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        <curCd>USD</curCd>
        <valUSD>363085.45</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>Repligen Corporation</name>
        <lei>54930006QJ0T5AUO1E71</lei>
        <title>REPLIGEN CORP COMMON STOCK USD.01</title>
        <cusip>759916109</cusip>
        <identifiers>
          <isin value="US7599161095"/>
          <ticker value="RGEN US"/>
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        <balance>2923</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>344387.86</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Royalty Pharma plc</name>
        <lei>N/A</lei>
        <title>ROYALTY PHARMA PLC COMMON STOCK</title>
        <cusip>76028H209</cusip>
        <identifiers>
          <isin value="GB00BMVP7Y09"/>
          <ticker value="RPRX US"/>
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        <balance>27659</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1326802.23</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Stoke Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STOKE THERAPEUTICS INC COMMON STOCK</title>
        <cusip>86150R107</cusip>
        <identifiers>
          <isin value="US86150R1077"/>
          <ticker value="STOK US"/>
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        <balance>10000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>325600</valUSD>
        <pctVal>0.1432937784</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Stryker Corporation</name>
        <lei>5493002F0SC4JTBU5137</lei>
        <title>STRYKER CORP COMMON STOCK USD.1</title>
        <cusip>863667101</cusip>
        <identifiers>
          <isin value="US8636671013"/>
          <ticker value="SYK US"/>
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        <balance>24345</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7999523.55</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Structure Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>STRUCTURE THERAPEUTICS INC ADR USD.0001</title>
        <cusip>86366E106</cusip>
        <identifiers>
          <isin value="US86366E1064"/>
          <ticker value="GPCR US"/>
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        <balance>28241</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1361216.2</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Summit Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SUMMIT THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>86627T108</cusip>
        <identifiers>
          <isin value="US86627T1088"/>
          <ticker value="SMMT US"/>
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        <balance>131177</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2487115.92</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Tango Therapeutics Inc</name>
        <lei>N/A</lei>
        <title>TANGO THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>87583X109</cusip>
        <identifiers>
          <isin value="US87583X1090"/>
          <ticker value="TNGX US"/>
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        <balance>14300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>299156</valUSD>
        <pctVal>0.1316559999</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Tarsus Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>TARSUS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>87650L103</cusip>
        <identifiers>
          <isin value="US87650L1035"/>
          <ticker value="TARS US"/>
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        <balance>4510</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>316376.5</valUSD>
        <pctVal>0.1392345948</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Tectonic Therapeutic Inc.</name>
        <lei>N/A</lei>
        <title>TECTONIC THERAPEUTIC INC COMMON STOCK USD.0001</title>
        <cusip>878972108</cusip>
        <identifiers>
          <isin value="US8789721086"/>
          <ticker value="TECX US"/>
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        <balance>2700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>83457</valUSD>
        <pctVal>0.0367287127</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Tenax Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>TENAX THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>88032L605</cusip>
        <identifiers>
          <isin value="US88032L6056"/>
          <ticker value="TENX US"/>
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        <balance>1202</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>19219.98</valUSD>
        <pctVal>0.0084585490</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Tenet Healthcare Corporation</name>
        <lei>0W9AIBT6U6ADJ2I8HK17</lei>
        <title>TENET HEALTHCARE CORP COMMON STOCK USD.05</title>
        <cusip>88033G407</cusip>
        <identifiers>
          <isin value="US88033G4073"/>
          <ticker value="THC US"/>
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        <balance>12442</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2347929.82</valUSD>
        <pctVal>1.0333038554</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Terns Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>TERNS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>880881107</cusip>
        <identifiers>
          <isin value="US8808811074"/>
          <ticker value="TERN US"/>
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        <balance>13841</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>729697.52</valUSD>
        <pctVal>0.3211336448</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Thermo Fisher Scientific Inc.</name>
        <lei>HCHV7422L5HDJZCRFL38</lei>
        <title>THERMO FISHER SCIENTIFIC INC COMMON STOCK USD1.0</title>
        <cusip>883556102</cusip>
        <identifiers>
          <isin value="US8835561023"/>
          <ticker value="TMO US"/>
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        <balance>19052</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>9364629.56</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Tyra Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>TYRA BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>90240B106</cusip>
        <identifiers>
          <isin value="US90240B1061"/>
          <ticker value="TYRA US"/>
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        <balance>6900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>264270</valUSD>
        <pctVal>0.1163029693</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>United Therapeutics Corporation</name>
        <lei>N/A</lei>
        <title>UNITED THERAPEUTICS CORP COMMON STOCK USD.01</title>
        <cusip>91307C102</cusip>
        <identifiers>
          <isin value="US91307C1027"/>
          <ticker value="UTHR US"/>
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        <balance>5491</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3256053.18</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>UnitedHealth Group Incorporated</name>
        <lei>549300GHBMY8T5GXDE41</lei>
        <title>UNITEDHEALTH GROUP INC COMMON STOCK USD.01</title>
        <cusip>91324P102</cusip>
        <identifiers>
          <isin value="US91324P1021"/>
          <ticker value="UNH US"/>
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        <balance>26309</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7118952.31</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Vaxcyte Inc.</name>
        <lei>N/A</lei>
        <title>VAXCYTE INC COMMON STOCK USD.001</title>
        <cusip>92243G108</cusip>
        <identifiers>
          <isin value="US92243G1085"/>
          <ticker value="PCVX US"/>
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        <balance>7498</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Vera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>VERA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>92337R101</cusip>
        <identifiers>
          <isin value="US92337R1014"/>
          <ticker value="VERA US"/>
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        <balance>27378</balance>
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        <curCd>USD</curCd>
        <valUSD>1101416.94</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Vertex Pharmaceuticals Incorporated</name>
        <lei>54930015RAQRRZ5ZGJ91</lei>
        <title>VERTEX PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>92532F100</cusip>
        <identifiers>
          <isin value="US92532F1003"/>
          <ticker value="VRTX US"/>
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        <balance>12528</balance>
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        <curCd>USD</curCd>
        <valUSD>5594253.12</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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      <invstOrSec>
