MANNING & NAPIER FUND, INC.

Supplement dated April 1, 2010 to the following Prospectuses

The combined Prospectus (the “Combined Prospectus”) dated May 1, 2009, as amended

August 6, 2009 and supplemented August 28, 2009, September 22, 2009, and

November 20, 2009 for the following Series:

Small Cap Series	High Yield Bond Series
Commodity Series	Global Fixed Income Series
Technology Series	Financial Services Series
International Series	Core Bond Series
Life Sciences Series	Core Plus Bond Series
World Opportunities Series	Real Estate Series

The Prospectus dated May 1, 2009 as supplemented November 20, 2009

for the Technology Series (the “Technology Series Prospectus”)

The Prospectus dated May 1, 2009 as supplemented July 27, 2009 and November 20, 2009

for the International Series (the “International Series Prospectus”)

This supplement provides new and additional information beyond that contained in the Prospectuses and should be read in conjunction with the Prospectuses.

Due to the re-assignment of duties within the Research Department of Manning & Napier Advisors, Inc. (the “Advisor”), the following changes have been made to the Research Teams of the Technology Series and the International Series: Ajay M. Sadarangani has been replaced as a member of the Technology Series’ Research Team by Tariq Siddiqi, and Jeffrey A. Herrmann has been replaced as a member of the International Series’ Research Team by Sidharth Abrol. Accordingly, each of the Prospectuses identified above is revised as follows:

1. The following information is hereby added to the “Portfolio Managers” section of the Combined Prospectus and the Technology Series Prospectus:

Name and Title	Tariq Siddiqi, CFA®, Junior Analyst
Business Experience During Last Five Years	Joined the Advisor in 2003. Current position held since 2008. Member of the Technology Series Research Team since 2010. Previous position held in last five years: Research Associate, 2005 – 2008.

2. The information with respect to Ajay M. Sadarangani in the “Portfolio Managers” section of the Combined Prospectus and the Technology Series Prospectus is hereby deleted.

3. The following information is hereby added to the “Portfolio Managers” section of the Combined Prospectus and the International Series Prospectus:

Name and Title	Sidharth Abrol, CFA®, Junior Analyst
Business Experience During Last Five Years	Joined the Advisor in 2002. Current position held since 2007. Member of the International Series Research Team since 2010. Previous position held in last five years: Research Associate, 2005 – 2007.

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4. The information with respect to Jeffrey A. Herrmann in the “Portfolio Managers” section of the Combined Prospectus is hereby deleted and replaced with the following:

Name and Title	Jeffrey A. Herrmann, CFA®, Co-Director of Research / Managing Director of Themes and Overviews Group
Business Experience During Last Five Years	Joined the Advisor in 1986. Current position held since 1988. Co-Director of Research since 1992. Member of Senior Research Group since 1992. Executive Group Member* since 2002. Member of Real Estate Series Research Team since 2009.

5. The information with respect to Jeffrey A. Herrmann in the “Portfolio Managers” section of the International Series Prospectus is hereby deleted and replaced with the following:

Name and Title	Jeffrey A. Herrmann, CFA®, Co-Director of Research / Managing Director of Themes and Overviews Group
Business Experience During Last Five Years	Joined the Advisor in 1986. Current position held since 1988. Co-Director of Research since 1992. Member of Senior Research Group since 1992. Executive Group Member* since 2002.

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Manning & Napier Fund, Inc.

Supplement dated April 1, 2010 to the

Statement of Additional Information (“SAI”) dated May 1, 2009

as supplemented July 27, 2009, September 22, 2009, November 20, 2009,

and March 3, 2010

This supplement applies to the SAI of each of the following series of Manning & Napier Fund, Inc. (the “Fund”): Small Cap Series (Class A, B, Z, D, and E Shares), Commodity Series, Technology Series, High Yield Bond Series, International Series, Life Sciences Series, Global Fixed Income Series, World Opportunities Series (Class A, B, Z, D, and E Shares), New York Tax Exempt Series, Ohio Tax Exempt Series, Diversified Tax Exempt Series, Financial Services Series, Core Bond Series, and Core Plus Bond Series.

This supplement provides new and additional information beyond that contained in the SAI and should be read in conjunction with the SAI.

Due to the re-assignment of duties within the Research Department of Manning & Napier Advisors, Inc. (the “Advisor”), the following changes have been made to the Research Teams of the Technology Series and the International Series: Ajay M. Sadarangani has been replaced as a member of the Technology Series’ Research Team by Tariq Siddiqi, and Jeffrey A. Herrmann has been replaced as a member of the International Series’ Research Team by Sidharth Abrol. Accordingly, the “Portfolio Managers” section of the SAI is hereby deleted and replaced by the following:

Portfolio Managers

This section includes information about the Series’ portfolio managers, including information about the dollar range of Fund shares they own, how they are compensated, and other accounts they manage.

