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Note 15 - Subsequent Events (Details Textual) - USD ($)
Jul. 06, 2017
Jun. 30, 2017
Jun. 26, 2017
Jun. 09, 2017
Dec. 31, 2016
Class of Warrant or Right, Number of Securities Called by Warrants or Rights     506,630 790,411  
Class of Warrant or Right, Exercise Price of Warrants or Rights   $ 21.22 $ 1.65 $ 2.70 $ 9.39
July 2017 Direct Offering [Member] | Subsequent Event [Member]          
Stock Issued During Period, Shares, New Issues 2,050,000        
Share Price $ 2.07        
Proceeds from Issuance of Common Stock, Gross $ 4,243,500        
July 2017 Direct Offering [Member] | Subsequent Event [Member] | Pre-Funded Series CCC Warrants [Member]          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights 385,000        
Beneficial Ownership Percentage Threshold 9.99%        
Class of Warrant or Right, Offered Price of Warrants or Rights $ 2.06        
Proceeds from Issuance of Warrants $ 793,100        
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 0.01        
July 2017 Direct Offering [Member] | Subsequent Event [Member] | Series AAA Warrants [Member]          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights 2,435,000        
Warrants Issued, Expiration Period 5 years 182 days        
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 2.07        
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right 1        
Class of Warrant or Right, Exercisable Period 6 years        
July 2017 Direct Offering [Member] | Subsequent Event [Member] | Series BBB Warrants [Member]          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights 2,435,000        
Warrants Issued, Expiration Period 1 year        
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 4.75        
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right 1