        <name>AbbVie Inc.</name>
        <lei>FR5LCKFTG8054YNNRU85</lei>
        <title>ABBVIE INC COMMON STOCK USD.01</title>
        <cusip>00287Y109</cusip>
        <identifiers>
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          <ticker value="ABBV US"/>
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        <balance>30125</balance>
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        <curCd>USD</curCd>
        <valUSD>6551886.25</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Immuneering Corporation</name>
        <lei>N/A</lei>
        <title>IMMUNEERING CORP COMMON STOCK USD.001</title>
        <cusip>45254E107</cusip>
        <identifiers>
          <isin value="US45254E1073"/>
          <ticker value="IMRX US"/>
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        <balance>17357</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>91471.39</valUSD>
        <pctVal>0.0402557773</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Immunome Inc.</name>
        <lei>N/A</lei>
        <title>IMMUNOME INC COMMON STOCK USD.0001</title>
        <cusip>45257U108</cusip>
        <identifiers>
          <isin value="US45257U1088"/>
          <ticker value="IMNM US"/>
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        <balance>39589</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>865811.43</valUSD>
        <pctVal>0.3810362137</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Immunocore Holdings plc</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC ADR GBP.0001</title>
        <cusip>45258D105</cusip>
        <identifiers>
          <isin value="US45258D1054"/>
          <ticker value="IMCR US"/>
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        <balance>16454</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>496088.1</valUSD>
        <pctVal>0.2183241347</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Danaher Corporation</name>
        <lei>S4BKK9OTCEWQ3YHPFM11</lei>
        <title>DANAHER CORP COMMON STOCK USD.01</title>
        <cusip>235851102</cusip>
        <identifiers>
          <isin value="US2358511028"/>
          <ticker value="DHR US"/>
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        <balance>24964</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>4733174.4</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Denali Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DENALI THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>24823R105</cusip>
        <identifiers>
          <isin value="US24823R1059"/>
          <ticker value="DNLI US"/>
        </identifiers>
        <balance>14063</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>270009.6</valUSD>
        <pctVal>0.1188289183</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Dianthus Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>DIANTHUS THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>252828108</cusip>
        <identifiers>
          <isin value="US2528281080"/>
          <ticker value="DNTH US"/>
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        <balance>11216</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>941246.72</valUSD>
        <pctVal>0.4142346404</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Disc Medicine Inc.</name>
        <lei>N/A</lei>
        <title>DISC MEDICINE INC COMMON STOCK USD.0001</title>
        <cusip>254604101</cusip>
        <identifiers>
          <isin value="US2546041011"/>
          <ticker value="IRON US"/>
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        <balance>5239</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>334981.66</valUSD>
        <pctVal>0.1474225668</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Edwards Lifesciences Corporation</name>
        <lei>YA13X31F3V31L8TMPR58</lei>
        <title>EDWARDS LIFESCIENCES CORP COMMON STOCK USD1.0</title>
        <cusip>28176E108</cusip>
        <identifiers>
          <isin value="US28176E1082"/>
          <ticker value="EW US"/>
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        <balance>12785</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1023822.8</valUSD>
        <pctVal>0.4505756678</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Eikon Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>EIKON THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>282564103</cusip>
        <identifiers>
          <isin value="US2825641036"/>
          <ticker value="EIKN US"/>
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        <balance>7211</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>76292.38</valUSD>
        <pctVal>0.0335756247</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Climb Bio Inc.</name>
        <lei>N/A</lei>
        <title>CLIMB BIO INC COMMON STOCK</title>
        <cusip>28658R106</cusip>
        <identifiers>
          <isin value="US28658R1068"/>
          <ticker value="CLYM US"/>
        </identifiers>
        <balance>38800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>265780</valUSD>
        <pctVal>0.1169675074</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Encompass Health Corporation</name>
        <lei>549300FVRPM9DRQZRG64</lei>
        <title>ENCOMPASS HEALTH CORP COMMON STOCK USD.01</title>
        <cusip>29261A100</cusip>
        <identifiers>
          <isin value="US29261A1007"/>
          <ticker value="EHC US"/>
        </identifiers>
        <balance>3941</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>381212.93</valUSD>
        <pctVal>0.1677685538</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Saluda Medical Inc.</name>
        <lei>N/A</lei>
        <title>SALUDA MEDICAL INC CDI</title>
        <cusip>BRC373908</cusip>
        <identifiers>
          <isin value="AU0000432114"/>
          <ticker value="SLD AU"/>
        </identifiers>
        <balance>79512</balance>
        <units>NS</units>
        <currencyConditional curCd="AUD" exchangeRt="1.44938"/>
        <valUSD>45704.23</valUSD>
        <pctVal>0.0201140412</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>BeOne Medicines Ltd</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEONE MEDICINES LTD COMMON STOCK USD.0001</title>
        <cusip>BVDKGC900</cusip>
        <identifiers>
          <isin value="CH1391448177"/>
          <ticker value="6160 HK"/>
        </identifiers>
        <balance>124598</balance>
        <units>NS</units>
        <currencyConditional curCd="HKD" exchangeRt="7.8412"/>
        <valUSD>2795033.77</valUSD>
        <pctVal>1.2300704842</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Sensorion</name>
        <lei>N/A</lei>
        <title>SENSORION SA COMMON STOCK EUR.1</title>
        <cusip>BWSW4N905</cusip>
        <identifiers>
          <isin value="FR0012596468"/>
          <ticker value="ALSEN FP"/>
        </identifiers>
        <balance>326680</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.865164"/>
        <valUSD>155116.02</valUSD>
        <pctVal>0.0682652352</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>HCA Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>HCA HEALTHCARE INC COMMON STOCK USD.01</title>
        <cusip>40412C101</cusip>
        <identifiers>
          <isin value="US40412C1018"/>
          <ticker value="HCA US"/>
        </identifiers>
        <balance>4436</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2099292.64</valUSD>
        <pctVal>0.9238807566</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Hims and Hers Health Inc.</name>
        <lei>N/A</lei>
        <title>HIMS and HERS HEALTH INC COMMON STOCK USD.0001</title>
        <cusip>433000106</cusip>
        <identifiers>
          <isin value="US4330001060"/>
          <ticker value="HIMS US"/>
        </identifiers>
        <balance>2300</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47748</valUSD>
        <pctVal>0.0210134869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>IDEAYA Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>IDEAYA BIOSCIENCES INC COMMON STOCK</title>
        <cusip>45166A102</cusip>
        <identifiers>
          <isin value="US45166A1025"/>
          <ticker value="IDYA US"/>
        </identifiers>
        <balance>7862</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>261961.84</valUSD>
        <pctVal>0.1152871678</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>IDEXX Laboratories Inc.</name>
        <lei>OGMTXK0LUU1HKV2P0J84</lei>
        <title>IDEXX LABORATORIES INC COMMON STOCK USD.1</title>
        <cusip>45168D104</cusip>
        <identifiers>
          <isin value="US45168D1046"/>
          <ticker value="IDXX US"/>
        </identifiers>
        <balance>1028</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>577622.92</valUSD>
        <pctVal>0.2542069125</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>McKesson Corporation</name>
        <lei>549300WZWOM80UCFSF54</lei>
