<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0101</schemaVersion>

    <submissionType>EFFECT</submissionType>

    <act>33</act>

    <testOrLive>LIVE</testOrLive>

    <effectiveData>
        <finalEffectivenessDispDate>2017-04-19</finalEffectivenessDispDate>
        <accessionNumber>0000754915-17-000016</accessionNumber>
        <submissionType>485APOS</submissionType>
        <filer>
            <cik>0000754915</cik>
            <entityName>T. Rowe Price High Yield Fund, Inc.</entityName>
            <fileNumber>002-93707</fileNumber>
            <seriesClassContractData>
                <existing>
                    <seriesId>S000057617</seriesId>
                    <seriesName>T. Rowe Price U.S. High Yield Fund</seriesName>
                    <classContractId>C000183992</classContractId>
                    <classContractName>T. Rowe Price U.S. High Yield Fund</classContractName>
                </existing>
                <existing>
                    <seriesId>S000057617</seriesId>
                    <seriesName>T. Rowe Price U.S. High Yield Fund</seriesName>
                    <classContractId>C000183993</classContractId>
                    <classContractName>T. Rowe Price U.S. High Yield Fund-Advisor Class</classContractName>
                </existing>
                <existing>
                    <seriesId>S000057617</seriesId>
                    <seriesName>T. Rowe Price U.S. High Yield Fund</seriesName>
                    <classContractId>C000183994</classContractId>
                    <classContractName>T. Rowe Price U.S. High Yield Fund-I Class</classContractName>
                </existing>
            </seriesClassContractData>
        </filer>
    </effectiveData>
</edgarSubmission>
