<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0000754813</cik>
        <entityName>CLACENDIX, INC.</entityName>
        <issuerAddress>
            <street1>100 Commerce Boulevard</street1>
            <city>Cincinnati</city>
            <stateOrCountry>OH</stateOrCountry>
            <zipCode>45140</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(513) 618-0911</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>Ion Networks, Inc.</previousName>
            <previousName>Microframe, Inc.</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>DE</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Dhadphale</firstName>
                <middleName></middleName>
                <lastName>Lalit</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Clacendix, Inc.</street1>
                <street2>100 Commerce Boulevard</street2>
                <city>Cincinnati</city>
                <stateOrCountry>OH</stateOrCountry>
                <zipCode>45140</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Patrick</firstName>
                <middleName>E.</middleName>
                <lastName>Delaney</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Clacendix, Inc.</street1>
                <street2>100 Commerce Boulevard</street2>
                <city>Cincinnati</city>
                <stateOrCountry>OH</stateOrCountry>
                <zipCode>45140</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Wayne</firstName>
                <middleName>A.</middleName>
                <lastName>Corona</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Clacendix</street1>
                <street2>100 Commerce Boulevard</street2>
                <city>Cincinnati</city>
                <stateOrCountry>OH</stateOrCountry>
                <zipCode>45140</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Stephen</firstName>
                <middleName>M.</middleName>
                <lastName>Deixler</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Clacendix, Inc.</street1>
                <street2>100 Commerce Boulevard</street2>
                <city>Cincinnati</city>
                <stateOrCountry>OH</stateOrCountry>
                <zipCode>45140</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Norman</firstName>
                <middleName>E.</middleName>
                <lastName>Corn</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Clacendix, Inc.</street1>
                <street2>100 Commerce Boulevard</street2>
                <city>Cincinnati</city>
                <stateOrCountry>OH</stateOrCountry>
                <zipCode>45140</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Retailing</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1,000,001 - $5,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-05-14</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>true</isBusinessCombinationTransaction>
            <clarificationOfResponse>On May 14, 2009, Clacendix acquired HealthWarehouse.com, Inc. by issuing 155,194,563 shares of its common stock in exchange for all of HW's outstanding stock, at a rate of 141.008 shares of Clacendix common stock for each HW share.</clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>6515643</totalOfferingAmount>
            <totalAmountSold>6515643</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>Based on an assumed value of $5.92004 of each share of HW stock exchanged, which consisted of 1,060,000 shares of Class A Common Stock and 40,608 shares of Class B common stock.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>true</hasNonAccreditedInvestors>
            <numberNonAccreditedInvestors>6</numberNonAccreditedInvestors>
            <totalNumberAlreadyInvested>49</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>There were no cash proceeds from the share exchange transaction.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Clacendix, Inc.</issuerName>
                <signatureName>/s/ Lalit Dhadphale</signatureName>
                <nameOfSigner>Lalit Dhadphale</nameOfSigner>
                <signatureTitle>President, Chief Executive Officer and Director</signatureTitle>
                <signatureDate>2009-05-28</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