        <title>MCKESSON CORP COMMON STOCK USD.01</title>
        <cusip>58155Q103</cusip>
        <identifiers>
          <isin value="US58155Q1031"/>
          <ticker value="MCK US"/>
        </identifiers>
        <balance>608</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>526138.88</valUSD>
        <pctVal>0.2315492263</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Sartorius Aktiengesellschaft</name>
        <lei>N/A</lei>
        <title>SARTORIUS AG PREFERENCE</title>
        <cusip>584332902</cusip>
        <identifiers>
          <isin value="DE0007165631"/>
          <ticker value="SRT3 GR"/>
        </identifiers>
        <balance>1256</balance>
        <units>NS</units>
        <currencyConditional curCd="EUR" exchangeRt="0.865164"/>
        <valUSD>314272.23</valUSD>
        <pctVal>0.1383085236</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EP</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Medpace Holdings Inc.</name>
        <lei>549300H8TYEUVTW14A54</lei>
        <title>MEDPACE HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>58506Q109</cusip>
        <identifiers>
          <isin value="US58506Q1094"/>
          <ticker value="MEDP US"/>
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        <balance>500</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>240095</valUSD>
        <pctVal>0.1056637584</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Merck and Co. Inc.</name>
        <lei>4YV9Y5M8S0BRK1RP0397</lei>
        <title>MERCK and CO INC COMMON STOCK USD.5</title>
        <cusip>58933Y105</cusip>
        <identifiers>
          <isin value="US58933Y1055"/>
          <ticker value="MRK US"/>
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        <balance>65688</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7901609.52</valUSD>
        <pctVal>3.4774308464</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Mirum Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MIRUM PHARMACEUTICALS INC COMMON STOCK</title>
        <cusip>604749101</cusip>
        <identifiers>
          <isin value="US6047491013"/>
          <ticker value="MIRM US"/>
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        <balance>7430</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>686383.4</valUSD>
        <pctVal>0.3020714706</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Moderna Inc.</name>
        <lei>N/A</lei>
        <title>MODERNA INC COMMON STOCK USD.0001</title>
        <cusip>60770K107</cusip>
        <identifiers>
          <isin value="US60770K1079"/>
          <ticker value="MRNA US"/>
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        <balance>12539</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>636981.2</valUSD>
        <pctVal>0.2803299844</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Molina Healthcare Inc.</name>
        <lei>549300NQQCEQ46YHZ591</lei>
        <title>MOLINA HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>60855R100</cusip>
        <identifiers>
          <isin value="US60855R1005"/>
          <ticker value="MOH US"/>
        </identifiers>
        <balance>2454</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>327118.2</valUSD>
        <pctVal>0.1439619253</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Monopar Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>MONOPAR THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>61023L207</cusip>
        <identifiers>
          <isin value="US61023L2079"/>
          <ticker value="MNPR US"/>
        </identifiers>
        <balance>864</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47338.56</valUSD>
        <pctVal>0.0208332958</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MediWound Ltd</name>
        <lei>N/A</lei>
        <title>MEDIWOUND LTD COMMON STOCK ILS.01</title>
        <cusip>M68830112</cusip>
        <identifiers>
          <isin value="IL0011316309"/>
          <ticker value="MDWD US"/>
        </identifiers>
        <balance>2287</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>36843.57</valUSD>
        <pctVal>0.0162145404</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>IL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Immatics N.V.</name>
        <lei>N/A</lei>
        <title>IMMATICS NV COMMON STOCK</title>
        <cusip>N44445109</cusip>
        <identifiers>
          <isin value="NL0015285941"/>
          <ticker value="IMTX US"/>
        </identifiers>
        <balance>14000</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>137760</valUSD>
        <pctVal>0.0606269991</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DE</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Pharvaris N.V.</name>
        <lei>N/A</lei>
        <title>PHARVARIS NV COMMON STOCK EUR.12</title>
        <cusip>N69605108</cusip>
        <identifiers>
          <isin value="NL00150005Y4"/>
          <ticker value="PHVS US"/>
        </identifiers>
        <balance>8899</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>251396.75</valUSD>
        <pctVal>0.1106375620</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Wave Life Sciences Ltd.</name>
        <lei>54930070006GPKFYZ813</lei>
        <title>WAVE LIFE SCIENCES LTD COMMON STOCK</title>
        <cusip>Y95308105</cusip>
        <identifiers>
          <isin value="SG9999014716"/>
          <ticker value="WVE US"/>
        </identifiers>
        <balance>47883</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>347151.75</valUSD>
        <pctVal>0.1527785195</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>SG</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Arrowhead Pharmaceuticals Inc.</name>
        <lei>549300O3CSB8T7OZ3D66</lei>
        <title>ARROWHEAD PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>04280A100</cusip>
        <identifiers>
          <isin value="US04280A1007"/>
          <ticker value="ARWR US"/>
        </identifiers>
        <balance>7841</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>491630.7</valUSD>
        <pctVal>0.2163624711</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ascendis Pharma A/S</name>
        <lei>N/A</lei>
        <title>ASCENDIS PHARMA A/S ADR DKK1.0</title>
        <cusip>04351P101</cusip>
        <identifiers>
          <isin value="US04351P1012"/>
          <ticker value="ASND US"/>
        </identifiers>
        <balance>14430</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3300573.9</valUSD>
        <pctVal>1.4525543766</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Beam Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BEAM THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>07373V105</cusip>
        <identifiers>
          <isin value="US07373V1052"/>
          <ticker value="BEAM US"/>
        </identifiers>
        <balance>25010</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>595988.3</valUSD>
        <pctVal>0.2622893593</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>BeOne Medicines Ltd</name>
        <lei>549300JFUK6FRD5MH739</lei>
        <title>BEONE MEDICINES LTD ADR USD.0001</title>
        <cusip>07725L102</cusip>
        <identifiers>
          <isin value="US07725L1026"/>
          <ticker value="ONC US"/>
        </identifiers>
        <balance>1214</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>360521.58</valUSD>
        <pctVal>0.1586624674</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Belite Bio Inc</name>
        <lei>N/A</lei>
        <title>BELITE BIO INC ADR USD.0001</title>
        <cusip>07782B104</cusip>
        <identifiers>
          <isin value="US07782B1044"/>
          <ticker value="BLTE US"/>
        </identifiers>
        <balance>4800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>765312</valUSD>
        <pctVal>0.3368072731</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Beta Bionics Inc.</name>
        <lei>N/A</lei>
        <title>BETA BIONICS INC COMMON STOCK USD.0001</title>
        <cusip>08659B102</cusip>
        <identifiers>
          <isin value="US08659B1026"/>
          <ticker value="BBNX US"/>
        </identifiers>
        <balance>2619</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>26242.38</valUSD>
        <pctVal>0.0115490472</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bicycle Therapeutics plc</name>
        <lei>N/A</lei>
        <title>BICYCLE THERAPEUTICS PLC ADR USD.01</title>
        <cusip>088786108</cusip>
        <identifiers>
          <isin value="US0887861088"/>
          <ticker value="BCYC US"/>
        </identifiers>
        <balance>25602</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>118793.28</valUSD>
        <pctVal>0.0522799077</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Natera Inc.</name>
        <lei>N/A</lei>
        <title>NATERA INC COMMON STOCK</title>
        <cusip>632307104</cusip>
        <identifiers>
