX US"/>
        </identifiers>
        <balance>12026</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5973674.98</valUSD>
        <pctVal>2.3771626784</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Viatris Inc.</name>
        <lei>N/A</lei>
        <title>VIATRIS INC COMMON STOCK</title>
        <cusip>92556V106</cusip>
        <identifiers>
          <isin value="US92556V1061"/>
          <ticker value="VTRS US"/>
        </identifiers>
        <balance>108200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1718216</valUSD>
        <pctVal>0.6837464312</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Viridian Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>VIRIDIAN THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>92790C104</cusip>
        <identifiers>
          <isin value="US92790C1045"/>
          <ticker value="VRDN US"/>
        </identifiers>
        <balance>32067</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>589070.79</valUSD>
        <pctVal>0.2344146780</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Waters Corporation</name>
        <lei>5T547R1474YC9HOD8Q74</lei>
        <title>WATERS CORP COMMON STOCK USD.01</title>
        <cusip>941848103</cusip>
        <identifiers>
          <isin value="US9418481035"/>
          <ticker value="WAT US"/>
        </identifiers>
        <balance>1800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>675072</valUSD>
        <pctVal>0.2686379773</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC COMMON STOCK USD.01</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <ticker value="XNCR US"/>
        </identifiers>
        <balance>13179</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>212181.9</valUSD>
        <pctVal>0.0844356105</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nanobiotix S.A.</name>
        <lei>N/A</lei>
        <title>NANOBIOTIX SA COMMON STOCK</title>
        <cusip>B8X9FN901</cusip>
        <identifiers>
          <isin value="FR0011341205"/>
          <ticker value="NANO FP"/>
        </identifiers>
        <balance>5041</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.875197"/>
        <valUSD>185626.73</valUSD>
        <pctVal>0.0738682530</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BeOne Medicines Ltd</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEONE MEDICINES LTD COMMON STOCK USD.0001</title>
        <cusip>BVDKGC900</cusip>
        <identifiers>
          <isin value="CH1391448177"/>
          <ticker value="6160 HK"/>
        </identifiers>
        <balance>42798</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.84285"/>
        <valUSD>932817.58</valUSD>
        <pctVal>0.3712051868</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sensorion</name>
        <lei>N/A</lei>
        <title>SENSORION SA COMMON STOCK EUR.1</title>
        <cusip>BWSW4N905</cusip>
        <identifiers>
          <isin value="FR0012596468"/>
          <ticker value="ALSEN FP"/>
        </identifiers>
        <balance>272325</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.875197"/>
        <valUSD>73588.06</valUSD>
        <pctVal>0.0292836136</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alkermes Public Limited Company</name>
        <lei>549300YHRMYLL071E243</lei>
        <title>ALKERMES PLC COMMON STOCK USD.01</title>
        <cusip>G01767105</cusip>
        <identifiers>
          <isin value="IE00B56GVS15"/>
          <ticker value="ALKS US"/>
        </identifiers>
        <balance>11200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>586824</valUSD>
        <pctVal>0.2335205910</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC COMMON STOCK USD.25</title>
        <cusip>G0593M107</cusip>
        <identifiers>
          <isin value="GB0009895292"/>
          <ticker value="AZN US"/>
        </identifiers>
        <balance>6448</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1222669.76</valUSD>
        <pctVal>0.4865488884</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Ltd.</name>
        <lei>N/A</lei>
        <title>BIOHAVEN LTD COMMON STOCK</title>
        <cusip>G1110E107</cusip>
        <identifiers>
          <isin value="VGG1110E1079"/>
          <ticker value="BHVN US"/>
        </identifiers>
        <balance>18515</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>275503.2</valUSD>
        <pctVal>0.1096336722</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Icon Public Limited Company</name>
        <lei>N/A</lei>
        <title>ICON PLC COMMON STOCK EUR.06</title>
        <cusip>G4705A100</cusip>
        <identifiers>
          <isin value="IE0005711209"/>
          <ticker value="ICLR US"/>
        </identifiers>
        <balance>2700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>469017</valUSD>
        <pctVal>0.1866405038</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Roivant Sciences Ltd.</name>
        <lei>N/A</lei>
        <title>ROIVANT SCIENCES LTD COMMON STOCK USD.0000001</title>
        <cusip>G76279101</cusip>
        <identifiers>
          <isin value="BMG762791017"/>
          <ticker value="ROIV US"/>
        </identifiers>
        <balance>53184</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1882181.76</valUSD>
        <pctVal>0.7489949234</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immatics N.V.</name>
        <lei>N/A</lei>
        <title>IMMATICS NV COMMON STOCK</title>
        <cusip>N44445109</cusip>
        <identifiers>
          <isin value="NL0015285941"/>
          <ticker value="IMTX US"/>
        </identifiers>
        <balance>11700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>118521</valUSD>
