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Note 12 - Earn-out Milestone Liability (Tables)
9 Months Ended
Sep. 30, 2017
Notes Tables  
Schedule of Changes in Earn out Milestone Liabilities [Table Text Block]
Balance at January 1, 2017
  $
13,188,226
 
Non-cash
benefit from the adjustment for the change in fair value included in net loss
   
(1,246,151
)
Balance at
September 30, 2017
  $
12,518,054
 
Schedule of Milestone Risk Adjustment Assessment [Table Text Block]
Date
 
Risk-adjustment Assessment
of each Milestone
   
Discount
Rate
   
Estimated Time
to Achieve
(years)
 
                                 
September
30, 2017
   
35%
to
80%
     
9
%    
1.25
to
1.75
 
June 30, 2017
   
50%
to
80%
     
9
%    
1.50
to
2.00
 
December 31, 2016
   
50%
to
80%
     
9
%    
2.00
to
2.50
 
                                 
September 30,
2016
   
10%
to
75%
     
9
%    
0.50
to
1.75
 
June 30, 2016
   
10%
to
75%
     
9
%    
0.50
to
2.00
 
December 31, 2015
   
10%
to
75%
     
9
%    
0.50
to
2.50