          <isin value="US6323071042"/>
          <ticker value="NTRA US"/>
        </identifiers>
        <balance>12057</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2411279.43</valUSD>
        <pctVal>1.0611834776</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Novo Nordisk A/S</name>
        <lei>549300DAQ1CVT6CXN342</lei>
        <title>NOVO NORDISK A/S ADR</title>
        <cusip>670100205</cusip>
        <identifiers>
          <isin value="US6701002056"/>
          <ticker value="NVO US"/>
        </identifiers>
        <balance>9240</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>339570</valUSD>
        <pctVal>0.1494418561</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>DK</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nuvalent Inc.</name>
        <lei>N/A</lei>
        <title>NUVALENT INC COMMON STOCK USD.0001</title>
        <cusip>670703107</cusip>
        <identifiers>
          <isin value="US6707031075"/>
          <ticker value="NUVL US"/>
        </identifiers>
        <balance>10208</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1045809.6</valUSD>
        <pctVal>0.4602518706</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nurix Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>NURIX THERAPEUTICS INC COMMON STOCK</title>
        <cusip>67080M103</cusip>
        <identifiers>
          <isin value="US67080M1036"/>
          <ticker value="NRIX US"/>
        </identifiers>
        <balance>31364</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>486142</valUSD>
        <pctVal>0.2139469411</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Nuvation Bio Inc.</name>
        <lei>N/A</lei>
        <title>NUVATION BIO INC COMMON STOCK USD.0001</title>
        <cusip>67080N101</cusip>
        <identifiers>
          <isin value="US67080N1019"/>
          <ticker value="NUVB US"/>
        </identifiers>
        <balance>4972</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21329.88</valUSD>
        <pctVal>0.0093870980</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>CONTRA GENERATION BIO COMMON STOCK</name>
        <lei>N/A</lei>
        <title>CONTRA GENERATION BIO COMMON STOCK</title>
        <cusip>N/A</cusip>
        <identifiers>
          <other otherDesc="Custodian Identifier" value="371CVR010"/>
        </identifiers>
        <balance>3769</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3952.55</valUSD>
        <pctVal>0.0017394835</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>3</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Gilead Sciences Inc.</name>
        <lei>549300WTZWR07K8MNV44</lei>
        <title>GILEAD SCIENCES INC COMMON STOCK USD.001</title>
        <cusip>375558103</cusip>
        <identifiers>
          <isin value="US3755581036"/>
          <ticker value="GILD US"/>
        </identifiers>
        <balance>43100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>6006847</valUSD>
        <pctVal>2.6435620483</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ginkgo Bioworks Holdings Inc.</name>
        <lei>N/A</lei>
        <title>GINKGO BIOWORKS HOLDINGS INC COMMON STOCK USD.0001</title>
        <cusip>37611X209</cusip>
        <identifiers>
          <isin value="US37611X2099"/>
          <ticker value="DNA US"/>
        </identifiers>
        <balance>1971</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>12082.23</valUSD>
        <pctVal>0.0053172862</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Crescent Biopharma Inc.</name>
        <lei>N/A</lei>
        <title>CRESCENT BIOPHARMA INC COMMON STOCK USD.001</title>
        <cusip>38000Q201</cusip>
        <identifiers>
          <isin value="KYG2545C1042"/>
          <ticker value="CBIO US"/>
        </identifiers>
        <balance>5959</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>109466.83</valUSD>
        <pctVal>0.0481754167</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Ocular Therapeutix Inc.</name>
        <lei>N/A</lei>
        <title>OCULAR THERAPEUTIX INC COMMON STOCK USD.0001</title>
        <cusip>67576A100</cusip>
        <identifiers>
          <isin value="US67576A1007"/>
          <ticker value="OCUL US"/>
        </identifiers>
        <balance>31800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>269346</valUSD>
        <pctVal>0.1185368736</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Olema Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>OLEMA PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>68062P106</cusip>
        <identifiers>
          <isin value="US68062P1066"/>
          <ticker value="OLMA US"/>
        </identifiers>
        <balance>17454</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>260239.14</valUSD>
        <pctVal>0.1145290223</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ORIC Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ORIC PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>68622P109</cusip>
        <identifiers>
          <isin value="US68622P1093"/>
          <ticker value="ORIC US"/>
        </identifiers>
        <balance>41012</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>519622.04</valUSD>
        <pctVal>0.2286812207</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Oruka Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ORUKA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>687604108</cusip>
        <identifiers>
          <isin value="US6876041087"/>
          <ticker value="ORKA US"/>
        </identifiers>
        <balance>9120</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>447336</valUSD>
        <pctVal>0.1968687520</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Guardant Health Inc.</name>
        <lei>N/A</lei>
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        <cusip>40131M109</cusip>
        <identifiers>
          <isin value="US40131M1099"/>
          <ticker value="GH US"/>
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        <balance>22713</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2097999.81</valUSD>
        <pctVal>0.9233117932</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Immunocore Holdings plc</name>
        <lei>N/A</lei>
        <title>IMMUNOCORE HOLDINGS PLC SR UNSECURED 02/30 2.5</title>
        <cusip>45258DAB1</cusip>
        <identifiers>
          <isin value="US45258DAB10"/>
          <ticker value="IMCR"/>
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        <balance>277000</balance>
        <units>PA</units>
        <curCd>USD</curCd>
        <valUSD>248434.38</valUSD>
        <pctVal>0.1093338483</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>DBT</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <debtSec>
          <maturityDt>2030-02-01</maturityDt>
          <couponKind>Fixed</couponKind>
          <annualizedRt>2.500000000000</annualizedRt>
          <isDefault>N</isDefault>
          <areIntrstPmntsInArrs>N</areIntrstPmntsInArrs>
          <isPaidKind>N</isPaidKind>
          <isMandatoryConvrtbl>N</isMandatoryConvrtbl>
          <isContngtConvrtbl>N</isContngtConvrtbl>
          <dbtSecRefInstruments>
            <dbtSecRefInstrument>
              <name>Immunocore Holdings PLC</name>
              <title>Immunocore Holdings PLC</title>
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                <isin value="US45258D1054"/>
                <ticker value="IMCR"/>
                <other otherDesc="BLOOMBERG" value="EQ0000000089216579"/>
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          </dbtSecRefInstruments>
          <currencyInfos>
            <currencyInfo convRatio="10.560100000000" curCd="USD"/>
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          <delta>XXXX</delta>
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        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Immix Biopharma Inc.</name>
        <lei>N/A</lei>
        <title>IMMIX BIOPHARMA INC COMMON STOCK USD.0001</title>
        <cusip>45258H106</cusip>
        <identifiers>
          <isin value="US45258H1068"/>
          <ticker value="IMMX US"/>
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        <balance>7200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>65592</valUSD>
        <pctVal>0.0288664788</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Immunovant Inc.</name>
        <lei>N/A</lei>
        <title>IMMUNOVANT INC COMMON STOCK USD.0001</title>
        <cusip>45258J102</cusip>
        <identifiers>
          <isin value="US45258J1025"/>
          <ticker value="IMVT US"/>
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        <balance>1800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>44712</valUSD>
        <pctVal>0.0196773692</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Incyte Corporation</name>
        <lei>549300Z4WN6JVZ3T4680</lei>
        <title>INCYTE CORP COMMON STOCK USD.001</title>
