497

August 16, 2013

VIA EDGAR TRANSMISSION

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Re: Manning & Napier Fund, Inc. (the “Company”)

File Nos. 2-92633 and 811-04087

Ladies and Gentlemen:

On behalf of the Company, attached for filing pursuant to Rule 497(e) under the Securities Act of 1933, as amended (the “1933 Act”), are exhibits containing interactive data format risk/return summary information that mirrors the risk/return summary information contained in the Prospectus dated May 1, 2013 as supplemented August 1, 2013 and filed pursuant to Rule 497(e) under the 1933 Act. The purpose of this filing is to submit the revised data in XBRL format for the Company.

Any questions or comments regarding this filing should be directed to the undersigned at (585) 325-6880.

Very truly yours,

/s/ Amy J. Williams

Amy J. Williams

Director of Fund Documentation

XML

Label	Element	Value
Risk/Return:	rr_RiskReturnAbstract
Registrant Name	dei_EntityRegistrantName	MANNING & NAPIER FUND, INC /NY/
Prospectus Date	rr_ProspectusDate	May 01, 2013
Document Creation Date	dei_DocumentCreationDate	Jul. 31, 2013

XML

Label

Element

Value

Risk/Return:

rr_RiskReturnAbstract

Registrant Name

dei_EntityRegistrantName

MANNING & NAPIER FUND, INC /NY/

Prospectus Date

rr_ProspectusDate

May 01, 2013

Supplement [Text Block]

mnfi_SupplementTextBlock

MANNING & NAPIER FUND, INC.

Supplement dated August 1, 2013 to the combined Prospectus (the “Prospectus”) dated May 1, 2013 for the following Series:

Small Cap Series – Class A	Core Bond Series
Commodity Series	Core Plus Bond Series
Technology Series	Real Estate Series – Class S and I
International Series – Class S and I	Emerging Markets Series
Life Sciences Series	Inflation Focus Equity Series
World Opportunities Series – Class A	Diversified Tax Exempt Series
High Yield Bond Series – Class S and I	New York Tax Exempt Series
Global Fixed Income Series – Class S and I	Ohio Tax Exempt Series

This supplement provides new and additional information beyond that contained in the Prospectus and should be read in conjunction with the Prospectus.

1. Effective August 1, 2013, the shares of the Core Plus Bond Series, which previously did not have a class name designation, have been redesignated as Class S Shares. Class S Shares of the Core Plus Bond Series are offered in a separate prospectus. Accordingly, effective August 1, 2013, shares of the Core Plus Bond Series are no longer offered in the Prospectus, and all references to the Core Plus Bond Series in the Prospectus are hereby deleted.

Core Plus Bond Series

Risk/Return:

rr_RiskReturnAbstract

Supplement [Text Block]

mnfi_SupplementTextBlock

MANNING & NAPIER FUND, INC.

Supplement dated August 1, 2013 to the combined Prospectus (the “Prospectus”) dated May 1, 2013 for the following Series:

Small Cap Series – Class A	Core Bond Series
Commodity Series	Core Plus Bond Series
Technology Series	Real Estate Series – Class S and I
International Series – Class S and I	Emerging Markets Series
Life Sciences Series	Inflation Focus Equity Series
World Opportunities Series – Class A	Diversified Tax Exempt Series
High Yield Bond Series – Class S and I	New York Tax Exempt Series
Global Fixed Income Series – Class S and I	Ohio Tax Exempt Series

This supplement provides new and additional information beyond that contained in the Prospectus and should be read in conjunction with the Prospectus.

1. Effective August 1, 2013, the shares of the Core Plus Bond Series, which previously did not have a class name designation, have been redesignated as Class S Shares. Class S Shares of the Core Plus Bond Series are offered in a separate prospectus. Accordingly, effective August 1, 2013, shares of the Core Plus Bond Series are no longer offered in the Prospectus, and all references to the Core Plus Bond Series in the Prospectus are hereby deleted.

XML

MANNING & NAPIER FUND, INC.

Supplement dated August 1, 2013 to the combined Prospectus (the “Prospectus”) dated May 1, 2013 for the following Series:

Small Cap Series – Class A	Core Bond Series
Commodity Series	Core Plus Bond Series
Technology Series	Real Estate Series – Class S and I
International Series – Class S and I	Emerging Markets Series
Life Sciences Series	Inflation Focus Equity Series
World Opportunities Series – Class A	Diversified Tax Exempt Series
High Yield Bond Series – Class S and I	New York Tax Exempt Series
Global Fixed Income Series – Class S and I	Ohio Tax Exempt Series

This supplement provides new and additional information beyond that contained in the Prospectus and should be read in conjunction with the Prospectus.

1. Effective August 1, 2013, the shares of the Core Plus Bond Series, which previously did not have a class name designation, have been redesignated as Class S Shares. Class S Shares of the Core Plus Bond Series are offered in a separate prospectus. Accordingly, effective August 1, 2013, shares of the Core Plus Bond Series are no longer offered in the Prospectus, and all references to the Core Plus Bond Series in the Prospectus are hereby deleted.

XML

Document and Entity Information	12 Months Ended
	May 01, 2013
Risk/Return:
Document Type	Other
Document Period End Date	Dec. 31, 2012
Registrant Name	MANNING & NAPIER FUND, INC /NY/
Central Index Key	0000751173
Amendment Flag	false
Document Creation Date	Jul. 31, 2013
Document Effective Date	Jul. 31, 2013
Prospectus Date	May 01, 2013