The Advisor’s Senior Research Group establishes the broad investment policies and guidelines used in the management of each Series.

For the Series of the Fund that include equity securities, other than the World Opportunities Series, a designated Research Team for each Series implements those policies and guidelines, as well as monitors the investment portfolio for the Series. Each Series’ Research Team works with the Advisor’s analysts to develop stock recommendations for the Series in line with the Senior Research Group’s policies and guidelines. Recommendations for security purchases and sales must be approved by two members of the Series’ Research Team and one member of the Senior Research Group before implementation. No specific member of the Series’ Research Team or Senior Research Group is required to approve securities purchases and sales.

For the World Opportunities Series, the Advisor’s analysts work with members of the Senior Research Group to develop stock recommendations for the Series in line with the Senior Research Group’s policies and guidelines. Recommendations for security purchases must be approved by the Senior Research Group prior to implementation.

For the Series of the Fund that invest solely in fixed income securities, the Series’ Research Team, led by Jack Bauer, constructs and monitors the Series’ portfolio. The Research Team develops an interest rate overview and a credit approved list that is reviewed by the Senior Research Group.

The following individuals serve on the Advisor’s Senior Research Group and/or the Research Teams of specific Series of the Fund, as noted. Except as noted, the information is as of December 31, 2008.

Name and Title	Fund Management Role	Dollar Range of Equity Securities Beneficially Owned by the Portfolio Manager in the Series covered by this SAI	Dollar Range of Equity Securities Beneficially Owned by the Portfolio Manager in all Manning & Napier Fund Series
Sidharth Abrol, CFA, Junior Analyst**	Member of International Series Research Team	None	Between $1 and $10,000
Christian A. Andreach, CFA, Senior Analyst/Managing Director of Consumer Group	Member of Senior Research Group	Life Sciences Series – between $1 and $10,000 Financial Services Series – between $1 and $10,000 International Series – between $1 and $10,000	Between $100,001 and $500,000
Jack Bauer, Senior Analyst/Managing Director of Fixed Income Group	Member of Senior Research Group, Member of Tax Exempt Series, Core Bond Series, Core Plus Bond Series, Global Fixed Income Series, and High Yield Bond Series Research Teams	None	Between $100,001 and $500,000
Marc Bushallow, CFA®, Senior High Yield Analyst	Member of Core Plus Bond Series and High Yield Bond Series Research Teams	None	Between $50,001 and $100,000
Jeffrey S. Coons, Ph.D., CFA, Co-Director of Research/ Managing Director of Quantitative Strategies Group	Member of Senior Research Group	None	Between $500,001 and $1,000,000
Eric L. Daniels, Senior Analyst	Member of Life Sciences Series Research Team	None	Between $1 and $10,000
Jeffrey W. Donlon, CFA, Senior Analyst/Managing Director of Technology Group	Member of Senior Research Group, Member of Technology Series Research Team	None	Between $10,001 and $50,000
Brian P. Gambill, CFA, Senior Analyst/Managing Director of Capital Goods & Materials Group	Member of Senior Research Group	None	Between $100,001 and $500,000

R. Keith Harwood, Fixed Income Analyst	Member of Core Bond Series, Core Plus Bond Series, and High Yield Bond Series Research Teams	None	Between $50,001 and $100,000
Jeffrey A. Herrmann, CFA, Co-Director of Research/ Managing Director of Themes & Overviews Group	Member of Senior Research Group	Life Sciences Series – between $10,001 and $50,000 Technology Series – between $1 and $10,000 Small Cap Series – between $1 and $10,000 World Opportunities Series – between $1 and $10,000	Between $100,001 and $500,000