        <cusip>45337C102</cusip>
        <identifiers>
          <isin value="US45337C1027"/>
          <ticker value="INCY US"/>
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        <balance>10734</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1010284.08</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Insmed Incorporated</name>
        <lei>N/A</lei>
        <title>INSMED INC COMMON STOCK USD.01</title>
        <cusip>457669307</cusip>
        <identifiers>
          <isin value="US4576693075"/>
          <ticker value="INSM US"/>
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        <balance>15382</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>2515264.64</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Inspire Medical Systems Inc.</name>
        <lei>N/A</lei>
        <title>INSPIRE MEDICAL SYSTEMS INC COMMON STOCK USD.001</title>
        <cusip>457730109</cusip>
        <identifiers>
          <isin value="US4577301090"/>
          <ticker value="INSP US"/>
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        <balance>2800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>144424</valUSD>
        <pctVal>0.0635597686</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Intuitive Surgical Inc.</name>
        <lei>54930052SRG011710797</lei>
        <title>INTUITIVE SURGICAL INC COMMON STOCK USD.001</title>
        <cusip>46120E602</cusip>
        <identifiers>
          <isin value="US46120E6023"/>
          <ticker value="ISRG US"/>
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        <balance>18275</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>8424592.25</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Ionis Pharmaceuticals Inc.</name>
        <lei>549300SI4ZGLG0BLUZ92</lei>
        <title>IONIS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>462222100</cusip>
        <identifiers>
          <isin value="US4622221004"/>
          <ticker value="IONS US"/>
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        <balance>19249</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1445407.41</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Iovance Biotherapeutics Inc.</name>
        <lei>N/A</lei>
        <title>IOVANCE BIOTHERAPEUTICS INC COMMON STOCK USD.000041666</title>
        <cusip>462260100</cusip>
        <identifiers>
          <isin value="US4622601007"/>
          <ticker value="IOVA US"/>
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        <balance>66187</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>232316.37</valUSD>
        <pctVal>0.1022404498</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>IQVIA Holdings Inc.</name>
        <lei>N/A</lei>
        <title>IQVIA HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>46266C105</cusip>
        <identifiers>
          <isin value="US46266C1053"/>
          <ticker value="IQV US"/>
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        <balance>4791</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>817057.14</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Janux Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>JANUX THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>47103J105</cusip>
        <identifiers>
          <isin value="US47103J1051"/>
          <ticker value="JANX US"/>
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        <balance>1511</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>21002.9</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Palvella Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>PALVELLA THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>697947109</cusip>
        <identifiers>
          <isin value="US6979471090"/>
          <ticker value="PVLA US"/>
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        <balance>3373</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>420444.45</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Revvity Inc.</name>
        <lei>549300IKL1SDPFI7N655</lei>
        <title>REVVITY INC COMMON STOCK USD1.0</title>
        <cusip>714046109</cusip>
        <identifiers>
          <isin value="US7140461093"/>
          <ticker value="RVTY US"/>
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        <balance>6470</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>566836.7</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Sonova Holding AG</name>
        <lei>N/A</lei>
        <title>SONOVA HOLDING AG COMMON STOCK CHF.05</title>
        <cusip>715603908</cusip>
        <identifiers>
          <isin value="CH0012549785"/>
          <ticker value="SOON SW"/>
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        <balance>2403</balance>
        <units>NS</units>
        <currencyConditional curCd="CHF" exchangeRt="0.7996"/>
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        <pctVal>0.2411332916</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CH</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>2</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>AstraZeneca PLC</name>
        <lei>PY6ZZQWO2IZFZC3IOL08</lei>
        <title>ASTRAZENECA PLC COMMON STOCK USD.25</title>
        <cusip>G0593M107</cusip>
        <identifiers>
          <isin value="GB0009895292"/>
          <ticker value="AZN US"/>
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        <balance>37129</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>7322581.38</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>GB</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      </invstOrSec>
      <invstOrSec>
        <name>Biohaven Ltd.</name>
        <lei>N/A</lei>
        <title>BIOHAVEN LTD COMMON STOCK</title>
        <cusip>G1110E107</cusip>
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          <isin value="VGG1110E1079"/>
          <ticker value="BHVN US"/>
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        <balance>31509</balance>
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        <curCd>USD</curCd>
        <valUSD>266566.14</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Kestra Medical Technologies Ltd</name>
        <lei>N/A</lei>
        <title>KESTRA MEDICAL TECHNOLOGIES LT COMMON STOCK USD100.0</title>
        <cusip>G52441105</cusip>
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          <isin value="BMG524411052"/>
          <ticker value="KMTS US"/>
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        <balance>17599</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>350748.07</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Roivant Sciences Ltd.</name>
        <lei>N/A</lei>
        <title>ROIVANT SCIENCES LTD COMMON STOCK USD.0000001</title>
        <cusip>G76279101</cusip>
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          <isin value="BMG762791017"/>
          <ticker value="ROIV US"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Evommune Inc.</name>
        <lei>N/A</lei>
        <title>EVOMMUNE INC COMMON STOCK USD.0001</title>
        <cusip>30054Y107</cusip>
        <identifiers>
          <isin value="US30054Y1073"/>
          <ticker value="EVMN US"/>
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        <balance>5551</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>127617.49</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Generate Biomedicines Inc.</name>
        <lei>N/A</lei>
        <title>GENERATE BIOMEDICINES INC COMMON STOCK</title>
        <cusip>370920100</cusip>
        <identifiers>
          <isin value="US3709201004"/>
          <ticker value="GENB US"/>
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        <balance>18234</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>227925</valUSD>
        <pctVal>0.1003078453</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
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          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Alto Neuroscience Inc.</name>
        <lei>N/A</lei>
        <title>ALTO NEUROSCIENCE INC COMMON STOCK USD.0001</title>
        <cusip>02157Q109</cusip>
        <identifiers>
          <isin value="US02157Q1094"/>
          <ticker value="ANRO US"/>
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        <balance>5900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>132632</valUSD>
        <pctVal>0.0583702101</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
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      </invstOrSec>
      <invstOrSec>
        <name>Alumis Inc.</name>
        <lei>N/A</lei>
        <title>ALUMIS INC COMMON STOCK USD.0001</title>
        <cusip>022307102</cusip>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Cencora Inc.</name>
        <lei>AI8GXW8LG5WK7E9UD086</lei>
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        <assetCat>EC</assetCat>
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      <invstOrSec>
