Consolidated Statements of Changes in Stockholders' Equity - USD ($)	Common Stock [Member]	Additional Paid-in Capital [Member]	Treasury Stock [Member]	AOCI Attributable to Parent [Member]	Retained Earnings [Member]	Total
Balance (in shares) at Dec. 31, 2015	1,665,663		5,423
Balance at Dec. 31, 2015	$ 16,711	$ 239,885,476	$ (1,382,305)	$ (3,858)	$ (218,130,360)	$ 20,385,664
Net loss					(22,053,726)	(22,053,726)
Registered direct common stock offerings (in shares)	532,472
Registered direct common stock offerings	$ 5,325	6,769,691				6,775,016
Conversion of common stock warrants (in shares)	17,857
Conversion of common stock warrants	$ 179	2,321				2,500
Realized and unrealized gains and losses, net, on investments securities				3,858		3,858
Stock-based compensation expense		1,332,838				1,332,838
Issuance of restricted stock (in shares)	9,037
Issuance of restricted stock	$ 90	178,095				178,185
Issuance of common stock out of treasury (in shares)	5,089		(5,089)
Issuance of common stock out of treasury			$ 1,297,117		(1,195,626)	101,491
Balance (in shares) at Dec. 31, 2016	2,230,118		334
Balance at Dec. 31, 2016	$ 22,305	248,168,421	$ (85,188)		(241,379,712)	6,725,826
Net loss					(20,402,176)	(20,402,176)
Registered direct common stock offerings (in shares)	7,296,352
Registered direct common stock offerings	$ 72,964	17,837,437				17,910,401
Conversion of common stock warrants (in shares)	7,617,148
Conversion of common stock warrants	$ 76,171	21,064,133				21,140,304
Realized and unrealized gains and losses, net, on investments securities				(10,164)		(10,164)
Stock-based compensation expense		1,105,245				1,105,245
Issuance of restricted stock (in shares)	3,357
Issuance of restricted stock	$ 34	(34)
Shares issued to satisfy certain obligations (in shares)	130,055
Shares issued to satisfy certain obligations	$ 1,301	233,771				235,072
Modification of warrant exercise prices		345,685				345,685
Deemed dividend related to warrant exercise price modifications		(345,685)				(345,685)
Effect of reverse stock split (in shares)	(65)
Effect of reverse stock split	$ (3)	3
Balance (in shares) at Dec. 31, 2017	17,276,965		334
Balance at Dec. 31, 2017	$ 172,772	$ 288,408,976	$ (85,188)	$ (10,164)	$ (261,781,888)	$ 26,704,508