Note 7 - Other Accrued Liabilities (Details) - Accrued Liabilities - USD ($)	Dec. 31, 2015	Dec. 31, 2014
Accrued Liabilities [Abstract]
Amounts due to Contract Research Organizations and other contractual agreements	$ 571,615	$ 857,730
Accrued payroll and related benefits	947,078	961,440
Accrued professional fees	319,200	502,300
Accrued interest on notes payable	62,136	96,875
Other	19,740	38,020
Total	$ 1,919,769	$ 2,456,365