        <name>Amgen Inc.</name>
        <lei>62QBXGPJ34PQ72Z12S66</lei>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Annexon Inc.</name>
        <lei>N/A</lei>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Elevance Health Inc.</name>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Apogee Therapeutics Inc.</name>
        <lei>N/A</lei>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>argenx SE</name>
        <lei>N/A</lei>
        <title>ARGENX SE ADR</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>NL</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BillionToOne Inc.</name>
        <lei>N/A</lei>
        <title>BILLIONTOONE INC COMMON STOCK USD.00001</title>
        <cusip>090168105</cusip>
        <identifiers>
          <isin value="US0901681058"/>
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        <balance>5603</balance>
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        <curCd>USD</curCd>
        <valUSD>442300.82</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Bio-Rad Laboratories Inc.</name>
        <lei>549300ZC1GPV35XYDK53</lei>
        <title>BIO-RAD LABORATORIES INC COMMON STOCK USD.0001</title>
        <cusip>090572207</cusip>
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          <isin value="US0905722072"/>
          <ticker value="BIO US"/>
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        <balance>1537</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>Boston Scientific Corporation</name>
        <lei>Y6ZDD9FP4P8JSSJMW954</lei>
        <title>BOSTON SCIENTIFIC CORP COMMON STOCK USD.01</title>
        <cusip>101137107</cusip>
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          <isin value="US1011371077"/>
          <ticker value="BSX US"/>
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        <balance>34293</balance>
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        <curCd>USD</curCd>
        <valUSD>2151885.75</valUSD>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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          <isCashCollateral>N</isCashCollateral>
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      <invstOrSec>
        <name>BridgeBio Oncology Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BRIDGEBIO ONCOLOGY THERAPEUTIC COMMON STOCK USD.0001</title>
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          <isin value="US1079241022"/>
          <ticker value="BBOT US"/>
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        <balance>9785</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>

        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BridgeBio Pharma Inc.</name>
        <lei>N/A</lei>
        <title>BRIDGEBIO PHARMA INC COMMON STOCK</title>
        <cusip>10806X102</cusip>
        <identifiers>
          <isin value="US10806X1028"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>BrightSpring Health Services Inc.</name>
        <lei>N/A</lei>
        <title>BRIGHTSPRING HEALTH SERVICES I COMMON STOCK USD100.0</title>
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          <ticker value="BTSG US"/>
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        <balance>54000</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>The Cigna Group</name>
        <lei>N/A</lei>
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        <cusip>125523100</cusip>
        <identifiers>
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          <ticker value="CI US"/>
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        <balance>6670</balance>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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        <name>CVS Health Corporation</name>
        <lei>549300EJG376EN5NQE29</lei>
        <title>CVS HEALTH CORP COMMON STOCK USD.01</title>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Cabaletta Bio Inc.</name>
        <lei>N/A</lei>
        <title>CABALETTA BIO INC COMMON STOCK USD.00001</title>
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          <ticker value="CABA US"/>
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        <curCd>USD</curCd>
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        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <name>Cardinal Health Inc.</name>
        <lei>CCU46N3GJMF4OK4N7U60</lei>
        <title>CARDINAL HEALTH INC COMMON STOCK</title>
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          <ticker value="CAH US"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Caris Life Sciences Inc.</name>
        <lei>N/A</lei>
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          <ticker value="CAI US"/>
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        <assetCat>EC</assetCat>
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      <invstOrSec>
        <name>Aktis Oncology Inc.</name>
        <lei>N/A</lei>
        <title>AKTIS ONCOLOGY INC COMMON STOCK</title>
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          <ticker value="AKTS US"/>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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      <invstOrSec>
        <name>Alignment Healthcare Inc.</name>
        <lei>N/A</lei>
        <title>ALIGNMENT HEALTHCARE INC COMMON STOCK USD.001</title>
        <cusip>01625V104</cusip>
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          <ticker value="ALHC US"/>
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        <balance>34394</balance>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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      <invstOrSec>
        <name>Allogene Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ALLOGENE THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>019770106</cusip>
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          <ticker value="ALLO US"/>
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        <curCd>USD</curCd>
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        <assetCat>EC</assetCat>
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        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>CG Oncology Inc.</name>
        <lei>N/A</lei>
        <title>CG ONCOLOGY INC COMMON STOCK</title>
        <cusip>156944100</cusip>
        <identifiers>
          <isin value="US1569441009"/>
          <ticker value="CGON US"/>
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        <curCd>USD</curCd>
        <valUSD>1628110.08</valUSD>
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        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
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        <fairValLevel>1</fairValLevel>
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      <invstOrSec>
        <name>Charles River Laboratories International Inc.</name>
        <lei>549300BSQ0R4UZ5KX287</lei>
        <title>CHARLES RIVER LABORATORIES INT COMMON STOCK USD.01</title>
        <cusip>159864107</cusip>
        <identifiers>
          <isin value="US1598641074"/>
          <ticker value="CRL US"/>
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        <balance>2002</balance>
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        <curCd>USD</curCd>
        <valUSD>345345</valUSD>
        <pctVal>0.1519833842</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
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          <isLoanByFund>N</isLoanByFund>
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      <invstOrSec>
        <name>Cogent Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>COGENT BIOSCIENCES INC COMMON STOCK USD.001</title>
        <cusip>19240Q201</cusip>
        <identifiers>
          <isin value="US19240Q2012"/>
          <ticker value="COGT US"/>
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        <balance>7984</balance>
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        <curCd>USD</curCd>
        <valUSD>307304.16</valUSD>
        <pctVal>0.1352419355</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Corvus Pharmaceuticals Inc.</name>
        <lei>549300I3AVJ8F75NCX65</lei>
        <title>CORVUS PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>221015100</cusip>
        <identifiers>
          <isin value="US2210151005"/>
          <ticker value="CRVS US"/>
        </identifiers>
        <balance>19845</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>290332.35</valUSD>
        <pctVal>0.1277727869</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Crinetics Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>CRINETICS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>22663K107</cusip>
        <identifiers>
          <isin value="US22663K1079"/>
          <ticker value="CRNX US"/>
        </identifiers>
        <balance>25378</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>921728.96</valUSD>
