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Note 11 - Stock-based Compensation (Tables)
 9 Months Ended
Sep. 30, 2017
Notes Tables  
Schedule of Share-based Compensation Stock Options and Restricted Stock Awards Activity [Table Text Block]
   
Stock Options
    
Restricted Stock
Awards
    
Weighted
Average
  
Equity Awards
  
Options
Outstanding
    
Weighted
Average
Exercise
Price
    
Non-vested
Restricted
Stock
Outstanding
    
Weighted
Average
Grant
Date
Fair Value
    
Contractual
Terms of
Equity
Awards
(in years)
  
                                         
Equity awards outstanding at December 31, 2016
    
210,023
     $
59.77
      
4,785
     $
37.42
      
 
  
                                         
Equity awards granted
    
513,464
     $
2.69
      
(3,357
)
    
42.20
      
 
  
                                         
Equity awards forfeited, cancelled or expired
    
(43,735
)
   $
164.12
      
(1,428
)
   $
26.18
      
 
  
                                         
Equity awards outstanding at
September 30, 2017
    
679,752
     $
9.94
      
–
     $
–
      
9.40
  
                                         
Aggregate intrinsic value of outstanding awards at
September 30, 2017
   $
–
      
 
     $
–
      
 
      
 
  
                                         
Equity awards exercisable at
September 30, 2017
    
401,920
     $
13.83
      
 
      
 
      
9.13
  
                                         
Aggregate intrinsic value of awards exercisable at
September 30, 2017
   $
–
      
 
      
 
      
 
      
 
  
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
   
Nine
Months Ended
September
30,
  
   
2017
    
2016
  
Risk-free interest rate
    
2.21
%
  
 1.55
–
1.87%
 
Expected volatility
    
90.4
%
  
 87.4
–
89.1%
 
Expected life (in years)
    
10.00
    
 
10.00
 
  
Expected forfeiture rate
    
─
%
  
 
10%
 
 
Expected dividend yield
     ─
%
     ─%