Note 7 - Other Accrued Liabilities (Tables)

12 Months Ended

Dec. 31, 2015

Payables and Accruals [Abstract]

Schedule of Accrued Liabilities [Table Text Block]

	Year Ended December 31,
	2015		2014
Amounts due to Contract Research Organizations and other contractual agreements	$	571,615	$	857,730
Accrued payroll and related benefits		947,078		961,440
Accrued professional fees		319,200		502,300
Accrued interest on notes payable		62,136		96,875
Other		19,740		38,020
Total	$	1,919,769	$	2,456,365