        <pctVal>0.4056450410</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cullinan Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CULLINAN THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>230031106</cusip>
        <identifiers>
          <isin value="US2300311063"/>
          <ticker value="CGEM US"/>
        </identifiers>
        <balance>15200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>215992</valUSD>
        <pctVal>0.0950562340</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Cytokinetics Incorporated</name>
        <lei>549300BE5DY1HW7IHA64</lei>
        <title>CYTOKINETICS INC COMMON STOCK USD.001</title>
        <cusip>23282W605</cusip>
        <identifiers>
          <isin value="US23282W6057"/>
          <ticker value="CYTK US"/>
        </identifiers>
        <balance>14740</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>971513.4</valUSD>
        <pctVal>0.4275547477</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Alnylam Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>ALNYLAM PHARMACEUTICALS INC COMMON STOCK USD.01</title>
        <cusip>02043Q107</cusip>
        <identifiers>
          <isin value="US02043Q1076"/>
          <ticker value="ALNY US"/>
        </identifiers>
        <balance>11541</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3818570.67</valUSD>
        <pctVal>1.6805203298</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Enliven Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ENLIVEN THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>29337E102</cusip>
        <identifiers>
          <isin value="US29337E1029"/>
          <ticker value="ELVN US"/>
        </identifiers>
        <balance>1200</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>47040</valUSD>
        <pctVal>0.0207019021</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Entrada Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ENTRADA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>29384C108</cusip>
        <identifiers>
          <isin value="US29384C1080"/>
          <ticker value="TRDA US"/>
        </identifiers>
        <balance>11642</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>146922.04</valUSD>
        <pctVal>0.0646591347</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Erasca Inc.</name>
        <lei>N/A</lei>
        <title>ERASCA INC COMMON STOCK USD.0001</title>
        <cusip>29479A108</cusip>
        <identifiers>
          <isin value="US29479A1088"/>
          <ticker value="ERAS US"/>
        </identifiers>
        <balance>28600</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>462748</valUSD>
        <pctVal>0.2036514415</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Abivax SA</name>
        <lei>N/A</lei>
        <title>ABIVAX SA ADR EUR.01</title>
        <cusip>00370M103</cusip>
        <identifiers>
          <isin value="US00370M1036"/>
          <ticker value="ABVX US"/>
        </identifiers>
        <balance>9016</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1003931.6</valUSD>
        <pctVal>0.4418217206</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>FR</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Adlai Nortye Ltd.</name>
        <lei>N/A</lei>
        <title>ADLAI NORTYE LTD ADR USD.0001</title>
        <cusip>00704R109</cusip>
        <identifiers>
          <isin value="US00704R1095"/>
          <ticker value="ANL US"/>
        </identifiers>
        <balance>4767</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>32987.64</valUSD>
        <pctVal>0.0145175786</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>KY</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Spyre Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>SPYRE THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>00773J202</cusip>
        <identifiers>
          <isin value="US00773J2024"/>
          <ticker value="SYRE US"/>
        </identifiers>
        <balance>19484</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>982772.96</valUSD>
        <pctVal>0.4325099839</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Agios Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>AGIOS PHARMACEUTICALS INC COMMON STOCK USD.001</title>
        <cusip>00847X104</cusip>
        <identifiers>
          <isin value="US00847X1046"/>
          <ticker value="AGIO US"/>
        </identifiers>
        <balance>3270</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>110624.1</valUSD>
        <pctVal>0.0486847213</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Atrium Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>ATRIUM THERAPEUTICS INC COMMON STOCK</title>
        <cusip>04965N104</cusip>
        <identifiers>
          <isin value="US04965N1046"/>
          <ticker value="RNA US"/>
        </identifiers>
        <balance>14900</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>199213</valUSD>
        <pctVal>0.0876719394</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Aura Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>AURA BIOSCIENCES INC COMMON STOCK USD.00001</title>
        <cusip>05153U107</cusip>
        <identifiers>
          <isin value="US05153U1079"/>
          <ticker value="AURA US"/>
        </identifiers>
        <balance>10426</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>69749.94</valUSD>
        <pctVal>0.0306963527</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Axsome Therapeutics Inc.</name>
        <lei>549300EXGR0XLRJEIB95</lei>
        <title>AXSOME THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>05464T104</cusip>
        <identifiers>
          <isin value="US05464T1043"/>
          <ticker value="AXSM US"/>
        </identifiers>
        <balance>3961</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>669488.22</valUSD>
        <pctVal>0.2946360462</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Bicara Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>BICARA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>055477103</cusip>
        <identifiers>
          <isin value="US0554771032"/>
          <ticker value="BCAX US"/>
        </identifiers>
        <balance>17135</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>340815.15</valUSD>
        <pctVal>0.1499898359</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Celcuity Inc.</name>
        <lei>N/A</lei>
        <title>CELCUITY INC COMMON STOCK USD.001</title>
        <cusip>15102K100</cusip>
        <identifiers>
          <isin value="US15102K1007"/>
          <ticker value="CELC US"/>
        </identifiers>
        <balance>11819</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1349020.66</valUSD>
        <pctVal>0.5936924678</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Celldex Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>CELLDEX THERAPEUTICS INC COMMON STOCK USD.001</title>
        <cusip>15117B202</cusip>
        <identifiers>
          <isin value="US15117B2025"/>
          <ticker value="CLDX US"/>
        </identifiers>
        <balance>10510</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>333377.2</valUSD>
        <pctVal>0.1467164577</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centene Corporation</name>
        <lei>549300Z7JJ4TQSQGT333</lei>
        <title>CENTENE CORP COMMON STOCK USD.001</title>
        <cusip>15135B101</cusip>
        <identifiers>
          <isin value="US15135B1017"/>
          <ticker value="CNC US"/>
        </identifiers>
        <balance>13351</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>437111.74</valUSD>
        <pctVal>0.1923691425</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Centessa Pharmaceuticals plc</name>
        <lei>N/A</lei>
        <title>CENTESSA PHARMACEUTICALS PLC ADR USD.0001</title>
        <cusip>152309100</cusip>
        <identifiers>
          <isin value="US1523091007"/>
          <ticker value="CNTA US"/>
        </identifiers>
        <balance>31457</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1249472.04</valUSD>
        <pctVal>0.5498819706</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Johnson and Johnson</name>
        <lei>549300G0CFPGEF6X2043</lei>
        <title>JOHNSON and JOHNSON COMMON STOCK USD1.0</title>
        <cusip>478160104</cusip>
        <identifiers>
          <isin value="US4781601046"/>
          <ticker value="JNJ US"/>
        </identifiers>
        <balance>22972</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>5615275.68</valUSD>
        <pctVal>2.4712348555</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kodiak Sciences Inc.</name>
        <lei>N/A</lei>
        <title>KODIAK SCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>50015M109</cusip>
        <identifiers>
          <isin value="US50015M1099"/>
          <ticker value="KOD US"/>
        </identifiers>
        <balance>21314</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>812489.68</valUSD>
