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Note 13 - Earn-out Milestone Liability (Tables)
6 Months Ended
Jun. 30, 2016
Notes Tables  
Schedule of Changes in Earn out Milestone Liabilities [Table Text Block]
Balance at January 1, 2016
  $ 13,921,412  
Non-cash charge from the adjustment for the change in fair value included in net loss
    (106,028
)
Balance at June 30, 2016
  $ 13,815,384  
Schedule of Milestone Risk Adjustment Assessment [Table Text Block]
Date
 
Risk-adjustment Assessment
of each Milestone
 
 
Discount Rate
 
 
Estimated Time
to Achieve (years)
 
                             
June 30, 2016
  10% to 75%       9 %   0.50  to 2.00  
March 31, 2016
  10% to 75%       9 %   0.25  to 2.25  
December 31, 2015
  10% to 75%       9 %   0.50  to 2.50  
June 30, 2015
  10% to 75%       9 %   0.92 to 3.00  
March 31, 2015
  10% to 67%       9 %   1.17  to 6.26  
December 31, 2014
  10% to 75%       9 %   1.25 to 6.50