PRUDENTIAL INVESTMENT PORTFOLIOS 6

655 Broad Street, 17^th Floor

Newark, New Jersey 07102

June 28, 2016

VIA EDGAR

U.S. Securities and Exchange Commission

450 Fifth Street, N.W.

Washington, D.C. 20549

Re: 497 Filing for Prudential Investment Portfolios 6

Registration numbers 002-91215 and 811-04024

Dear Sir or Madam:

We are filing today via EDGAR an exhibit under Rule 497 containing interactive data format risk/return summary information. The exhibit mirrors the risk/return summary information in a supplement, dated June 10, 2016 (SEC accession number 0000067590-16-002129), to the Prospectus, dated November 3, 2015 for the Prudential California Muni Income Fund. The purpose of the filing is to submit the 497 filing dated June 10, 2016 in XBRL for the Fund.

Thank you for your attention to this filing. Please direct any questions regarding this filing to the undersigned at (973) 802-6469.

Sincerely,

/s/ Jonathan D. Shain

Jonathan D. Shain

Assistant Secretary