Brian W. Lester, CFA, Senior Analyst/Managing Director of Life Sciences Group	Member of Senior Research Group, Member of Life Sciences Series Research Team	Small Cap Series – between $1 and $10,000 World Opportunities Series – between $10,001 and $50,000	Between $100,001 and $500,000
Michael J. Magiera, CFA, Senior Analyst/Managing Director of Real Estate Group	Member of Senior Research Group	Small Cap Series – between $10,001 and $50,000 Financial Services Series – between $10,001 and $50,000 World Opportunities Series – between $1 and $10,000	Between $500,001 and $1,000,000
Jeffrey D. McCormack, CFA, Analyst	Member of Life Sciences Series Research Team	None	Between $10,001 and $50,000
John D. Mitchell, CFA, Analyst	Member of Financial Services Series Research Team	Financial Services Series – between $1 and $10,000	Between $50,001 and $100,000
William Moore, CFA, Analyst	Member of Financial Services Series Research Team	None	Between $10,001 and $50,000
James Nawrocki, Senior Analyst	Member of Tax Exempt Series, Core Bond Series, Core Plus Bond Series, and Global Fixed Income Series Research Teams	None	Between $50,001 and $100,000
Robert F. Pickels, CFA, Senior Analyst	Member of Small Cap Series Research Team	Small Cap Series – between $1 and $10,000	Between $100,000 and $500,001
Ben V. Rozin, Junior Analyst*	Member of International Series Research Team	None	Between $10,001 and $50,000
Tariq Siddiqi, Junior Analyst**	Member of Technology Series Research Team	None	Between $10,001 and $50,000
Walter B. Stackow, CFA, Senior Analyst*	Member of Small Cap Series Research Team	None	Between $10,001 and $50,000
Marc Tommasi, Senior Analyst/Managing Director of Global Strategies Group	Member of Senior Research Group, Member of International Series and Global Fixed Income Series Research Teams	None	Between $100,000 and $500,001
Virge J. Trotter, III, CFA, Senior Analyst/Managing Director of Services Group	Member of Senior Research Group, Member of Financial Service Series Research Team	None	Between $100,001 and $500,000
Jeffrey M. Tyburski, CFA, Senior Analyst	Member of Small Cap Series Research Team	Small Cap Series – between $1 and $10,000	Between $100,001 and $500,000
Jay Welles, CFA, Senior Analyst	Member of Technology Series Research Team	None	Between $100,001 and $500,000

* Information as of June 30, 2009

** Information as of December 31, 2009

Compensation. Equity and fixed income analyst compensation is provided in two basic forms: base salary and bonus. Bonuses may be several times the level of base salary for successful analysts. The analyst bonus system has been established to provide a strong incentive for analysts to make investment decisions in the best interest of Manning & Napier Advisors, Inc. clients, including Series shareholders.

In the analyst bonus system, the gains/losses of securities recommended and reviewed by an analyst are measured over trailing 12-month, 24-month and 36-month time periods and compared to several hurdles. In the case of equity analysts, those hurdles include 0% (i.e., positive returns) and the gain/loss of the S&P 500 Index^®. For fixed income analysts, the hurdles are 0% (i.e., positive returns) and the gain/loss on a representative bond benchmark such as the Barclays Capital Aggregate Index. A bonus rate is established for each time period based upon the number of hurdles surpassed by the analyst. The bonus rate could result in a negative, zero, or positive bonus for the period, generally depending upon whether no hurdles, one hurdle, or multiple hurdles are surpassed by an analyst. Bonuses are calculated by multiplying the analyst’s total gain/loss and the bonus rate for each time period and summed over the three time periods. If this calculation results in a negative bonus (e.g., returns below 0% and the benchmark index), then the negative is carried forward until the analyst achieves a positive bonus to offset the negative balance. In total, the bonus system provides incentives to pursue both downside protection and competitive returns versus benchmarks.

Additional compensation may be provided to certain research analysts in the form of fixed bonuses determined by the Co-Directors of Research or based on a portion of the bonuses paid in the analyst bonus system described above. Also, certain employees may be selected to purchase equity in Manning & Napier Advisors, Inc. based upon a combination of performance and tenure. The Advisor may utilize a bonus when recruiting new research employees to help defray relocation costs, if applicable. Equity ownership in the Advisor represents an important incentive for senior investment professionals and serves as another method to align the long-term interest of employees with the best interest of our clients.

Management of Other Portfolios. Manning & Napier Advisors, Inc. does not use a portfolio manager-based structure for the management of investment portfolios. Instead, the Advisor manages mutual funds, other commingled funds and separate accounts using an analyst-driven process. For funds and separate accounts, the investment recommendations made by an equity analyst will be applied to all portfolios with investment objectives for which the recommendation is appropriate. As a result, the investment professionals involved in managing the Series of the Manning & Napier Fund that invest in equities are also responsible for managing all other portfolios for clients of the Advisor that pursue similar investment objectives (“Similarly Managed Accounts”).

Accordingly, each portfolio manager listed below has been assigned portfolio management responsibility for portions of the Advisor’s Similarly Managed Accounts. The Senior Research Group sets broad investment guidelines, and the individual analysts, including those that serve on the Research Teams of Fund Series, select individual securities subject to a peer review process. Because the portfolio management role of these individuals extends across all the Advisor’s Similarly Managed Accounts that hold

equities, the information for each portfolio manager listed below relates to all the Similarly Managed Accounts. None of these accounts is subject to a performance-based fee. Except as noted, this information is as of December 31, 2008.

