Note 7 - Other Accrued Liabilities - Other Accrued Liabilities (Details) - USD ($)	Dec. 31, 2016	Dec. 31, 2015
Amounts due to contract research organizations and other contractual agreements	$ 1,115,193	$ 571,615
Accrued payroll and related benefits	1,066,751	947,078
Accrued professional fees	259,550	319,200
Accrued interest on notes payable	22,241	62,136
Other	20,021	19,740
Total	$ 2,483,756	$ 1,919,769