Note 13 - Earn-out Milestone Liability (Tables)

3 Months Ended

Mar. 31, 2016

Notes Tables

Schedule of Milestone Risk Adjustment Assessment [Table Text Block]

Date	Risk-adjustment Assessment of each Milestone				Discount Rate		Estimated Time to Achieve (years)
March 31, 2016		10%	to	75%		9%		0.25	to	2.25
December 31, 2015		10%	to	75%		9%		0.50	to	2.50
March 31, 2015		10%	to	67%		9%		1.17	to	6.26
December 31, 2014		10%	to	75%		9%		1.25	to	6.50

Schedule of Changes in Earn out Milestone Liabilities [Table Text Block]

Balance at January 1, 2016	$	13,921,412
Non-cash charge from the adjustment for the change in fair value included in net loss		302,656
Balance at March 31, 2016	$	14,224,068