Note 12 - Earn-out Milestone Liability - Summary of the Changes in the Earn-out Milestone Liability (Details) - USD ($)	12 Months Ended
	Dec. 31, 2016	Dec. 31, 2015
Balance	$ 13,921,412	$ 13,663,710
Non-cash loss from the adjustment for the change in fair value	(733,186)	257,702
Balance at December 31, 2016	$ 13,188,226	$ 13,921,412