        <pctVal>0.0471642161</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>NewAmsterdam Pharma Company N.V.</name>
        <lei>N/A</lei>
        <title>NEWAMSTERDAM PHARMA CO NV COMMON STOCK</title>
        <cusip>N62509109</cusip>
        <identifiers>
          <isin value="NL00150012L7"/>
          <ticker value="NAMS US"/>
        </identifiers>
        <balance>20200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>684578</valUSD>
        <pctVal>0.2724207925</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pharvaris N.V.</name>
        <lei>N/A</lei>
        <title>PHARVARIS NV COMMON STOCK EUR.12</title>
        <cusip>N69605108</cusip>
        <identifiers>
          <isin value="NL00150005Y4"/>
          <ticker value="PHVS US"/>
        </identifiers>
        <balance>6668</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>230579.44</valUSD>
        <pctVal>0.0917567228</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Wave Life Sciences Ltd.</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD COMMON STOCK</title>
        <cusip>Y95308105</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
          <ticker value="WVE US"/>
        </identifiers>
        <balance>29983</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>174201.23</valUSD>
        <pctVal>0.0693215925</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centene Corporation</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>CENTENE CORP COMMON STOCK USD.001</title>
        <cusip>15135B101</cusip>
        <identifiers>
          <isin value="US15135B1017"/>
          <ticker value="CNC US"/>
        </identifiers>
        <balance>23851</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1530995.69</valUSD>
        <pctVal>0.6092440294</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CG Oncology Inc.</name>
        <lei>N/A</lei>
        <title>CG ONCOLOGY INC COMMON STOCK</title>
        <cusip>156944100</cusip>
        <identifiers>
          <isin value="US1569441009"/>
          <ticker value="CGON US"/>
        </identifiers>
        <balance>10805</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>767695.25</valUSD>
        <pctVal>0.3054964495</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Charles River Laboratories International Inc.</name>
        <lei>549300BSQ0R4UZ5KX287</lei>
        <title>CHARLES RIVER LABORATORIES INT COMMON STOCK USD.01</title>
        <cusip>159864107</cusip>
        <identifiers>
          <isin value="US1598641074"/>
          <ticker value="CRL US"/>
        </identifiers>
        <balance>7267</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1648082.93</valUSD>
        <pctVal>0.6558376954</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cogent Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>COGENT BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>19240Q201</cusip>
        <identifiers>
          <isin value="US19240Q2012"/>
          <ticker value="COGT US"/>
        </identifiers>
        <balance>8684</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>336070.8</valUSD>
        <pctVal>0.1337359273</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Guardant Health Inc.</name>
        <lei>N/A</lei>
        <title>GUARDANT HEALTH INC COMMON STOCK USD.00001</title>
        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
          <ticker value="GH US"/>
        </identifiers>
        <balance>21513</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3227595.39</valUSD>
        <pctVal>1.2843884757</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Hemab Therapeutics Holdings Inc.</name>
        <lei>N/A</lei>
        <title>HEMAB THERAPEUTICS HOLDINGS IN COMMON STOCK USD.0001</title>
        <cusip>423494103</cusip>
        <identifiers>
          <isin value="US4234941031"/>
          <ticker value="COAG US"/>
        </identifiers>
        <balance>4285</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>157388.05</valUSD>
        <pctVal>0.0626309600</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Humana Inc.</name>
        <lei>N/A</lei>
        <title>HUMANA INC COMMON STOCK USD.1666666</title>
        <cusip>444859102</cusip>
        <identifiers>
          <isin value="US4448591028"/>
          <ticker value="HUM US"/>
        </identifiers>
        <balance>2360</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>937439.2</valUSD>
        <pctVal>0.3730443131</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>West Pharmaceutical Services Inc.</name>
        <lei>5493007NKRGM1RJQ1P16</lei>
        <title>WEST PHARMACEUTICAL SERVICES I COMMON STOCK USD.25</title>
        <cusip>955306105</cusip>
        <identifiers>
          <isin value="US9553061055"/>
          <ticker value="WST US"/>
        </identifiers>
        <balance>1800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>646200</valUSD>
        <pctVal>0.2571486611</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Medtronic Public Limited Company</name>
        <lei>549300GX3ZBSQWUXY261</lei>
        <title>MEDTRONIC PLC COMMON STOCK USD.1</title>
        <cusip>585055106</cusip>
        <identifiers>
          <isin value="IE00BTN1Y115"/>
          <ticker value="MDT US"/>
        </identifiers>
        <balance>14700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1149981</valUSD>
        <pctVal>0.4576231421</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IE</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Medpace Holdings Inc.</name>
        <lei>549300H8TYEUVTW14A54</lei>
        <title>MEDPACE HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>58506Q109</cusip>
        <identifiers>
          <isin value="US58506Q1094"/>
          <ticker value="MEDP US"/>