        <pctVal>0.3575697671</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Krystal Biotech Inc.</name>
        <lei>N/A</lei>
        <title>KRYSTAL BIOTECH INC COMMON STOCK USD.00001</title>
        <cusip>501147102</cusip>
        <identifiers>
          <isin value="US5011471027"/>
          <ticker value="KRYS US"/>
        </identifiers>
        <balance>5944</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1535454.08</valUSD>
        <pctVal>0.6757402232</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kymera Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYMERA THERAPEUTICS INC COMMON STOCK USD.0001</title>
        <cusip>501575104</cusip>
        <identifiers>
          <isin value="US5015751044"/>
          <ticker value="KYMR US"/>
        </identifiers>
        <balance>22089</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>1839792.81</valUSD>
        <pctVal>0.8096770983</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Kyverna Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>KYVERNA THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>501976104</cusip>
        <identifiers>
          <isin value="US5019761049"/>
          <ticker value="KYTX US"/>
        </identifiers>
        <balance>32113</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>277135.19</valUSD>
        <pctVal>0.1219648296</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Lantheus Holdings Inc.</name>
        <lei>N/A</lei>
        <title>LANTHEUS HOLDINGS INC COMMON STOCK USD.01</title>
        <cusip>516544103</cusip>
        <identifiers>
          <isin value="US5165441032"/>
          <ticker value="LNTH US"/>
        </identifiers>
        <balance>2700</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>204795</valUSD>
        <pctVal>0.0901285299</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>LENZ Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>LENZ THERAPEUTICS INC COMMON STOCK USD.00001</title>
        <cusip>52635N103</cusip>
        <identifiers>
          <isin value="US52635N1037"/>
          <ticker value="LENZ US"/>
        </identifiers>
        <balance>3467</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>31723.05</valUSD>
        <pctVal>0.0139610433</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Eli Lilly and Company</name>
        <lei>FRDRIPF3EKNDJ2CQJL29</lei>
        <title>ELI LILLY and CO COMMON STOCK</title>
        <cusip>532457108</cusip>
        <identifiers>
          <isin value="US5324571083"/>
          <ticker value="LLY US"/>
        </identifiers>
        <balance>25208</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>23185562.16</valUSD>
        <pctVal>10.2037678325</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Liquidia Corporation</name>
        <lei>N/A</lei>
        <title>LIQUIDIA CORP COMMON STOCK USD.001</title>
        <cusip>53635D202</cusip>
        <identifiers>
          <isin value="US53635D2027"/>
          <ticker value="LQDA US"/>
        </identifiers>
        <balance>5811</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>219307.14</valUSD>
        <pctVal>0.0965151988</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>MBX Biosciences Inc.</name>
        <lei>N/A</lei>
        <title>MBX BIOSCIENCES INC COMMON STOCK USD.0001</title>
        <cusip>55287L101</cusip>
        <identifiers>
          <isin value="US55287L1017"/>
          <ticker value="MBX US"/>
        </identifiers>
        <balance>17761</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>530165.85</valUSD>
        <pctVal>0.2333214614</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Madrigal Pharmaceuticals Inc.</name>
        <lei>N/A</lei>
        <title>MADRIGAL PHARMACEUTICALS INC COMMON STOCK USD.0001</title>
        <cusip>558868105</cusip>
        <identifiers>
          <isin value="US5588681057"/>
          <ticker value="MDGL US"/>
        </identifiers>
        <balance>1671</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>874718.37</valUSD>
        <pctVal>0.3849560819</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Replimune Group Inc.</name>
        <lei>N/A</lei>
        <title>REPLIMUNE GROUP INC COMMON STOCK USD.001</title>
        <cusip>76029N106</cusip>
        <identifiers>
          <isin value="US76029N1063"/>
          <ticker value="REPL US"/>
        </identifiers>
        <balance>41036</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>313925.4</valUSD>
        <pctVal>0.1381558867</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</name>
        <lei>N/A</lei>
        <title>ROWE T PRICE GOV RES FD 20340919 00000.0000000000</title>
        <cusip>76105Y109</cusip>
        <identifiers>
          <isin value="US76105Y1091"/>
          <ticker value="76105Y109010"/>
        </identifiers>
        <balance>986092.09</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>986092.09</valUSD>
        <pctVal>0.4339707046</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>STIV</assetCat>
        <issuerCat>RF</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Revolution Medicines Inc.</name>
        <lei>N/A</lei>
        <title>REVOLUTION MEDICINES INC COMMON STOCK</title>
        <cusip>76155X100</cusip>
        <identifiers>
          <isin value="US76155X1000"/>
          <ticker value="RVMD US"/>
        </identifiers>
        <balance>32474</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>3158096.5</valUSD>
        <pctVal>1.3898512901</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Viatris Inc.</name>
        <lei>N/A</lei>
        <title>VIATRIS INC COMMON STOCK</title>
        <cusip>92556V106</cusip>
        <identifiers>
          <isin value="US92556V1061"/>
          <ticker value="VTRS US"/>
        </identifiers>
        <balance>20800</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>281008</valUSD>
        <pctVal>0.1236692202</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Viridian Therapeutics Inc.</name>
        <lei>N/A</lei>
        <title>VIRIDIAN THERAPEUTICS INC COMMON STOCK USD.01</title>
        <cusip>92790C104</cusip>
        <identifiers>
          <isin value="US92790C1045"/>
          <ticker value="VRDN US"/>
        </identifiers>
        <balance>8729</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>170739.24</valUSD>
        <pctVal>0.0751408809</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>West Pharmaceutical Services Inc.</name>
        <lei>5493007NKRGM1RJQ1P16</lei>
        <title>WEST PHARMACEUTICAL SERVICES I COMMON STOCK USD.25</title>
        <cusip>955306105</cusip>
        <identifiers>
          <isin value="US9553061055"/>
          <ticker value="WST US"/>
        </identifiers>
        <balance>2100</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>526344</valUSD>
        <pctVal>0.2316394978</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Xencor Inc.</name>
        <lei>549300V5IF65437JKG30</lei>
        <title>XENCOR INC COMMON STOCK USD.01</title>
        <cusip>98401F105</cusip>
        <identifiers>
          <isin value="US98401F1057"/>
          <ticker value="XNCR US"/>
        </identifiers>
        <balance>13179</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>158938.74</valUSD>
        <pctVal>0.0699475817</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>US</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
      <invstOrSec>
        <name>Zai Lab Limited</name>
        <lei>N/A</lei>
        <title>ZAI LAB LTD ADR USD.00006</title>
        <cusip>98887Q104</cusip>
        <identifiers>
          <isin value="US98887Q1040"/>
          <ticker value="ZLAB US"/>
        </identifiers>
        <balance>8626</balance>
        <units>NS</units>
        <curCd>USD</curCd>
        <valUSD>162255.06</valUSD>
        <pctVal>0.0714070658</pctVal>
        <payoffProfile>Long</payoffProfile>
        <assetCat>EC</assetCat>
        <issuerCat>CORP</issuerCat>
        <invCountry>CN</invCountry>
        <isRestrictedSec>N</isRestrictedSec>

        <fairValLevel>1</fairValLevel>
        <securityLending>
          <isCashCollateral>N</isCashCollateral>
          <isNonCashCollateral>N</isNonCashCollateral>
          <isLoanByFund>N</isLoanByFund>
        </securityLending>
      </invstOrSec>
    </invstOrSecs>
    <explntrNotes>
      <explntrNote note="Returns are reported without deduction of sales loads and redemption fees, if applicable." noteItem="B.5.a"/>
    </explntrNotes>
    <signature>
      <ncom:dateSigned>2026-04-29</ncom:dateSigned>
      <ncom:nameOfApplicant>John Hancock Variable Insurance Trust</ncom:nameOfApplicant>
      <ncom:signature>/s/Salvatore Schiavone</ncom:signature>
      <ncom:signerName>Salvatore Schiavone</ncom:signerName>
      <ncom:title>Treasurer</ncom:title>
    </signature>
  </formData>
  <documents>XXXX</documents>
</edgarSubmission>
