Note 2 - Financial Condition and Going Concern (Details Textual) - USD ($)			12 Months Ended		47 Months Ended
	Feb. 14, 2017	Oct. 02, 2015	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2016
Net Income (Loss) Attributable to Parent			$ (22,053,726)	$ (22,461,084)
Net Cash Provided by (Used in) Operating Activities			(18,379,364)	(20,830,563)
Retained Earnings (Accumulated Deficit)			(241,379,712)	$ (218,130,360)	$ (241,379,712)
Cash, Cash Equivalents, and Short-term Investments			4,300,000		4,300,000
Notes Payable			2,600,000		2,600,000
February 2017 Public Offering [Member] | Subsequent Event [Member]
Proceeds from Issuance of Common Stock Gross	$ 5,000,000
ATM Agreement [Member]
Proceeds from Issuance of Common Stock Gross					$ 7,600,000
Aggregate Offering Price, Additions		$ 7,500,000	$ 7,500,000