Note 3 - Financial Condition and Going Concern (Details Textual) - USD ($)	Feb. 14, 2017	Oct. 02, 2015	Mar. 31, 2017	Dec. 31, 2016	Mar. 31, 2016	Dec. 31, 2015
Retained Earnings (Accumulated Deficit)			$ (246,539,848)	$ (241,379,712)
Cash and Cash Equivalents, at Carrying Value			4,469,576	$ 2,624,162	$ 14,310,542	$ 9,265,144
Notes Payable			$ 1,500,000
Aggregate Offering Price, Additions		$ 7,500,000
February 14, 2017 Public Offering [Member]
Proceeds from Issuance of Common Stock	$ 5,000,000