Name	Registered Investment Companies			Other Pooled Investment Vehicles			Other Accounts
	Number of Accts	Total Assets*		Number of Accts	Total Assets		Number of Accts	Total Assets
Sidharth Abrol***	21	$	10,054,171,341	19	$	2,227,396,302	8,325	$	15,595,173,476
Christian A. Andreach	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Jeffrey S. Coons	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Eric L. Daniels	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Jeffrey W. Donlon	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Brian P. Gambill	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Jeffrey A. Herrmann	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Brian W. Lester	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Jason P. Lisiak	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Michael J. Magiera	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Jeffrey D. McCormack	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
John D. Mitchell	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
William Moore	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Robert F. Pickels	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Ben V. Rozin**	20	$	5,619,998,478	19	$	1,682,222,708	8,065	$	12,076,212,249
Tariq Siddiqi***	21	$	10,054,171,341	19	$	2,227,396,302	8,325	$	15,595,173,476
Walter B. Stackow**	20	$	5,619,998,478	19	$	1,682,222,708	8,065	$	12,076,212,249
Marc Tommasi	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Virge J. Trotter, III	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Jeffrey M. Tyburski	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368
Jay Welles	20	$	3,921,061,077	19	$	1,434,917,389	8,285	$	10,297,412,368

* At times assets of the Other Accounts in column 3 may be invested in these registered investment companies.

** Information as of June 30, 2009.

*** Information as of December 31, 2009.

The Advisor’s fixed income portfolio managers manage the fixed income Series of the Fund, separate accounts with fixed income objectives, and the fixed income portions of mixed asset class investment accounts, other pooled investment vehicles, and separate accounts. Because the portfolio management role of these individuals extends across all the Advisor’s accounts that hold fixed income securities, the information for each portfolio manager listed below relates to all the other accounts under the Advisor’s management. These accounts are not subject to performance-based fees. This information is as of December 31, 2008.

Name	Registered Investment Companies			Other Pooled Investment Vehicles			Other Accounts
	Number of Accts	Total Assets*		Number of Accts	Total Assets		Number of Accts	Total Assets
Jack Bauer	15	$	1,863,792,185	16	$	1,349,273,453	7,642	$	8,788,519,074
Marc Bushallow	15	$	1,863,792,185	16	$	1,349,273,453	7,642	$	8,788,519,074
R. Keith Harwood	15	$	1,863,792,185	16	$	1,349,273,453	7,642	$	8,788,519,074
James Nawrocki	15	$	1,863,792,185	16	$	1,349,273,453	7,642	$	8,788,519,074

Management of Conflicts of Interest. The Advisor has established policies and procedures to ensure that the purchase and sale of securities among all accounts it manages are fairly and equitably allocated.

For the Fund, other pooled investment vehicles, and Other Accounts that have authorized it to do so, the Advisor trades equities and most fixed income investments on an aggregate basis to increase efficiency of execution. Fixed income securities in the Core Bond Series and Core Plus Bond Series are also generally traded on a aggregate basis. In the event of a partially filled order, the Advisor allocates securities first to the Core Bond Series and Core Plus Bond Series and then uses a computer generated randomizer to objectively assign the order of execution among other accounts. Each account that participates in an aggregated order on a particular day will participate at the average security price for that day with all transaction costs shared on a pro-rata basis.

The Advisor’s trading function for equities and most fixed income investments (other than certain fixed income investments, such as new bond issues, as discussed below) is separate from its research function; that is, the individuals recommending and approving security purchases are not the same individuals responsible for executing the trades. For equities and most fixed income securities trades, traders exercise individual discretion in order to get the Advisor’s clients the best possible execution on trades, but guidelines as to security, position size, and price are set by the analysts recommending the security. Proprietary and third-party reporting systems monitor implementation of trading programs across the account base. To remove the incentive for unauthorized trading and speculation in client accounts, traders are not compensated for profits generated, since investment directives are issued from outside the trading area and then merely implemented by the traders. In addition, the compensation program for individuals recommending securities purchases are based on the returns of the particular security recommended, rather than on the performance of any individual account.

For the Tax Exempt Series, High Yield Bond Series, and Global Fixed Income Series, the trading function for the Series is separate from the trading function for other accounts. For these Series, the respective Series’ Research Team identifies the securities to be purchased and a member of the team executes the trades. The team members do not execute trades in the types of securities held in the Series’ portfolios for other accounts managed by the Advisor. Rather, when similar fixed income securities are to be purchased for such other accounts, traders exercise individual discretion in order to get the Advisor’s clients the best possible execution on trades, but strict guidelines as to security, position size, and price are set by the analysts recommending the security.

Occasionally, such as when purchasing new bond issues, a member of the Research Team of the Core Bond Series or Core Plus Bond Series identifies the securities to be purchased and a member of the team executes the trades. With respect to any account of the Advisor not receiving a full allocation, the Advisor may purchase more bonds on behalf of such account in the secondary market. In such case, the purchase price of such bonds will likely be different than that of the initial issue.

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