Note 7 - Accrued Liabilities - Other Accrued Liabilities (Details) - USD ($)	Jun. 30, 2017	Dec. 31, 2016
Amounts due to contract research organizations and other contractual agreements	$ 804,762	$ 1,115,193
Accrued payroll and related benefits	1,841,208	1,066,751
Accrued professional fees	245,900	259,550
Accrued interest on notes payable		22,241
Other	20,021	20,021
Total	$ 2,911,891	$ 2,483,756