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Note 18 - Subsequent Events (Details Textual) - USD ($)
$ / shares in Units, $ in Millions
Feb. 14, 2017
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Class of Warrant or Right, Exercise Price of Warrants or Rights   $ 1.88 $ 6.37 $ 8.18
February 2017 Public Offering [Member] | Subsequent Event [Member]        
Stock Issued During Period, Shares, New Issues 19,385,869      
Share Price $ 0.23      
Proceeds from Issuance of Common Stock Gross $ 5.0      
February 2017 Public Offering [Member] | Subsequent Event [Member] | Series AA Warrant [Member]        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights 16,489,402      
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 0.23      
Warrants Issued Expiration Period 5 years      
February 2017 Public Offering [Member] | Subsequent Event [Member] | Pre-Funded Series BB Warrant [Member]        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights 2,600,000      
Class of Warrant or Right, Exercise Price of Warrants or Rights $ 0.01      
Class of Warrant or Right, Offered Price of Warrants or Rights $ 0.22