Note 12 - Earn-out Milestone Liability (Details) - Summary of the Changes in the Earn-Out Milestone Liability - USD ($)	12 Months Ended
Dec. 31, 2015	Dec. 31, 2014
Summary of the Changes in the Earn-Out Milestone Liability [Abstract]
Balance	$ 13,663,710
Fair value of Earn-Out Payments at date of EGEN Purchase Agreement (Note 5)		$ 13,878,204
Non-cash gain (loss) from the adjustment for the change in fair value	257,702	(213,494)
Balance	$ 13,921,412	$ 13,663,710

Amount of liabilities incurred by the acquirer as part of consideration transferred in a business combination.

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 30
-Section 25
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=6911189&loc=d3e6405-128476

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 30
-Section 30
-Paragraph 7
-URI http://asc.fasb.org/extlink&oid=6911251&loc=d3e6578-128477

Reference 3: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 805
-SubTopic 30
-Section 30
-Paragraph 8
-URI http://asc.fasb.org/extlink&oid=6911251&loc=d3e6613-128477

Name:	us-gaap_BusinessCombinationConsiderationTransferredLiabilitiesIncurred
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration