Note 8 - Accrued Liabilities - Other Accrued Liabilities (Details) - USD ($)	Sep. 30, 2017	Dec. 31, 2016
Amounts due to contract research organizations and other contractual agreements	$ 907,850	$ 1,115,193
Accrued payroll and related benefits	1,514,253	1,066,751
Accrued professional fees	248,850	259,551
Accrued interest on notes payable		22,241
Other	20,020	20,020
Total	$ 2,690,973	$ 2,483,756