        </identifiers>
        <balance>1861</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>985566.99</valUSD>
        <pctVal>0.3921962734</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Merck and Co. Inc.</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK + CO INC COMMON STOCK USD.5</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
          <ticker value="MRK US"/>
        </identifiers>
        <balance>82388</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>10586858</valUSD>
        <pctVal>4.2129315376</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Mirum Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MIRUM PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>604749101</cusip>
        <identifiers>
          <isin value="US6047491013"/>
          <ticker value="MIRM US"/>
        </identifiers>
        <balance>11071</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1296081.97</valUSD>
        <pctVal>0.5157625243</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Scholar Rock Holding Corporation</name>
        <lei>N/A</lei>
        <title>SCHOLAR ROCK HOLDING CORP COMMON STOCK USD.001</title>
        <cusip>80706P103</cusip>
        <identifiers>
          <isin value="US80706P1030"/>
          <ticker value="SRRK US"/>
        </identifiers>
        <balance>17260</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>949300</valUSD>
        <pctVal>0.3777641968</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Seaport Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SEAPORT THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>81221K108</cusip>
        <identifiers>
          <isin value="US81221K1088"/>
          <ticker value="SPTX US"/>
        </identifiers>
        <balance>21025</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>456663</valUSD>
        <pctVal>0.1817243563</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>GeneDx Holdings Corp.</name>
        <lei>N/A</lei>
        <title>GENEDX HOLDINGS CORP GENEDX HOLDINGS CORP</title>
        <cusip>81663L119</cusip>
        <identifiers>
          <isin value="US81663L1199"/>
          <ticker value="WGSWW"/>
        </identifiers>
        <balance>4862</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>14.1</valUSD>
        <pctVal>0.0000056110</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Shattuck Labs Inc.</name>
        <lei>N/A</lei>
        <title>SHATTUCK LABS INC COMMON STOCK USD.0001</title>
        <cusip>82024L103</cusip>
        <identifiers>
          <isin value="US82024L1035"/>
          <ticker value="STTK US"/>
        </identifiers>
        <balance>39749</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>275858.06</valUSD>
        <pctVal>0.1097748851</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sionna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SIONNA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>829401108</cusip>
        <identifiers>
          <isin value="US8294011080"/>
          <ticker value="SION US"/>
        </identifiers>
        <balance>6272</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>275905.28</valUSD>
        <pctVal>0.1097936758</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SomaLogic Inc.</name>
        <lei>N/A</lei>
        <title>SOMALOGIC INC WARRANTS CALL EXP 31AUG26</title>
        <cusip>83444K113</cusip>
        <identifiers>
          <isin value="US83444K1135"/>
          <ticker value="SLGCW"/>
        </identifiers>
        <balance>2050</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>0</valUSD>
        <pctVal>0.0000000000</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>SpyGlass Pharma Inc.</name>
        <lei>N/A</lei>
        <title>SPYGLASS PHARMA INC COMMON STOCK USD.00001</title>
        <cusip>85220G109</cusip>
        <identifiers>
          <isin value="US85220G1094"/>
          <ticker value="SGP US"/>
        </identifiers>
        <balance>5992</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>133381.92</valUSD>
        <pctVal>0.0530779668</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stoke Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STOKE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>86150R107</cusip>
        <identifiers>
          <isin value="US86150R1077"/>
          <ticker value="STOK US"/>
        </identifiers>
        <balance>9300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>304296</valUSD>
        <pctVal>0.1210914716</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>STRYKER CORP COMMON STOCK USD.1</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
          <ticker value="SYK US"/>
        </identifiers>
        <balance>14947</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4705913.48</valUSD>
        <pctVal>1.8726699946</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Structure Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STRUCTURE THERAPEUTICS INC ADR USD.0001</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
          <ticker value="GPCR US"/>
        </identifiers>
        <balance>9141</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>490597.47</valUSD>
        <pctVal>0.1952282305</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Returns are reported without deduction of sales loads and redemption fees, if applicable." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2026-07-27</ncom:dateSigned>
      <ncom:nameOfApplicant>John Hancock Variable Insurance Trust</ncom:nameOfApplicant>
      <ncom:signature>/s/Salvatore Schiavone</ncom:signature>
      <ncom:signerName>Salvatore Schiavone</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
</edgarSubmission>
