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Note 7 - Other Accrued Liabilities (Tables)
12 Months Ended
Dec. 31, 2016
Notes Tables  
Schedule of Accrued Liabilities [Table Text Block]
 
 
Year
E
nded
December 31,
 
 
 
2016
 
 
2015
 
Amounts due to contract research organizations and other contractual agreements
  $
1,115,193
    $
571,615
 
Accrued payroll and related benefits
   
1,066,751
     
947,078
 
Accrued professional fees
   
259,550
     
319,200
 
Accrued interest on notes payable
   
22,241
     
62,136
 
Other
   
20,021
     
19,740
 
Total
  $
2,483,756
    $
1,919,769