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Note 12 - Earn-out Milestone Liability (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 12 Months Ended
Jun. 20, 2014
Sep. 30, 2017
Dec. 31, 2016
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Gain (Loss) from Change in Fair Value of Earn out Milestone Liability   $ 1,200,000   $ 649,701 $ 733,186  
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)       2,520,000 1,444,023  
Indefinite-lived in Process Research and Development [Member]            
Gain (Loss) from Change in Fair Value of Earn out Milestone Liability     $ (700,000)      
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)     1,400,000      
EGEN Inc [Member]            
Business Combination, Contingent Consideration Arrangements, Range of Outcomes, Value, High $ 30,400,000     24,400,000    
Business Combination, Consideration Transferred, Liabilities Incurred $ 13,900,000     12,500,000 $ 13,200,000 $ 13,900,000
Gain (Loss) from Change in Fair Value of Earn out Milestone Liability       $ 600,000    
EGEN Inc [Member] | Indefinite-lived in Process Research and Development [Member]            
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)   $ 1,400,000 $ 700,000      
EGEN Inc [Member] | Minimum [Member]            
Risk Adjusted Assessment of Each Milestone 10.00%   50.00% 50.00% 50.00%  
Estimated Time to Achieve the Milestone 1 year 182 days     1 year 109 days 2 years  
EGEN Inc [Member] | Maximum [Member]            
Risk Adjusted Assessment of Each Milestone 67.00%   80.00% 80.00% 80.00%  
Estimated Time to Achieve the Milestone 2 years 182 days     1 year 182 days 2 years 182 days