EX-99

Prudential Investment Portfolios 6
Gateway Center Three
100 Mulberry Street, 9th Floor
Newark, NJ 07102-4077



			November 28, 2011

Securities and Exchange Commission
450 Fifth Street, NW
Washington, DC 20549

Re: Rule 24f-2 Notice for Prudential Investment Portfolios 6
		File Nos. 002-91215 and 811-04024

	On behalf of the Prudential Investment Portfolios 6 enclosed
for filing under the Investment Company Act of 1940 is one copy
of the Rule 24f-2 Notice.  This document has been filed using the
EDGAR system.  Should you have any questions, please contact
me at (973) 367-7503.



            Very truly yours,

			            		/s/ Grace C. Torres
						Grace C. Torres
					            Treasurer and Principal
						Financial and Accounting
						Officer

24F-2NT

U.S. SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 24F-2
ANNUAL NOTICE OF SECURITES SOLD PURSUANT TO RULE 24F-2
READ INSTRUCTIONS AT END OF FORM BEFORE PREPARING FORM.
1.	Name and address of issuer:
Prudential Investment Portfolios 6
100 Mulberry Street
Gateway Center Three
Newark, New Jersey 07102-4077

2.	The name of each series or class of securities for which this Form is filed
(If the Form is being filed for all series and classes of securities of the
issuer, check the box but do not list series or classes):[x]
3.	Investment Company Act File Number:  811-04024
Securities Act File Number:  002-91215
4.	(a)	Last day of fiscal year for which this Form is filed:  August 31, 2011
(b)	[ ] Check box if this Form is being filed late (i.e., more than 90
       calendar days after the end of the issuer's fiscal year).
       (See Instruction A.2)

NOTE: IF THE FORM IS BEING FILED LATE, INTEREST MUST BE PAID
ON THE REGISTRATION FEE DUE.
(c)	[ ] Check box if this is the last time the issuer will be filing this Form.
5.	Calculation of registration fee:
(i)	Aggregate sale price of securities
sold during the fiscal year
pursuant
to section 24(f):
$33,166,075
(ii)	Aggregate price of securities
redeemed or repurchased during
the fiscal year:
$47,284,106
(iii)	Aggregate price of securities
redeemed or repurchased during
any PRIOR fiscal year ending no
earlier than October 11, 1995
that
were not previously used to
reduce registration fees payable
to the
Commission:
$321,487,368
(iv)	Total available redemption
credits [add items 5(ii) and
5(iii)]:
$368,771,474
(v)	Net sales -- if item 5(i) is greater
than Item 5(iv) [subtract Item
5(iv)
from Item 5(i)]:
$0
(vi)	Redemption credits available for
use in future years -- if Item 5(i)
is
less than Item 5(iv) [subtract
Item
5(iv) from Item 5(i)]:
$(335,605,399)
(vii)	Multiplier for determining
registration fee (See Instruction
C.9):
x  0.0001146
(viii)	Registration fee due [multiply
Item 5(v) by Item 5(vii)] (enter
"0" if
no fee is due):
= $0

6.	Prepaid Shares
If the response to Item 5(i) was determined by deducting an amount of
securities that were registered under the Securities Act of 1933 pursuant to
rule 24e-2 as in effect before October 11, 1997, then report the amount of
securities (number of shares or other units) deducted here: 0. If there is a
number of shares or other units that were registered pursuant to rule 24e-2
remaining unsold at the end of the fiscal year for which this form is filed
that are available for use by the issuer in future fiscal years, then state
that number here: 0.
7.	Interest due -- if this Form is being filed more than 90 days after the
       end of the issuer's fiscal year (see Instruction D): $0
8.	Total of the amount of the registration fee due plus any interest due
       [Item 5(viii) plus Item 7]: = $0
9.	Date the registration fee and any interest payment was sent to the
       Commission's lockbox depository:  N/A
Method of Delivery:
[   ] Wire Transfer
[   ] Mail or other means


SIGNATURES

       This report has been signed below by the following
persons on behalf of the issuer and in the capacities
and on the dates indicated.

By: (Signature and Title)
/s/ Grace C. Torres

Grace C. Torres

Treasurer and Principal Financial
and Accounting Officer

Date: November 28, 2011

3
NYB 1476879.1

NYB 1476879.1