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Note 12 - Earn-out Milestone Liability (Tables)
12 Months Ended
Dec. 31, 2015
Earn Out Milestone Liability Disclosure [Abstract]  
Schedule of Changes in Earn-Out Milestone Liabilites [Table Text Block]

Balance at January 1, 2014

  $  

Fair value of Earn-Out Payments at date of EGEN Purchase Agreement (Note 5)

    13,878,204  

Non-cash gain from the adjustment for the change in fair value included in 2014 net loss

    (213,494

)

Balance at December 31, 2014

  $ 13,663,710  

Non-cash loss from the adjustment for the change in fair value included in 2015 net loss

    257,702  

Balance at December 31, 2015

  $ 13,921,412