<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2016-06-30</periodOfReport>

    <issuer>
        <issuerCik>0000749647</issuerCik>
        <issuerName>Celsion CORP</issuerName>
        <issuerTradingSymbol>CLSN</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001392992</rptOwnerCik>
            <rptOwnerName>Chow Pok Yu Augustine</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CELSION CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>997 LENOX DRIVE, SUITE 100</rptOwnerStreet2>
            <rptOwnerCity>LAWRENCEVILLE</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>08648</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Celsion Corporation Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2016-06-30</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>J</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>7539</value>
                    <footnoteId id="F2"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>1.27</value>
                    <footnoteId id="F3"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>20215</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Director received their quarterly director fees in Celsion Corporation Common Stock in lieu of cash.</footnote>
        <footnote id="F2">The number of shares issued to the director was calculated by dividing the second quarter director fees by the ending stock price of $1.27 on June 30, 2016.</footnote>
        <footnote id="F3">Represents the ending stock price for one share of Celsion Corporation Common Stock on the date of receipt.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Timothy J Tumminello, Controller and CAO</signatureName>
        <signatureDate>2016-07-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
