Note 2 - Financial Condition (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Net Income (Loss) Attributable to Parent	$ (20,402,176)	$ (22,053,726)
Net Cash Provided by (Used in) Operating Activities	(16,642,076)	(18,379,364)
Retained Earnings (Accumulated Deficit)	(261,781,888)	$ (241,379,712)
Cash, Cash Equivalents, and Short-term Investments	24,200,000
Aggregate Offering Price, Additions	$ 13,500,000