<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2004-12-15</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000745788</issuerCik>
        <issuerName>VioQuest Pharmaceuticals</issuerName>
        <issuerTradingSymbol>VQPH.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001308379</rptOwnerCik>
            <rptOwnerName>Lipschutz Lester E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>WOLF, BLOCK, SCHORR AND SOLIS-COHEN LLP</rptOwnerStreet1>
            <rptOwnerStreet2>1650 ARCH STREET, 22ND FLOOR</rptOwnerStreet2>
            <rptOwnerCity>PHILADELPHIA</rptOwnerCity>
            <rptOwnerState>PA</rptOwnerState>
            <rptOwnerZipCode>19103</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>No Securities are beneficially owned.  As trustee of (i) the Rosenwald 2000 Family Trusts and (ii) the Lindsay A. Rosenwald Alaska Irrevocable Indenture of Trust and adviser of (i) the Lindsay A. Rosenwald 2000 (Delaware) Irrevocable Indenture of Trust and (ii) the Lindsay A. Rosenwald Rhode Island Irrevocable Indenture of Trust, Mr. Lipschutz has beneficial ownership within the meaning of Rule 13d-3 of more than 10% of the Issuer's securities, but does not have a pecuniary interest in such securities within the meaning of Rule 16a-1(a)(2).</remarks>

    <ownerSignature>
        <signatureName>Lester E. Lipschutz</signatureName>
        <signatureDate>2004-12-16</signatureDate>
    </ownerSignature>
</ownershipDocument>

