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Note 10 - Stock-based Compensation (Tables)
 6 Months Ended
Jun. 30, 2017
Notes Tables  
Schedule of Share-based Compensation Stock Options and Restricted Stock Awards Activity [Table Text Block]
 
 
Stock Options
 
 
Restricted Stock
Awards
 
 
Weighted
Average
 
Equity Awards
 
Options
Outstanding
 
 
Weighted
Average
Exercise
Price
 
 
Non-vested
Restricted
Stock
Outstanding
 
 
Weighted
Average
Grant
Date
Fair Value
 
 
Contractual
Terms of
Equity
Awards
(in years)
 
                                         
Equity awards outstanding at December 31, 2016
    
210,023
     $
59.77
      
4,785
     $
37.42
      
 
  
                                         
Equity awards granted
    
513,464
     $
2.69
      
–
      
–
      
 
  
                                         
Equity awards forfeited, cancelled or expired
    
(42,545
)
   $
157.97
      
(1,428
)
   $
26.18
      
 
  
                                         
Equity awards outstanding at June 30, 2017
    
680,942
     $
10.59
      
3,357
     $
42.20
      
9.38
  
                                         
Aggregate intrinsic value of outstanding awards at June 30,2017
   $
–
      
 
     $
6,882
      
 
      
 
  
                                         
Equity awards exercisable at
June 30, 2017
    
405,075
     $
14.97
      
 
      
 
      
9.10
  
                                         
Aggregate intrinsic value of awards exercisable at
June 30, 2017
   $
–
      
 
      
 
      
 
      
 
  
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
 
 
Six Months Ended
June 30
,
 
 
 
201
7
 
 
201
6
 
Risk-free interest rate
    
2.21
%
    
1.87
%
Expected volatility
    
90.4
%
    
89.1
%
Expected life (in years)
    
10.00
      
10.00
  
Expected forfeiture rate
    
─
%
    
10
%
Expected dividend yield
     ─
%
     ─
%